PAR-27-055-Full-Announcement.html

Department of Health and Human Services

Part 1. Overview Information

Participating Organization(s)

National Institutes of Health (NIH)

Components of Participating Organizations

National Institute of General Medical Sciences (NIGMS)

Funding Opportunity Title

Limited Competition: Centers of Biomedical Research Excellence: Expansion/Sustainability Phases (COBRE-E/S) (P30 - Clinical Trial Not Allowed)

Activity Code

P30 Center Core Grants

Announcement Type

Reissue of

PAR-23-063

Related Notices

Funding Opportunity Number (FON)

PAR-27-055

Companion Notice of Funding Opportunity

None

Number of Applications

See Section III. 3. Additional Information on Eligibility.

Assistance Listing Number(s)

93.859

Notice of Funding Opportunity Purpose

The Institutional Development Award (IDeA) program supports biomedical research capacity building in states that have historically received low levels of NIH funding. The Centers of Biomedical Research Excellence: Expansion/Sustainability Phases (COBRE-E/S) Notice of Funding Opportunity (NOFO) supports the expansion and sustainability of biomedical research centers in IDeA-eligible institutions. These centers will focus on building research capacity in broad scientific areas of strategic importance for the institutions. The goal of COBRE-E is to expand research capacity by growing the institutional faculty base and supporting research projects and core facilities in the new area. The objective of COBRE-S is to sustain the infrastructure by continuing the growth of the faculty base and consolidating research cores. This is a Notice of Funding Opportunity (NOFO) for a Limited Competition that will invite application(s) from eligible organization(s) to apply. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered.

Funding Opportunity Goal(s)

The National Institute of General Medical Sciences (NIGMS) supports basic research that increases our understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment, and prevention. To ensure the vitality and continued productivity of the research enterprise, NIGMS provides leadership in supporting the training of future scientists and developing research capacity throughout the country.

Key Dates

Posted Date

June 18, 2026

Open Date (Earliest Submission Date)

August 25, 2026

The following table includes NIH standard due dates marked with an asterisk.

September 25, 2026 *

September 25, 2026 *

Not Applicable

July 2027

January 25, 2027 *

January 25, 2027 *

Not Applicable

December 2027

May 25, 2027 *

May 25, 2027 *

Not Applicable

April 2028

September 25, 2027 *

September 25, 2027 *

Not Applicable

July 2028

January 25, 2028 *

January 25, 2028 *

Not Applicable

December 2028

May 25, 2028 *

May 25, 2028 *

Not Applicable

April 2029

September 25, 2028 *

September 25, 2028 *

Not Applicable

July 2029

January 25, 2029 *

January 25, 2029 *

Not Applicable

December 2029

May 25, 2029 *

May 25, 2029 *

Not Applicable

April 2030

All applications are due by 5:00 PM local time of applicant organization.

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

Expiration Date

May 26, 2029

Due Dates for E.O. 12372

Not Applicable

Required Application Instructions

It is critical that applicants follow the Multi-Project (M) Instructions in the How to Apply - Application Guide, except where instructed to do otherwise (in this NOFO or in a Notice from the NIH Guide for Grants and Contracts). Conformance to all requirements (both in the How to Apply - Application Guide and the NOFO) is required and strictly enforced. Applicants must read and follow all application instructions in the How to Apply - Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the How to Apply - Application Guide, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.

Table of Contents

Part 1. Overview Information Key Dates Part 2. Full Text of Announcement Section I. Notice of Funding Opportunity Description Section II. Award Information Section III. Eligibility Information Section IV. Application and Submission Information Section V. Application Review Information Section VI. Award Administration Information Section VII. Agency Contacts Section VIII. Other Information

Part 2. Full Text of Announcement

Section I. Notice of Funding Opportunity Description

Authorized by the U.S. Congress in 1993, the National Institutes of Health (NIH) established the Institutional Development Award (IDeA) program to build biomedical research capacity in 23 U.S. states and Puerto Rico (See Section III for IDeA state eligibility), which had historically low NIH grant funding success rates. IDeA funding programs collectively support biomedical research in basic, clinical, behavioral, and translational science in IDeA-eligible states by developing faculty investigators, providing research opportunities to students, and enhancing research infrastructure. This is a Notice of Funding Opportunity (NOFO) for a Limited Competition that will invite application(s) from eligible organization(s) to apply. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered.

One of the components of IDeA is the Centers of Biomedical Research Excellence (COBRE) program, which supports the establishment and development of innovative biomedical research centers of excellence in an area of strategic importance to the organization and in alignment with the mission and priorities of the NIH.

The COBRE program has two tracks that provide grantees with the means to build biomedical research capacity. The COBRE D-E-S track (three phases, maximum 15 years of support) is targeted toward institutions without any existing research capacity in the proposed broad area of research. The COBRE E-S track (two phases, maximum 10 years of support) is intended for institutions with an existing degree of research capacity amenable to expansion and growth in the proposed area of research. This Notice of Funding Opportunity (NOFO) supports applications to both the COBRE-E and COBRE-S phases of the program. The five-year phases of the COBRE program are as follows:

COBRE-E and COBRE-S Program Requirements For COBRE-E, the applicant organization should have already established a level of research capacity infrastructure to drive and expand research toward the proposed scientific focus of the Center. The research area should be sufficiently broad to enable growth and enhancements to the applicant organization's existing biomedical research capacity. To this end, institutions must possess either:

to be eligible to apply. Applicant organizations with a pending COBRE-E application may not submit an application with a similar scientific theme to the COBRE-D funding opportunity (PAR-27-054).

For COBRE-S, the applicant organization must hold an active COBRE Phase 2 or COBRE-E award. Submissions should demonstrate how the applicant organization will further guide early career investigators towards independence and modernize and consolidate core facilities to enable the Center's research.

Overall Plan (required): COBRE-E and COBRE-S awards provide research support and mentoring to faculty investigators as well as enhancements to the institution's research infrastructure in the Center's scientific area. The Overall Plan should demonstrate how the applicant organization will implement its strategic priorities. A COBRE-E award supports the expansion of biomedical research resources at the applicant institution and strengthening the existing faculty base. COBRE-E applications must include a Sustainability Plan to be implemented during the COBRE-S phase that should address plans and prospects for long-term sustainability of institutional enhancements resulting from COBRE funding, including how the award may be leveraged to build a broader base of support. The focus of the COBRE-S award is to solidify the research base built in previous COBRE Phases and to implement a Sustainability Plan to continue research excellence beyond COBRE funding. An Advisory Committee (AC) comprised of institutional leadership and external experts in the scientific area is required to provide advice on scientific and administrative matters critical to the success of the Center.

Applications proposing to establish a Center in a scientific area closely related to one previously supported by a COBRE award to the institution or in an area for which the institution has a strong and sustained record of institutional research capacity are of low programmatic priority.

Administrative Core, required: The Administrative Core implements the Center's overall plan and manages its operations. Responsibilities include:

Scientific Research Program (SRP), required: The SRP manages the research activities of the center and ensures the continued scientific and career development of its investigators and the institution's biomedical research base. The application must include plans that specify how applicants will administer the center's research portfolio with the goal of enhancing the scientific potential and increasing the competitiveness of the center's investigators for peer-reviewed research independence. Prior to award, the applicant organization will assemble a group of investigators from an existing pool of early career investigators to be selected as SRP Investigators (SIs) to conduct research within the COBRE's proposed scope. Mid-career investigators who complement the scientific breadth of the center and are working towards the renewal of their first Research Project Grant (RPG) or "at-risk" investigators who will have no substantial research grant funding in the upcoming fiscal year may also form part of the potential pool. The existing pool of investigators will be complemented with potential faculty hires that broaden and enhance the expertise of the center and the institution. In addition, the SRP will:

Research Core(s), optional: New research cores may be proposed during the COBRE-E phase provided they are essential to support proposed research and do not duplicate existing services or facilities at the applicant organization. No new cores may be established in the COBRE-S phase. The consolidation of existing Cores for technology advancement and/or administrative efficiency and the sharing of research facilities supported by other IDeA programs (e.g., INBRE, CTR, and other COBREs) is strongly encouraged.

See Section VIII. Other Information for award authorities and regulations.

Section II. Award Information

Funding Instrument

Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.

Application Types Allowed

New

Resubmission

Revision

The OER Glossary and the How to Apply - Application Guide provides details on these application types. Only those application types listed here are allowed for this NOFO.

Clinical Trial?

Not Allowed: Only accepting applications that do not propose clinical trials. Note: Applications may propose activities involving human subjects that are not deemed clinical trials.

Need help determining whether you are doing a clinical trial?

Funds Available and Anticipated Number of Awards

The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Award Budget

Application budgets must not exceed $1.5 million in annual direct costs, excluding consortium facilities and administrative (F&A) costs.

Award Project Period

The project period is limited to five years.

NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.

Section III. Eligibility Information

1. Eligible Applicants

Eligible Organizations

Nonprofits Other Than Institutions of Higher Education

Foreign Organizations/International Collaborations

Non-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Unfunded foreign components are allowed with prior approval. An unfunded foreign component would be a collaboration with investigators at a foreign site anticipated to result in co-authorship but with no IDeA funds transferred to the institution(s) or investigator(s) in a foreign country. Please also see NOT-OD-26-084.

Foreign PIs or organizations may use center resources as a fee-for-service. In such cases, resulting publications cannot cite or acknowledge NIH grant support.

Required Registrations

Applicant organizations Applicant organizations must complete and maintain the following registrations as described in the How to Apply- Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. Failure to complete registrations in advance of a due date is not a valid reason for a late submission, please reference NIH Grants Policy Statement Section 2.3.9.2 Electronically Submitted Applications for additional information.

System for Award Management (SAM) – Applicants must complete and maintain an active registration, which requires renewal at least annually. The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code. Foreign organizations must obtain a NATO Commercial and Government Entity (NCAGE) Code (in lieu of a CAGE code) in order to register in SAM. Unique Entity Identifier (UEI)- A UEI is issued as part of the SAM.gov registration process. The same UEI must be used for all registrations, as well as on the grant application.

Program Directors/Principal Investigators (PD(s)/PI(s)) All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.

All PD(s)/PI(s) must be registered with ORCID. The personal profile associated with the PD(s)/PI(s) eRA Commons account must be linked to a valid ORCID ID. For more information on linking an ORCID ID to an eRA Commons personal profile see the ORCID topic in our eRA Commons online help.

Eligible Individuals (Program Director/Principal Investigator)

Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the How to Apply - Application Guide.

The PD(s)/PI(s) is expected to be an established biomedical research scientist with the administrative and mentoring experience necessary to lead the Center. The PD(s)/PI(s) of a COBRE Phase 1 award transitioning to COBRE-E or a COBRE Phase 2 award transitioning to COBRE-S may continue serving in that role provided their scientific background falls within the breadth of the proposed scientific area. Alternatively, new PD(s)/PI(s) may be proposed by the applicant organization.

At the time of submission, the COBRE PD/PI must have a primary appointment at the applicant organization and be the PD/PI on at least one active, peer-reviewed, and externally funded research grant within the general scientific area of the COBRE. If a COBRE PD/PI's qualifying research grant is a multiple PD/PI award to a different organization, the applicant organization must receive the COBRE PD/PI's research funds via a subcontract.

For multiple PD/PI COBRE applications, all non-contact PD(s)/PI(s) must also have at least one active, peer-reviewed, and externally funded research grant within the general scientific area of the COBRE.

A COBRE PD/PI may not simultaneously lead more than one IDeA (INBRE, CTR, or other COBRE) program award. Previous COBRE PD(s)/PI(s) of different COBRE Centers, except those who have served in that capacity on an interim basis, are not eligible to lead a COBRE-E or COBRE-S application. All investigators who intend to apply as PD(s)/PI(s) are encouraged to consult with the Scientific/Research Contact listed in Section VII prior to preparing an application to confirm eligibility.

Eligible Individuals (Scientific Research Program) The applicant organization will identify, prior to award, individuals from a pool of existing investigators to be supported by the COBRE's Scientific Research Program (SRP). It is the responsibility of the organization to establish the qualifications of the prospective SRP Investigators (SIs) before they are supported by the program. SIs must:

A COBRE SI cannot receive simultaneous research support from any other IDeA program award (e.g., INBRE, CTR, COBRE), but may be eligible to serve as a project lead of a supplement to an IDeA award.

2. Cost Sharing This NOFO does not require cost sharing as defined in the NIH Grants Policy Statement Section 1.2- Definitions of Terms.

3. Additional Information on Eligibility Number of Applications

Applicant organizations may submit more than one application, provided that each application is scientifically distinct.

The NIH will not accept duplicate or highly overlapping applications under review at the same time per NIH Grants Policy Statement Section 2.3.7.4 Submission of Resubmission Application. This means that the NIH will not accept:

A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application.

A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application.

An application that has substantial overlap with another application pending appeal of initial peer review (see NIH Grants Policy Statement 2.3.9.4 Similar, Essentially Identical, or Identical Applications).

Section IV. Application and Submission Information

1. Requesting an Application Package The application forms package specific to this opportunity must be accessed through ASSIST or an institutional system-to-system solution. A button to apply using ASSIST is available in Part 1 of this NOFO. See the administrative office for instructions if planning to use an institutional system-to-system solution.

2. Content and Form of Application Submission It is critical that applicants follow the Multi-Project (M) Instructions in the How to Apply - Application Guide, except where instructed in this notice of funding opportunity to do otherwise (in this NOFO, in a policy notice, or other notice from NIH Guide for Grants and Contracts) and where instructions in the How to Apply - Application Guide are directly related to the Grants.gov downloadable forms currently used with most NIH opportunities. Conformance to the requirements in the How to Apply - Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.

Page Limitations All page limitations described in the How to Apply- Application Guide and the Table of Page Limits must be followed.

Required

Required

Optional

Required

Instructions for the Submission of Multi-Component Applications

The following section supplements the instructions found in How to Apply- Application Guide and should be used for preparing a multi-component application.

Overall Component When preparing the application, use Component Type 'Overall'.

All instructions in the How to Apply - Application Guide must be followed, with the following additional instructions, as noted.

SF424(R&R) Cover (Overall) Complete entire form.

PHS 398 Cover Page Supplement (Overall) Follow standard instructions.

Research & Related Other Project Information (Overall) Follow standard instructions.

Other Attachments: Please include a header or footer label on each page of the other attachments with the corresponding material title.

The following attachment must be included:

Existing SRP Investigator Pool: Applicants must include a Biographical Sketch Common Form and NIH Biographical Supplement for each investigator appointed at the institution who could potentially be selected as SIs. The Personal Statement in the NIH Biographical Sketch Supplement should be tailored to the unique attributes and requirements of the COBRE and must not include Specific Aims nor preliminary data. See Section III. Eligibility Information for details.

Project/Performance Site Locations (Overall) Enter primary site only.

A summary of Project/Performance Sites in the Overall section of the assembled application image in eRA Commons compiled from data collected in the other components will be generated upon submission.

Research and Related Senior/Key Person Profile (Overall) Include only the Project Director/Principal Investigator (PD/PI) and any multi-PDs/PIs (if applicable to this NOFO) for the entire application.

Biographical Sketch: Each PD/PI should include a description of their administrative and mentoring experience in the Personal Statement of the NIH Biographical Sketch Supplement. The Biographical Sketch Common Form and NIH Biographical Sketch Supplement should provide evidence of the PD/PI's leadership experience in the Center's broad area of research, mentoring of early and mid-career investigators, and administration, including directing and managing a previous phase of a COBRE award, if applicable.

Current & Pending Support : Attach a copy of the PD/PI's Current and Pending (Other) Support Common Form which is critical information for determining the PD/PI's eligibility and suitability to lead the Center.

A summary of Senior/Key Persons followed by their Biographical Sketches in the Overall section of the assembled application image in eRA Commons will be generated upon submission.

Budget (Overall) The only budget information included in the Overall component is the Estimated Project Funding section of the SF424 (R&R) Cover.

A budget summary in the Overall section of the assembled application image in eRA Commons compiled from detailed budget data collected in the other components will be generated upon submission.

PHS 398 Research Plan (Overall) Introduction to Application: For Resubmission and Revision applications, an Introduction to Application is required in the Overall component.

Research Strategy: This section must include the following elements:

A. Justification for the Center Applicants should provide a strong rationale for the need to request support for the Center in the chosen scientific area and how it fits within the applicant organization's strategic plan. The research area of the Center should be sufficiently broad to enable a significant expansion of biomedical research capacity while maintaining cohesion among its components. The justification should describe the organization's:

B. Organization and Management Plan The Organization and Management Plan for the Center should clearly convey a strategy that demonstrates an effective use of the available funding, the proposed configuration of the Center and its cores, and the approaches to expand (COBRE-E) or sustain (COBRE-S) biomedical research capacity. Describe:

C. Sustainability Plan The Sustainability Plan should outline the actions to be undertaken during the E-phase to ensure the enhancements to research infrastructure endure through the S-phase and beyond the duration of COBRE support. COBRE-S applicants should outline the actions the organization will take to successfully sustain the center's resources. Similarly, the plan should describe strategies to continue building sustained scientific growth across the entire research area of the Center once COBRE support ends. Strategies to promote the retention of center-associated faculty as well as plans to ensure continuity of leadership through the recruitment of administrative leaders should also be included. This could also include long-term collaborations between the IDeA awardee and applicable collaborators in non-IDeA states.

D. Advisory Committee An Advisory Committee (AC) composed of three external, nationally recognized scientists with balanced expertise directly relevant to the broad scientific area of the Center, one senior institutional official (such as a Dean or Vice-President for Research), and one senior faculty member appointed by the senior institutional official must be assembled to advise the PD(s)/PI(s). AC members who previously served as external advisors may continue to serve in this role. The AC should meet at least twice per year. An AC member may not hold any other position in the Center, including serving as a mentor to an SI.

Responsibilities of the AC include but are not limited to:

Plans for the AC should describe:

E. Career Development Plan A Career Development Plan is required that will be implemented by the SRP to support the success of the SIs. Leadership and management training for the SIs should be infused into the Center to foster career and professional advancement. Additionally, as part of the career development efforts, SIs should each be assigned a mentor. The mentor should be an established investigator who is able to provide scientific advice and career guidance to the SI. If a suitable mentor at the applicant institution is not available, it is acceptable to enlist an appropriate mentor from another organization, including those located in non-IDeA states. The Career Development Plan should describe:

Letters of Support: A single letter of support from a senior institutional official (for example, President or Dean) must be included outlining the institution's strategic plan and how the proposed COBRE aligns with its priorities for expanding (COBRE-E) and sustaining (COBRE-S) biomedical research capacity. The letter must also provide detailed evidence of the existing institutional resources and commitment to the growth and sustainability of the Center. If applicable, the letter should include a list of prior and active COBRE awards.

Applications that do not include this Letter of Institutional Support will be considered incomplete, and the application will be withdrawn prior to review. Do not include any additional Letters of Support.

Resource Sharing Plan:

Individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the How to Apply - Application Guide.

Other Plan(s):

All instructions in the How to Apply- Application Guide must be followed, with the following additional instructions:

A Data Management and Sharing Plan (DMS Plan) is required for any NIH-funded or conducted research that will generate scientific data. Applicants must submit the DMS Plan at the time of application using the NIH DMS Plan Format Page. The DMS Plan must address the elements in the structured format. Where the DMS Plan Format Page requires a "Yes or No" response, no additional narrative is allowed. The Data Management and Sharing (DMS) Plan must be provided in the Overall component.

A Data Management and Sharing Plan (DMS Plan) is required for any NIH-funded or conducted research that will generate scientific data. Applicants must submit the DMS Plan at the time of application using the NIH DMS Plan Format Page. The DMS Plan must address the elements in the structured format. Where the DMS Plan Format Page requires a "Yes or No" response, no additional narrative is allowed.

Appendix:

Only limited items are allowed in the Appendix. Follow all instructions for the Appendix as described in How to Apply- Application Guide; any instructions provided here are in addition to the How to Apply - Application Guide instructions.

PHS Human Subjects and Clinical Trials Information (Overall) When involving human subjects research, clinical research, and/or NIH-defined clinical trials follow all instructions for the PHS Human Subjects and Clinical Trials Information form in the How to Apply - Application Guide, with the following additional instructions:

If you answered "Yes" to the question "Are Human Subjects Involved?" on the R&R Other Project Information form, there must be at least one human subjects study record using the Study Record: PHS Human Subjects and Clinical Trials Information form or a Delayed Onset Study record within the application. The study record(s) must be included in the component(s) where the work is being done, unless the same study spans multiple components. To avoid the creation of duplicate study records, a single study record with sufficient information for all involved components must be included in the Overall component when the same study spans multiple components.

Study Record: PHS Human Subjects and Clinical Trials Information All instructions in the How to Apply - Application Guide must be followed.

Delayed Onset Study

Note: Delayed onset does NOT apply to a study that can be described but will not start immediately (i.e., delayed start). All instructions in the How to Apply- Application Guide must be followed.

PHS Assignment Request Form (Overall) All instructions in the How to Apply- Application Guide must be followed.

Administrative Core When preparing your application, use Component Type 'Admin Core.' All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions, as noted.

SF424 (R&R) Cover (Administrative Core) Complete only the following fields:

PHS 398 Cover Page Supplement (Administrative Core) Follow standard instructions.

Research & Related Other Project Information (Administrative Core) Human Subjects: Answer only the 'Are Human Subjects Involved?' and 'Is the Project Exempt from Federal regulations?' questions.

Vertebrate Animals: Answer only the 'Are Vertebrate Animals Used?' question.

Project Narrative: Do not complete. Note: ASSIST screens will show an asterisk for this attachment indicating it is required. However, eRA systems only enforce this requirement in the Overall component and applications will not receive an error if omitted in other components.

Project /Performance Site Location(s) (Administrative Core) List all performance sites that apply to the specific component.

Note: The Project Performance Site form allows up to 300 sites, prior to using additional attachment for additional entries.

Research & Related Senior/Key Person Profile (Administrative Core)

Budget (Administrative Core) Budget forms appropriate for the specific component will be included in the application package.

A minimum level of effort (LOE) of three person-months is required of each PD/PI to devote to administrative oversight of the Center and provide career guidance to investigators. A maximum of six person-months of annual salary support may be requested collectively for all PDs/PIs. A PD/PI may not use COBRE funds to supplement research activities for their laboratory or research team and is not eligible for research project support from this COBRE or any other COBRE, INBRE, or CTR award. Funds should be requested in the Administrative Core budget to:

Funds cannot be used by collaborators or for collaboration at organizations in non-IDeA states or at foreign sites. However, funds may be used at other U.S. organizations for fee-for-service activities, such as learning new techniques, carrying out sample and data analysis, attending workshops, or obtaining scientific advising/consulting/mentoring (as described above).

The PD(s)/PI(s) of the Centers funded through this NOFO must attend the National IDeA Symposium of Biomedical Research Excellence (NISBRE) biennial meeting.

Note: The R&R Budget form included in many of the component types allows for up to 100 Senior/Key Persons in section A and 100 Equipment Items in section C prior to using attachments for additional entries. All other SF424 (R&R) instructions apply.

PHS 398 Research Plan (Administrative Core) Introduction to Application: For Resubmission applications, an Introduction to Application is allowed for each component.

Specific Aims: The SF424 application Guide must be followed.

Research Strategy: Include a description of:

Letters of Support: Not allowed. Support for the Administrative Core should be included in the Institutional Letter of Support of the Overall Component.

Resource Sharing Plan: Individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the SF424 (R&R) Application Guide.

Other Plan(s):

All instructions in the How to Apply - Application Guide must be followed, with the following additional instructions:

Do not include a Data Management and Sharing (DMS) Plan within this Component. If a DMS Plan is required for this NOFO, it must be included within the Overall Component.

Appendix: Only limited items are allowed in the Appendix. Follow all instructions for the Appendix as described in the SF424 (R&R) Application Guide.

PHS Human Subjects and Clinical Trials Information (Administrative Core) When involving human subjects research, clinical research, and/or NIH-defined clinical trials follow all instructions for the PHS Human Subjects and Clinical Trials Information form in the SF424 (R&R) Application Guide, with the following additional instructions:

If you answered "Yes" to the question "Are Human Subjects Involved?" on the R&R Other Project Information form, you must include at least one human subjects study record using the Study Record: PHS Human Subjects and Clinical Trials Information form or a Delayed Onset Study record.

Study Record: PHS Human Subjects and Clinical Trials Information Do not complete. Human subjects research is not allowed in the Administrative Core.

Delayed Onset Study Note: Delayed onset does NOT apply to a study that can be described but will not start immediately (i.e., delayed start). All instructions in the SF424 (R&R) Application Guide must be followed.

Research Core Research Cores should be made available to other investigators at the institution as well as those from other IDeA state institutions. Cores that duplicate services already available at the applicant institution are not allowed. Utilization, modification, or expansion of existing Core resources supported by institutional funds or other IDeA programs to accomplish the goals of proposed COBRE research is strongly encouraged.

When preparing your application, use Component Type 'Core'.

All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions, as noted.

SF424 (R&R) Cover (Research Core) Complete only the following fields:

PHS 398 Cover Page Supplement (Research Core) Follow standard instructions.

Research & Related Other Project Information (Research Core) Human Subjects: Answer only the 'Are Human Subjects Involved?' and 'Is the Project Exempt from Federal regulations?' questions.

Vertebrate Animals: Answer only the 'Are Vertebrate Animals Used?' question.

Project Narrative: Do not complete. Note: ASSIST screens will show an asterisk for this attachment indicating it is required. However, eRA systems only enforce this requirement in the Overall component and applications will not receive an error if omitted in other components.

Project /Performance Site Location(s) (Research Core) Research Cores proposed by the applicant organization must be located at the primary Performance Site.

Note: The Project Performance Site form allows up to 300 sites, prior to using additional attachment for additional entries.

Research & Related Senior/Key Person Profile (Research Core)

The Director(s) of Research Core facilities must be full-time staff member(s) at the applicant organization and be experienced with the requisite knowledge, authority, leadership, administrative skills, and capabilities to direct the core. The Core Director will lead a team that provides services to:

Budget (Research Core) Budget forms appropriate for the specific component will be included in the application package.

Funds may be requested to establish Research Core facilities and/or to use, modify, or expand existing resources that are necessary for accomplishing the scientific goals of the Center. In addition to personnel and supply costs, the acquisition of new equipment and modernization of instrumentation may be proposed. Alteration and Renovation (A&R) of core facilities cannot be proposed under this component.

Core facilities should have a detailed budget for the entire proposed project period (five years).

Note: The R&R Budget form included in many of the component types allows for up to 100 Senior/Key Persons in section A and 100 Equipment Items in section C prior to using attachments for additional entries. All other SF424 (R&R) instructions apply.

PHS 398 Research Plan (Research Core) Introduction to Application: For Resubmission applications, an Introduction to Application is allowed (but not required) in the Research Core component.

Specific Aims: The SF424 application Guide must be followed.

Research Strategy: Describe and justify:

Letters of Support: Not allowed. Support for any Research Cores should be included in the…