RFA-AR-28-001-Full-Announcement.html

Department of Health and Human Services

Part 1. Overview Information

Participating Organization(s)

National Institutes of Health (NIH)

Components of Participating Organizations

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

All applications to this funding opportunity announcement should fall within the mission of the Institutes/Centers. The following NIH Offices may co-fund applications assigned to those Institutes/Centers.

Office of Research on Women's Health (ORWH)

Note: Not all NIH Institutes, Centers, and Offices (ICOs) participate in Announcements. Applicants should carefully note which ICOs participate in this announcement and view their respective areas of research interest at the ICO-Specific Scientific Interests website. ICOs that do not participate in this announcement will not consider applications for funding.

Funding Opportunity Title

NIAMS P30 Centers Program (P30 - Clinical Trial Not Allowed)

Activity Code

P30 Center Core Grants

Announcement Type

Reissue of

RFA-AR-23-002

RFA-AR-24-001

RFA-AR-24-002

RFA-AR-24-003

Related Notices

Funding Opportunity Number (FON)

RFA-AR-28-001

Companion Notice of Funding Opportunity

None

Number of Applications

Only one application per institution is allowed, as defined in Section III. 3. Additional Information on Eligibility.

Assistance Listing Number(s)

93.846, 93.313

Notice of Funding Opportunity Purpose

The overall goal of this program is to accelerate scientific discovery, improve research efficiency, and enhance the translation of research findings into improved health outcomes. Centers funded under this program will also foster multidisciplinary collaboration, support workforce development across career stages, and promote training in emerging areas such as data science, artificial intelligence, and implementation research. The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) requests applications for the NIAMS P30 Centers Program to support integrated research Centers within its mission areas of skin biology and diseases; bone, muscle, and orthopaedic research; and rheumatic diseases.

The NIAMS P30 Centers Program supports Centers that provide coordinated research infrastructure, shared resources, and methodological expertise to advance basic, translational, and clinical research.

These Centers are expected to integrate state-of-the-art research resources with capabilities that support clinical and translational research, including the development, testing, and dissemination of novel analytical methods, study designs, outcome measures, and data-driven approaches.

Funding Opportunity Goal(s)

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) mission is to support research into the causes, treatment, and prevention of arthritis and musculoskeletal and skin diseases; training of basic and clinical scientists to carry out this research; and dissemination of information on research progress in these diseases. The Extramural Program promotes and supports basic, translational, and clinical studies of Systemic Rheumatic and Autoimmune Diseases, Skin Biology and Diseases, Bone Biology and Diseases, Muscle Biology and Diseases, and Joint Biology and Diseases and Orthopaedics. NIAMS Systemic Rheumatic and Autoimmune Diseases programs address basic, translational, and clinical research, including clinical trials and observational and mechanistic studies, focused on immune-mediated arthritis and autoimmune-related acute and chronic disorders in adults and children.

Key Dates

Posted Date

October 09, 2026

Open Date (Earliest Submission Date)

January 01, 2027

February 01, 2027

March 01, 2027

Not Applicable

December 2027

February 01, 2028

March 01, 2028

Not Applicable

December 2028

February 01, 2029

March 01, 2029

Not Applicable

December 2029

All applications are due by 5:00 PM local time of applicant organization.

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

No late applications will be accepted for this Notice of Funding Opportunity (NOFO).

Expiration Date

March 02, 2029

Due Dates for E.O. 12372

Not Applicable

Required Application Instructions

It is critical that applicants follow the Multi-Project (M) Instructions in the How to Apply - Application Guide, except where instructed to do otherwise (in this NOFO or in a Notice from the NIH Guide for Grants and Contracts). Conformance to all requirements (both in the How to Apply - Application Guide and the NOFO) is required and strictly enforced. Applicants must read and follow all application instructions in the How to Apply - Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the How to Apply - Application Guide, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.

Table of Contents

Part 1. Overview Information Key Dates Part 2. Full Text of Announcement Section I. Notice of Funding Opportunity Description Section II. Award Information Section III. Eligibility Information Section IV. Application and Submission Information Section V. Application Review Information Section VI. Award Administration Information Section VII. Agency Contacts Section VIII. Other Information

Part 2. Full Text of Announcement

Section I. Notice of Funding Opportunity Description

Background NIAMS utilizes the P30 Center Core Grant mechanism to support integrated Centers that combine shared research infrastructure, scientific expertise, and collaborative scientific leadership to advance research within the NIAMS mission.

Centers supported under this NOFO are expected to provide shared resources, foster team science, and support basic, translational, and/or clinical research as appropriate to the Center's focus. The Center's components should work together as an integrated whole to accelerate scientific discovery, improve research efficiency, and enhance translation to improved health outcomes.

Centers supported under this NOFO must:

Resource Cores may include a wide range of shared services and expertise, including but not limited to technological, analytical, methodological, computational, clinical, or translational support, as appropriate to the needs of the research community.

Potential applicant(s) are strongly encouraged to contact the Scientific/Research Contact listed in Section VII. Agency Contacts early in the application planning process to discuss the NIAMS mission relevance and NOFO responsiveness.

Applications Not Responsive to this NOFO The following types of applications are not responsive to this NOFO and will not be reviewed:

See Section VIII. Other Information for award authorities and regulations.

Section II. Award Information

Funding Instrument

Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.

Application Types Allowed

New

Renewal

The OER Glossary and the How to Apply - Application Guide provides details on these application types. Only those application types listed here are allowed for this NOFO.

Clinical Trial?

Not Allowed: Only accepting applications that do not propose clinical trials.

Need help determining whether you are doing a clinical trial?

Funds Available and Anticipated Number of Awards

NIAMS intends to commit up to $17 million direct costs to fund up to 30 awards over the duration of this NOFO. Awards pursuant to this funding opportunity are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Future year amounts will depend on annual appropriations.

NIAMS intends to fund a minimum of one new center that has not yet received NIH Centers funding, based on the scientific and technical merit of the proposed Resource Cores as determined by peer review, availability of funds, and relevance of the proposed application to scientific priorities.

Award Budget

Application budgets are limited to $500,000 direct costs per year.

Award Project Period

The scope of the proposed project should determine the project period. The maximum project period is 5 years.

NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.

Section III. Eligibility Information

1. Eligible Applicants

Eligible Organizations

Nonprofits Other Than Institutions of Higher Education

For-Profit Organizations

Local Governments

Federal Governments

Eligible Agencies of the Federal Government

U.S. Territory or Possession

Other

Independent School Districts

Public Housing Authorities/Indian Housing Authorities

Native American Tribal Organizations (other than Federally recognized tribal governments)

Faith-based or Community-based Organizations

Regional Organizations

Foreign Organizations/International Collaborations

Non-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.

Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

Required Registrations

Applicant organizations Applicant organizations must complete and maintain the following registrations as described in the How to Apply- Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. Failure to complete registrations in advance of a due date is not a valid reason for a late submission, please reference NIH Grants Policy Statement Section 2.3.9.2 Electronically Submitted Applications for additional information.

System for Award Management (SAM) – Applicants must complete and maintain an active registration, which requires renewal at least annually. The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code. Foreign organizations must obtain a NATO Commercial and Government Entity (NCAGE) Code (in lieu of a CAGE code) in order to register in SAM. Unique Entity Identifier (UEI)- A UEI is issued as part of the SAM.gov registration process. The same UEI must be used for all registrations, as well as on the grant application.

Program Directors/Principal Investigators (PD(s)/PI(s)) All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.

All PD(s)/PI(s) must be registered with ORCID. The personal profile associated with the PD(s)/PI(s) eRA Commons account must be linked to a valid ORCID ID. For more information on linking an ORCID ID to an eRA Commons personal profile see the ORCID topic in our eRA Commons online help.

Eligible Individuals (Program Director/Principal Investigator)

Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the How to Apply - Application Guide.

2. Cost Sharing This NOFO does not require cost sharing as defined in the NIH Grants Policy Statement Section 1.2- Definitions of Terms.

3. Additional Information on Eligibility Number of Applications

Applicant organizations may submit more than one application, provided that each application is scientifically distinct.

The NIH will not accept duplicate or highly overlapping applications under review at the same time per NIH Grants Policy Statement Section 2.3.7.4 Submission of Resubmission Application. This means that the NIH will not accept:

A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application.

A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application.

An application that has substantial overlap with another application pending appeal of initial peer review (see NIH Grants Policy Statement 2.3.9.4 Similar, Essentially Identical, or Identical Applications).

Section IV. Application and Submission Information

1. Requesting an Application Package The application forms package specific to this opportunity must be accessed through ASSIST or an institutional system-to-system solution. A button to apply using ASSIST is available in Part 1 of this NOFO. See the administrative office for instructions if planning to use an institutional system-to-system solution.

2. Content and Form of Application Submission It is critical that applicants follow the Multi-Project (M) Instructions in the How to Apply - Application Guide, except where instructed in this notice of funding opportunity to do otherwise (in this NOFO, in a policy notice, or other notice from NIH Guide for Grants and Contracts) and where instructions in the How to Apply - Application Guide are directly related to the Grants.gov downloadable forms currently used with most NIH opportunities. Conformance to the requirements in the How to Apply - Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.

Page Limitations All page limitations described in the How to Apply- Application Guide and the Table of Page Limits must be followed.

Required

Required

Required

NA

Instructions for the Submission of Multi-Component Applications

The following section supplements the instructions found in How to Apply- Application Guide and should be used for preparing a multi-component application.

Overall Component When preparing the application, use Component Type 'Overall'.

All instructions in the How to Apply - Application Guide must be followed, with the following additional instructions, as noted.

SF424(R&R) Cover (Overall) Complete entire form.

PHS 398 Cover Page Supplement (Overall)

Research & Related Other Project Information (Overall) Follow standard instructions.

Facilities and Other Resources: For each institution that is hosting a Resource Core(s), briefly describe the features of the institutional environment that are relevant to the effective implementation of the proposed Center. List institutional resources available to the Center and elaborate on how these resources will contribute to the success of the Center. As appropriate, describe available resources, such as clinical and laboratory facilities, participating and affiliated units, patient populations, geographic distribution of space and personnel, and consultative resources. Include a list of who occupies specific space, the square feet and equipment in that space, and a designation of the Center functions associated with the spaces. Applicants may include Campus maps and floor plans to illustrate the physical space available for the proposed Resource Cores and Administrative Core. Describe institutional commitments for space or other resources for the proposed Center.

Required Attachment: Resource Utilization and Impact Summary (2 pages maximum):

Applicants must include this attachment as part of their application. This summary should provide evidence that summarizes the impact, high demand for, and productivity of the resource for the expected project period.

The summary should include data with projections of how the resource achieves or will achieve economies of scale. Existing resources should document their support of a substantial number of users. For new resources, applicants should provide well-justified projections of a substantial user base for the resource.

Additional evidence that should be provided may include: (a) the number of publications enabled by the resource through collaboration or service activities, (b) service hours provided, (c) number of users, (d) summaries of instrument use time logs, (e) requests for access, and (f) white papers and editorials that demonstrate community interest.

Project/Performance Site Locations (Overall) Enter primary site only.

A summary of Project/Performance Sites in the Overall section of the assembled application image in eRA Commons compiled from data collected in the other components will be generated upon submission.

Research and Related Senior/Key Person Profile (Overall) Include only the Project Director/Principal Investigator (PD/PI) and any multi-PDs/PIs (if applicable to this NOFO) for the entire application.

A summary of Senior/Key Persons followed by their Biographical Sketches in the Overall section of the assembled application image in eRA Commons will be generated upon submission.

Budget (Overall) The only budget information included in the Overall component is the Estimated Project Funding section of the SF424 (R&R) Cover.

A budget summary in the Overall section of the assembled application image in eRA Commons compiled from detailed budget data collected in the other components will be generated upon submission.

PHS 398 Research Plan (Overall) Introduction to Application: For Resubmission and Revision applications, an Introduction to Application is required in the Overall component.

Specific Aims: Describe the broad long-term objectives and specific aims of the proposed Center. Include the objectives for each of the Cores proposed, as well as the objectives of the Administrative Core.

Research Strategy:

The Research Strategy section of the Overall Component describes the overall significance and innovation of the Center. This section also highlights how the Center and its unique resources will impact the research community and the field(s) covered by the Center. A clear description of the Center's major research objectives, the focus (or theme) of research addressed, and details about the placement/contribution of each core in the overall scheme of the center must be included.

A description of how the center as a whole will benefit from any unique cohorts and samples, collaborations, or resources should be included, as well as a summary of any special features in the environment and/or resources that make the overall center strong or unique. When applicable, the research community or those who will use Center resources must be defined. For the purposes of this NOFO, members of a research community may work in the same field or related fields and interact through meetings, collaborations, and/or shared activities.

If the Center involves clinical research, concisely describe overall plans for ensuring the feasibility of recruiting sufficient participants from the proposed population(s) to achieve the stated objectives.

The Research Strategy section of the Overall Component should be organized in the following fashion:

Orientation to the Overall Center Component

Research Community

Significance

Innovation

Approach

Progress Report (if application is a Renewal Application) Provide the following information in composite summary/progress report:

Letters of Support: Include letters of support from appropriate institutional officials of each performance site. These letters should confirm commitments of space and other resources required by the Center. Include a letter of agreement from existing resources (such as the CTSA PD(s)/PI(s)) if collaborative linkages are being developed. Letters from research community investigators should document their research interests, interactions with other Center investigators, the need for and impact of shared resources, and likely use of Center resources. Provide a table listing individuals providing letters of support and their institutions.

Resource Sharing Plan:

Individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the How to Apply - Application Guide.

Other Plan(s):

All instructions in the How to Apply- Application Guide must be followed, with the following additional instructions:

A Data Management and Sharing Plan (DMS Plan) is required for any NIH-funded or conducted research that will generate scientific data. Applicants must submit the DMS Plan at the time of application using the NIH DMS Plan Format Page. The DMS Plan must address the elements in the structured format. Where the DMS Plan Format Page requires a "Yes or No" response, no additional narrative is allowed. The Data Management and Sharing (DMS) Plan must be provided in the Overall component.

Appendix:

Only limited items are allowed in the Appendix. Follow all instructions for the Appendix as described in How to Apply- Application Guide; any instructions provided here are in addition to the How to Apply - Application Guide instructions.

PHS Human Subjects and Clinical Trials Information (Overall) When involving human subjects research, clinical research, and/or NIH-defined clinical trials follow all instructions for the PHS Human Subjects and Clinical Trials Information form in the How to Apply - Application Guide, with the following additional instructions:

If you answered "Yes" to the question "Are Human Subjects Involved?" on the R&R Other Project Information form, there must be at least one human subjects study record using the Study Record: PHS Human Subjects and Clinical Trials Information form or a Delayed Onset Study record within the application. The study record(s) must be included in the component(s) where the work is being done, unless the same study spans multiple components. To avoid the creation of duplicate study records, a single study record with sufficient information for all involved components must be included in the Overall component when the same study spans multiple components.

Study Record: PHS Human Subjects and Clinical Trials Information All instructions in the How to Apply - Application Guide must be followed.

Delayed Onset Study

Note: Delayed onset does NOT apply to a study that can be described but will not start immediately (i.e., delayed start). All instructions in the How to Apply- Application Guide must be followed.

PHS Assignment Request Form (Overall) All instructions in the How to Apply- Application Guide must be followed.

Administrative Core When preparing your application, use Component Type 'Admin Core.' All instructions in the How to Apply- Application Guide must be followed, with the following additional instructions, as noted.

SF424 (R&R) Cover (Administrative Core) Complete only the following fields:

PHS 398 Cover Page Supplement (Administrative Core) Follow standard instructions.Research & Related Other Project Information (Administrative Core) Human Subjects: Answer only the 'Are Human Subjects Involved?' and 'Is the Project Exempt from Federal regulations?' questions.

Vertebrate Animals: Answer only the 'Are Vertebrate Animals Used?' question.

Project Narrative: Do not complete. Note: ASSIST screens will show an asterisk for this attachment indicating it is required. However, eRA systems only enforce this requirement in the Overall component and applications will not receive an error if omitted in other components.

Project /Performance Site Location(s) (Administrative Core) List all performance sites that apply to the specific component.

Note: The Project Performance Site form allows up to 300 sites, prior to using additional attachment for additional entries.

Research & Related Senior/Key Person Profile (Administrative Core)

Budget (Administrative Core) Budget forms appropriate for the specific component will be included in the application package.

The budget of the Administrative Core may include appropriate salary for the Director, Associate Director, and support personnel, expenses related to the Advisory Committee (e.g., travel, teleconferences, etc.), expenses associated with outreach to the broader research community, and expenses associated with the Career Enhancement Program or Pilot & Feasibility Program. Carefully explain and justify requested support.

Indicate the level of time commitment by the Director and Associate Director devoted specifically to the Center. Administrative support personnel may be budgeted at no more than one full-time equivalent (FTE), which may be divided among one or more positions. This FTE must be fully justified.

The Center Director is expected to make a commitment of at least 1.8 person months (PM) to the overall administration of the Center; while the Center Associate Director is expected to commit at least 1.2 PM to Center administration efforts. These commitment levels cannot be reduced in later years of the award.

Required PM effort for Directors of the Resource Core(s) should equal 1.8 person months. This commitment cannot be reduced in later years of the award. Note that this is a minimum level of effort that should be increased as appropriate to meet the needs of the work. Applicants should justify minimum effort, based on the proposed activities of the Core.

The Center must allocate a minimum of $20,000 and up to $100,000 direct costs each year to the Career Enhancement Program, which will be administered through the Administrative Core.

The Administrative Core may allocate a minimum of $25,000 and up to $60,000 direct costs in each year (except year 1) to its Pilot and Feasibility (P&F) Program. There is a maximum of two P&F awards per year.

Note: The R&R Budget form included in many of the component types allows for up to 100 Senior/Key Persons in section A and 100 Equipment Items in section C prior to using attachments for additional entries. All other SF424 (R&R) instructions apply.

PHS 398 Research Plan (Administrative Core) Specific Aims: Describe the broad long-term objectives and goals of the proposed Administrative Core. In addition, state the Core's relationship to the associated Resource Core(s) Research Strategy:

The Administrative Core manages the overall Center, including the Pilot and Feasibility (P&F) Program (if proposed) and the Career Enhancement Program (if applicable). Applicants are encouraged to organize the Research Strategy section of the Administrative Core to align with the Centers' review criteria for the Administrative Core. Please include the following headings:

Leadership Define the responsibilities of the Director and Associate Director, Advisory Committee, Core Directors (if applicable), institution officials, and other involved parties.

The Administrative Core will also manage interactions with the Advisory Committee. Describe the plans and procedures for nominating and selecting members of this committee. Describe the expected composition of the Advisory Committee (e.g., number of members, types of expertise, etc.), but do NOT name the members of the committee who are not from the Center Institution in the application. The Advisory Committee should include both users of the Cores and investigators external to the Center who may have expertise in the design and management of other core facilities or expertise in the technologies, services, or resources offered by the Cores or expertise in the research fields covered by the research community.

Management and Evaluation The Administrative Core is responsible for coordinating and integrating the Center components and activities.

Communication Describe plans for maintaining effective communication within the Center and with the research community and other potential users of the Core(s). Explain how communication plans will coordinate and integrate the investigators and activities of the Center. Describe plans for effectively communicating with Center investigators and Core Directors who are physically located 100 miles or more away from the primary Center.

Career Enhancement Program Incorporate enrichment activities and educational opportunities to support investigators at varying levels (e.g., ESIs, NIs, students, fellows).

Pilot and Feasibility Program (optional) If included, describe plans for soliciting, reviewing, selecting, managing, and reporting on pilot and feasibility (P&F) projects. Include any plans to select mentees and their projects in the application.

Sustainability Plan Include a plan for transitioning to self-sustainable funding during the project period. Describe steps to increase the likelihood of continuing the Center's positive impact post-NIAMS support.

Examples of Sustainability: Commitments of institutional support, partnerships with existing institutional resources, future plans for obtaining external funding, self-sustaining business models, or maintaining collaborations.

Resource Sharing Plan: Individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the How to Apply- Application Guide, with the following modification:

Other Plan(s):

All instructions in the How to Apply - Application Guide must be followed, with the following additional instructions:

Do not include a Data Management and Sharing (DMS) Plan within this Component. If a DMS Plan is required for this NOFO, it must be included within the Overall Component.

Appendix:

Only limited items are allowed in the Appendix. Follow all instructions for the How to Apply- Application Guide; any instructions provided here are in addition to those in the How to Apply- Application Guide instructions.

PHS Human Subjects and Clinical Trials Information (Administrative Core) When involving human subjects research, clinical research, and/or NIH-defined clinical trials follow all instructions for the PHS Human Subjects and Clinical Trials Information form in the How to Apply- Application Guide, with the following additional instructions:

If you answered "Yes" to the question "Are Human Subjects Involved?" on the R&R Other Project Information form, you must include at least one human subjects study record using the Study Record: PHS Human Subjects and Clinical Trials Information form or a Delayed Onset Study record.

Study Record: PHS Human Subjects and Clinical Trials Information All instructions in the How to Apply- Application Guide must be followed.

Delayed Onset Study Note: Delayed onset does NOT apply to a study that can be described but will not start immediately (i.e., delayed start). All instructions in the How to Apply- Application Guide must be followed.

Resource Core When preparing your application, use Component Type 'Core'.

A Resource Core can be defined in multiple ways and may provide shared technologies, services, expertise, or resources that enable investigators to conduct research more efficiently and effectively.

Resource Cores may support basic, translational, and/or clinical research and may include, but are not limited to:

Resource Cores may also provide analytical, methodological, computational, or translational expertise tailored to the needs of the research community. These capabilities should be appropriate to the Center's focus and may support basic, translational, and/or clinical research.

Resource Cores should be justified by the needs of the research community and should be appropriate for the focus of the Center. This may include cores that provide methodological, analytical, or translational expertise.

All instructions in the How to Apply- Application Guide must be followed, with the following additional instructions, as noted.

SF424 (R&R) Cover (Resource Core) Complete only the following fields:

PHS 398 Cover Page Supplement (Resource Core) Follow standard instructions.Research & Related Other Project Information (Resource Core) Human Subjects: Answer only the 'Are Human Subjects Involved?' and 'Is the Project Exempt from Federal regulations?' questions.

Vertebrate Animals: Answer only the 'Are Vertebrate Animals Used?' question.

Project Narrative: Do not complete. Note: ASSIST screens will show an asterisk for this attachment indicating it is required. However, eRA systems only enforce this requirement in the Overall component and applications will not receive an error if omitted in other components.

Project /Performance Site Location(s) (Resource Core) List all performance sites that apply to the specific component.

Note: The Project Performance Site form allows up to 300 sites, prior to using additional attachment for additional entries.

Research & Related Senior/Key Person Profile (Resource Core) In the Project Director/Principal Investigator section of the form, use Project Role of 'Other' with Category of 'Project Lead' and provide a valid eRA Commons ID in the Credential field.

In the additional Senior/Key Profiles section, list Senior/Key persons that are working in the component.

Include a single Biographical Sketch for each Senior/Key person listed in the application regardless of the number of components in which they participate. When a Senior/Key person is listed in multiple components, the Biographical Sketch can be included in any one component.

If more than 100 Senior/Key persons are included in a component, the Additional Senior Key Person attachments should be used.

Budget (Resource Core) Budget forms appropriate for the specific component will be included in the application package.

Required PM effort for Directors of the Resource Cores should equal 1.8 person months per year to the Core. This commitment cannot be reduced in later years of the award. Note that this is a minimum level of effort that should be increased as appropriate to meet the needs of the work. Applicants should justify minimum effort, based on the proposed activities of the Core.

Resource Core support may include personnel, equipment, supplies, services, and facilities. It is important to provide comprehensive budgetary justifications and to discuss mechanisms for reimbursing Core services.

This NOFO is not intended for acquisition of high-cost equipment. Equipment purchases in excess of $25,000 for any year of the grant requires special justification. Under unusual circumstances where costly items of equipment are requested, the application must document available equipment within the institution and provide clear justification in terms of core service to be provided by the Center. Costly items of equipment should be funded through other sources.

Note: The R&R Budget form included in many of the component types allows for up to 100 Senior/Key Persons in section A and 100 Equipment Items in section C prior to using attachments for additional entries. All other SF424 (R&R) instructions apply.

PHS 398 Research Plan (Resource Core) Introduction to Application:

The most commonly referenced Research Plan attachments are listed below for your convenience.

Specific Aims: Describe the broad, long-term objectives and the specific aims to be accomplished by the Core. Include any proposed research to enhance the Core's capabilities (e.g. development or adaptation of technologies, methodologies, analytical approaches, or services) and/or education and training activities.

Research Strategy:

Describe the background information and gaps that led…