RFA-RM-27-015-Full-Announcement.html

Department of Health and Human Services

Part 1. Overview Information

Participating Organization(s)

National Institutes of Health (NIH)

Components of Participating Organizations

Office of Strategic Coordination (Common Fund)

This Notice of Funding Opportunity (NOFO) is developed as a Common Fund Initiative (https://commonfund.nih.gov/) through the Office of the NIH Director, Office of Strategic Coordination (https://commonfund.nih.gov/). All NIH Institutes and Centers participate in Common Fund initiatives. The NOFO will be administered by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) on behalf of the NIH.

Note: Not all NIH Institutes, Centers, and Offices (ICOs) participate in Announcements. Applicants should carefully note which ICOs participate in this announcement and view their respective areas of research interest at the ICO-Specific Scientific Interests website. ICOs that do not participate in this announcement will not consider applications for funding.

Funding Opportunity Title

Logistics Center for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (U24 Clinical Trials Not Allowed)

Activity Code

U24 Resource-Related Research Projects – Cooperative Agreements

Announcement Type

New

Related Notices

Check for any recent Notices of NIH Policy Changes that may impact application requirements.

Funding Opportunity Number (FON)

RFA-RM-27-015

Companion Funding Opportunity

RFA-RM-27-011

, U01 Research Project (Cooperative Agreements)

RFA-RM-27-012

UG3/

UH3

Phase 1 Exploratory/Developmental Cooperative Agreement/Exploratory/Developmental Cooperative Agreement Phase II

RFA-RM-27-013

UG3/

UH3

Phase 1 Exploratory/Developmental Cooperative Agreement/Exploratory/Developmental Cooperative Agreement Phase II

RFA-RM-27-014

, U54 Specialized Center (Cooperative Agreements)

Number of Applications

See Part 2, Section III. 3. Additional Information on Eligibility.

Assistance Listing Number(s)

93.310

Funding Opportunity Purpose

The overarching goal of this notice of funding opportunity (NOFO) and its companion opportunities is to establish the Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Program to support development of innovative, reliable, cost-effective, and sustainable multimodal AI-based clinical decision support (CDS) tools. PRIMED-AI CDS tools are based on the integration of clinical imaging with other types of multimodal health data to enhance care for patients with a wide range of health conditions. The PRIMED-AI Program seeks to catalyze the adoption of AI-based CDS tools into clinical workflows to enable novel personalized medicine strategies that address significant health challenges.

The purpose of this NOFO is to create a Logistics Center for the PRIMED-AI Program to facilitate and coordinate PRIMED-AI activities to maximize impact for the PRIMED-AI community. Within the Logistics Center, three integrated Cores will serve the functions of Administration, Evaluation, and Outreach for the PRIMED-AI Consortium. It is expected that the Logistics Center will work closely with other PRIMED-AI consortium members to collect, curate and disseminate information regarding tools developed by the PRIMED-AI award recipients, and will facilitate widespread access and awareness across the relevant scientific, patient, and clinical communities.

Funding Opportunity Goal(s)

The Office of Strategic Coordination (Common Fund) supports research and other projects that will accelerate fundamental biomedical discovery and translation of that knowledge into effective prevention strategies and new treatments.

Key Dates

Posted Date

June 30, 2026

Open Date (Earliest Submission Date)

September 02, 2026

October 02, 2026

Not Applicable

Not Applicable

July 2027

All applications are due by 5:00 PM local time of applicant organization.

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

No late applications will be accepted for this Notice of Funding Opportunity (NOFO).

Expiration Date

October 03, 2026

Due Dates for E.O. 12372

Not Applicable

Required Application Instructions

It is critical that applicants follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide, except where instructed to do otherwise (in this NOFO or in a Notice from NIH Guide for Grants and Contracts).

Conformance to all requirements (both in the How to Apply - Application Guide and the NOFO) is required and strictly enforced. Applicants must read and follow all application instructions in the How to Apply - Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the How to Apply - Application Guide, follow the program-specific instructions.

Applications that do not comply with these instructions may be delayed or not accepted for review.

Table of Contents

Part 1. Overview Information Key Dates Part 2. Full Text of Announcement Section I. Notice of Funding Opportunity Description Section II. Award Information Section III. Eligibility Information Section IV. Application and Submission Information Section V. Application Review Information Section VI. Award Administration Information Section VII. Agency Contacts Section VIII. Other Information

Part 2. Full Text of Announcement

Section I. Notice of Funding Opportunity Description

Purpose The Logistics Center will provide the administrative infrastructure necessary to facilitate and coordinate PRIMED-AI activities to maximize the impact of the PRIMED-AI Program. Within the Logistics Center, three integrated Cores will serve the functions of Administration, Evaluation, and Outreach. The Logistics Center is responsible for management of steering committee (SC) meetings, advisory boards, workshops, community interfaces, outreach, and coordination of teaming activities in consultation with NIH PRIMED-AI staff. In addition to these functions, the Logistics Center will work closely with the Validation Center to maintain strong communication and cross-pollination across the PRIMED-AI Consortium. Finally, the Logistics Center is expected to develop and manage a PRIMED-AI web portal to showcase tools developed as a result of the PRIMED-AI Consortium. It is expected that the Logistics Center will work closely with other PRIMED-AI award recipients to collect, curate and disseminate information regarding tools developed in the PRIMED-AI projects, and will facilitate wide-spread access and awareness.

Background Clinical imaging plays a pivotal role in diagnosis, treatment, and assessment of health outcomes; however, it is often utilized in isolation from other types of data during the development of artificial intelligence (AI)-based clinical decision support (CDS) tools. Current AI applications typically leverage a single imaging modality from radiological or ophthalmological sources. Because health is shaped by a variety of interconnected factors–clinical, biological, genetic, environmental and social–the Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Program seeks to integrate clinical imaging with relevant, complementary multimodal data (MMD). The overarching goal of the PRIMED-AI Program is to catalyze the development and adoption of innovative AI-based CDS tools into clinical workflows. The PRIMED-AI Program initiatives collectively aim to tackle complex clinical challenges by fostering cross-disciplinary collaboration to create innovative, reliable, cost-effective, and sustainable AI solutions that enable precision medicine strategies.

Prior to applying, applicants are encouraged to check the PRIMED-AI Program website for updates to relevant FAQs and informational webinars, and are also encouraged to read all companion NOFOs to ensure they are aware of the goals and responsibilities of all PRIMED-AI award recipients, including methods PRIMED-AI intends to utilize to address error mitigation and technical management. Familiarity with the companion NOFOs may better inform proposed Logistics Center interconnections with other aspects of the PRIMED-AI Program.

Key Terms used in PRIMED-AI Program (listed alphabetically):

Key Requirements of the Logistics Center Specifically, the Logistics Center must include the following Core components tasked as follows:

Administrative Core:

Provide logistical and administrative assistance in arranging PRIMED-AI Steering Committee (SC) and working group meetings, conference calls, workshops, and in-person annual consortium meetings;

Prepare documents, develop policies, and provide recordkeeping for the PRIMED-AI Consortium;

In coordination with the Validation Center, work towards developing and implementing standard procedures for data and metadata collection, storage and sharing, as well as facilitating the Validation Center's subproject management;

Through the use of restricted funds as detailed in Section IV below, support research teaming projects in consultation with NIH PRIMED-AI staff that address critical needs in the PRIMED-AI Program pipeline (e.g., underutilized data, robustness, CDS tool user interfaces) that arise as the Program matures;

Through the use of restricted funds, support development of innovative curricula and outreach activities to facilitate communication between physicians, data scientists, and patients on topics in the PRIMED-AI space in consultation with NIH staff.

Evaluation Core:

Develop and manage an external advisory group to provide feedback on the spectrum of issues from data science to clinical uses and implications of multimodal AI CDS tools and resources developed by the Consortium;

Provide timely reports to NIH staff as needed on activities and progress made by the PRIMED-AI Consortium, maintain and make accessible to NIH and the PRIMED-AI Consortium all significant related documents, including policies, guidelines, records, assets, publications, and meeting minutes generated by the various PRIMED-AI Program committees, topical working groups, and consultants.

Outreach Core:

Implement a PRIMED-AI Consortium-wide data and resource sharing infrastructure via development of a web portal that ensures sustainable sharing and coordination between PRIMED-AI members;

In addition to the above, the Logistics Center will be responsible for the development of a PRIMED-AI Consortium consensus policy document, to include policies associated with (1) data sharing, security, privacy, ethics and usage, (2) data sequestration and AI-readiness, (3) error mitigation and technical management of tools developed in the PRIMED-AI Consortium, (4) subproject lifecycle management, (5) data and model interoperability, (6) opportunities for collaborations and stakeholder engagement, and (7) operational guidelines, among others. These policies will apply to all award recipients and external groups who wish to utilize PRIMED-AI resources.

Because of the expertise needed to manage the Logistics Center and the collaborative nature of this Center, a multiple PD/PI (multi-PI) application is required.

See Section VIII. Other Information for award authorities and regulations.

Section II. Award Information

Funding Instrument

Cooperative Agreement: A financial assistance mechanism used when there will be substantial Federal scientific or programmatic involvement. Substantial involvement means that, after award, NIH scientific or program staff will assist, guide, coordinate, or participate in project activities. See Section VI.2 for additional information about the substantial involvement for this NOFO.

Application Types Allowed

New

The OER Glossary and the How to Apply - Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.

Clinical Trial?

Not Allowed: Only accepting applications that do not propose clinical trials. Note: Applications may propose activities involving human subjects that are not deemed clinical trials.

Need help determining whether you are doing a clinical trial?

Funds Available and Anticipated Number of Awards

The NIH Common Fund intends to commit approximately $750,000 in FY2027. One award is anticipated, contingent upon availability of funds and receipt of a sufficient number of meritorious applications.

Award Budget

Application budgets are limited to $575,000 direct costs for the first year and up to $2,500,000 direct costs per year for the remaining four years of the project. Requested budgets need to reflect the actual needs of the proposed project.

Award Project Period

The scope of the proposed project should determine the project period. The maximum project period is 5 years.

NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.

Section III. Eligibility Information

1. Eligible Applicants

Eligible Organizations

Nonprofits Other Than Institutions of Higher Education

For-Profit Organizations

Local Governments

Other

Independent School Districts

Public Housing Authorities/Indian Housing Authorities

Native American Tribal Organizations (other than Federally recognized tribal governments)

Faith-based or Community-based Organizations

Regional Organizations

Foreign Organizations/Foreign Collaborations

Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Required Registrations

Applicant Organizations Applicant organizations must complete and maintain the following registrations as described in the How to Apply - Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. Failure to complete registrations in advance of a due date is not a valid reason for a late submission, please reference NIH Grants Policy Statement Section 2.3.9.2 Electronically Submitted Applications for additional information System for Award Management (SAM) – Applicants must complete and maintain an active registration, which requires renewal at least annually. The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code. Foreign organizations must obtain a NATO Commercial and Government Entity (NCAGE) Code (in lieu of a CAGE code) in order to register in SAM. Unique Entity Identifier (UEI)- A UEI is issued as part of the SAM.gov registration process. The same UEI must be used for all registrations, as well as on the grant application.

Program Directors/Principal Investigators (PD(s)/PI(s)) All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.

All PD(s)/PI(s) must be registered with ORCID. The personal profile associated with the PD(s)/PI(s) eRA Commons account must be linked to a valid ORCID ID. For more information on linking an ORCID ID to an eRA Commons personal profile see the ORCID topic in our eRA Commons online help.

Eligible Individuals (Program Director/Principal Investigator)

Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with their organization to develop an application for support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the How to Apply - Application Guide.

Effective management will require a significant commitment by the Program Director(s)/Principal Investigator(s). A multi-PD/PI application is required - one PD/PI is expected to commit at least 2 person months annually and the other(s) should devote at least 1 person month each.

2. Cost Sharing This NOFO does not require cost sharing as defined in the NIH Grants Policy Statement NIH Grants Policy Statement Section 1.2 Definition of Terms.

3. Additional Information on Eligibility Number of Applications

Applicant organizations may submit more than one application, provided that each application is scientifically distinct.

The NIH will not accept duplicate or highly overlapping applications under review at the same time, per NIH Grants Policy Statement Section 2.3.7.4 Submission of Resubmission Application. This means that the NIH will not accept:

Section IV. Application and Submission Information

1. Requesting an Application Package The application forms package specific to this opportunity must be accessed through ASSIST, Grants.gov Workspace or an institutional system-to-system solution. Links to apply using ASSIST or Grants.gov Workspace are available in Part 1 of this NOFO. See your administrative office for instructions if you plan to use an institutional system-to-system solution.

2. Content and Form of Application Submission It is critical that applicants follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide except where instructed in this notice of funding opportunity to do otherwise (in this NOFO, in a policy notice, or other notice from NIH Guide for Grants and Contracts). Conformance to the requirements in the How to Apply - Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.

Page Limitations All page limitations described in the How to Apply – Application Guide and the Table of Page Limits must be followed.

Instructions for Application Submission

The following section supplements the instructions found in the How to Apply – Application Guide and should be used for preparing an application to this NOFO.

SF424(R&R) Cover All instructions in the How to Apply - Application Guide must be followed.

SF424(R&R) Project/Performance Site Locations

SF424(R&R) Other Project Information

Other Attachments:

Milestones, Timelines and Progress Reporting Plan – (3-page limit) Applicants must define a clear set of goals for the proposed Logistics Center and semi-annual milestones with metrics that will document progress towards the achievement of the ultimate goals of the PRIMED-AI Program. The filename "Milestones Timelines and Progress Reporting Plan.pdf" should be used for this attachment. This plan must include a Gantt chart of proposed timelines and milestones, as well as a detailed list of all milestones with associated details. Applicants will include plans for critically evaluating and revising these milestones on a regular basis. The number and duration of milestones will depend on the project being proposed, so applicants should include these items for every year, as appropriate. Applicants must describe how they will prioritize their activities to ensure that the main goals of the PRIMED-AI Program will be achieved. Milestones may be revised at the time of the award. Milestones must address all aspects of the plans submitted as part of the research strategy, including a timeline for Consortium consensus policy development, expected milestones for distribution of restricted funds, and proposed plans for reporting progress to the NIH.

SF424(R&R) Senior/Key Person Profile

R&R Budget

Restricted Funds for Collaborative PRIMED-AI Consortium activities For award years 2-5, budgets must contain $2,500,000 each year to fund collaborations with other PRIMED-AI Program members and/or external entities to:

Approximately $1,000,000 of restricted funds per year must be utilized to address collaboration and teaming needs (e.g., underutilized data, robustness, CDS tool user interfaces) that arise as the Program matures. It is intended that these collaborations will be established with at least one PRIMED-AI member and can include new members (e.g., academic, industry, clinical) who may contribute unique expertise and varied perspectives. At least 75% of restricted funds must go to selected collaborators and/or non-Logistics Center award recipients. Under "Other Expenses" category, enter the corresponding amount of direct costs as "Collaboration Restricted Fund."

Approximately $1,500,000 of restricted funds per year must be utilized to develop and deliver innovative curricula to facilitate communication between physicians, data scientists, and patients on topics in the PRIMED-AI space. Innovative projects will be sought to enrich communication and trust-building towards the translation and use of PRIMED-AI CDS tools. For example, materials may be developed to address behavioral (professional and societal) barriers to adoption of PRIMED-AI CDS tools. Groups who receive these funds in collaboration with the Logistics Center will also work collaboratively with the Validation Center to focus on topics related to error mitigation and technical management pertinent to PRIMED-AI goals. At least 50% of restricted funds must go to selected collaborators and/or non-Logistics Center award recipients. Under "Other Expenses" category, enter the corresponding amount of direct costs as "Outreach Restricted Fund."

Proposals for utilization of restricted funds must be approved by the PRIMED-AI SC and submitted to the NIH PO of record starting in the first quarter starting year two of the Logistics Center award and continuing first quarter of each year thereafter. The NIH PRIMED-AI working group will determine if the proposals are appropriate (ie within scope of the PRIMED-AI Program) and release funds after being approved for use on the proposed projects.

The Logistics Center may propose adjustments to the allocation amounts listed above based on shifting programmatic needs - these adjustments must be thoroughly justified by the Center PIs and approved by NIH staff. All these funds are restricted and require NIH prior approval for use. If the NIH PRIMED-AI Working Group, via the Steering Committee, deems such collaborations scientifically unwarranted or out of scope, the restricted budget may be re-allocated to the primary project or other PRIMED-AI award recipients on a yearly basis. A prior approval request is required to re-allocate these funds to other studies.

MPI and Logistics Center staff requirements Effective management will require a significant commitment by the Program Director(s)/Principal Investigator(s). A multi-PD/PI application is required - one PD/PI is expected to commit at least 2 person months annually and the other(s) should devote at least 1 person month each.

The Logistics Center is responsible for managing in person meetings and regular conference calls. Budgets should reflect costs associated with managing and hosting these meetings, both in person and virtual. Applicants should also request funds for 2-6 group members to attend annual in person meetings, Program-led tutorials, and open innovation meetings, as appropriate.

The Logistics Center should budget at least 6 person months for a dedicated project manager/director (PM/PD) for the project with the appropriate scientific expertise and project management responsibilities, who would support the PI(s) with project management. The PM/PD will be the primary liaison with the PRIMED-AI Program and Steering Committee.

R&R Subaward Budget

PHS 398 Cover Page Supplement

PHS 398 Research Plan All instructions in the How to Apply - Application Guide must be followed, with the following additional instructions:

Research Strategy Due to the PRIMED-AI Program's significant focus on imaging data, it is expected that the proposed Logistics Center team members will have significant experience with imaging, and/or will include imaging data experts.

As part of the research strategy, applicants are required to submit the following:

Resource Sharing Plan: Individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the How to Apply - Application Guide.

Other Plan(s):

All instructions in the How to Apply - Application Guide must be followed, with the following additional instructions:

A Data Management and Sharing Plan (DMS Plan) is required for any NIH-funded or conducted research that will generate scientific data. Applicants must submit the DMS Plan at the time of application using the NIH DMS Plan Format Page. The DMS Plan must address the elements in the structured format. Where the DMS Plan Format Page requires a "Yes or No" response, no additional narrative is allowed.

Appendix: Only limited Appendix materials are allowed. Follow all instructions for the Appendix as described in the How to Apply - Application Guide.

No publications or other material, with the exception of blank questionnaires or blank surveys, may be included in the Appendix.

PHS Human Subjects and Clinical Trials Information When involving human subjects research, clinical research, and/or NIH-defined clinical trials (and when applicable, clinical trials research experience) follow all instructions for the PHS Human Subjects and Clinical Trials Information form in the How to Apply - Application Guide, with the following additional instructions:

If you answered "Yes" to the question "Are Human Subjects Involved?" on the R&R Other Project Information form, you must include at least one human subjects study record using the Study Record: PHS Human Subjects and Clinical Trials Information form or Delayed Onset Study record.

Study Record: PHS Human Subjects and Clinical Trials Information

Delayed Onset Study

Note: Delayed onset does NOT apply to a study that can be described but will not start immediately (i.e., delayed start). All instructions in the How to Apply - Application Guide must be followed.

PHS Assignment Request Form

3. Unique Entity Identifier and System for Award Management (SAM) See Part 2. Section III.1 for information regarding the requirement for obtaining a unique entity identifier and for completing and maintaining active registrations in System for Award Management (SAM), NATO Commercial and Government Entity (NCAGE) Code (if applicable), eRA Commons, and Grants.gov

4. Submission Dates and Times Part I. contains information about Key Dates and times. Applicants are encouraged to submit applications before the due date to ensure they have time to make any application corrections that might be necessary for successful submission. When a submission date falls on a weekend or Federal holiday, the application deadline is automatically extended to the next business day.

Organizations must submit applications to Grants.gov (the online portal to find and apply for grants across all Federal agencies). Applicants must then complete the submission process by tracking the status of the application in the eRA Commons, NIH's electronic system for grants administration. NIH and Grants.gov systems check the application against many of the application instructions upon submission. Errors must be corrected and a changed/corrected application must be submitted to Grants.gov on or before the application due date and time. If a Changed/Corrected application is submitted after the deadline, the application will be considered late. Applications that miss the due date and time are subjected to the NIH Grants Policy Statement Section 2.3.9.2 Electronically Submitted Applications.

Applicants are responsible for viewing their application before the due date in the eRA Commons to ensure accurate and successful submission.

Information on the submission process and a definition of on-time submission are provided in the How to Apply – Application Guide.

5. Intergovernmental Review (E.O. 12372) This initiative is not subject to intergovernmental review.

6. Funding Restrictions All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.

Pre-award costs are allowable only as described in the NIH Grants Policy Statement Section 7.9.1 Selected Items of Cost.

7. Other Submission Requirements and Information Applications must be submitted electronically following the instructions described in the How to Apply - Application Guide. Paper applications will not be accepted.

Applicants must complete all required registrations before the application due date. Section III. Eligibility Information contains information about registration.

For assistance with your electronic application or for more information on the electronic submission process, visit How to Apply – Application Guide. If you encounter a system issue beyond your control that threatens your ability to complete the submission process on-time, you must follow the Dealing with System Issues guidance. For assistance with application submission, contact the Application Submission Contacts in Section VII.

Important reminders:

All PD(s)/PI(s) must include their eRA Commons ID in the Credential field of the Senior/Key Person Profile form. Failure to register in the Commons and to include a valid PD/PI Commons ID in the credential field will prevent the successful submission of an electronic application to NIH. See Section III of this NOFO for information on registration requirements.

The applicant organization must ensure that the unique entity identifier provided on the application is the same identifier used in the organization's profile in the eRA Commons and for the System for Award Management. Additional information may be found in the How to Apply - Application Guide.

See more tips for avoiding common errors.

Upon receipt, applications will be evaluated for completeness and compliance with application instructions by the Center for Scientific Review and responsiveness by components of participating organizations, NIH. Applications that are incomplete, non-compliant and/or nonresponsive will not be reviewed.

Mandatory Disclosure

Recipients or subrecipients must submit any information related to violations of federal criminal law involving fraud, bribery, or gratuity violations potentially affecting the federal award. See Mandatory Disclosures, 2 CFR 200.113 and NIH Grants Policy Statement Section 4.1.35.

Send written disclosures to the NIH Chief Grants Management Officer listed on the Notice of Award for the IC that funded the award and to the HHS Office of Inspector Grant Self Disclosure Program at grantdisclosures@oig.hhs.gov.

Post Submission Materials Applicants are required to follow the instructions for post-submission materials, as described in the policy

Any instructions provided here are in addition to the instructions in the policy.

Section V. Application Review Information

1. Criteria Only the review criteria described below will be considered in the review process. Applications submitted to the NIH in support of the NIH mission are evaluated for scientific and technical merit through the NIH peer review system.

Overall Impact

Reviewers will provide an overall impact score to reflect their assessment of the likelihood for the project to exert a sustained, powerful influence on the research field(s) involved, in consideration of the following review criteria and additional review criteria (as applicable for the project proposed).

Scored Review Criteria

Reviewers will consider each of the review criteria below in the determination of scientific merit and give a separate score for each. An application does not need to be strong in all categories to be judged likely to have major scientific impact. For example, a project that by its nature is not innovative may be essential to advance a field.

Significance

Does the proposed Logistics Center address the needs of the PRIMED-AI Consortium that it will coordinate? Is the scope of activities proposed for the Logistics Center appropriate to meet those needs? Will successful completion of the aims bring unique advantages or capabilities to the PRIMED-AI Consortium?

Investigator(s)

Are the PD(s)/PI(s) and other personnel well suited to their roles in the Logistics Center? Do they have appropriate experience and training, and have they demonstrated experience and an ongoing record of accomplishments in managing AI-focused research? Do the investigators demonstrate significant experience with coordinating collaborative technology or clinical research? If the Center is multi-PD/PI, do the investigators have complementary and integrated expertise and skills; are their leadership approach, governance, plans for conflict resolution, and organizational structure appropriate for the Logistics Center? Does the applicant have experience overseeing selection and management of subawards, if needed?

Innovation

Does the application propose novel organizational concepts, management strategies, or instrumentation that is important to coordinating the Primed AI Consortium that the Logistics Center will serve? Are the concepts, strategies, or instrumentation novel to one type of research program or applicable in a broad sense? Is a refinement, improvement, or new application of organizational concepts, management strategies or instrumentation proposed?

Approach

Are the overall strategy, operational plan, and organizational structure well-reasoned and appropriate to accomplish the goals of the Primed AI Consortium the Logistics Center will serve? Will the investigators promote strategies to ensure a robust scientific approach across the Primed AI Consortium, as appropriate for the work proposed? Are potential problems, alternative strategies, and benchmarks for success presented? Does the proposed strategy adequately establish feasibility and manage the risks associated with the activities of the Primed AI Consortium? Are an appropriate plan for work-flow and a well-established timeline proposed? Have the investigators presented adequate plans to ensure consideration of relevant biological variables, such as sex, for studies of vertebrate animals or human subjects?

Environment

Will the institutional…