Purchase Description - Robot Stereotaxic.pdf

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

PURCHASE DESCRIPTION

1. Statement of Need and Purpose:

The National Institute on Aging (NIA) requires a robot stereotaxicsystem for mice. Investing in a robot stereotaxic system for neuroscience research is crucial for several reasons. Firstly, it offers unparalleled precision in targeting specific brain regions during experimental procedures, minimizing variability and ensuring consistent results across experiments. This precision is especially vital when conducting delicate surgeries or inserting electrodes for recording or stimulation. Additionally, a robot stereotaxic system can streamline experimental workflows, allowing researchers to perform procedures more efficiently and thus increasing productivity in the lab. Moreover, the automation provided by such a system reduces the risk of human error, enhancing the reliability and reproducibility of research findings. Overall, acquiring a robot stereotaxic system not only improves the quality of neuroscience research but also enhances the welfare of experimental animals by minimizing surgical invasiveness and optimizing experimental outcomes.

2. Background Information and Objective:

Stereotaxic surgeries are a common and essential technique in neurosciences. Injection of substances and biologicals, or implantation of cannulas, electrodes, lenses, and optic fibers in specific regions of the brain are all powerful interventions in neuroscience yielding valuable information. Robotic stereotaxic systems represent a revolutionary advancement in neuroscience research methodology. Traditionally, stereotaxic procedures rely on manual manipulations, which are subject to human error and lack the precision demanded by modern experimental designs. Robotic stereotaxic systems address these limitations by offering unparalleled accuracy and reproducibility in targeting specific brain regions. Equipped with sophisticated imaging and navigation technologies, these systems enable researchers to precisely position probes, electrodes, or cannulas with submillimeter accuracy, facilitating intricate experimental manipulations such as deep brain stimulation, optogenetics, or pharmacological infusions. By automating and standardizing these procedures, robotic stereotaxic systems enhance experimental consistency, reproducibility, and the reliability of research outcomes. Moreover, they optimize the welfare of experimental animals by minimizing surgical invasiveness and reducing procedure durations. In essence, the integration of robotic stereotaxic systems in neuroscience research aims to revolutionize experimental methodologies, accelerating the pace of discovery and advancing our understanding of the brain's intricate functions.

3. Generic Name of Product:

Robot stereotaxic.

4. Purchase Description

Robot stereotaxic composed of Drill & Microinjection Robot (Mouse) including Drill Autostop Function, with Drill Automated Craniotomy Function, Automated synchronization device for cannula and drill bit, Smart Angle Device, Adaptor for Sagittal Angle Adjustment, Smart BregmaFinder, Heating Pad, Mouse Gas Anesthesia Head Holder, and Non-Rupture Ear Bars (Mouse).

5. Salient characteristics

All deliverables required under this contract shall be packaged, marked and shipped in accordance with government specifications. At a minimum, all deliverables shall be marked with the contract number and contractor name. The contractor shall guarantee that all required materials shall be delivered in immediate usable and acceptable condition. Vendor must be able to provide the following specifications for robot stereotaxic:

1. Drill & Microinjection Robot (mouse) including Drill Autostop Function Interconnected Automated Drill and Microinjection Robot Including Robot Stereotaxic System with Atlas Integration Including Motorized Drill & Microinjection Module Full control by the Robot Stereotaxic software Full Integrated Stereotaxic Atlas, Zeroing at Lambda/Bregma Correction for Tilt Errors, Individual Atlas Scaling Intuitive Movement Control Drill Autostop function Automated drilling procedure without damaging the underlying brain tissue High accuracy positioning of Burr Hole with depth control No tool exchange after drilling Use of Bregma-related coordinates Full computer controlled Microinjector Easy injection procedure, User defined Injection Rates Real-time atlas-based visualization of syringe tip and injection sites Adapts to most commercially available syringes

2. Drill Automated Craniotomy Function

3. Automated synchronization device for cannula and drill bit

Allows automated synchronization between the drill and syringe Optical detection of the drill bit and of the syringe needle

4. Smart Angle Device digital readout, high precision, 0.5° software integration detachable, coronal angle adjustment

5. Adaptor for Sagittal Angle Adjustment

6. Smart BregmaFinder

Dual Camera System for high resolution 3D real-time probe monitoring Automatic, Hands-Free, Precise positioning of the Probe over landmark Smart Add-On to the Motorized Stereotaxic with Atlas Integration

7. Heating Pad Heating pad with integrated closed-loop controller Full integration in the Robot Stereotaxic control software Real-time display of temperature, heating state, running state High precision temperature control, resolution of 0.1oC , set range of 20-450C Celsius and Fahrenheit, Dimensions: 106x66 mm

8. Mouse Gas Anesthesia Head Holder

9. Non-Rupture Ear Bars (Mouse)

6. Quantity: 1

7. Delivery Date: Delivery date of 3-6 months after receipt of completed purchase order

8. Period of Performance: Manufacturer warranty for one calendar year beginning date of receipt