Amendment_2.pdf

Amendment No. 2

REQUEST FOR PROPOSALS (RFP)

RFP-NIAID-DAIT-NIHAI2016062

“Maintenance of NIAID Specific Pathogen-Free Macaque Breeding Colonies”

Amendment Number: Two (2)

Amendment Issue Date: June 16, 2016

Response Date (Unchanged): September 13, 2016, at 3:00 PM, EST

Issued By: Tom Bahrami

Contracting Officer

OA/DEA/NIAID/NIH/DHHS

5601 Fishers Lane, Room 3C20, MSC 9821 Rockville, Maryland 20852

Points of Contact: PRIMARY:

George Ralis, Contracting Officer ralisg@niaid.nih.gov

Phone: 240-669-5146

SECONDARY:

Tom Bahrami, Contracting Officer bahramit@niaid.nih.gov

Phone: 240-669-5147

Please note that we do NOT intend to extend the due date for submission of proposals as a result of this amendment. The date specified for receipt of proposals remains unchanged.

Offerors must acknowledge receipt of this Amendment by identifying this amendment number and date of the amendment on each copy of the proposal submitted. Failure to receive your acknowledgement may result in the rejection of your proposal. Except as provided herein, all terms and conditions of the solicitation remain unchanged and in full force and effect.

PURPOSE:

AMENDMENT NO. 2 PROVIDES ADDITIONAL INFORMATION TO HELP

PROSPECTIVE OFFERORS ASSESS COLONY HOUSING REQUIREMENTS.

The following approximate size and status of the colony and social groups in 2015 was provided in the RFP under Attachment 6: “Additional Technical Proposal Instructions, Format For Technical Proposal, and Table of Contents” and Attachment 7: “Additional Business Proposal Instructions and Uniform Cost Assumptions”:

mailto:ralisg@niaid.nih.gov mailto:bahramit@niaid.nih.gov

Species Total # Breeder males/ future breeders

Breeder females/ future breeders

Research and future research

Number of groups

Range of group sizes

Rhesus 1100 70/30 380/220 400 33 15-60

Mauritius cynomolgus

330 15/25 100/110 80 10 10-70

Indonesian cynomolgus

424 16/16 125/130 137 12 10-50

Project requirements were also provided in the related Sources Sought Notice [HHS-NIH-NIAID(AI)- SBSS-16-062], posted to Fedbizopps, which indicated:

• Provision of up to approximately 240-300 research-aged SPF animals a year at full colony strength. (For purposes of this contract research-age is at least two (2) years and three (3) years for rhesus and cynomolgus macaques, respectively.)

• Assume an initial colony strength of approximately 1100 Indian-origin rhesus macaques and 420 Indonesian-origin and 330 Mauritius-origin cynomolgus macaques;

• Provision of appropriate housing for the approximate 1850 animals, assuming 55 social groups of between 10 – 70 animals each, and the capability to increase housing as the colonies’ sizes increase to enable provision of the approximate 240-300 research-aged animals each year.

The following information is provided only as an update for planning purposes and does not change the requirements stated in the RFP. The total expectation of 240-300 research aged animals per year of all species/sub-species combined remains. The number per individual colonies below are hypothetical and may vary considerably over time.

JUNE 1, 2016 STATUS OF SOCIAL HOUSING GROUPS AND COLONY AGES

I. Indian origin rhesus macaques (Macaca mulatta):

Approximately 1200 total; assuming 150 animals per year provided for research 2 years old or older (generally ages 2-4 years); however this number may change significantly.

Infants (< 1 year) 123 Yearlings 197 2-3 Years 330

Social Groups: Total of 46; with total of 1150 animals in social housing.

Range of Animal Numbers

Number of Groups

4-14 13 19-25 11 26-35 15 36-44 4 48-58 3

II. Indonesian origin cynomolgus macaques (Macaca fascicularis)

Approximately 470 total; assume approximately 50 per year are targeted for research when colony matures ages 3 years and older (generally ages 3-4 years). Note the 50 per year is only an approximation and may change significantly.

Infants (< 1 year) 18 Yearlings 84 2-3 Years 118 4 Years 44

Social Groups: Total of 12; with a total of approximately 460 in social groups Range of Animal Numbers

Number of Groups

9-13 3 20-36 3 52-61 6

III. Mauritius-origin cynomolgus macaques (Macaca fascicularis)

Approximately 370 total; assume approximately 100 per year are targeted for research when colony is matures ages 3 years and older (generally ages 3-4 years);

however, this number of animals for research may change significantly.

Infants (< 1 year) 18 Yearlings 77 2-3 Years 78 4 Years 59 Social Groups: Total of 11; with a total of approximately 360 in social groups

Range of Animal Numbers

Number of Groups

4-13 4 31-39 4 52-79 3

END OF AMENDMENT No. 2