PWS Attachment 1_Germline Genetics Price Schedule 03032022 - REVISED WE.xlsx
XLSX spreadsheet 29 KB Posted
- Attached to
- Q301--Germline Genetic Lab Testing Services_VHA_National Oncology Program Amendment 0001 - Post Answers to Vendor Questions Federal contract opportunity
- Solicitation number
- 36C10X22Q0164
About this file
This solicitation requests proposals for germline genetic testing services to support the Department of Veterans Affairs Veterans Health Administration National Oncology Program. The solicitation seeks a contractor to provide a range of genetic tests including single gene tests, custom gene panels, cancer predisposition panels, and expanded carrier screening. Key requirements include the ability to create custom gene panels at no additional cost and providing genetic tests for conditions such as breast cancer, colon cancer, cardiac disorders, and mitochondrial disorders. Pricing is requested for base and option ordering periods. The Strategic Acquisition Center Frederick is the contracting agency. Responses are due by the date specified in amendment 0001 to the solicitation.
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Other files for this federal contract opportunity
| File | Type | Posted |
|---|---|---|
| 36C10X22Q0164 0001_1.docx | DOCX document | |
| 36C10X22Q0164_2.docx | DOCX document | |
| QUESTIONS TEMPLATE.xlsx | XLSX spreadsheet | |
| BUSINESS ASSOCIATE AGREEMENT - GERMLINE.pdf |
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Text version
Genomic Tests
| Services require the ordering provider is able to create custom gene panels at no additional cost. | |||||||||||
| BASE PERIOD | OPTION PERIOD 1 | OPTION PERIOD 2 | OPTION PERIOD 3 | ||||||||
| Completed by VA | Complete by VA | Mandatory or Preferred | Completed by VA | Completed by Vendor | Completed by Vendor | Completed by Vendor | Completed by Vendor | Completed by Vendor | Completed by Vendor | Completed by Vendor | Completed by Vendor |
| Generic Name | Genes Included (examples) | Estimated Quantity Per Year | Company Code | Cost Per Test | Company Code | Cost Per Test | Company Code | Cost Per Test | Company Code | Cost Per Test | |
| Single Gene | varies depending on familial mutation | Mandatory | 280 | ||||||||
| Custom Panel | varies depending on personal/family history | Preferred | 500 | ||||||||
| Breast Cancer Panel | ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, NBN, NF1, PALB2, PTEN, RAD50, STK11, TP53 | Mandatory | 90 | ||||||||
| Breast/Gyn Cancer Panel | ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, DICER1, EPCAM, MLH1, MSH2, MSH6, NBN, NF1, PALB2, PMS2, PTEN, RAD50, RAD51C, RAD51D, SMARCA4, STK11, TP53 | Mandatory | 160 | ||||||||
| Colorectal Cancer Panel | APC, AXIN2, BMPR1A, CDH1, CHEK2, EPCAM, GREM1, MLH1, MSH2, MSH3, MSH6, MUTYH, NTHL1, PMS2, POLD1, POLE, PTEN, SMAD4, STK11, TP53, ATM, BLM, BUB1B, CEP57, ENG, FLCN, GALNT12, MLH3, RNF43, RPS20 | Mandatory | 150 | ||||||||
| Common Hereditary Cancers | APC, ATM, AXIN2, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A, CHEK2, CTNNA1, DICER1, EPCAM, GREM1, HOXB13, KIT, MEN1, MLH1, MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NTHL1, PALB2, PDGFRA, PMS2, POLD1, POLE, PTEN, RAD50, RAD51C, RAD51D, SDHA, SDHB, SDHC, SDHD, SMAD4, SMARCA4, STK11, TP53, TSC1, TSC2, VHL | Mandatory | 250 | ||||||||
| Multicancer Panel | AIP ALK APC ATM AXIN2 BAP1 BARD1 BLM BMPR1A BRCA1 BRCA2 BRIP1 CASR CDC73 CDH1 CDK4 CDKN1B CDKN1C CDKN2A CEBPA CHEK2 CTNNA1 DICER1 DIS3L2 EGFR EPCAM FH FLCN GATA2 GPC3 GREM1 HOXB13 HRAS KIT MAX MEN1 MET MITF MLH1 MSH2 MSH3 MSH6 MUTYH NBN NF1 NF2 NTHL1 PALB2 PDGFRA PHOX2B PMS2 POLD1 POLE POT1 PRKAR1A PTCH1 PTEN RAD50 RAD51C RAD51D RB1 RECQL4 RET RUNX1 SDHA SDHAF2 SDHB SDHC SDHD SMAD4 SMARCA4 SMARCB1 SMARCE1 STK11 SUFU TERC TERT TMEM127 TP53 TSC1 TSC2 VHL WRN WT1 | Mandatory | 615 | ||||||||
| Prostate Cancer Panel | ATM, BARD1, BRCA1, BRCA2, BRIP1, CHEK2, FANCL, EPCAM, HOXB13, MLH1, MSH2, MSH6, NBN, PALB2, PMS2, RAD51C, RAD51D, TP53 | Mandatory | 2500 | ||||||||
| Renal/Urinary Tract Cancer Panel | BAP1, CDC73, CDKN1C, DICER1, DIS3L2, EPCAM, FH, FLCN, GPC3, MET, MLH1, MSH2, MSH6, PMS2, PTEN, REST, SDHB, SDHC, SMARCA4, SMARCB1, TP53, TSC1, TSC2, VHL, WT1 | Mandatory | 35 | ||||||||
| Pancreatic Cancer Panel | APC, ATM, BMPR1A, BRCA1, BRCA2, CDKN2A, EPCAM, MEN1, MLH1, MSH2, MSH6, NF1, PALB2, PMS2, SMAD4, STK11, TP53, TSC1, TSC2, VHL | Mandatory | 300 | ||||||||
| Pancreatitis Panel | CASR, CFTR, CPA1, CTRC, PRSS1, SPINK1 | Mandatory | 10 | ||||||||
| Paraganglioma/Pheochromocytoma Panel | MAX, NF1, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, TMEM127, VHL | Mandatory | 10 | ||||||||
| Melanoma Panel | BAP1, BRCA2, CDK4, CDKN2A, MITF, POT1, PTEN, RB1, TP53 | Mandatory | 18 | ||||||||
| Gastric Cancer Panel | APC, BMPR1A, CDH1, CTNNA1, EPCAM, KIT, MLH1, MSH2, MSH6, NF1, PDGFRA, PMS2, SDHA, SDHB, SDHC, SDHD, SMAD4, STK11, TP53 | Mandatory | 27 | ||||||||
| Hyperparathyroidism Panel | AP2S1, CASR, CDC73, CDKN1B, GNA11, MEN1, RET | Mandatory | 10 | ||||||||
| Lynch Syndrome Panel | EPCAM, MLH1, MSH2, MSH6, PMS2 | Mandatory | 45 | ||||||||
| Schwannomatosis Panel | LZTR1, NF2, SMARCB1 | Mandatory | 4 | ||||||||
| Neurofibromatosis Type 1 | NF1 | Mandatory | 10 | ||||||||
| Neurofibromatosis Type 2 | NF2 | Mandatory | 4 | ||||||||
| Polyposis Panel | APC, MSH3, MUTYH, NTHL1, POLD1, POLE | Mandatory | 20 | ||||||||
| Familial Hypercholesterolemia Panel | APOB, LDLR, LDLRAP1, PCSK9 | Mandatory | 45 | ||||||||
| Cardiomyopathy Panel | ABCC9, ACTC1, ACTN2, AGL, BAG3, CACNA1C, CAV3, CRYAB, CSRP3, DES, DMD, DOLK, DSC2, DSG2, DSP, EMD, EYA4, FHL1, FKRP, FKTN, FLNC, GAA, GLA, HCN4, JUP, LAMP2, LMNA, MYBPC3, MYH7, MYL2, MYL3, PKP2, PLN, PRKAG2, RAF1, RBM20, RYR2, SCN5A, SGCD, SLC22A5, TAZ, TCAP, TMEM43, TNNC1, TNNI3, TNNT2, TPM1, TTN, TTR, VCL | Mandatory | 50 | ||||||||
| Hypertrophic Cardiomyopathy Panel | ACTC1, ACTN2, AGL, BAG3, CACNA1C, CAV3, CSRP3, DES, FHL1, FLNC, GAA, GLA, LAMP2, MYBPC3, MYH7, MYL2, MYL3, PLN, PRKAG2, TCAP, TNNC1, TNNI3, TNNT2, TPM1, TTR, VCL | Mandatory | 27 | ||||||||
| Dilated Cardiomyopathy Panel | ABCC9, ACTC1, ACTN2, BAG3, CAV3, CRYAB, CSRP3, DES, DMD, DOLK, DSC2, DSG2, DSP, EMD, EYA4, FKRP, FKTN, FLNC, JUP, LAMP2, LMNA, MYBPC3, MYH7, PKP2, PLN, RAF1, RBM20, RYR2, SCN5A, SGCD, SLC22A5, TAZ, TCAP, TMEM43, TNNC1, TNNI3, TNNT2, TPM1, TTN, TTR, VCL | Mandatory | 20 | ||||||||
| Hereditary Hemorrhagic Telangiectasia | ACVRL1, ENG, GDF2, RASA1, SMAD4 | Mandatory | 6 | ||||||||
| Familial Transthyretin Amyloidosis | TTR | Mandatory | 35 | ||||||||
| Arrhythmia Panel | ABCC9, ACTN2, ANK2, CACNA1C, CACNB2, CALM1, CALM2, CALM3, CASQ2, CAV3, DES, DSC2, DSG2, DSP, EMD, FLNC, GPD1L, HCN4 ,JUP, KCNA5, KCNE1, KCNE2, KCNH2, KCNJ2, KCNQ1, LMNA, MYL4, NKX2-5, PKP2, PLN, PRKAG2, RBM20, RYR2, SCN5A, TMEM43, TNNI3, TNNT2, TRDN, TTN | Mandatory | 20 | ||||||||
| Long QT Panel | ANK2, CACNA1C, CALM1, CALM2, CALM3, CAV3, KCNE1, KCNE2, KCNH2, KCNJ2, KCNQ1, SCN5A, TRDN | Mandatory | 20 | ||||||||
| Polycystic Kidney Disease Panel | DNAJB11, GANAB, HNF1B, PKD1, PKD2 | Mandatory | 20 | ||||||||
| Muscular Dystrophy Panel | ANO5, B3GALNT2, B4GAT1, CAPN3, CAV3, CHKB, COL12A1, COL6A1, COL6A2, COL6A3, DAG1, DES, DMD, DNAJB6, DPM1, DPM2, DPM3, DYSF, EMD, FHL1, FKRP, FKTN, GAA, GMPPB, ISPD, ITGA7, LAMA2, LARGE1, LMNA, MYOT, PLEC, PNPLA2, POMGNT1, POMGNT2, POMK, POMT1, POMT2, RXYLT1, SGCA, SGCB, SGCD, SGCG, TCAP, TNPO3, TOR1AIP1, TRAPPC11, TRIM32, TTN | Mandatory | 10 | ||||||||
| Limb Girdle Muscular Dystrophy Panel | ANO5, CAPN3, CAV3, DAG1, DES, DMD, DNAJB6, DYSF, FKRP, FKTN, GAA, GMPPB, ISPD, LMNA, MYOT, PLEC, PNPLA2, POMGNT1, POMK, POMT1, POMT2, SGCA, SGCB, SGCD, SGCG, TCAP, TNPO3, TOR1AIP1, TRAPPC11, TRIM32, TTN | Mandatory | 10 | ||||||||
| Hereditary Neuropathy Panel | AARS, AIFM1, ATL1, ATL3, ATP7A, BICD2, BSCL2, CHCHD10, DCTN1, DNAJB2, DNM2, DNMT1, DST, DYNC1H1, EGR2, ELP1, FBXO38, FGD4, FIG4, GAN, GARS, GDAP1, GJB1, GNB4, HARS, HINT1, HSPB1, HSPB8, IGHMBP2, INF2, KIF1A, LITAF, LMNA, LRSAM1, MED25, MFN2, MORC2, MPZ, MTMR2, NDRG1, NEFL, NGF, NTRK1, PDK3, PLEKHG5, PMP22, PRPS1, PRX, RAB7A, REEP1, RETREG1, SBF2, SCN11A, SCN9A, SH3TC2, SIGMAR1, SLC25A46, SLC52A2, SLC52A3, SLC5A7, SPG11, SPTLC1, SPTLC2, TFG, TRIM2, TRPV4, TTR, UBA1, VAPB, VRK1, WNK1, YARS | Mandatory | 27 | ||||||||
| Charcot-Marie Tooth Panel | AARS, AIFM1, BSCL2, DNAJB2, DNM2, DYNC1H1, EGR2, FGD4, FIG4, GARS, GDAP1, GJB1, GNB4, HARS, HINT1, HSPB1, HSPB8, IGHMBP2, INF2, LITAF, LMNA, LRSAM1, MED25, MFN2, MORC2, MPZ, MTMR2, NDRG1, NEFL, PDK3, PLEKHG5, PMP22, PRPS1, PRX, RAB7A, SBF2, SH3TC2, SLC25A46, SPG11, TFG, TRIM2, TRPV4, YARS | Mandatory | 18 | ||||||||
| Ataxia Repeat Expansion Panel | ATN1, ATXN1, ATXN10, ATXN2, ATXN3, ATXN7, ATXN8OS, BEAN1, CACNA1A, FMR1, FXN, NOP56, PPP2R2B, TBP | Preferred | 35 | ||||||||
| ALS Panel | ALS2, CHCHD10, DCTN1, FUS, KIF5A, OPTN, PFN1, SETX, SOD1, SPG11, TARDBP, TBK1, TFG, UBQLN2, VAPB, VCP, CHMP2B, MATR3, SIGMAR1, SQSTM1 | Mandatory | 20 | ||||||||
| Frontotemporal Dementia Panel | CHCHD10, DCTN1, FUS, GRN, MAPT, TARDBP, TBK1, UBQLN2, VCP, CHMP2B, HNRNPA2B1, PSEN1, SQSTM1 | Mandatory | 18 | ||||||||
| C9orf72 Gene | C9ORF72 | Preferred | 18 | ||||||||
| Spinal Bulbar Muscular Atrophy | AR gene | Preferred | 9 | ||||||||
| Myotonic Dystrophy Type 1 | DMPK | Preferred | 18 | ||||||||
| Myotonic Dystrophy Type 2 | CNBP | Preferred | 9 | ||||||||
| Huntington Disease | HTT | Preferred | 35 | ||||||||
| CADASIL | NOTCH3, HTRA1 | Mandatory | 9 | ||||||||
| Inherited Alzheimer disease | APP, PSEN1, PSEN2 | Mandatory | 9 | ||||||||
| Hereditary Spastic Paraplegia Panel | ABCD1, ALDH18A1, ALS2, AP4B1, AP4E1, AP4M1, AP4S1, AP5Z1, ATL1, B4GALNT1, BSCL2, C12orf65, CYP2U1, CYP7B1, DDHD1, DDHD2, ERLIN2, FA2H, GBA2, GJC2, HEXA, HSPD1, KDM5C, KIF1A, KIF1C, KIF5A, L1CAM, NIPA1, NT5C2, PLP1, PNPLA6, REEP1, REEP2, RTN2, SACS, SLC16A2, SPART, SPAST, SPG11, SPG21, SPG7, TECPR2, VAMP1, WASHC5, ZFYVE26 | Mandatory | 18 | ||||||||
| Pulmonary Hypertension | ACVRL1, BMPR2, CAV1, ENG, SMAD9 | Mandatory | 2 | ||||||||
| Malignant Hyperthermia | CACNA1S, RYR1, STAC3 | Mandatory | 9 | ||||||||
| Macular Dystrophies Panel | ABCA4, BEST1, C1QTNF5, CDH3, CERKL, CFH, CNGB3, CRB1, CTNNA1, EFEMP1, ELOVL4, FSCN2, GUCA1B, HMNCN1, IMPG1, IMPG2, MFSD8, PRDM13, PROM1, PRPH2, RBP3, RDH12, RLBP1, RPIl1, RPGR, RPGRIP1, RS1, TIMP3 | Mandatory | 9 | ||||||||
| Retinitis Pigementosa Panel | up to 80 genes | Mandatory | 18 | ||||||||
| Familial Hypocalciuric Hypercalecemia | AP2S1, CASR, GNA11 | Mandatory | 27 | ||||||||
| Maturity Onset Diabetes of the Young | ABCC8, APPL1, BLK, GCK, HNF1A, HNF1B, HNF4A, INS, KCNJ11, KLF11, NUEROD1, PAX4, PDX1 | Mandatory | 9 | ||||||||
| Acute hepatic porphyria | ALAD, CPOX, HMBS, PPOX | Mandatory | 4 | ||||||||
| Myopathy panel | Mandatory | 9 | |||||||||
| Primary Immunodeficiences | Mandatory | 9 | |||||||||
| Focal Segmental Glomerulosclerosis | Preferred | 3 | |||||||||
| Carrier Screen | CFTR, SMN1, FMR1 | Preferred | 35 | ||||||||
| Expanded Carrier Screen | ABCC8, ABCD1, ACADM, ASPA, ASS1, BCKDHA, BCKDHB, BLM, CFTR, CLN3, CLRN1, DHCR7, DLD, DMD, ELP1, FAH, FANCC, FKTN, FMR1, G6PC, GAA, GALC, GALT, GBA, GJB2, HBA1, HBA2, HBB, HEXA, IDUA, IL2RG, MCOLN1, NEB, OTC, PAH, PCDH15, PEX1, PEX6, PEX7, PKHD1, PMM2, SLC26A4, SMN1, SMPD1, TMEM216, USH2A | Preferred | 35 | ||||||||
| Connective tissue panel/aortopathies | ABCC6, ACTA2, ADAMTS2, AEBP1, ALDH18A1, ATP6V0A2, ATP6V1E1, B3GALT6, B3GAT3, B4GALT7, BGN, C1R, C1S, CBS, CHST14, COL11A1, COL11A2, COL12A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL5A1, COL5A2, COL9A1, COL9A2, CRTAP, DSE, EFEMP2, ELN, FBLN5, FBN1, FBN2, FKBP14, FLNA, LOX, LTBP4, MAT2A, MED12, MFAP5, MYH11, MYLK, NOTCH1, P3H1, PLOD1, PRDM5, PRKG1, PYCR1, RIN2, SGMS2, SKI, SLC2A10, SLC39A13, SMAD3, SMAD4, TGFB2, TGFB3, TGFBR1, TGFBR2, TNXB, ZNF469 | Mandatory | 209 | ||||||||
| Decreased Bone Density Panel/Osteogenesis imperfecta | ALPL, ANO5, B4GALT7, BMP1, CLCN5, COL1A1, COL1A2, CRTAP, DMP1, ENPP1, FGF23, FKBP10, GNAS, GORAB, IFITM5, LMNA, LRP5, MAFB, MMP2, NOTCH2, P3H1, PHEX, PLOD2, PPIB, SERPINF1, SERPINH1, SLC34A3, SP7, SPARC, TMEM38B, TNFRSF11A, WNT1 | Mandatory | 9 | ||||||||
| Mitochondrial Panel | AAAS, AARS, AARS2, AASS, ABAT, ABCB11, ABCB4, ABCB6, ABCB7, ABCB8, ABCC8, ABCC9, ABCD1, ABCD3, ABCD4, ABHD5, ACACA, ACAD8, ACAD9, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACHE, ACLY, ACO2, ACSF3, ACSL4, ACSL5, ACSM3, ADSL, AFG3L2, AGK, AGL, AGPS, AGXT, AGXT2, AIFM1, AK2, AK3, AKAP10, AKR7A2, AKT1, AKT2, ALAS2, ALDH18A1, ALDH2, ALDH3A2, ALDH4A1, ALDH5A1, ALDH6A1, ALDH7A1, ALDOA, ALDOB, ALG1, ALG11, ALG13, ALG2, ALG3, ALG6, ALG9, AMACR, AMT, ANK2, ANKRD26, APOPT1, APTX, ARG1, ARMS2, ARX, AS3MT, ASL, ASS1, ATAD3A, ATAD3B, ATIC, ATP10D, ATP5F1A, ATP5F1B, ATP5F1E, ATP7B, ATP8B1, ATPAF2, ATXN7, AUH, B4GALT1, BAX, BCAT1, BCAT2, BCKDHA, BCKDHB, BCL2, BCS1L, BOLA3, C12orf65, C19orf12, CA5A, CACNA1A, CACNA1S, CACNA2D1, CARS2, CASP8, CCT7, CDC42BPB, CDKL5, CFTR, CHAT, CHCHD10, CHDH, CHKB, CHRNA4, CHRNB2, CISD2, CKM, CKMT1B, CLCN1, CLCN2, CLCN5, CLCN7, CLCNKB, CLN3, CLN5, CLN6, CLN8, CLPB, CLPP, CLYBL, CNR1, COA5, COA6, COASY, COG4, COG5, COG6, COG7, COG8, COMT, COQ2, COQ4, COQ5, COQ6, COQ7, COQ8A, COQ8B, COQ9, COX10, COX14, COX15, COX20, COX4I1, COX4I2, COX6A1, COX6B1, COX7A1, COX7A2, COX7B, COX8A, CPOX, CPS1, CPT1A, CPT1B, CPT2, CTSD, CYB5A, CYB5R3, CYBA, CYBB, CYC1, CYCS, CYP11A1, CYP11B1, CYP11B2, CYP24A1, CYP27A1, CYP27B1, D2HGDH, DARS, DARS2, DBT, DDAH1, DDC, DDHD1, DDHD2, DDOST, DECR1, DGUOK, DHODH, DHTKD1, DIABLO, DISC1, DLAT, DLD, DMAC2, DMGDH, DNA2, DNAJC19, DNAJC5, DNM1L, DNM2, DOLK, DPAGT1, DPM1, DPM3, DTNBP1, EARS2, ECHS1, ECI1, ECSIT, ELAC2, ELN, ENO1, ENO3, ETFA, ETFB, ETFDH, ETHE1, FAAH, FAH, FARS2, FASN, FASTKD2, FBP1, FBXL4, FDPS, FDX2, FECH, FH, FLAD1, FOLR1, FOXC1, FOXG1, FOXRED1, FTH1, FXN, G6PC, G6PD, GAA, GAD1, GAD2, GALC, GAMT, GARS, GATD3A, GATM, GBE1, GCDH, GCK, GCSH, GDAP1, GFER, GFM1, GFM2, GK, GLDC, GLO1, GLRA1, GLRX5, GLS, GLUD1, GLYCTK, GMPPA, GNAS, GNPAT, GPAM, GPD1, GPD2, GPI, GPX1, GPX4, GSS, GTPBP3, GYG1, GYG2, GYS1, GYS2, H6PD, HADH, HADHA, HADHB, HARS, HARS2, HCCS, HCFC1, HIBCH, HIGD2A, HK1, HK2, HLCS, HMGCL, HMGCS2, HOGA1, HSD17B10, HSD17B4, HSD3B1, HSD3B2, HSPA9, HSPB7, HSPD1, HSPE1, HTRA2, IARS2, IBA57, IDE, IDH1, IDH2, IDH3B, IMMP2L, IMMT, INPP5E, INSR, ISCA2, ISCU, IVD, KARS, KCNA1, KCNE1, KCNE2, KCNH2, KCNJ11, KCNJ2, KCNQ1, KCNQ2, KCNQ3, KIF1B, KRT5, KYNU, L2HGDH, LAMP2, LARS, LARS2, LDHA, LDHB, LETM1, LIAS, LIPT1, LMBRD1, LRPPRC, LRRK2, LYRM4, LYRM7, MAOA, MAOB, MARS, MARS2, MAVS, MCCC1, MCCC2, MCEE, MDH1, MECP2, MECR, MED23, MEN1, MFF, MFN2, MFSD8, MGAT2, MGLL, MGME1, MGST3, MICU1, MLYCD, MMAA, MMAB, MMACHC, MMADHC, MOCOS, MOCS1, MOCS2, MOGS, MPC1, MPDU1, MPI, MPV17, MRPL12, MRPL15, MRPL19, MRPL3, MRPL43, MRPL44, MRPL48, MRPL57, MRPS12, MRPS16, MRPS17, MRPS18A, MRPS22, MRPS7, MRRF, MTCH2, MTFMT, MTHFD1, MTHFD1L, MTO1, MTPAP, MTR, MTRR, MUT, MUTYH, NADK2, NAGS, NARS2, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA4, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAF1, NDUFAF2, NDUFAF3, NDUFAF4, NDUFAF5, NDUFAF6, NDUFAF7, NDUFB1, NDUFB11, NDUFB3, NDUFB6, NDUFB8, NDUFB9, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, NFS1, NFU1, NGLY1, NIPSNAP1, NIPSNAP3A, NLRX1, NME1, NNT, NOS3, NPL, NR2F1, NRXN1, NUBPL, OAT, OGG1, OPA1, OPA3, OTC, OXCT1, PACRG, PAH, PAK5, PANK2, PARL, PARP1, PARS2, PC, PCCA, PCCB, PCK1, PCK2, PDHA1, PDHB, PDHX, PDP1, PDSS1, PDSS2, PDX1, PET100, PEX1, PEX10, PEX11B, PEX12, PEX13, PEX14, PEX16, PEX19, PEX2, PEX26, PEX3, PEX5, PEX6, PEX7, PFKM, PGAM2, PGK1, PGM1, PHB, PHKA1, PHKA2, PHKB, PHKG2, PHYH, PKLR, PMM2, PNKD, PNMT, PNPT1, POLG, POLG2, POLRMT, PPARGC1A, PPOX, PPT1, PREPL, PRKAG2, PRKN, PRODH, PRPS1, PTGES2,REEP1, RFT1, RMND1, RMRP, RNASEL, RPL35A, RPS14, RRM2B, RSPH9, RYR1, RYR2, SACS, SARDH, SARS2, SCN1A, SCN1B, SCN2A, SCN4A, SCN5A, SCO1, SCO2, SCP2, SDHA, SDHAF1, SDHAF2, SDHB, SDHC, SDHD, SECISBP2, SERAC1, SFXN4, SHMT1, SHMT2, SIRT1, SIRT3, SIRT5, SLC16A1, SLC19A2, SLC19A3, SLC22A4, SLC22A5, SLC25A1, SLC25A12, SLC25A13, SLC25A15, SLC25A16, SLC25A19, SLC25A20, SLC25A21, SLC25A22, SLC25A3, SLC25A32, SLC25A35, SLC25A38, SLC25A39, SLC25A4, SLC25A42, SLC25A5, SLC25A6, SLC27A4, SLC2A1, SLC2A2, SLC35A1, SLC35A2, SLC35C1, SLC37A4, SLC3A1, SLC5A8, SLC6A8, SLC7A7, SOD2, SPART, SPAST, SPG7, SPR, SPTLC1, SPTLC2, SRD5A3, SSR4, STAR, STT3A, STT3B, STXBP1, SUCLA2, SUCLG1, SUGCT, SUOX, SURF1, TACO1, TAP1, TARS2, TAT, TAZ, TCIRG1, TDP1, TFAM, TFB1M, TIMM13, TIMM44, TIMM50, TIMM8A, TIMM9, TK2, TKT, TMEM126A, TMEM165, TMEM70, TOMM40, TOP1MT, TP53, TPH2, TPI1, TPK1, TPP1, TRIT1, TRMU, TRNT1, TSFM, TSPO, TST, TTC19, TUFM, TWNK, TXN2, TXNRD2, TYMP, UBE3A, UCP1, UCP2, UCP3, UNG, UQCC2, UQCC3, UQCRB, UQCRC2, UQCRQ, UROS, USP24, VARS2, WARS2, WDR4, WFS1, WWOX, XPNPEP3, YARS2, MT-ATP6, MT-ATP8, MT-CO1, MT-CO2, MT-CO3, MT-CYB, MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6, MT-RNR1, MT-RNR2, MT-TA, MT-TC, MT-TD, MT-TE, MT-TF, MT-TG, MT-TH, MT-TI, MT-TK, MT-TL1, MT-TL2, MT-TM, MT-TN, MT-TP, MT-TQ, MT-TR, MT-TS1, MT-TS2, MT-TT, MT-TV, MT-TW, MT-TY | Preferred | 18 | ||||||||
| Comprehensive Metabolic Panel | ABCC8, ABCD1, ABCD4, ACAA1, ACAD9, ACADL, ACADM, ACADS, ACADVL, ACAT1, ACOX1, ACSF3, ACY1, ADAMTSL2, ADAR, ADSL, AGA, AGK, AGL, AGPAT2, AKT2, ALAD, ALAS2, ALDH5A1, ALDH7A1, ALDOA, ALG1, ALG11, ALG12, ALG13, ALG2, ALG3, ALG6, ALG8, ALG9, AMACR, AMT, ANO10, ANTXR2, APTX, ARG1, ARSA, ARSB, ASAH1, ASL, ASPA, ASS1, ATP13A2, ATP6V0A2, AUH, B3GLCT, B4GALT1, BCKDHA, BCKDHB, BSCL2, BTD, C12orf65, CA2, CACNA1S, CAV1, CAV3, CAVIN1, CBS, CD320, CKMT1A, CKMT1B, CKMT2, CLCN1, CLDN16, CLDN19, CLN3, CLN5, CLN6, CLN8, CNNM1, CNNM2, CNNM4, COG1, COG4, COG5, COG6, COG7, COG8, COL11A2, COL2A1, COQ2, COQ6, COQ8A, COQ9, CPOX, CPS1, CPT1A, CPT1B, CPT2, CTNS, CTSA, CTSC, CTSD, CTSK, DBT, DDOST, DGUOK, DHCR7, DHDDS, DLD, DOLK, DPAGT1, DPM1, DPM2, DPM3, DPYD, DYM, ECHS1, EGF, ENO3, EPM2A, ETFA, ETFB, ETFDH, FAH, FBP1, FBXL4, FECH, FH, FLNA, FLNB, FOLR1, FUCA1, FXYD2, G6PC, GAA, GALC, GALNS, GAMT, GATM, GBA, GBE1, GCDH, GCH1, GCK, GIF, GLA, GLB1, GLDC, GLUD1, GMPPA, GNE, GNPAT, GNPTAB, GNPTG, GNS, GPC3, GPHN, GUSB, GYG1, GYS1, GYS2, HADH, HADHA, HADHB, HAMP, HCFC1, HEXA, HEXB, HFE, HGSNAT, HJV, HLCS, HMBS, HMGCL, HMGCS2, HNF1A, HNF1B, HNF4A, HPD, HRAS, HSD17B10, HSD17B4, HYAL1, IDS, IDUA, IFIH1, INSR, ISCU, IVD, KCNA1, KCNJ11, KCNJ2, L2HGDH, LAMA2, LAMP2, LDB3, LDHA, LIPA, LMBRD1, LMNA, LPIN1, MAGT1, MAN1B1, MANBA, MCCC1, MCCC2, MCEE, MCOLN1, MFN2, MFSD8, MGAT2, MMAA, MMAB, MMACHC, MMADHC, MMGT1, MOCS1, MOCS2, MOGS, MPDU1, MPI, MPV17, MTHFR, MTR, MTRR, MUT, MYOT, NAGLU, NAGS, NDUFS1, NEU1, NHLRC1, NIPA2, NPC1, NPC2, OAT, OPA1, OPA3, OTC, OXCT1, PAH, PC, PCBD1, PCCA, PCCB, PCK1, PCK2, PDHA1, PDHB, PDHX, PDSS1, PDSS2, PDX1, PEX1, PEX10, PEX11B, PEX12, PEX13, PEX16, PEX2, PEX26, PEX3, PEX5, PEX6, PEX7, PFKM, PGAM2, PGK1, PGM1, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PHYH, PLIN1, PLPBP, PMM2, POLG, POLG2, PPARG, PPOX, PPT1, PRKAG2, PRKAG3, PRODH, PSAP, PTS, PYGL, PYGM, QDPR, RAI1, RBCK1, RFT1, RNASEH2A, RNASEH2B, RNASEH2C, RPN2, RRM2B, RYR1, SAMHD1, SCN4A, SEC23B, SGSH, SLC12A3, SLC16A1, SLC17A5, SLC22A5, SLC25A13, SLC25A15, SLC25A20, SLC25A3, SLC25A4, SLC2A2, SLC30A10, SLC35A1, SLC35A2, SLC35C1, SLC37A4, SLC39A4, SLC3A1, SLC40A1, SLC41A2, SLC41A3, SLC46A1, SLC6A19, SLC6A8, SLC7A7, SLC7A9, SMPD1, SPG7, SRD5A3, SSR4, STT3A, STT3B, SUCLA2, SUCLG1, SUMF1, SUOX, TAZ, TBC1D4, TCF4, TCN2, TFR2, TIMM8A, TK2, TMEM126A, TMEM165, TMEM70, TPP1, TREX1, TRPM6, TRPM7, TUSC3, TWNK, TYMP, UCP2, UROD, UROS, WFS1, ZMPSTE24 | Mandatory | TBD | ||||||||
| Rhabdomyolysis Panel | ACAD9, ACADL, ACADM, ACADVL, AGL, AMPD1, CPT1B, CPT2, ETFA, ETFB, GAA, GYS1, HADHA, HADHB, LPIN1, OPA1, OPA3, PFKM, PGAM2, PGM1, PHKA1, POLG, POLG2, PYGM, RRM2B, RYR1, SUCLA2, TK2, TWNK, TYMP | Mandatory | 9 | ||||||||
| Comprehensive Cardiac Panel | A2ML1, ABCC9, ACADVL, ACTA2, ACTB, ACTC1, ACTG1, ACTN2, ACVR2B, ACVRL1, ADA2, AGL, AKAP9, ALMS1, ANK2, ANKRD1, APOA5, APOB, B4GALT7, BAG3, BBS10, BCOR, BMPR2, BRAF, C1R, C1S, CACNA1C, CACNA2D1, CACNB2, CALM1, CALM2, CALM3, CALR3, CASQ2, CAV1, CAV3, CAVIN4, CBL, CBS, CCDC103, CCDC39, CCDC40, CHD7, CHRM2, COL3A1, COL5A1, COL5A2, COX15, CPT1A, CPT2, CRELD1, CRYAB, CSRP3, CTF1, CTNNA3, DEPDC5, DES, DMD, DNAAF1, DNAAF2, DNAAF3, DNAAF4, DNAAF5, DNAH11, DNAH5, DNAI1, DNAI2, DNAJC11, DNAJC19, DNAL1, DOLK, DSC2, DSG2, DSP, DTNA, EFEMP2, ELAC2, ELN, EMD, ENG, EYA4, FBN1, FBN2, FGD1, FHL1, FHL2, FKRP, FKTN, FLNA, FLNC, FOXH1, FXN, GAA, GATA4, GATA6, GATAD1, GDF1, GJA1, GJA5, GLA, GPC3, GPD1L, GYG1, HAMP, HAND1, HCN4, HFE, HJV, HRAS, ILK, INVS, JAG1, JPH2, JUP, KAT6B, KCNA5, KCND3, KCNE1, KCNE2, KCNE3, KCNE5, KCNH2, KCNJ2, KCNJ5, KCNJ8, KCNK3, KCNQ1, KCNQ2, KCNQ3, KCNT1, KRAS, LAMA4, LAMP2, LDB3, LDLR, LDLRAP1, LEFTY2, LMNA, LZTR1, MAP2K1, MAP2K2, MED12, MED13L, MFAP5, MIB1, MKS1, MMP21, MRPL3, MTO1, MYBPC3, MYH11, MYH6, MYH7, MYL2, MYL3, MYLK, MYLK2, MYOM1, MYOZ2, MYPN, NDUFAF1, NDUFB11, NEBL, NEK8, NEXN, NF1, NKX2-5, NKX2-6, NME8, NODAL, NOTCH1, NPHP3, NPPA, NR2F2, NRAS, NSD1, OFD1, PCDH19, PCSK9, PDLIM3, PKD1L1, PKP2, PLN, PLOD1, PRDM16, PRKAG2, PRKG1, PRRT2, PSEN2, PTPN11, RAF1, RANGRF, RASA1, RBM20, RIT1, RRAS, RYR2, SCN10A, SCN1A, SCN1B, SCN2B, SCN3B, SCN4B, SCN5A, SCN8A, SCN9A, SDHA, SGCD, SHOC2, SKI, SLC22A5, SLC25A20, SLC2A1, SLC2A10, SLC40A1, SLMAP, SMAD3, SMAD4, SMAD6, SMAD9, SNTA1, SOS1, SOS2, SPRED1, SYNE1, TAZ, TBX1, TBX20, TBX5, TCAP, TFR2, TGFB2, TGFB3, TGFBR1, TGFBR2, TMEM43, TMEM70, TMPO, TNNC1, TNNI3, TNNT2, TPM1, TRDN, TRPM4, TTC8, TTN, TTR, TXNRD2, VCL, YWHAE, ZFPM2, ZIC3 | Mandatory | 27 | ||||||||
| Exome Sequencing | All 22,000 Genes | Preferred | 25 | ||||||||
| Whole Genome Sequencing | Preferred | 5 | |||||||||
| Polygenic risk scores | breast cancer, prostate cancer, colon cancer, cardiovascular | Preferred | 300 | ||||||||
| Pharmacogenetic | HLA-A, HLA-B, HLA-DQA1, HLA-DRB1, NAT2, CYP2D6, TPMT, NUDT15, UGT1A1, DPYD, CYP2C9, CYP2C19, BCHE, CYP3A5, CYP4F2, VKORC1, SLO1B1 | Preferred | 50 | ||||||||
| Pharmacogenetic | HLA-A, HLA-B, CYP2B6, CYP2D6, CYP2C9, CYP2C19, CYP3A5, CYP4F2, UGT1A1, TPMT, NUDT15, DPYD, CACNA1S, RYR1, CFTR, IFNL3, IFNL4, G6PD, SLCO1B1, VKORC1, POLG, MT-RNR1, GBA, | Preferred | 50 | ||||||||
| Paired tumor/germline | Following abnormal Lynch syndrome screening or VUS in multiple cancer types | Preferred | 100 | ||||||||
| 6515 |
File details come from the government source that posted it. Updated .