PAR-27-056-Revised-Full-Announcement.html

Department of Health and Human Services

Part 1. Overview Information

Participating Organization(s)

National Institutes of Health (NIH)

Components of Participating Organizations

National Institute of General Medical Sciences (NIGMS)

Note: Not all NIH Institutes, Centers, and Offices (ICOs) participate in Announcements. Applicants should carefully note which ICOs participate in this announcement and view their respective areas of research interest at the ICO-Specific Scientific Interests website. ICOs that do not participate in this announcement will not consider applications for funding.

Funding Opportunity Title

Limited Competition: Institutional Development Award (IDeA) for Clinical & Translational Research (CTR) (P30 - CT Optional)

Activity Code

P30 Center Core Grants

Announcement Type

Reissue of

PAR-23-241

Reissue of

PAR-23-257

Related Notices

Funding Opportunity Number (FON)

PAR-27-056

Companion Notice of Funding Opportunity

None

Number of Applications

Only one application per applicant organization is allowed, as defined in Section III. 3. Additional Information on Eligibility.

Assistance Listing Number(s)

93.859

Notice of Funding Opportunity Purpose

The Institutional Development Award (IDeA) program develops biomedical research capacity in states that have historically received low levels of NIH funding (IDeA states). The IDeA Clinical & Translational Research (CTR) program supports two programmatic tracks to build clinical and translational (C&T) research capacity to enable research on diseases and health challenges prevalent in IDeA states. IDeA CTR Development (CTR-D) awards focus on C&T research workforce development and infrastructure enhancement at health research organizations with limited clinical research capacity in IDeA states. IDeA CTR Network (CTR-N) awards support statewide (or multi-state) networks of health research organizations to expand existing infrastructure, develop the research workforce to enhance the network organization's ability to design and implement competitive C&T research programs, and coordinate clinical research activities state-wide and/or across IDeA states.

This is a Notice of Funding Opportunity (NOFO) for a Limited Competition that will invite application(s) from eligible organization(s) to apply. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered.

Funding Opportunity Goal(s)

To ensure the vitality and continued productivity of the research enterprise, NIGMS provides leadership in supporting the training of future scientists and developing research capacity throughout the country.

Key Dates

Posted Date

August 19, 2026

Open Date (Earliest Submission Date)

September 15, 2026

October 15, 2026

October 15, 2026

Not Applicable

July 2027

January 28, 2027

January 28, 2027

Not Applicable

December 2027

May 28, 2027

May 28, 2027

Not Applicable

April 2028

September 28, 2027

September 28, 2027

Not Applicable

July 2028

January 28, 2028

January 28, 2028

Not Applicable

December 2028

May 30, 2028

May 30, 2028

Not Applicable

April 2029

September 28, 2028

September 28, 2028

Not Applicable

July 2029

January 29, 2029

January 29, 2029

Not Applicable

December 2029

May 30, 2029

May 30, 2029

Not Applicable

April 2030

All applications are due by 5:00 PM local time of applicant organization.

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

Expiration Date

May 31, 2029

Due Dates for E.O. 12372

Not Applicable

Required Application Instructions

It is critical that applicants follow the Multi-Project (M) Instructions in the How to Apply - Application Guide, except where instructed to do otherwise (in this NOFO or in a Notice from the NIH Guide for Grants and Contracts). Conformance to all requirements (both in the How to Apply - Application Guide and the NOFO) is required and strictly enforced. Applicants must read and follow all application instructions in the How to Apply - Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the How to Apply - Application Guide, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.

Table of Contents

Part 1. Overview Information Key Dates Part 2. Full Text of Announcement Section I. Notice of Funding Opportunity Description Section II. Award Information Section III. Eligibility Information Section IV. Application and Submission Information Section V. Application Review Information Section VI. Award Administration Information Section VII. Agency Contacts Section VIII. Other Information

Part 2. Full Text of Announcement

Section I. Notice of Funding Opportunity Description

Background This is a Notice of Funding Opportunity (NOFO) for a limited competition that invites applications from eligible organizations to apply. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, the applications will be peer-reviewed, and only meritorious applications will be considered.

Authorized by the U.S. Congress in 1993, the National Institutes of Health (NIH) established the Institutional Development Award (IDeA) program to build biomedical research capacity in 23 U.S. states and Puerto Rico, which had historically low NIH grant funding success rates. IDeA programs support biomedical research in basic, clinical, behavioral, and translational science in IDeA-eligible states by developing faculty investigators, providing research opportunities to students, and enhancing research infrastructure.

One of the components of IDeA is the Clinical & Translational Research (IDeA-CTR) program. This program builds or expands clinical and translational (C&T) research capacity to enable research on diseases and health conditions which are prevalent in IDeA states and in alignment with the mission and priorities of the NIH. The program has two tracks:

To ensure that organizations apply to the track that best fits their current level of development, applicants should clearly justify their choice of track.

Organizations that already receive IDeA-CTR, CTR-N, or CTR-D funding and choose to apply for the CTR-D track must explain:

Current CTR-D award recipients who have made progress in building clinical and translational research capacity are encouraged to consider applying to the CTR-N track, if they meet eligibility requirements.

Program Overview Health research organizations located in an IDeA state and committed to the goals of building, developing or expanding C&T research capacity are encouraged to apply. Lead organization(s) should have a well-established research administration infrastructure to manage C&T research projects and identify the population health needs and the C&T research workforce gaps of the state(s). The proposed research areas should be sufficiently broad to address relevant diseases and health conditions in the state(s).

IDeA-CTR programs provide a vision for building or enhancing C&T research capacity in the state(s), and a coordinated plan to integrate activities of all the components and partner organizations as necessary, including community clinics and Practice Based Research Networks (PBRNs). CTR-N applications must include a nexus of community clinics and PBRNs to demonstrate active PBRN engagement as a required element of research capacity.

Developing a strong C&T research capacity often requires tailored strategies and realistic timelines.

An IDeA-CTR consists of the following two committees and five required cores.

Committees:

Cores:

Together, these project types create a continuum that builds investigator capacity, produces publishable results, and strengthens the overall research enterprise in IDeA states.

Key Terms and Definitions in this NOFO

Applications Not Responsive to this NOFO Applications with a narrow disease or population focus are not responsive to this NOFO and will not be accepted for review.

Investigators proposing NIH-defined clinical trials may refer to the Research Methods Resources website for information about developing statistical methods and study designs.

See Section VIII. Other Information for award authorities and regulations.

Section II. Award Information

Funding Instrument

Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.

Application Types Allowed

New

Renewal

Resubmission

Revision

The OER Glossary and the How to Apply - Application Guide provides details on these application types. Only those application types listed here are allowed for this NOFO.

Clinical Trial?

Optional: Accepting applications that either propose or do not propose clinical trial(s).

Need help determining whether you are doing a clinical trial?

Funds Available and Anticipated Number of Awards

The number of awards is contingent upon NIH appropriations and the number of meritorious applications submitted.

Award Budget

IDeA CTR Development Track: Applications may request up to $1.0 million in year 1 in direct costs, and up to $1.75 million in years 2 through 5 in annual direct costs, excluding consortium facilities and administrative (F&A) costs.

IDeA CTR Network Track: Application budgets may request up to $3.0 million in year 1 in direct costs, and up to $3.5 million in years 2 through 5 in annual direct costs, excluding consortium facilities and administrative (F&A) costs.

Award Project Period

The scope of the proposed project should determine the project period. The maximum project period is 5 years.

NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.

Section III. Eligibility Information

1. Eligible Applicants

Eligible Organizations

Nonprofits Other Than Institutions of Higher Education

For-Profit Organizations

Local Governments

Federal Governments

Eligible Agencies of the Federal Government

U.S. Territory or Possession

Organizations must meet all eligibility rules at the time of application submission and award.

Additional Eligibility Criteria for Lead Organizations To apply as the lead, the organization must:

Already have externally-funded clinical and translational (C&T) research.

Additional Eligibility Criteria for Partner Organizations To participate as a partner, the organization must Be in the same state or multi-state region as the lead organization.

Note:

Foreign Organizations/International Collaborations

Non-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Unfunded foreign components are allowed with prior approval. An unfunded foreign component would be a collaboration with investigators at a foreign site anticipated to result in co-authorship but with no IDeA funds transferred to the institution(s) or investigator(s) in a foreign country. Please also see NOT-OD-26-084.

Foreign PIs or organizations may use center resources as a fee-for-service. In such cases, resulting publications cannot cite or acknowledge NIH grant support.

Required Registrations

Applicant organizations Applicant organizations must complete and maintain the following registrations as described in the How to Apply- Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. Failure to complete registrations in advance of a due date is not a valid reason for a late submission, please reference NIH Grants Policy Statement Section 2.3.9.2 Electronically Submitted Applications for additional information.

System for Award Management (SAM) – Applicants must complete and maintain an active registration, which requires renewal at least annually. The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code. Foreign organizations must obtain a NATO Commercial and Government Entity (NCAGE) Code (in lieu of a CAGE code) in order to register in SAM. Unique Entity Identifier (UEI)- A UEI is issued as part of the SAM.gov registration process. The same UEI must be used for all registrations, as well as on the grant application.

Program Directors/Principal Investigators (PD(s)/PI(s)) All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. Obtaining an eRA Commons account can take up to 2 weeks.

All PD(s)/PI(s) must be registered with ORCID. The personal profile associated with the PD(s)/PI(s) eRA Commons account must be linked to a valid ORCID ID. For more information on linking an ORCID ID to an eRA Commons personal profile see the ORCID topic in our eRA Commons online help.

Eligible Individuals (Program Director/Principal Investigator)

Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the How to Apply - Application Guide.

At the time of submission, the primary appointment of the contact PD/PI must be at the applicant organization. An IDeA-CTR PD/PI (including any MPIs) may not simultaneously lead an IDeA COBRE or INBRE award. Only PDs/PIs associated with the eligible applicant organizations as outlined above may apply.

NIGMS strongly encourages multiple PD/PI (MPI) applications, particularly given the complexities of C&T research and CTs. An established clinician scientist with a track record of leading externally funded C&T/CT research projects or programs is expected to lead the IDeA-CTR as the contact PD/PI. The PD/PI should have:

This expertise is important to unite the participating organizations into a cohesive network and to properly integrate the IDeA-CTR's components to maximize efficiency and effectiveness.

The MPI team should also include a PD/PI with relevant scientific expertise to guide the center.

2. Cost Sharing This NOFO does not require cost sharing as defined in the NIH Grants Policy Statement Section 1.2- Definitions of Terms.

3. Additional Information on Eligibility Number of Applications

Only one application per institution (normally identified by having a unique entity identifier (UEI) or NIH IPF number) is allowed.

The NIH will not accept duplicate or highly overlapping applications under review at the same time per NIH Grants Policy Statement Section 2.3.7.4 Submission of Resubmission Application. This means that the NIH will not accept:

Section IV. Application and Submission Information

1. Requesting an Application Package The application forms package specific to this opportunity must be accessed through ASSIST or an institutional system-to-system solution. A button to apply using ASSIST is available in Part 1 of this NOFO. See the administrative office for instructions if planning to use an institutional system-to-system solution.

2. Content and Form of Application Submission It is critical that applicants follow the Multi-Project (M) Instructions in the How to Apply - Application Guide, except where instructed in this notice of funding opportunity to do otherwise (in this NOFO, in a policy notice, or other notice from NIH Guide for Grants and Contracts) and where instructions in the How to Apply - Application Guide are directly related to the Grants.gov downloadable forms currently used with most NIH opportunities. Conformance to the requirements in the How to Apply - Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.

Page Limitations All page limitations described in the How to Apply- Application Guide and the Table of Page Limits must be followed.

Required

Required

Required

Required

Required

Required

Instructions for the Submission of Multi-Component Applications

The following section supplements the instructions found in How to Apply- Application Guide and should be used for preparing a multi-component application.

Overall Component When preparing the application, use Component Type 'Overall'.

All instructions in the How to Apply - Application Guide must be followed, with the following additional instructions, as noted.

SF424(R&R) Cover (Overall) Complete entire form.

The title of the application should indicate the CTR track in the format of "CTR-D: [Title]" or "CTR-N: [Title]"

PHS 398 Cover Page Supplement (Overall)

Research & Related Other Project Information (Overall) Follow standard instructions.

Project/Performance Site Locations (Overall) Enter primary site only.

A summary of Project/Performance Sites in the Overall section of the assembled application image in eRA Commons compiled from data collected in the other components will be generated upon submission.

Research and Related Senior/Key Person Profile (Overall) Include only the Project Director/Principal Investigator (PD/PI) and any multi-PDs/PIs (if applicable to this NOFO) for the entire application.

Current & Pending Support: Attach a copy of the PD/PI's Current and Pending (Other) Support Common Form, which is critical information for determining the PD/PI's eligibility and suitability to lead the Center:

A summary of Senior/Key Persons followed by their Biographical Sketches in the Overall section of the assembled application image in eRA Commons will be generated upon submission.

Budget (Overall) The only budget information included in the Overall component is the Estimated Project Funding section of the SF424 (R&R) Cover.

A budget summary in the Overall section of the assembled application image in eRA Commons compiled from detailed budget data collected in the other components will be generated upon submission.

PHS 398 Research Plan (Overall) Introduction to Application: For Resubmission and Revision applications, an Introduction to Application is required in the Overall component.

Research Strategy: The IDeA-CTR aims to build or expand C&T research capacity. All cores must work together to provide shared, non-duplicative resources that strengthen infrastructure, expertise, and workforce development. Applicants should describe the major health challenges of the population in the state(s) served and how the center will build or expand C&T research capacity to address them.

Provide the Overall Plan for the IDeA-CTR, which must include the following sections:

A. Goals of the IDeA-CTR: Describe the goals of the IDeA-CTR and the roles of the lead organization and any partner organizations in meeting those objectives. Key elements to include are:

Plans to leverage resources and infrastructure supported by other IDeA awards (such as INBRE, COBRE, and IDeA Clinical Research Resource Center) or those supported by other NIH-funded C&T programs.

B. Organizational Structure and Governance Model: The applicant should provide a clear organizational structure that illustrates the relationships among the lead organization, partner organizations, committees, and cores within the IDeA-CTR. Key elements to include are:

A description of the required committees,their responsibilities, and how these commitees will assist the PD(s)/PI(s) in administering the award: Internal Advisory Committee (IAC): Committee composition: PD(s)/PI(s) The contact PD/PI serves as the chair

C. Capacity for C&T Research:

To properly assess the baseline level of C&T research capacity in the organization or network, describe the current C&T research capacity of lead and partner organizations (use tables where appropriate). Key elements to include are:

A summary of non-research project C&T research supported by supplement awards and/or current IDeA-CTR cores.

Optional Letters of Support (10-page maximum): The application may include additional letters

Letters of support that repeat material or do not add new content should not be included in the application.

Resource Sharing Plan:

Individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the How to Apply - Application Guide.

Other Plan(s):

All instructions in the How to Apply- Application Guide must be followed, with the following additional instructions:

A Data Management and Sharing Plan (DMS Plan) is required for any NIH-funded or conducted research that will generate scientific data. Applicants must submit the DMS Plan at the time of application using the NIH DMS Plan Format Page. The DMS Plan must address the elements in the structured format. Where the DMS Plan Format Page requires a "Yes or No" response, no additional narrative is allowed. The Data Management and Sharing (DMS) Plan must be provided in the Overall component.

Appendix:

Only limited items are allowed in the Appendix. Follow all instructions for the Appendix as described in How to Apply- Application Guide; any instructions provided here are in addition to the How to Apply - Application Guide instructions.

PHS Human Subjects and Clinical Trials Information (Overall) When involving human subjects research, clinical research, and/or NIH-defined clinical trials follow all instructions for the PHS Human Subjects and Clinical Trials Information form in the How to Apply - Application Guide, with the following additional instructions:

If you answered "Yes" to the question "Are Human Subjects Involved?" on the R&R Other Project Information form, there must be at least one human subjects study record using the Study Record: PHS Human Subjects and Clinical Trials Information form or a Delayed Onset Study record within the application. The study record(s) must be included in the component(s) where the work is being done, unless the same study spans multiple components. To avoid the creation of duplicate study records, a single study record with sufficient information for all involved components must be included in the Overall component when the same study spans multiple components.

Study Record: PHS Human Subjects and Clinical Trials Information All instructions in the How to Apply - Application Guide must be followed.

Delayed Onset Study

Note: Delayed onset does NOT apply to a study that can be described but will not start immediately (i.e., delayed start). All instructions in the How to Apply- Application Guide must be followed.

PHS Assignment Request Form (Overall) All instructions in the How to Apply- Application Guide must be followed.

Administrative Core The Administrative Core administers the IDeA-CTR award. The contact PD/PI is expected to lead the AC. The AC administers the IDeA-CTR award and works closely with the other cores and organizational leadership to develop and implement plans that will meet the strategic goals of the organization(s) to support C&T research and synergize existing strengths and resources. The AC assesses the C&T/CT research capacity building needs of the organization(s) and develops and executes plans needed to meet those needs.

When preparing your application, use Component Type 'Admin Core.' All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions, as noted.

SF424 (R&R) Cover (Administrative Core) Complete only the following fields:

PHS 398 Cover Page Supplement (Administrative Core) Follow standard instructions.

Research & Related Other Project Information (Administrative Core) Human Subjects: Answer only the 'Are Human Subjects Involved?' and 'Is the Project Exempt from Federal regulations?' questions.

Vertebrate Animals: Answer only the 'Are Vertebrate Animals Used?' question.

Project Narrative: Do not complete. Note: ASSIST screens will show an asterisk for this attachment indicating it is required. However, eRA systems only enforce this requirement in the Overall component and applications will not receive an error if omitted in other components.

Project /Performance Site Location(s) (Administrative Core) List all performance sites that apply to the specific component.

Note: The Project Performance Site form allows up to 300 sites, prior to using additional attachment for additional entries.

Research & Related Senior/Key Person Profile (Administrative Core) In the Project Director/Principal Investigator section of the form, use Project Role of 'Other' with Category of 'Core Lead' and provide a valid eRA Commons ID in the Credential field. The Core Lead should be the PD/PI or contact PD/PI for multi-PI applications.

Budget (Administrative Core) Budget forms appropriate for the specific component will be included in the application package.

A maximum annual level-of-effort of 6.0 person-months may be requested for all PDs/PIs, collectively. For multi-PI applications, no more than 2 PD(s)/PI(s) are allowed and the minimum level of effort for each PD/PI is 3.0 person-months.

Funds cannot be used by or for collaborators at organizations in non-IDeA states or at foreign sites. However, funds may be used in IDeA and non-IDeA states for fee-for-service activities such as learning new techniques (for example, biostatistics or clinical research design courses), sample and data analysis, attending workshops, or obtaining scientific, methodological or biostatistical advising/consulting/mentoring.

Note: The R&R Budget form included in many of the component types allows for up to 100 Senior/Key Persons in section A and 100 Equipment Items in section C prior to using attachments for additional entries. All other SF424 (R&R) instructions apply.

PHS 398 Research Plan (Administrative Core) Research Strategy:

This section should describe how the Core will:

Letters of Support: Not allowed. Organizational Letters of Support, including support for the Administrative Core, should be included in the Overall Component.

PHS Human Subjects and Clinical Trials Information (Admin Core) When involving human subjects research, clinical research, and/or NIH-defined clinical trials follow all instructions for the PHS Human Subjects and Clinical Trials Information form in the SF424 (R&R) Application Guide, with the following additional instructions:

If you answered "Yes" to the question "Are Human Subjects Involved?" on the R&R Other Project Information form, you must include at least one human subjects study record using the Study Record: PHS Human Subjects and Clinical Trials Information form or a Delayed Onset Study record.

Study Record: PHS Human Subjects and Clinical Trials Information All instructions in the SF424 (R&R) Application Guide must be followed.

Delayed Onset Study Note: Delayed onset does NOT apply to a study that can be described but will not start immediately (i.e., delayed start). All instructions in the SF424 (R&R) Application Guide must be followed.

Professional Development (PD) Core The PD Core oversees workforce development for the IDeA-CTR and organizes professional development activities. These activities should be tailored to the needs of the IDeA-CTR's C&T research workforce, including investigators eligible for HR Core funding and members of their research teams. The PD Core is expected to collaborate with other IDeA-CTR cores to identify needs for additional expertise and to ensure training in research regulations, mentoring, and the ability to provide scientific and technical review of post-award applications.

When preparing your application, use Component Type 'Core.' All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions, as noted.

SF424 (R&R) Cover (PD Core) Complete only the following fields:

PHS 398 Cover Page Supplement (PD Core) Follow standard instructions.

Research & Related Other Project Information (PD Core) Human Subjects: Answer only the 'Are Human Subjects Involved?' and 'Is the Project Exempt from Federal regulations?' questions.

Vertebrate Animals: Answer only the 'Are Vertebrate Animals Used?' question.

Project Narrative: Do not complete. Note: ASSIST screens will show an asterisk for this attachment indicating it is required. However, eRA systems only enforce this requirement in the Overall component and applications will not receive an error if omitted in other components.

Project /Performance Site Location(s) (PD Core) List all performance sites that apply to the specific component.

Note: The Project Performance Site form allows up to 300 sites, prior to using additional attachment for additional entries.

Research & Related Senior/Key Person Profile (PD Core)

Budget (PD Core) Budget forms appropriate for the specific component will be included in the application package.