RPP-26-12-Prevent ARDS_RFI_SSN_Att A Questions.docx

This file is an attachment containing vendor questions for a Request for Information (RFI) and Sources Sought Notice (SSN) issued by the Department of Health and Human Services Office of the Assistant Secretary for Preparedness and Response (ASPR/BARDA).

The document presents five questions designed to gather market research and refine requirements for host-directed therapeutics intended to prevent progression to acute respiratory distress syndrome (ARDS) in hospitalized patients with viral respiratory infections requiring supplemental oxygen. The questions address: (1) identification of any missing technical activities from the draft RFP relative to the period of performance and proposed solutions; (2) whether the organization provides comparable services competitively in substantial quantities through established catalog or market prices under standard commercial terms; (3) small business status under NAICS 541714; (4) the number of days required to submit a thorough response upon solicitation opening; and (5) additional feedback regarding operational efficiencies or pandemic response considerations for RFP improvements. This RFI/SSN indicates BARDA anticipates making awards to multiple contractors and seeks performers with products in ongoing Phase 3 clinical trials or with supportive Phase 2 data demonstrating efficacy in preventing severe disease worsening in hospitalized viral respiratory infection patients. The underlying opportunity is a pre-solicitation intended to support late-stage clinical development of host-directed therapeutic products.