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This file is an Application Guide for NIH FORMS-H submissions related to the NCI Pathway to Independence Award for Early-Stage Postdoctoral Researchers (K99/R00 - Independent Clinical Trial Required). The guide directs applicants to use either the General Instructions or the Career Development Instructions (available in HTML and PDF formats) when preparing their applications, with specific instructions provided for Career Development applicants. Application form packages may contain optional forms, and applicants should refer to the funding opportunity announcement and application instructions to determine submission requirements. References to detailed instructions are provided via links to the NIH grants website.

The underlying grant opportunity targets postdoctoral fellows with research and/or clinical doctoral degrees in cancer control, prevention, and data sciences who plan to serve as lead investigators of independent clinical trials, clinical trial feasibility studies, or ancillary clinical trials. Applicants must be transitioning to independent tenure-track or equivalent faculty positions. The application deadline is October 14, 2026. Awards are made through the Cancer Research Manpower program (CFDA 93.398) under the National Institutes of Health, offering up to five years of total support including salary and research project costs. Eligible applicants include U.S. universities, colleges, hospitals, nonprofit research institutions, and certain designated institutions (HBCUs, Hispanic-serving institutions, tribal colleges, and others), with awardees required to be U.S. citizens or permanent residents. Non-domestic entities and foreign components are not eligible to apply as primary applicants.

Application Instructions

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PKG00289157.pdf PDF
PAR-23-287-Full-Announcement.html HTML file

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Application Guide: FORMS-H

How to Apply – Application Guide

• Use either the General Instructions (HTML / PDF) or the filtered Career Development Instructions (PDF).

• In addition to the basic instructions, follow the form instructions for Career

Development applications when applying to this opportunity.

Career Development instructions are identified as follows:

• Application form packages may contain optional forms. Refer to the funding opportunity and application instructions for submission requirements.

https://grants.nih.gov/grants/how-to-apply-application-guide.html https://grants.nih.gov/grants/how-to-apply-application-guide/forms-h/general/g.100-how-to-use-the-application-instructions.htm https://grants.nih.gov/grants/how-to-apply-application-guide/forms-h/general-forms-h.pdf https://grants.nih.gov/grants/how-to-apply-application-guide/forms-h/career-forms-h.pdf

Application Guide: FORMS-H

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