Salient Characteristics.doc

Salient Characteristics

C.1 Objective

In an effort to conduct research for the characterization or protein unfolding/re-folding to progress customer and mission related programs at the Weapons and Materials Research Directorate (WMRD) within the Army Research Laboratory (APG), the supply of one (1) capillary differential scanning calorimeter (DSC) and related accessories that cover APG’s entire technical specifications is required.

The Contractor shall supply the aforementioned, in accordance with section C.2 of this document. The Contractor shall include all parts, equipment, material, and delivery to the operating point of use C.2 Requirements

C.2.1 The Contractor shall deliver a quantity of one (1) capillary differential scanning calorimeter (DSC) and related accessories that cover APG’s entire technical specifications is required. The required lead time for delivery is no more than 14 weeks After Receipt of Order (ARO). The delivery location shall be APG, Aberdeen Proving Ground, Maryland 21005. The required one (1) capillary differential scanning calorimeter (DSC) shall meet the following salient characteristics:

The Contractor shall provide one (1) capillary differential scanning calorimeter (DSC) and related accessories in accordance with the following specifications:

1. The capillary DSC shall have a minimum temperature range of 2°C – 130°C.

2. The capillary DSC shall have a minimum scan rate range of 0.1 – 2°C/min.

3. The capillary DSC shall have a capacity ranging between 100 – 350 mL. (microliter, 10^-6 L)

4. The capillary DSC shall have a noble metal capillary (e.g., Pt) to reduce susceptibility to acids, bases, and enzyme or detergent cleaning protocols.

5. The capillary DSC shall have the capacity to accommodate auto sampling capability, taking samples from 96-well plates. The system must have a capacity of at least two 96-well plates.

6. Autosampler 96-well plates must be maintained from 4°C to ambient temperature.

7. The capillary DSC shall have the ability to run cleaning subroutines between samples.

8. The capillary DSC shall have a system response time of 5s or less.

9. The capillary DSC shall have the capability to scan forward (heating) and backward (cooling).

10. The capillary DSC shall have sensitivity sufficient to measure protein folding at 20 mg/L (ca. 6 ng/300 mL).

11. The capillary DSC shall be provided with the capability to degas/minimize dissolved gases in samples prepared in the 96-well plate format.

Contracting Officer:

Template last updated 07/28/2016