PD_Waters_AutoPur-SQD2_PD_LC220201003206.pdf
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Purchase Description Statement of Need and Purpose:
Background Information and Objective:
Generic Name of Product:
Purchase Description:
Salient Characteristics:
Quantity:
Delivery Date:
Period of Performance:
Option(s):
9.0.0.2.20101008.1.734229
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| Include a general narrative of the need of the requirement and the desired results.: This requisition is to purchase a Waters AutoPurification System with SQD2 MS Detector for the Analytical Chemistry Core (ACC) within the Division of Preclinical Innovation (DPI) at NCATS |
| Include a brief history of the requirement, the importance of the requirement, and the overall program objectives.: NCATS has become a key partner in the Antiviral Program for Pandemics (APP), a multi-agency initiative that includes NIAID and BARDA, to accelerate antiviral development through early discovery and preclinical development of safe and effective oral antivirals. The initial priority for the APP is to develop treatments for SARS-CoV-2 and other coronaviruses, with the program expanding to address other virus families with pandemic potential. NCATS will apply its proficiency in drug discovery and development and its cutting-edge technologies to fill critical needs of the APP, such as (i) target validation, (ii) high-throughput screening (HTS) for drug starting points, (iii) medicinal chemistry for lead optimization, and (iv) preclinical, investigational new drug (IND)-enabling development. APP chemists within DPI are tasked with the discovery and development potential small molecule antiviral treatments for a range of viruses that have pandemic potential. In order to meet the increased demand for sample purification and analysis, the Analytical Chemistry Core (ACC) needs to improve throughput and expand capabilities through procurement of additional instrumentation and equipment, as well as the application of new technologies. |
The ACC provides analytical chemistry services involving the isolation, purification, identification, and analysis of therapeutic modalities for targeted disease states. This is accomplished through the development and usage of the SMART Centralized Sample Purification and Processing Platform. This workflow employs both Gilson and Waters semi-preparative liquid chromatography systems with a selection of preparative columns capable of purifying a wide range of small molecules and peptides. The Gilson platform utilizes UV-directed sample collection while the Waters platform employs both UV- and mass-directed detection and collection. The current Gilson purification system in the Bldg A Chemistry lab is over 10 yrs old and has been experiencing more severe malfunctions with increasing frequency. This has contributed to a greater backlog of samples and a decrease in productivity. The obsolete instrument needs to be replaced due to the increased service needs, longer down times, and an observed reduction in product recovery amounts. As such, the ACC requires the acquisition of a replacement purification system, specifically a Waters AutoPurification System with SQD2 MS Detector, which is the same Waters instrument employed in the Bldg C Chemistry lab. By utilizing the same instrumentation across all labs, we enable greater standardization and efficiency of the SMART Centralized Sample Purification and Processing Platform. Additionally, the redundancy of Waters AutoPurification systems will provide increased consistency with purification results, as well as allow better cross-coverage due to instrument familiarity by the chromatography chemists. The new purification system will provide higher robustness, greater performance, and increased capabilities for the purification of compounds synthesized by APP, ETB, TDB, and CGB medicinal chemists within DPI.
| Specify the generic name of the component or system, e.g., freezer, microscope, cell sorter, etc.: Semi-preparative high-performance liquid chromatography system with mass spectrometry detector |
| Specify 1) trade name; 2) product’s brand name; 3) manufacturer's name; 4) model, type, catalog, and/or part number(s.): Waters AutoPurification System with SQD2 MS Detector |
| Specify the significant, essential physical, functional, performance, or material element(s) (the distinguishing characteristic) of a product, system, component, or service required. Specify the functions that a system or component must perform to meet the Government’s objectives. Include required levels of performance, features or characteristics of the system or component that are essential to meet the government’s objectives. Specify the Government’s minimum acceptable standards.: The unique features of the Waters AutoPurification System with SQD2 MS Detector are: |
1. 176804203 - Waters AutoPurification System
With the following configuration:
a. 176003182 - AutoPurification Core System w/SFO
b. 176002670 - SQD2 MS
c. 176002685 - Vac Rough Pump + Freq Conv
d. 700002741 - ACQUITY / Quattro micro or Quattro Premier MS Start-up Solution Kit
e. 700006006 - Xevo TQD Standard Kit
f. 716000765 - Fractionlynx Dye kit
g. 716000261 - STANDARD FRACTION LYNX
h. 176002998 - 2998 Photodiode Array Detector
i. 205000439 - Splitter, Flow, 5000:1, 30-100mL
j. 176001064 - FractionLynx
k. 176001303 - ML Standard PC for AutoPurification
l. 668000273 - MONITOR, 23"
m. WAT207000 - ASSY, HPLC PUMP, M515
n. 205000108 - KIT, 27X7 13 MM TUBE INJ RACK
o. 205000117 - KIT 2767 16MM FRACTION COLLECTOR RACK
p. 741000322 - FRACTIONLYNX MS INSTALLATION CERT
q. 741000520 - System Disposal-Customer
r. 750000491 - NA - On-Site Autopur Trg Ed Cert (3days)
2. 720002242EN - Implementation Kit
| Specify quantity. : Two (2) of item# 1m and one (1) each of the other products listed in salient characteristics |
| Specify desired delivery date after receipt of order (30-60 days.): Thirty (30) days after receipt of the award |
| Specify period of performance for software license, warranty, or maintenance agreements.: One (1) twelve (12) month period of included manufacturer's warranty to begin after completion of instrument installation |
| Specify if options for additional quantities or options to extend the term of the contract for service agreements.: N/A |
File details come from the government source that posted it. Updated .