PD_Purchase-Description_5 Kg_LC231113194153.pdf

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5Kg of non-GMP grade methyl 4-(((5-phenylpyrazin-2-yl)methyl)carbamoyl)benzoate (CAS 2654074-59-4)
Solicitation number
75N95024Q00089
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This purchase description outlines requirements for the procurement of 5 kg of methyl 4-(((5-phenylpyrazin-2-yl)methyl)carbamoyl)benzoate from Affinity Research Chemicals. The compound is needed as a key intermediate and regulatory starting material for the further process development and cGMP manufacture of NCGC00413972 on a scale greater than 2 kg. Delivery of the 5 kg quantity is required within 5-6 weeks of order placement. The period of performance for this procurement is 6 weeks after receipt of the order.

The related federal contract opportunity posted on the Department of Health and Human Services National Institutes of Health website with solicitation number 75N95024Q00089 is also for the procurement of 5 kg of non-GMP grade methyl 4-(((5-phenylpyrazin-2-yl)methyl)carbamoyl)benzoate (CAS 2654074-59-4) to meet the stated need.

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Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

TEMPLATE PURCHASE DESCRIPTION

INSTRUCTIONS: This template should be used when purchase equipment, products, supplies, software, software license agreements, warranty agreements, and maintenance service agreements.

Remove the instructions from the purchase description before submitting with the purchase request.

PURCHASE DESCRIPTION

1. Statement of Need and Purpose: To obtain 5Kg of non-GMP grade methyl 4-(((5-phenylpyrazin-2-yl)methyl)carbamoyl)benzoate (CAS 2654074-59-4)

2. Background Information and Objective: Methyl 4-(((5-phenylpyrazin-2-yl)methyl)carbamoyl)benzoate (CAS 2654074-59-4) is the key intermediate for the synthesis of NCGC00413972. A 3 step synthesis has been developed based on the availability of Methyl 4-(((5-phenylpyrazin-2-yl)methyl)carbamoyl)benzoate which can be further justified as a regulatory starting material for GMP manufacturing of

NCGC00413972. The acquision of 5Kg (Methyl 4-(((5-phenylpyrazin-2-yl)methyl)carbamoyl)benzoate (CAS 2654074-59-4) is critical for the further process development and cGMP manyfacture of NCGC00413972 in large scale (>2 Kg).

3. Generic Name of Product: methyl 4-(((5-phenylpyrazin-2-yl)methyl)carbamoyl)benzoate (CAS 2654074-59-4).

4. Purchase Description: 5 Kg of methyl 4-(((5-phenylpyrazin-2-yl)methyl)carbamoyl)benzoate (CAS 2654074-59-4) from Affinity Research

Chemicals.

5. Salient characteristics: This compound is the key intermediate and regulatory starting material for process development and GMP manufacturing 2 Kg of API.

6. Quantity:5 kg

7. Delivery Date: 5-6 weeks after receive the order

8. Period of Performance: 6 Weeks ARO

9. Option(s): n/a

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