RFP_75N95022R00106.pdf

NATIONAL INSTITUTE ON DRUG ABUSE

REQUEST FOR PROPOSAL (RFP) No. 75N95022R00106

“Using Rodent Behavioral Models to Identify Substance Abuse

Pharmacotherapies”

Issued by:

Joshua T. Lazarus, Contracting Officer

NIDA Section, Contracts Management Branch Red

Office of Acquisition, NIDA c/o 3WFN MSC 6012

301 N Stonestreet Ave

Bethesda, MD 20892

Point of Contact: Scott Duernberger, Contract Specialist

E-Mail: scott.duernberger@nih.gov

DATE ISSUED: September 21, 2022

PROPOSAL DUE: October 20th, 2022, 1:00 P.M. (Eastern Time)

The National Institute on Drug Abuse (NIDA) invites you to submit a proposal responding to the requirements of this RFP No. 75N95022R00106 for the “Using Rodent Behavioral Models to Identify Substance Abuse

Pharmacotherapies”.

This Request for Proposal is released under FULL AND OPEN Competition Procedures.

Please refer to Section M for mandatory criteria. All offerors must be REGISTERED and have an ACTIVE

System for Award Management http://www.sam.gov/ (www.sam.gov) account at the time an offer/proposal is submitted to the Government. All offerors registered in the System for Award Management http://www.sam.gov/

(www.sam.gov) must be in full compliance with FAR 52.204-13 System for Award Management Maintenance to be eligible to submit a proposal. The Government will not accept proposals from offerors who do not meet the SAM requirement.

NIDA prepared this Request for Proposal in accordance with the Uniform Contract Format prescribed for

Government Wide application by the Federal Acquisition Regulation (FAR). The Uniform Contract Format is both a Request for Proposal and a contract award document. The resulting contract will consist of Parts I, II, and III of the Uniform Contract Format.

NIDA anticipates the award of a fixed-price level of effort contract for a base period of approximately 12 months with potential for four 1-year option years and option quantities. We will fund options dependent on the previous year's performance and the availability of funds. NIDA anticipates that the period of performance of the base contract will be from January 4, 2022, through January 3, 2023.

Capable offerors must respond with technical and pricing proposals for the entire project and total period of performance, including the option years and the additional option tasks. Offerors must include separate pricing for each individual option period and option quantity. Offerors shall respond with technical and cost/price proposals based on the assumptions provided in Sections C and L.

General

Part IV of the RFP contains instructions, provisions, and evaluation factors for the submission and review of proposals. Attachment 2 is a "Proposal Intent Response Sheet." Please complete this form and return it to the below address on or before 1:00 p.m. on Tuesday, October 4th, 2022. The balance of Parts I, II, and III contain mailto:scott.duernberger@nih.gov http://www.sam.gov/ http://www.sam.gov/ http://www.sam.gov/ http://www.sam.gov/ provisions, clauses, and special requirements which will be made a part of any resultant award. Please review these sections and consider their impact on performance, capability, technical, and cost factors as you develop your proposal. Do not fill in blanks or otherwise complete portions of Parts I, II, and III which appear to require additional information. The Government will complete these items prior to contract award and, if negotiations are conducted, will tailor those items through final negotiations.

Requests for Information (RFIs)

Requests for clarification, additional information, or correction must be made in writing to the Contracting

Officer. RFIs must be submitted on or before 1:00 p.m. on Tuesday, October 4th, 2022. RFIs may be submitted by e-mail to scott.duernberger@nih.gov with the subject line “RFI – RFP 75N95022R00106.”

NOTE: A permanent approval for class deviations to FAR 52.227-11, Patent Rights and FAR Clause 52.227-17, Rights in Data- Special Works was issued for use by NIDA when procuring contracts for confidential routine screening, pharmacokinetic, pharmaceutic and product development services for compounds under NIDA’s

Medication Development Program. NIDA intends to include these clause deviations in any resulting contract from this solicitation, subject to approval of a determination of exceptional circumstances by the Director, NIH. The deviation clauses are set forth in ARTICLE I.4 of this solicitation. Please review and provide any comments on these deviated clauses in the offeror's questions due on or before 1:00 p.m. on Tuesday, October 4th, 2022.

The Technical Proposal

Offerors shall complete and attach the “Technical Proposal Cover Sheet” for each copy of their technical proposal.

It is important that you list all professional personnel and organizations named in the proposal that have any role in the proposed work. This includes your staff, subcontractors, collaborating organizations, and consultants. Show organization affiliation(s) for every person named. You may use extra sheets, as needed, following the format shown in the Technical Proposal Cover Sheet. We will use this information to ensure that no conflicts of interest exist with the selected review committee members. Please note that Technical proposals are limited to 200 pages total, any technical submission pages in excess of the 200 page shall not be reviewed for evaluation.

Technical Proposal are detailed in Section L.2.b.

The Business Proposal

You must have an authorized organizational official sign your Business Proposal. It must contain a detailed breakdown of costs by year and individual options. For each cost category/element, provide an explanation of the basis for all costs, and provide documentation to support these costs. We direct special attention to Breakdown of

Proposed Estimated Costs w/Excel Spreadsheet contained in the Business Proposal Cost Information, Attachment

11. Please submit business proposals with a spreadsheet in this format. Use of the above format will hasten review and award. A PDF copy of the spreadsheet must be included in the Business Proposal. Additionally, an electronic copy should be provided utilizing NIH’s Secure File Transfer program at https://secureemail.nih.gov.

Do not send encrypted files.

A completed Form NIH-2043, “Proposal Summary and Data Record” must be included with the Business Proposal.

Include the e-mail addresses of both the Principal Investigator and the responsible business representative on the form. Note that in addition to telephone and fax numbers, you should include the e-mail addresses of both the

Principal Investigator and the responsible business representative on the form.

The Offeror must submit its Small Business Subcontracting Plan, Travel Policy, Total Compensation Plan and

Annual Report with the initial Business Proposal. See Section L.2.c. for additional detail.

mailto:scott.duernberger@nih.gov http://ocm.od.nih.gov/contracts/rfps/TechCov.htm https://secureemail.nih.gov/ http://rcb.cancer.gov/rcb-internet/forms/2043.pdf

Submitting a Proposal

Proposals must be submitted via the electronic Contract Proposal Submission (eCPS) website (https://ecps.nih.gov) no later than October 20th, 2022, 1:00 P.M Eastern Time. Proposals submitted by facsimile, e-mail, or hard copy will not be accepted. An official authorized to bind your organization must sign the proposal.

Offerors are solely responsible for submitting proposals in a timely manner. Please note that creating an account to submit may take up to three (3) business days. Please plan accordingly. Additional instructions on how to submit a proposal via eCPS can be found at https://ecps.nih.gov/home/howto and in Attachment

01.

All notices related to this solicitation will be posted on SAM.gov (https://www.sam.gov) as well as the NIDA

Contracts Home Page https://www.drugabuse.gov/funding/funding-opportunities/nida-requests-contract-proposals-rfps. If you would like to receive e-mail notifications of updates to this solicitation, please register with www.SAM.gov.

In accordance with FAR 15.306(a)(3) and FAR 52.215-1, the Government intends to evaluate proposals and award a contract without discussions. Therefore, your initial proposal should contain the best terms from cost or price and technical standpoints. The Government does, however, reserve the right to conduct discussions if the

Contracting Officer determines them to be necessary.

Disclaimers

This RFP does not commit the Government to pay the costs for the preparation and submission of a proposal. The

Contracting Officer is the only individual who legally can commit the Government to the expenditure of public funds in connection with this acquisition.

Any contract award for this requirement is contingent on the availability of funds (see FAR 52.232-18, Availability of Funds – April 1984).

The National Institute on Drug Abuse appreciates your interest in this RFP and looks forward to receipt of your proposal. Requests for any information concerning this RFP should be directed to Scott Duernberger, Contract

Specialist, scott.duernberger@nih.gov, or the undersigned, at the NIDA Section, Contracts Management Branch

Red. We may be reached at (301) 443-6677; collect calls will not be accepted. Discussions with any other individual outside the NIDA Section, Contracts Management Branch Red should not occur.

Sincerely, Joshua T. Lazarus, Contracting Officer

National Institutes of Health, Office of Acquisition, NIDA https://ecps.nih.gov/ https://ecps.nih.gov/home/howto https://www.sam.gov/ https://www.drugabuse.gov/funding/funding-opportunities/nida-requests-contract-proposals-rfps https://www.drugabuse.gov/funding/funding-opportunities/nida-requests-contract-proposals-rfps mailto:scott.duernberger@nih.gov

- 1 -

SOLICITATION

SECTION A - SOLICITATION/CONTRACT FORM

1. Requisition or other Purchase Authority: P.L. 102-321 as amended.

2. Request for Proposal (RFP) Number:

75N95022R00106

3. Issue Date:

September 21, 2022

4. Set Aside:

[X] No

[ ] Yes See Part IV Section L

5. Title : Using Rodent Behavioral Models to Identify Substance Abuse Pharmacotherapies

6. ISSUED BY:

NIDA Section, Contracts Management Branch Red Office of Acquisitions, National Institute on Drug Abuse, NIH c/o 3WFN MSC 6012 301 N Stonestreet Ave Bethesda, MD 20892

7. SUBMIT OFFERS TO:

See Part III, Section J, "Packaging and Delivery of the Proposals for Use with the NIH electronic Contract Proposal Submission (eCPS) Website," ATTACHMENT 1 of this Solicitation.

8. Proposals for furnishing the supplies and/or services in THE SCHEDULE will be received at the place specified in, and in the number of copies specified in Attachment 1, "Packaging and Delivery of the Proposal," until 1:00 PM local time on October 20, 2022. Offers will be valid for 120 days unless a different period is specified by the offeror on the Attachment entitled, "Proposal Summary and Data Record, NIH 2043.

9. This solicitation requires delivery of proposals as stated in ATTACHMENT 1, "PACKAGING AND DELIVERY OF THE PROPOSAL." If proposals are required to be delivered to two different locations, the OFFICIAL POINT OF RECEIPT for determining TIMELY DELIVERY is the address provided for the OFFICE OF ACQUISITIONS.

IF YOUR PROPOSAL IS NOT RECEIVED BY THE CONTRACTING OFFICER OR HIS DESIGNEE AT THE PLACE AND TIME SPECIFIED FOR THE OFFICE OF ACQUISITIONS, THEN IT WILL BE CONSIDERED LATE AND HANDLED IN ACCORDANCE WITH subparagraph (c)(3) of FAR Clause 52.215-1, Instructions to Offerors--Competitive Acquisition," LOCATED IN SECTION L.1. OF THIS SOLICITATION.

10. Offeror must be registered in the System for Award Management (SAM) prior to award of a contract. Offerors must access the CCR through The System for Award Management (SAM) at https://www.sam.gov/SAM/.

11. FOR INFORMATION CALL: Scott Duernberger, Contract Specialist

PHONE: 301-594-0670

e-MAIL: scott.duernberger@nih.gov

COLLECT CALLS WILL NOT BE ACCEPTED.

Josh Lazarus Contracting Officer

RFP: 75N95022R00106

Ref: N01DA-23-8936 https://www.sam.gov/SAM/

- 2 -

Office of Acquisitions

RFP: 75N95022R00106

- 3 -

RFP TABLE OF CONTENTS

PART I - THE SCHEDULE

SECTION A - SOLICITATION/CONTRACT FORM

SECTION B - SUPPLIES OR SERVICES AND PRICES/COSTS

SECTION C - DESCRIPTION/SPECIFICATIONS/WORK STATEMENT

SECTION D - PACKAGING, MARKING AND SHIPPING

SECTION E - INSPECTION AND ACCEPTANCE

SECTION F - DELIVERIES OR PERFORMANCE

SECTION G - CONTRACT ADMINISTRATION DATA

SECTION H - SPECIAL CONTRACT REQUIREMENTS

PART II - CONTRACT CLAUSES

SECTION I - CONTRACT CLAUSES

ARTICLE I.1. GENERAL CLAUSES FOR A NEGOTIATED FIXED-PRICE RESEARCH AND DEVELOPMENT

CONTRACT

ARTICLE I.2. AUTHORIZED SUBSTITUTIONS OF CLAUSES

ARTICLE I.3. ADDITIONAL CONTRACT CLAUSES

ARTICLE I.4. ADDITIONAL FAR CONTRACT CLAUSES INCLUDED IN FULL TEXT

ARTICLE I.5. SERVICE CONTRACT LABOR STANDARDS

PART III - LIST OF DOCUMENTS, EXHIBITS AND OTHER ATTACHMENTS

SECTION J - LIST OF ATTACHMENTS

SOLICITATION ATTACHMENTS

TECHNICAL PROPOSAL ATTACHMENTS

BUSINESS PROPOSAL ATTACHMENTS

INFORMATIONAL ATTACHMENTS

PART IV - REPRESENTATIONS AND INSTRUCTIONS

SECTION K - REPRESENTATIONS, CERTIFICATIONS AND OTHER STATEMENTS OF OFFERORS

SECTION L - INSTRUCTIONS, CONDITIONS, AND NOTICES TO OFFERORS

1. GENERAL INFORMATION

a. INSTRUCTIONS TO OFFERORS--COMPETITIVE ACQUISITION

b. NAICS CODE AND SIZE STANDARD

c. TYPE OF CONTRACT AND NUMBER OF AWARDS

d. LEVEL OF EFFORT

e. COMMITMENT OF PUBLIC FUNDS

f. PROMOTING EFFICIENT SPENDING

g. COMMUNICATIONS PRIOR TO CONTRACT AWARD

h. RELEASE OF INFORMATION

i. CONCEPT REVIEW

j. PREPARATION COSTS

k. SERVICE OF PROTEST

2. INSTRUCTIONS TO OFFERORS

a. GENERAL INSTRUCTIONS

1. Contract Type and General Clauses

2. Authorized Official and Submission of Proposal

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3. Proposal Summary and Data Record (NIH-2043)

4. Separation of Technical and Business Proposals

5. Alternate Proposals

6. Evaluation of Proposals

7. Potential Award Without Discussions

8. Use of the Metric System of Measurement

9. Privacy Act - Treatment of Proposal Information

10. Selection of Offerors

11. Institutional Responsibility Regarding Investigator Conflicts of Interest

12. ROTC Access and Federal Military Recruiting on Campus

14. Past Performance Information

15. Electronic Information Technology Accessibility Notice, HHSAR 352.239-73 (December 2015)

b. TECHNICAL PROPOSAL INSTRUCTIONS

1. Technical Discussions

2. Other Considerations

3. Technical Evaluation

4. Care of Live Vertebrate Animals

5. Research Involving Live Vertebrate Animals

c. BUSINESS PROPOSAL INSTRUCTIONS

1. Basic Cost/Price Information

2. Proposal Cover Sheet

3. Information Other than Cost or Pricing Data

4. Requirements for Cost or Pricing Data or Information Other than Cost and Pricing Data

5. Salary Rate Limitation

6. Small Business Subcontracting Plan

7. Mentor Protege Program, HHSAR 352.219-70

8. HUBZone Small Business Concerns

9. Other Administrative Data

10. Qualifications of the Offeror

11. Subcontractors

12. Proposer's Annual Financial Report

13. Travel Costs/Travel Policy

SECTION M - EVALUATION FACTORS FOR AWARD

1. GENERAL

2. COST/PRICE EVALUATION

3. LIVE VERTEBRATE ANIMALS EVALUATION

4. MANDATORY QUALIFICATION CRITERIA

5. EVALUATION OF OPTIONS

6. TECHNICAL EVALUATION FACTORS

7. EVALUATION OF ELECTRONIC AND INFORMATION TECHNOLOGY ACCESSIBILITY- SECTION

8. PAST PERFORMANCE FACTOR

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PART I - THE SCHEDULE

THE INFORMATION SET FORTH IN SECTION A - SOLICITATION/CONTRACT FORM, HEREIN CONTAINS IMPORTANT INFORMATION FOR ANY OFFEROR INTERESTED IN RESPONDING TO THIS SOLICITATION.

ANY CONTRACT RESULTING FROM THIS SOLICITATION WILL INCLUDE IN ITS SECTION A - SOLICITATION/ CONTRACT FORM, ACCOUNTING, APPROPRIATION AND GENERAL INFORMATION APPLICABLE TO THE

CONTRACT AWARD.

THE CONTRACT SCHEDULE SET FORTH IN SECTIONS B THROUGH H, HEREIN, CONTAINS CONTRACTUAL INFORMATION PERTINENT TO THIS SOLICITATION. IT IS NOT AN EXACT REPRESENTATION OF THE CONTRACT DOCUMENT THAT WILL BE AWARDED AS A RESULT OF THIS SOLICITATION. THE CONTRACT COST OR PRICE AND OTHER CONTRACTUAL PROVISIONS PERTINENT TO THE OFFEROR (i.e., those relating to the organizational structure [e.g., Non-Profit, Commercial] and specific cost authorizations unique to the Offeror's proposal and requiring Contracting Officer Prior Approval) WILL BE DISCUSSED IN THE NEGOTIATION PROCESS AND WILL BE INCLUDED IN THE RESULTANT CONTRACT. THE ENCLOSED CONTRACT SCHEDULE IS

INTENDED TO PROVIDE THE OFFEROR WITH THE NECESSARY INFORMATION TO UNDERSTAND THE

TERMS AND CONDITIONS OF THE RESULTANT CONTRACT.

SECTION B - SUPPLIES OR SERVICES AND PRICES/COSTS

ARTICLE B.1. BRIEF DESCRIPTION OF SUPPLIES OR SERVICES

The purpose of this contract will be to provide testing capacity in the following rodent in vivo assays: mouse locomotor activity, rat drug discrimination, mouse conditioned place preference, and rat self-administration. These models are part of a larger pre-clinical testing hierarchy supported by separate contracts that fund the evaluation of compounds in the rat intracranial self-stimulation assay, various models of relapse to drug-seeking behavior, as well as the primate drug discrimination and self-administration models.

ARTICLE B.2. ESTIMATED PRICE

The estimated price of this contract is $ .

The prices set forth in this ARTICLE will cover the estimated contract period January 04, 2023 through January 03, 2028.

Upon delivery and acceptance of the services described in SECTION C of this contract and identified in the schedule of charges below, the Government shall pay to the Contractor the unit price set forth below. This is a fixed-price per hour contract. The contractor shall be reimbursed a fixed-price per hour rate for completing the tasks detailed in Article C.1 Statement of Work.

Description of Service (Direct Labor Hours)

Quantity (Hours)

Unit Price (Hourly Rate)

Total ($)

Professional (includes Principle Investigator)

Research Associate 1128

Research Technician 7520

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ARTICLE B.3. OPTION PRICES

a. Unless the Government exercises its option pursuant to the option clause referenced in ARTICLE I.3.

ADDITIONAL CONTRACT CLAUSES, this contract consists only of the Base Period specified in the Statement of Work as defined in SECTIONS C and F, for the price set forth in ARTICLE B.2. of this contract.

b. Pursuant to FAR Clause 52.217-7 Option for Increased Quantity- Separately Priced Line Item and FAR Clause 52.217-9 Option to Extend the Term of the Contract set forth in ARTICLE I.3. and ARTICLE I.4. ADDITIONAL CONTRACT CLAUSES of this contract, the Government may, by unilateral contract modification, require the Contractor to perform the Option Period(s) specified in the Statement of Work as defined in SECTIONS C and F of this contract. If the Government exercises this/these option(s), notice must be given before the expiration date of the contract. Specific information regarding the time frame for this notice is set forth in the OPTION PROVISION Article in SECTION H of this contract. The fixed price of this contract will be increased as set forth in paragraph c., below.

c. Upon the delivery and acceptance of the Option Itemdescribed in SECTION C of the contract and identified in the schedule of charges below, the Government shall pay the Contractor the unit price(s) set forth below:

Option Period Description of Option Item(s) -or- Option Service(s)

Quantity (Units) -or- Minimum & Maximum

Unit Price Total Price of Option -or- Minimum & Maximum

Option Period 1, Contract Year 2

Professional (includes Principle Investigator)

Option Period 1, Contract Year 2

Research Associate

Option Period 1, Contract Year 2

Research Technicians

Option Period 2, Contract Year 3

Professional (includes Principle Investigator)

Option Period 2, Contract Year 3

Research Associate

Option Period 2, Contract Year 3

Research Technicians

Option Period 3, Contract Year 4

Professional (includes Principle Investigator

Option Period 3, Contract Year 4

Research Associate

Option Period 3, Contract Year 4

Research Technicians

Option Period 4, Contract Year 5

Professional (includes Principle Investigator

Option Period 4, Contract Year 5

Research Associate

Option Period 4, Contract Year 5

Research Technicians

Labor Category Period 1 (Option Period

1) Year 2

(Option Period

1) Year 3

(Option Period1) Year 4

(Option Period 1)Year 5

Option Quantities

Quantity Option A 1880 1880 1880 1880 1880

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Labor Category Period 1 (Option Period

1) Year 2

(Option Period

1) Year 3

(Option Period1) Year 4

(Option Period 1)Year 5

Quantity Option B 1880 1880 1880 1880 1880

Quantity Option C $50,000 $50,000 $50,000 $50,000 $50,000

Quantity Option D $100,000 $100,000 $100,000 $100,000 $100,000

Quantity Option E $200,000 $200,000 $200,000 $200,000 $200,000

Quantity Option F $10,000 $10,000 $10,000 $10,000 $10,000

Quantity Option G $25,000 $25,000 $25,000 $25,000 $25,000

For Options C to G the increase will be calculated by dividing the amount by 1,000, and will be dispersed over the next 1,000 labor hours.

Example: If in Year 1 the Government requires $50,000 in equipment (Option C) , the $50,000 will result in an increase of $50 per labor hour across the next 1,000 expended hours.

For Options A and B the labor rate used will match the unit price for the corresponding labor category and year

ARTICLE B.4. PROVISIONS APPLICABLE TO DIRECT COSTS

This article will prohibit or restrict the use of contract funds, unless otherwise approved by the Contracting Officer. The following is a list of items that may be included in the resultant contract as applicable. 1) Conferences & Meetings, 2) Food for Meals, Light Refreshments & Beverages, 3) Promotional Items, 4) Acquisition, by purchase or lease, of any interest in real property; 5) Special rearrangement or alteration of facilities; 6) Purchase or lease of any item of general purpose office furniture or office equipment regardless of dollar value; 7) Travel Costs including Foreign Travel; 8) Consultant Costs; 9) Subcontract Costs; 10) Patient Care Costs; 11) Accountable Government Property; 12) Printing costs; and 13) Research Funding.

ARTICLE B.5. ADVANCE UNDERSTANDINGS

Specific elements of cost, which normally require prior written approval of the Contracting Officer before incurrence of the cost (e.g., foreign travel, consultant fees, subcontracts) will be included in this Article if the Contracting Officer has granted his/her approval prior to contract award.

RFP: 75N95022R00106

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SECTION C - DESCRIPTION/SPECIFICATIONS/WORK STATEMENT

ARTICLE C.1. STATEMENT OF WORK

a. Independently and not as an agent of the Government, the Contractor shall be required to furnish all the necessary services, qualified personnel, material, equipment, and facilities, not otherwise provided by the Government, as needed to perform the Statement of Work, attached hereto and made a part of this Solicitation (See SECTION J - List of Attachments).

ARTICLE C.2. REPORTING REQUIREMENTS

All reports required herein shall be submitted in electronic format as designated in Section F of the RFP.

All electronic reports submitted shall be compliant with Section 508 of the Rehabilitation Act of 1973. Additional information about testing documents for Section 508 compliance, including guidance and specific checklists, by application, can be found at: http://www.hhs.gov/web/508/index.html and at: https://www.section508.gov/create/ documents, "Create Accessible Documents."

a. Technical Progress Reports

In addition to the required reports set forth elsewhere in this Schedule, the preparation and submission of regularly recurring Technical Progress Reports will be required in any contract resulting from this solicitation. These reports will require descriptive information about the activities undertaken during the reporting period and will require information about planned activities for future reporting periods. The frequency and specific content of these reports will be determined prior to contract award.

For proposal preparation purposes only, it is estimated that these reports will be required as designated in Section F of the RFP.

[X] Monthly [ ] Quarterly [ ] Semi-Annually [X] Annually [ ] Annually (with a requirement for a Draft Annual Report) [X] Final - Upon final completion of the contract [ ] Final - Upon final completion of the contract (with a requirement for a Draft Final Report)

1. Monthly Progress Status Reports: Within the first 5 business days of each calendar month, the Contractor shall submit to the Contracting Officer Representative (COR) an electronic copy in Microsoft Word or PDF format of a report on activities during the preceding month. These reports shall be transmitted electronically and securely via a means designated by the COR. These reports, in tabular form, will briefly summarize the results obtained on compounds evaluated for the Addiction Treatment Discovery Program (ATDP) under the cocaine, methamphetamine and THC locomotor activity (standard or time course) assays; the cocaine, methamphetamine, delta-9-tetrahydrocannabinol (THC), nicotine and morphine drug discrimination (substitution, antagonism, or time course) assays; and the nicotine self-administration tests. The updated Compound Receipt and Compound Evaluation Tracking Logs (Task 6 and 7) relevant to the month under report shall also be included, with new information highlighted in some manner, for purposes of clarity. These reports shall also contain a section in which problems encountered are addressed and where recommended solutions are outlined. Where appropriate, a summary of any meetings which occurred during the month under report shall be included.

2. Compound Final Study Reports: For each compound evaluated under Tasks 1, 2, 3, 4, and 5, the Contractor shall submit to the COR an electronic copy in Microsoft Word or PDF format of a compound final study report within 14 business days of the completion of each compound studied. These reports shall be transmitted electronically and

RFP: 75N95022R00106

Ref: N01DA-23-8936 http://www.hhs.gov/web/508/index.html https://www.section508.gov/create/documents https://www.section508.gov/create/documents

- 9 -securely via a means designated by the COR. The purpose of these reports is to inform the ATDP, as well as the submitter whose compound has been tested, of the results obtained. These reports shall accurately and completely outline the results of each individual test on each test compound. A prototype of these reports will be provided to the Contractor by the COR. The format of the report shall include: title page, abstract, methods, data analysis, results and, graphs and tables.

3. Annual Progress Report(s): The Contractor shall submit Annual Progress Report(s), which shall be due on or before the 14th business day following the end of each year. These reports shall summarize the activities during the year under report. These reports, in tabular form, shall contain a list of all compounds evaluated, the specific test(s) conducted, and all results obtained. In addition, updated Compound Receipt and Compound Evaluation Tracking Logs (Task 6 and 7) for the year under report shall be included. These reports shall also contain a section in which problems encountered during the year and the solutions taken are summarized. Protocols for all studies shall be included. The Contractor shall send one copy to the COR and one copy to the Contracting Officer.

4, Electronic Data Transfer: As described under Task 8, the Contractor shall electronically transfer new data via a means designated by the COR when instructed by the COR. In lieu of the above, the COR may require the Contractor to submit the updated table by e-mail.

5. Laboratory Records and Compounds: On or before contract expiration, the Contractor shall send the laboratory records listed under Task 10 to the COR. Test compounds shall be returned to a NIDA contracted facility to be identified by the COR.

Final Report Summary of Salient Results

The Contractor will be required to submit a final report on or before the contract expiration date. This report is to incude a summation of the work performed and results obtained for the entire contract period of performance. This report shall be in sufficient detail to comprehensively describe how the contractor acheived the contract objectives. An annual report will not be required for the period when the final report is due.

The Contractor will be required to prepare and submit, with the final report, a summary (not to exceed 200 words) of salient results achieved during the performance of the contract. This report will be required on or before the expiration date of the contract.

b. Other Reports/Deliverables

1. Reporting of Financial Conflict of Interest (FCOI)

All reports and documentation required by 45 CFR Part 94, Responsible Prospective Contractors including, but not limited to, the New FCOI Report, Annual FCOI Report, Revised FCOI Report, and the Mitigation Report, shall be submitted to the Contracting Officer in Electronic format. Thereafter, reports shall be due in accordance with the regulatory compliance requirements in 45 CFR Part 94.

45 CFR Part 94 is available at: https://www.ecfr.gov/current/title-45/part-94. See Part 94.5, Responsibilities of Institutions regarding Investigator financial conflicts of interest for complete information on reporting requirements.

(Reference the INSTITUTIONAL RESPONSIBILITY REGARDING INVESTIGATOR FINANCIAL CONFLICTS OF INTEREST Article in SECTION H of this contract.)

2. Section 508 Annual Report

The Contractor must submit an annual Section 508 report in accordance with the schedule set forth by the Contracting Officer (CO)/Contracting Officer's Representative (COR). The Section 508 Report Template and Instructions for completing the report are available at: https://www.hhs.gov/sites/ default/files/web/508/contracting/technology/section_508_annual_report.doc.

RFP: 75N95022R00106

Ref: N01DA-23-8936 https://www.ecfr.gov/current/title-45/part-94 https://www.hhs.gov/sites/default/files/web/508/contracting/technology/section_508_annual_report.doc https://www.hhs.gov/sites/default/files/web/508/contracting/technology/section_508_annual_report.doc

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ARTICLE C.3. INVENTION REPORTING REQUIREMENT

All reports and documentation required by FAR Clause 52.227-11, Patent Rights-Ownership by the Contractor including, but not limited to, the invention disclosure report, the confirmatory license, and the Government support certification, shall be directed to the Division of Extramural Inventions and Technology Resources (DEITR), OPERA, OER, NIH, 6705 Rockledge Drive, Suite 310, MSC 7980, Bethesda, Maryland 20892-7980 (Telephone: 301-435-1986). In addition, one copy of an annual utilization report, and a copy of the final invention statement, shall be submitted to the Contracting Officer. The final invention statement (see FAR 27.303(b)(2)(ii)) shall be submitted to the Contracting Officer on the expiration date of the contract.

The annual utilization report shall be submitted in accordance with the DELIVERIES Article in SECTION F of this contract. The final invention statement (see FAR 27.303(b)(2)(ii)) shall be submitted on the expiration date of the contract. All reports shall be sent to the following address:

NIDA Section, Contracts Management Branch Red Office of Acquisitions, NIDA National Institute on Drug Abuse, NIH Office of Acquisition c/o 3WFN MSC 6012 301 N Stonestreet Ave Bethesda, Maryland 20892

If no invention is disclosed or no activity has occurred on a previously disclosed invention during the applicable reporting period, a negative report shall be submitted to the Contracting Officer at the address listed above.

To assist contractors in complying with invention reporting requirements of the clause, the NIH has developed "Interagency Edison," an electronic invention reporting system. Use of Interagency Edison is required as it streamlines the reporting process and greatly reduces paperwork. Access to the system is through a secure interactive Web site to ensure that all information submitted is protected. Interagency Edison and information relating to the capabilities of the system can be obtained from the Web ( http://www.iedison.gov), or by contacting the Extramural Inventions and Technology Resources Branch, OPERA, NIH.

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RFP: 75N95022R00106

http://www.iedison.gov

- 11 -

SECTION D - PACKAGING, MARKING AND SHIPPING

All deliverables required under this contract shall be packaged, marked and shipped in accordance with Government specifications. At a minimum, all deliverables shall be marked with the contract number and Contractor name. The Contractor shall guarantee that all required materials shall be delivered in immediate usable and acceptable condition.

[Remainder of the Page Left Intentionally Blank]

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SECTION E - INSPECTION AND ACCEPTANCE

a. The Contracting Officer or the duly authorized representative will perform inspection and acceptance of materials and services to be provided.

b. For the purpose of this SECTION, the Contracting Officer's Representative , whose position is described in Section G, is the authorized representative of the Contracting Officer.

c. Inspection and acceptance will be performed at:

National Institute on Drug Abuse National Institutes of Health c/o 3WFN MSC 6012 301 N Stonestreet Ave Bethesda, MD 20892

Acceptance may be presumed unless otherwise indicated in writing by the Contracting Officer or the duly authorized representative within 30 days of receipt.

The Government reserves the right to an Inspection period of calendar days, unless a different time period is stated when (the Record of Call/elsewhere in the contract). The receiving report, completed and signed by the appropriate official, constitutes acceptance and shall be acknowledged to the payment office (OFM).

d. This contract incorporates the following clause by reference, with the same force and effect as if it were given in full text. Upon request, the Contracting Officer will make its full text available.

FAR Clause 52.246-9, Inspection of Research and Development (Short Form) (April 1984).

{Remainder of the Page Left Intentionally Blank}

- 13 -

SECTION F - DELIVERIES OR PERFORMANCE

ARTICLE F.1. PERIOD OF PERFORMANCE

a. The estimated period of performance of this contract shall be from January 4, 2023 through January 3, 2024.

b. If the Government exercises its option(s) pursuant to the OPTION PROVISION Article in Section H of this contract, the period of performance will be increased as listed below:

Option Option Period

Option Period 1, Contract Year 2

January 4, 2024 - January 3, 2025

Option Period 2, Contract Year

January 4, 2025 - January 3, 2026

Option Period 3, Contract Year

January 4, 2026 - January 3, 2027

Option Period 4, Contract Year

January 4, 2027 - January 3, 2028

ARTICLE F.2. DELIVERIES

Satisfactory performance of the final contract shall be deemed to occur upon performance of the work described in the Description Article in SECTION C of this contract and upon delivery and acceptance by the Contracting Officer, or the duly authorized representative, of the following items in accordance with the stated delivery schedule:

a. The items specified below as described in the REPORTING REQUIREMENTS Article in SECTION C of this contract will be required to be delivered electronically in accordance with and by the date(s) specified below:

Item Description Quantity Delivery Schedule

(1) Monthly Progress Status

Reports 1 To COR on or before the

5th business day following each month

(2) Compound Final Study Reports

1 To COR on or before the

14th business day after completion of study

(3) Annual Progress Report(s) (if Option Period(s) are exercised)

2 To COR and CO on or before 14th business day following the end of each contract year

(4) Electronic Data Transfer 1 To COR per request by

COR

(5) Laboratory Records All To COR on or before contract expiration

(6) Test Compounds All To NIDA contract facility on or before contract expiration

(7) Section 508 Annual Report 1 Electronic copy to CO and COR; 1 hardcopy to CO within 15 business days

- 14 -

Item Description Quantity Delivery Schedule of the contract aniversary date

(8) Invention Report 1 Hardcopy to CO one year after effective date; and annually from contract effective date upon exercise of an option to extend the contract term but not for the final contract year

(9) Invention Report – Final Invention Statement

1 Hardcopy to CO on or before contract expiration

(10) Individual Subcontract Report

1 Electronic copy submitted to eSRS Semi-Annually on

April 30th and October 30th

(11) Summary Subcontract

Report 1 Electronic copy submitted to eSRS Annually on October 30th

(12) Financial Conflict of Intererst Report

1 Electronic copy and hardcopy to CO; See Article C.2.b.1.

"In accordance with FAR 4.804, following contract expiration/completion, the Contractor shall be responsible for providing the following items: Indirect cost rate proposals for all years (in which a proposal was not previously submitted); final property inventory (excluding intellectual property); standard forms 1428 and 1429 (if applicable);

settling all subcontract costs and any issues thereunder; subcontracting compliance reports for all years to the eSRS;

final patent and royalty reports; Contractor's release of claims, i.e. Contractor's closing statement; the Contractor's Assignment of Refunds, Rebates and Credits; and a final invoice or completion voucher (marked final)."

ARTICLE F.3. LEVEL OF EFFORT

a. During the period of performance of this contract, the Contractor shall provide 9212 direct labor Hours . The labor Hours Include vacation, holiday, and sick leave. These labor Hours Include subcontractor labor Hours .

It is estimated that the labor Hours are constituted as specified below and will be expended approximately as follows:

Labor Hours

Labor Category Year 1- Base

(Option Period 1)Year 2

(Option Period 2)Year 3

(Option Period 3)Year 4

(Option Period 4)Year 5

Professional (includes Principle Investigator)

564 564 564 564 564

Research Associate

1128 1128 1128 1128 1128

Research Technicians

7520 7520 7520 7520 7520

Totals 9212 9212 9212 9212 9212

- 15 -

Labor Category Year 1- Base

(Option Period

1) Year 2

(Option Period

1) Year 2

(Option Period

1) Year 2

(Option Period

1) Year 2

Quantity Option A 1880 1880 1880 1880

Quantity Option B 1880 1880 1880 1880

ARTICLE F.4. CLAUSES INCORPORATED BY REFERENCE, FAR 52.252-2 (FEB 1998)

This contract incorporates the following clause(s) by reference, with the same force and effect as if it were given in full text. Upon request, the Contracting Officer will make its full text available. Also, the full text of a clause may be accessed electronically at this address: https://www.acquisition.gov/?q=browsefar.

FEDERAL ACQUISITION REGULATION (48 CFR CHAPTER 1) CLAUSE:

52.242-15, Stop Work Order (August 1989)

Alternate I (April 1984) is not applicable to this contract.

RFP: 75N95022R00106

Ref: N01DA-23-8936

{Remainder of the page left intentionally blank} https://www.acquisition.gov/?q=browsefar

- 16 -

SECTION G - CONTRACT ADMINISTRATION DATA

ARTICLE G.1. CONTRACTING OFFICER'S REPRESENTATIVE (COR)

The following Contracting Officer Representative (COR) will represent the Government for the purpose of this contract:

(To be specified prior to award)

The COR is responsible for: (1) monitoring the Contractor's technical progress, including the surveillance and assessment of performance and recommending to the Contracting Officer changes in requirements; (2) interpreting the statement of work and any other technical performance requirements; (3) performing technical evaluation as required; (4) performing technical inspections and acceptances required by this contract; and (5) assisting in the resolution of technical problems encountered during performance.

NIH invoicing is in the process of moving to the Invoice Processing Platform (IPP). Two sets of invoice instructions are included in this document. Please follow the NIH Invoice and Payment Provisions dated February 10, 2021 and Submitting Electronic Invoices to OFM until you are notified in writing by the Contracting Officer that your contract has been converted to the IPP.

The Contracting Officer is the only person with authority to act as agent of the Government under this contract. Only the Contracting Officer has authority to: (1) direct or negotiate any changes in the statement of work; (2) modify or extend the period of performance; (3) change the delivery schedule; (4) authorize reimbursement to the Contractor for any costs incurred during the performance of this contract; (5) otherwise change any terms and conditions of this contract; or (6) sign written licensing agreements. Any signed agreement shall be incorporated by reference in Section K of the contract

The Government may unilaterally change its COR designation.

ARTICLE G.2. KEY PERSONNEL, HHSAR 352.237-75 (December 2015)

The key personnel specified in this contract are considered to be essential to work performance. At least 30 days prior to the contractor voluntarily diverting any of the specified individuals to other programs or contracts the Contractor shall notify the Contracting Officer and shall submit a justification for the diversion or replacement and a request to replace the individual. The request must identify the proposed replacement and provide an explanation of how the replacement's skills, experience, and credentials meet or exceed the requirements of the contract (including, when applicable, Human Subjects Testing requirements). If the employee of the contractor is terminated for cause or separates from the contractor voluntarily with less than thirty days notice, the Contractor shall provide the maximum notice practicable under the circumstances. The Contractor shall not divert, replace, or announce any such change to key personnel without the written consent of the Contracting Officer. The contract will be modified to add or delete key personnel as necessary to reflect the agreement of the parties.

(End of Clause)

The following individual(s) is/are considered to be essential to the work being performed hereunder:

Name Title

(TBD)

ARTICLE G.3. INVOICE SUBMISSION/CONTRACT FINANCING REQUEST AND CONTRACT

FINANCIAL REPORT

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a. Invoice Instructions for NIH Fixed-Price Type Contracts, NIH(RC)-2, are attached and made part of this contract.

The Contractor shall follow the attached instructions and submission procedures specified below to meet the requirements of a "proper invoice" pursuant to FAR Subpart 32.9, Prompt Payment.

1. The Contractor shall submit invoice to the National Institutes of Health (NIH)/Office of Financial Management (OFM) via email at invoicing@nih.gov with a copy to the approving official, as directed below. The Contractor must follow step-by-step instructions as stated in the NIH/OFM Electronic Invoicing Instructions for NIH Contractors/Vendors, which is included as an attachment in Section J of this contract. The invoice shall be transmitted as an attachment via email to the address listed above in one of the following formats: Word, or Adobe Portable Document Format (PDF). The Contractor must submit only one invoice per email. Do not submit supporting documentation (e.g., receipts, time sheets, vendor invoices, etc.) with your invoice unless specified elsewhere in the contract or requested by the Contracting Officer.

The Contractor shall submit a copy of the electronic invoice to the following Approving Official (Contracting Officer) and Contracting Officer Representative:

Approving Official: Contracting Officer

Name- TBD Email Address- TBD

Contracting Officer Representative

Name- TBD Email Address- TBD

For inquiries regarding the status of invoices, contact OFM Customer Service via email at ofm_customer_service@incontactemail.com or via phone at 301-496-6088. To send your inquiries via other available communication methods refer to the OFM Customer Service website at https:// ofm.od.nih.gov/Pages/Customer-Service.aspx.

Note: The OFM Customer Service is open Eastern Standard Time Monday - Friday from 8:30 a.m. to 5:00 p.m. and is closed between 12:00 p.m. to 1:00 p.m.

2. In addition to the requirements specified in FAR 32.905 for a proper invoice, the Contractor shall include the following information on the face page of all payment requests:

a. Name of the Office of Acquisitions. The Office of Acquisitions for this contract is Contracts Management Red Branch .

b. Federal Taxpayer Identification Number (TIN). If the Contractor does not have a valid TIN, it shall identify the Vendor Identification Number (VIN) on the payment request. The VIN is the number that appears after the Contractor's name on the face page of the contract. [Note: A VIN is assigned to new contracts awarded on or after June 4, 2007, and any existing contract modified to include the VIN number.] If the Contractor has neither a TIN, Unique Entity Identifier (UEI), or VIN, contact the Contracting Officer.

c. Unique Entity Identifier (UEI). The UEI is located in the System for Award Management (SAM) and replaces the Dun & Bradstreet Data Universal Numbering System (DUNS) number. The UEI number must identify the Contractor's name and address exactly as stated in the contract and as registered in the Central Contractor Registration (CCR) database. If the Contractor does not have a valid UEI number, it shall identify the Vendor Identification Number (VIN) on the payment request. The VIN is the number that appears after the Contractor's name on the face page of the contract. [Note: A VIN is assigned to new contracts awarded on or after June 4, 2007, and any existing contract modified to include the VIN number.] If the Contractor

RFP: 75N95022R00106

Ref: N01DA-23-8936 https://ofm.od.nih.gov/Pages/Home.aspx https://ofm.od.nih.gov/Pages/Home.aspx mailto:invoicing@nih.gov https://oamp.od.nih.gov/DGS/DGS-workform-information/attachment-files https://oamp.od.nih.gov/DGS/DGS-workform-information/attachment-files mailto:OFM%20Customer%20Service mailto:ofm_customer_service@incontactemail.com https://ofm.od.nih.gov/Pages/Customer-Service.aspx https://ofm.od.nih.gov/Pages/Customer-Service.aspx

- 18 -has neither a TIN, UEI, or VIN, contact the Contracting Officer. Note: The Contractor shall not include TIN if it is a Social Security Number.

d. Invoice Matching Option. This contract requires a two-way match.

e. Unique Invoice Number. Each payment request must be identified by a unique invoice number, which can only be used one time regardless of the number of contracts or orders held by an organization.

f. The Contract Title is:

Using Rodent Behavioral Models to Identify Substance Use Disorder Pharmacotherapies

g. Contract Line Items as follows:

Line Item # Line Item Description

Please note: NIH invoicing is in the process of moving to the Invoice Processing Platform (IPP). Two sets of invoice instructions are included in this document. Please follow the NIH Invoice and Payment Provisions dated February 10, 2021 and Submitting Electronic Invoices to OFM until you are notified in writing by the Contracting Officer that your contract has been converted to the IPP.

ARTICLE G.4. PROVIDING ACCELERATED PAYMENT TO SMALL BUSINESS

SUBCONTRACTORS, FAR 52.232-40 (Nov 2021)

a. Upon receipt of accelerated payments from the Government, the Contractor shall make accelerated payments to its small business subcontractors under this contract, to the maximum extent practicable and prior to when such payment is otherwise required under the applicable contract or subcontract, after receipt of a proper invoice and all other required documentation from the small business subcontractor.

b. The acceleration of payments under this clause does not provide any new rights under the prompt Payment Act.

c. Include the substance of this clause, include this paragraph c, in all subcontracts with small business concerns, including subcontracts with small business concerns for the acquisition of commercial items.

(End of Clause)

ARTICLE G.5. INDIRECT COST RATES

In accordance with Federal Acquisition Regulation (FAR) (48 CFR Chapter 1) Clause 52.216-7 (d)(2), Allowable Cost and Payment incorporated by reference in this contract in PART II, SECTION I, the cognizant Contracting Officer Representative responsible for negotiating provisional and/or final indirect cost rates is identified as follows:

Director, Division of Financial Advisory Services Office of Acquisition Management and Policy National Institutes of Health

6011 EXECUTIVE BLVD, ROOM 549C, MSC-7663

BETHESDA MD 20892-7663

These rates are hereby incorporated without further action of the Contracting Officer. Go to the Indirect Cost Submission web page: https://oamp.od.nih.gov/division-of-financial-advisory-services/indirect-cost-branch/indirect-cost-submission for electronic copies of the Branch's information package documents.

RFP: 75N95022R00106

Ref: N01DA-23-8936 https://oamp.od.nih.gov/division-of-financial-advisory-services/indirect-cost-branch/indirect-cost-submission https://oamp.od.nih.gov/division-of-financial-advisory-services/indirect-cost-branch/indirect-cost-submission

- 19 -

ARTICLE G.6. POST AWARD EVALUATION OF CONTRACTOR PERFORMANCE

a. Contractor Performance Evaluations

Interim and Final evaluations of Contractor performance will be prepared on this contract in accordance with FAR Subpart 42.15. The Final performance evaluation will be prepared at the time of completion of work. In addition to the Final evaluation, Interim evaluation(s) will be prepared annually after completion of the base year and if options are exercised.

Interim and Final evaluations will be provided to the Contractor as soon as practicable after completion of the evaluation. The Contractor will be permitted thirty days to review the document and to submit additional information or a rebutting statement. If agreement cannot be reached between the parties, the matter will be referred to an individual one level above the Contracting Officer, whose decision will be final.

Copies of the evaluations, Contractor responses, and review comments, if any, will be retained as part of the contract file, and may be used to support future award decisions.

b. Electronic Access to Contractor Performance Evaluations

Contractors may access evaluations through a secure Web site for review and comment at the following address:

http…