PAR-27-022-Full-Announcement.html

Department of Health and Human Services

Part 1. Overview Information

Participating Organization(s)

National Institutes of Health (NIH)

Components of Participating Organizations

Division of Program Coordination, Planning and Strategic Initiatives, Office of Research Infrastructure Programs (ORIP)

National Eye Institute (NEI)

National Institute on Aging (NIA)

National Institute of Allergy and Infectious Diseases (NIAID)

National Institute of General Medical Sciences (NIGMS)

All applications to this funding opportunity announcement should fall within the mission of the Institutes/Centers. The following NIH Offices may co-fund applications assigned to those Institutes/Centers.

Office of Data Science Strategy (ODSS)

Funding Opportunity Title

Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed)

Activity Code

S10 Biomedical Research Support Shared Instrumentation Grants

Announcement Type

Reissue of

PAR-24-264

PAR-24-265

PAR-24-326

Related Notices

Check for any recent Notices of NIH Policy Changes that may impact application requirements.

Funding Opportunity Number (FON)

PAR-27-022

Companion Funding Opportunity

PAR-27-021

, S10 Biomedical Research Support Shared Instrumentation Grants

Number of Applications

See Part 2, Section III. 3. Additional Information on Eligibility.

Assistance Listing Number(s)

93.351, 93.866, 93.859, 93.855, 93.867, 93.310

Funding Opportunity Purpose

This Notice of Funding Opportunity (NOFO) announces the restructured Shared Instrumentation Grant (SIG) Program that consolidates three existing shared-use instrumentation programs, i.e., the Shared Instrumentation Grant program, the High-End Instrumentation Grant program, and the Basic Instrumentation Grant program. The NOFO invites applications from groups of NIH-supported investigators to purchase or upgrade a single state-of-the-art commercially available instrument or an integrated instrumentation system. The instruments purchased through the SIG Program are required to be optimally shared among the users to ensure efficient and cost-effective research operations, enable rigorous and reproducible measurements, and encourage collaborative research and benefit broad research communities at large. The minimum award is $300,000. There is no cap on the total cost of the instrument; however, the maximum award is $5,000,000.

Funding Opportunity Goal(s)

The Office of Research Infrastructure Programs (ORIP) is a program office in the Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI) dedicated to supporting research infrastructure and related research resource programs. ORIP consists of the Division of Comparative Medicine (DCM) and the Division of Construction and Instruments (DCI).

Key Dates

Posted Date

June 25, 2026

Open Date (Earliest Submission Date)

June 27, 2026

July 27, 2026

July 27, 2026

Not Applicable

March 2027

July 01, 2027

July 01, 2027

Not Applicable

March 2028

July 01, 2028

July 01, 2028

Not Applicable

March 2029

All applications are due by 5:00 PM local time of applicant organization.

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

Expiration Date

July 02, 2028

Due Dates for E.O. 12372

Not Applicable

Required Application Instructions

It is critical that applicants follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide, except where instructed to do otherwise (in this NOFO or in a Notice from NIH Guide for Grants and Contracts).

Conformance to all requirements (both in the How to Apply - Application Guide and the NOFO) is required and strictly enforced. Applicants must read and follow all application instructions in the How to Apply - Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the How to Apply - Application Guide, follow the program-specific instructions.

Applications that do not comply with these instructions may be delayed or not accepted for review.

Table of Contents

Part 1. Overview Information Key Dates Part 2. Full Text of Announcement Section I. Notice of Funding Opportunity Description Section II. Award Information Section III. Eligibility Information Section IV. Application and Submission Information Section V. Application Review Information Section VI. Award Administration Information Section VII. Agency Contacts Section VIII. Other Information

Part 2. Full Text of Announcement

Section I. Notice of Funding Opportunity Description

The objective of the Shared Instrumentation Grant (SIG) Program is to support institutions in purchasing a single item of state-of-the-art, high-priced, commercially available research instrument, or an integrated instrumentation system for use in NIH-supported projects. An integrated instrumentation system refers to a dedicated set of components that rely on one another to perform a specific function that no individual component can achieve independently. NIH recognizes that cutting-edge research instruments produce high quality and reproducible data, provide sophisticated technologies to drive innovations in basic, translational, clinical, and biobehavioral research, empower researchers to achieve unprecedented productivity and cost-effective biomedical research operations.

Examples of eligible instruments include, but are not limited to, supercomputing clusters, radiology imaging systems, such as high field MRI, PET/MRI imagers, electron microscopes, biomedical imagers, light microscopes, RNA imagers, nuclear magnetic resonance spectrometers, mass spectrometers, flow cytometers, cell sorters, DNA and protein sequencers, and X-ray diffractometers. Applications for general purpose computer systems (e.g., supercomputers, computer clusters and data storage systems) will be considered only if the system is dedicated solely to biomedical research.

NIH strongly discourages requests for instruments under lease agreements. In exceptional cases, NIH may consider funding the depreciated value of a leased instrument, but only if it remains state-of-the-art at the time of award.

While foreign-made instruments are allowed, the reasons for choosing foreign-made instruments over domestically manufactured instruments will be justified. NIH urges that every effort should be made to give preference to domestically manufactured instruments to the maximum extent possible.

To maximize impact and promote efficient use, the instrument should, whenever possible, be housed in a core facility or shared resource. This ensures broad access amongst investigators, research groups, and departments, fosters collaboration in a multidisciplinary setting, and enhances the potential for regional or national impact.

Program Specifications Program Director/Principal Investigator (PD/PI): Each applicant institution will propose a PD/PI who can assume administrative and scientific oversight responsibility for the requested instrument. The PD/PI will also be responsible for:

Advisory Committee: An Advisory Committee will be named to assist the PD/PI in administering the grant and overseeing the usage of the instrument. The PD/PI and the Advisory Committee should convene regular meetings and issue annual reports on the instrument status, including their recommendations for the instrument operations. For details on the composition of the Advisory Committee, see Section IV.2 under "Administration." The PD/PI and the Advisory Committee are responsible for the development of guidelines for:

Special Use Instrument and Cost Sharing: For instruments that cost over $1,000,000 in direct cost and are expected to support a small fraction of billable clinical use, the institution may request a Special Use Instrument (SUI). Voluntary cost sharing is encouraged for an SUI. Eligibility requirements for SUI are described in Section III.3. Voluntary cost sharing is also encouraged for other high-end and premium instruments, as seen in Section III.2. Cost sharing for the purchase of the instrument is not required; institutional funds contributing to the cost of the purchase of the high-cost instrument are encouraged. All responsive applications, whether cost sharing is proposed or not, will proceed to a peer review.

Applications Not Responsive to this NOFO The following types of applications are not responsive to this NOFO and will not be reviewed:

Applications proposing such requests will be considered non-responsive and will not be reviewed or considered for funding.

See Section VIII. Other Information for award authorities and regulations.

Section II. Award Information

Funding Instrument

Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.

Application Types Allowed

New

Resubmission

The OER Glossary and the How to Apply - Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.

Clinical Trial?

Not Allowed: Only accepting applications that do not propose clinical trials. Note: Applications may propose activities involving human subjects that are not deemed clinical trials.

Need help determining whether you are doing a clinical trial?

Funds Available and Anticipated Number of Awards

The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Award Budget

Applications will be accepted that request a single, commercially available instrument or an integrated instrumentation system. The minimum award is $300,000. There is no upper limit on the cost of the instrument, but the maximum award is $5,000,000. S10 awards do not allow indirect costs.

Award Project Period

Awards are made for one year only.

NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.

Section III. Eligibility Information

1. Eligible Applicants

Eligible Organizations

Nonprofits Other Than Institutions of Higher Education

For-Profit Organizations

Local Governments

Federal Governments

Eligible Agencies of the Federal Government

U.S. Territory or Possession

Other

Independent School Districts

Public Housing Authorities/Indian Housing Authorities

Native American Tribal Organizations (other than Federally recognized tribal governments)

Faith-based or Community-based Organizations

Regional Organizations

Foreign Organizations/Foreign Collaborations

Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Required Registrations

Applicant Organizations Applicant organizations must complete and maintain the following registrations as described in the How to Apply - Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. Failure to complete registrations in advance of a due date is not a valid reason for a late submission, please reference NIH Grants Policy Statement Section 2.3.9.2 Electronically Submitted Applications for additional information System for Award Management (SAM) – Applicants must complete and maintain an active registration, which requires renewal at least annually. The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code. Foreign organizations must obtain a NATO Commercial and Government Entity (NCAGE) Code (in lieu of a CAGE code) in order to register in SAM. Unique Entity Identifier (UEI)- A UEI is issued as part of the SAM.gov registration process. The same UEI must be used for all registrations, as well as on the grant application.

Program Directors/Principal Investigators (PD(s)/PI(s)) All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.

All PD(s)/PI(s) must be registered with ORCID. The personal profile associated with the PD(s)/PI(s) eRA Commons account must be linked to a valid ORCID ID. For more information on linking an ORCID ID to an eRA Commons personal profile see the ORCID topic in our eRA Commons online help.

Eligible Individuals (Program Director/Principal Investigator)

Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with their organization to develop an application for support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the How to Apply - Application Guide.

2. Cost Sharing This NOFO does not require cost sharing as defined in the NIH Grants Policy Statement NIH Grants Policy Statement Section 1.2 Definition of Terms.

3. Additional Information on Eligibility Number of Applications

Applicant organizations may submit more than one application, provided that each application is scientifically distinct.

The NIH will not accept duplicate or highly overlapping applications under review at the same time, per NIH Grants Policy Statement Section 2.3.7.4 Submission of Resubmission Application. This means that the NIH will not accept:

There is no restriction on the number of applications an institution (as identified by a specific Unique Entity Identifier (UEI)) can submit to this NOFO each year, provided the applications request different types of equipment. Applicants are advised to discuss with the Scientific/Research Contact (see Section VII) about potential duplications before submitting two applications for the same type of instrument.

Major User Group and NIH User Group: At least three NIH funded Major Users who have a substantial need for the instrument must be identified. Each of the Major Users must be a PD/PI on a distinct active NIH research award (i.e., a grant or a cooperative agreement). An award given to multi-PDs/PIs is counted only once towards the fulfillment of this requirement. NIH training or fellowship grants (i.e., T and F mechanisms), other non-research and SBIR/STTR grants, Other Transaction (OT) awards and contracts cannot be counted towards the fulfillment of this requirement.

To justify the requested instrument, the projects supported by NIH research awards (i.e., grants or cooperative agreements) should together use the instrument at the 65 percent level of the Accessible Usage Time (AUT) or higher; see Section Other Project Information for the definition of AUT (under "Justification of Need"). If a SUI is requested, the projects supported by NIH research awards should together use the instrument at the 75 percent level of the Biomedical Research Time (BRT) (see below for the definition of SUI and BRT).

The NIH User Group must meet the eligibility requirement at the time of submission.

Special Use Instruments (SUI): In special circumstances, to extend the outreach of the Program to cases when an institution cannot justify the sole use of a high-end instrument for NIH-supported and other biomedical research, the institution may contribute a portion of the cost of the requested instrument commensurate with the proposed use of the instrument for other than biomedical research. The non-biomedical research activities supported by the instrument may include research in other fields, curricular instruction, and billable clinical care. This rare request will be designated as a SUI. In such situations, the instrument's Biomedical Research Time (BRT) must be at least 50% of the AUT or the percentage of the NIH contribution towards the purchase of the instrument, whichever is larger. In addition, voluntary cost share of 25% is encouraged for SUI. However, all responsive applications, whether cost sharing is proposed or not, will proceed to a peer review. Voluntary cost share is subject to the requirements of 2 CFR 200.306. All other requirements outlined in this NOFO still apply.

The Institution must provide specific long-term plans to secure and protect access to the instrument for biomedical researchers, as detailed in Section IV.2 under "SUI Request." If an Institution is considering a SUI request, the applicant is strongly advised to consult with Scientific/Research Contact(s) and Financial/Grants Management Contact(s) (see Section VII) before submitting an application as it is likely that special administrative procedures will have to be followed.

Quote: An itemized quote from the vendor with appropriate academic discounts and warranty terms (specified directly in the quote) is required and must be included in the application.

Section IV. Application and Submission Information

1. Requesting an Application Package The application forms package specific to this opportunity must be accessed through ASSIST, Grants.gov Workspace or an institutional system-to-system solution. Links to apply using ASSIST or Grants.gov Workspace are available in Part 1 of this NOFO. See your administrative office for instructions if you plan to use an institutional system-to-system solution.

2. Content and Form of Application Submission It is critical that applicants follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide except where instructed in this notice of funding opportunity to do otherwise (in this NOFO, in a policy notice, or other notice from NIH Guide for Grants and Contracts). Conformance to the requirements in the How to Apply - Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.

Page Limitations All page limitations described in the How to Apply – Application Guide and the Table of Page Limits must be followed.

Note: Letters of Support and Bibliography & References Cited Section are not included in the page limitations.

Instructions for Application Submission

The following section supplements the instructions found in the How to Apply – Application Guide and should be used for preparing an application to this NOFO.

SF424(R&R) Cover All instructions in the How to Apply - Application Guide must be followed.

Descriptive Title: Enter the generic name of the instrument requested in the title (for example, 600MHz NMR Spectrometer or High-Throughput DNA Sequencer).

Proposed Project: CY 2026 submission: enter start date 03/01/2027 and end date 02/28/2028; CY 2027 submission: enter start date 03/01/2028 and end date 02/28/2029; CY 2028 submission: enter start date 03/01/2029 and end date 02/28/2030.

Estimated Project Funding: Total Federal Funds Requested: Enter the total Federal funds for the requested instrument. This entry cannot exceed $5,000,000, which is the maximum award under the Program. If the requested amount is over $2,000,000, voluntary cost sharing (subject to the requirements of 2 CFR 200.306) is encouraged. See Section III.2, Cost Sharing.

Total Non-Federal Funds: If Total Federal Funds Requested (described immediately above) and Total Federal & Non-Federal Funds (described immediately below) are not the same, enter the difference in this line. Explain how the difference will be paid in the Equipment section on the SF424 (R&R) Other Project Information form (described below).

Total Federal & Non-Federal Funds: Enter the total cost of the instrument from the quote.

Program Income: Enter zero as this does not apply to the Program.

NOTE: A warning will be generated during submission for any S10 with a budget of more than $500,000. This warning can be ignored.

SF424(R&R) Project/Performance Site Locations

SF424(R&R) Other Project Information

For specific instructions, please visit the ORIP S10 FAQ page at https://orip.nih.gov/division-construction-instruments/s10-instrumentation-programs/pre-application/frequently-asked-questions.

Project Summary/Abstract: The Project Summary/Abstract should contain a succinct and accurate description of the requested instrument and an explanation of the need for the instrument to advance research projects of the Users. The application's broad, long-term objectives should be stated, concisely describing how access to the instrument will support the research projects.

Project Narrative: Using no more than two or three sentences of plain language, describe the relevance of this research to public health.

Bibliography & References Cited: List only publications that demonstrate the researchers' expertise in operation and usage of the requested instrument or that are relevant to research projects which will be supported by the instrument. References to the Research Projects Section may appear in this section or may be listed at the end of individual research subsections.

Facilities & Other Resources: Not Applicable. Do not include an attachment here.

Equipment: Describe the requested instrument by stating its manufacturer, model number, specific features, and accessories. Provide a detailed budget breakdown of the main instrument and requested accessories, including tax and import duties (tariffs), if applicable. An itemized quote from the vendor, with appropriate discounts and warranty terms, is required. The quote must be unaltered and combined in a single attachment with the equipment description as part of this upload. As described above in SF424 Cover form, include an explanation of Total Non-Federal Funds in this section (if applicable).

Applications without a valid quote will be deemed incomplete and will be withdrawn from review.

If human, animal, or infectious materials, which could create a potential biohazard, are to be analyzed, funds for accessory containment equipment for the instrument may be requested in the budget.

Do not describe the need for the instrument or accessories in this section; such narrative should be a part of the Justification of Need section of the Instrumentation Plan.

Other Attachments:

I) Instrumentation Plan (in lieu of Research Plan form) The entire Instrumentation Plan (with the sections described below) must be saved as a single PDF file - named Instrumentation Plan - and attached via Other Attachments. Organize the sections of the Instrumentation Plan in the specified order as described below, starting each section with the appropriate section heading (i.e., Justification of Need, Technical Expertise, Research Projects, etc.). Do not include links to websites for further information. Do not include animations/videos.

Requesting instruments under a lease agreement is strongly discouraged, consulting the Scientific/Research contact is strongly recommended.

Justify the instrument and specific model chosen. Explain why the chosen model and its manufacturer are the most suitable for your user group. Provide an inventory of similar instruments existing at your institution, neighboring research institutions, or otherwise accessible; describe why each similar instrument is unavailable or inappropriate for the proposed research. If similar instruments are listed as "unavailable," add a letter to the Letters of Support section from the instrument manager explaining why the instrument is not available to your user group. Preliminary data is not required, though if access to a demo instrument is practical, it can be included to justify the choice of the instrument.

Justify the need for software. All software supported by this program must be integrated into the operation of the instrument or be necessary for generation of high-quality data from the instrument. Depending on the needs of research projects, different configurations of such software may be needed to ensure productive scientific use of the instrument. Any additional software modules that are requested must be essential for the advancement of research projects of at least three Major Users. As noted previously, stand-alone workstations, duplicate software items, and software licenses are not allowed.

Define and justify the AUT for the requested instrument. The AUT is the number of annual hours the instrument can be practically used for research. AUT hours may be limited by the time an instrument operator is available if an operator is required, facilities' access schedules, planned maintenance, start-up and standardization, and any other factors that take time away from the use of the instrument for research. AUT may be limited by the type of technology requested; some instruments can be operated 24/7 while other technologies can be used only during operators' available hours. Therefore, justify the AUT based on the practical factors at your site to clarify that the AUT corresponds to realistic full-time use of the instrument at your institution.

If a SUI is requested, provide the BRT for the instrument. BRT is the number of annual hours that the instrument is available to conduct biomedical research. For an instrument exclusively used for biomedical research, the BRT is equal to AUT. For a SUI to be considered for funding via this program, its BRT must be at least 50% of AUT, or the percentage of the NIH contribution towards the purchase of the instrument, whichever is larger (see also Section III.3). The justification of need for a SUI can only be based on the requirements of NIH-funded or other BRT users, and not on the non-BRT needs. For special accessories, using the Table of Accessories may help clarify a description of SUI (see Summary Tables below).

Technical Expertise: Describe the technical expertise of individuals who will set up and run the instrument. Specify who will ensure that the instrument is safely operated and appropriately maintained. State who will train new users. If the instrument requires complex sample preparation or consultation for experimental designs, describe the expert individuals who will serve in that capacity. Address technical support for data collection, management, and analysis.

If an innovative instrument providing new research capabilities is requested, demonstrate the special technical expertise needed for increasing its adoption in biomedical research. Describe training for the investigators on using the novel technology to advance their research.

Research Projects: The Research Projects section should focus on explanation of how the requested instrument will advance research projects. In this section, describe the benefit of the requested instrument to enhance Users research projects. First, describe the research projects of Major Users. You can organize this section into subsections of Research Projects of Major Users or Specific Research Topics. The latter format may be especially useful to avoid redundancies in the presentation of research projects if several Major Users pursue research topics which follow similar protocols and the scientific benefits of the new instrument for their projects are comparable. All Major Users must have a substantial need for the requested instrument. Detailed eligibility requirements for Major Users are described in Section III.

Since the research projects have been previously peer-reviewed, their details should be described clearly and succinctly, and only as necessary to explain how the requested instrument will advance the projects research objectives. Present sufficient technical details about types of samples or specific experimental protocols to be employed to allow evaluation of whether the instrument is appropriate, will be effectively utilized, and would provide advantages over other methods and other similar existing or new instruments. Justify the need for special features, accessories, and special software modules of the requested instrument by at least three Major Users. Preliminary data is not required, but if available, it may be used to illustrate the benefits of the requested instrument to the research projects. Describe how generated data will be handled and analyzed so that the benefits of the entire experimental set-up can be evaluated. Summarize the benefits that the requested instrument will provide toward answering specific scientific questions.

If the Research Projects section is to be structured by the research projects of Major Users, limit the text to no more than 1 page per each Major User's project. In the beginning of each Major User's Project narrative, list the PI's name and grant information (number, title, project start and end dates). Specify the anticipated usage in annual hours for each project. The Research Project of Other Users subsection is strongly recommended to be succinct, describing 3 or more projects per page.

If the Research Projects section is structured by Specific Research Topics, list Major Users, their funded grants that you describe therein, and their cumulative usage as measured by annual usage hours, in the beginning of each subsection.

In cases of certain technologies (such as computer systems or cell sorters), many users may be expected. Keep in mind that the number of users alone is not a compelling factor to justify scientific needs for the requested instrument.

A section entitled Other Users Projects may be used to describe the need of the requested instrument to advance projects from Other Users and the user community at your institution (e.g., unfunded users who have a significant need for the instrument to develop their research programs or users whose expected needs are at the level of 1% or less of the expected usage time). Include a sum of the anticipated usage in annual hours for all Other Users.

Summary Tables: At the beginning of this section, re-state the AUT (and BRT if a SUI) in annual hours, as introduced in the Justification of Need Section.

Next, insert the following groups into the summary tables (sample Summary Table is available at ORIP S10 FAQ page): a) Research Projects of Major Users, and b) Research Projects of Other Users. The tables should have the following columns: User's name, grant number (for NIH awards, list the grant numbers such as R01IC123456), brief title of the project, grant start and end dates, and estimated usage in annual hours. If there are multiple Users funded by the same grant, list a total of their estimated usage in annual hours for projects supported by that grant. If applicable, include a separate table to indicate the users' needs for any requested accessory. If a SUI is requested, these tables should clarify accessories which are not needed for the Major or Other Users.

Do not list users whose annual usage is at the level of 1% of AUT or less.

Following the tables, state:

i. The total estimated usage time by all Users projects in annual hours,

ii. The percentage of the estimated usage time devoted to all NIH-funded projects.

All NIH-funded users should use the instrument at the level of at least 65% of the AUT (or 75% of the BRT).

Administration (Organizational/Management Plan): Describe the organizational plan to administer the grant. Describe where the instrument will be located, how it will be utilized, how requests to use the instrument will be made, how time will be allocated among users, how other projects and new users will be enlisted. Describe how users will be trained in experimental design, instrument operation and data analysis. Describe typical day-by-day management of the instrument. If the plans are to install the instrument in a setting other than a core or a shared resource facility, describe the procedures that will implement and assure broad access to the instrument and its use on a shared basis.

List the names and titles of the members of the local Advisory Committee. The membership of this Committee should represent the interests of different users and should include non-user members to avoid conflicts of interest who can resolve disputes if they arise. The membership of this Committee should include at least one senior institutional official who will represent the financial commitment of the institution. It is recommended that the Advisory Committee includes at least 4 members. Major Users of the instrument may be members, but none should be the Chairperson. The PD/PI cannot serve as the Chairperson or a voting member of the Advisory Committee.

The PD/PI and the Advisory Committee should convene meetings and prepare annual reports on the instrument status. The reports will become part of the Final Research Performance Progress Report (Final RPPR) and the Annual Usage Reports (AUR) (see Section VI.4).

Provide a plan about how the Users will be instructed and reminded about citing the S10 award in their publications and how their compliance will be verified.

Describe a plan for managing access to the instrument if users' projects involve human subjects, vertebrate animals, or biohazards such as infectious materials.

Financial Plan: Submit a specific financial plan for the long-term operation and maintenance of the instrument as such costs are not supported by the S10 Program. Explain how various operational costs will be met; specifically, costs associated with routine operation and maintenance of the instrument, and costs for support personnel. Enumerate the sources of income such as charge back fee structure, grants, or institutional support. The financial plan must include a table for years 1-5 of operation. For year 1, although the maintenance costs are fully covered by a one-year manufacturer warranty, enter anticipated expenditures and anticipated income, showing how these estimates were derived. For years 2-5, approximate amounts, based on data for year 1, must be considered in the financial plan. A description of projected changes to the financial plan over the four years is also needed.

Operation: Include salary support of expert personnel that will operate the instrument and oversee routine care and procedures for standardization.

Maintenance: May include a service contract, or funds for parts and local technical personnel who will maintain the instrument (if such personnel are qualified to do so).

Supplies: Include necessary supplies for operating the instrument such as chemicals, cryogenics, and other expendable items.

Software: Include costs for updates/maintenance of software licenses needed for the proper operation of the instrument or additional software for data analysis.

Anticipated Income: Enumerate the sources of income, such as any charge back fee structure, grants, or institutional support.

II) Letters of Support All letters of support should be combined into a single file named Letters of Support and uploaded as a separate attachment via Other Attachments. This combined file should include, as applicable:

1) S10 Grant Number.

2) Year of Award.

3) Installation Date of the Instrument.

4) PD/PI's name.

5) Generic Name of Instrument.

6) Instrument Status: Active (instrument in use), Pending (order placed, but instrument not delivered, instrument received but not installed or not calibrated for general use), Upgraded (or replaced), Not Available (sold, decommissioned, transferred); (If the instrument is currently non-functional, provide a succinct explanation of the instrument status immediately following this table).

7) Actual Usage Time: Actual total time in hours per year the instrument was used for research. If the instrument has been functioning for less than a year, the usage time can be extrapolated to reflect annual hours.

8) Maintenance Agreement: Active (Warranty in place), In-House (or Self-Insured), None (Fee for Service, Pending), Not Available (no longer supported by manufacturer).

9) Publications: Enter the number of research publications that cite the S10 award or have been linked with the S10 award in My NCBI. The number of reported publications should be verified in the NIH RePORTER. If there are no publications for any of the previously awarded S10-awarded instruments, provide an explanation immediately following this table.

Letter from Biosafety Official. If human, animal, or infectious materials, which could create a potential biohazard, are to be analyzed, a signed letter from the institutional biosafety officer is required. The letter should state that the proposed containment plan has been reviewed and adheres to documented biosafety regulations.

SF424(R&R) Senior/Key Person Profile

Include the profiles of the PD/PI, Major Users, and technical personnel, as applicable.

R&R Budget

R&R Subaward Budget

PHS 398 Cover Page Supplement

PHS 398 Research Plan All instructions in the How to Apply - Application Guide must be followed, with the following additional instructions:

Resource Sharing Plan: Individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the How to Apply - Application Guide.

Not Applicable

Other Plan(s):

All instructions in the How to Apply - Application Guide must be followed, with the following additional instructions:

A Data Management and Sharing Plan is not applicable for this NOFO.

Appendix: Only limited Appendix materials are allowed. Follow all instructions for the Appendix as described in the How to Apply - Application Guide.

No publications or other material, with the exception of blank questionnaires or blank surveys, may be included in the Appendix.

PHS Human Subjects and Clinical Trials Information When involving human subjects research, clinical research, and/or NIH-defined clinical trials (and when applicable, clinical trials research experience) follow all instructions for the PHS Human Subjects and Clinical Trials Information form in the How to Apply - Application Guide, with the following additional instructions:

If you answered "Yes" to the question "Are Human Subjects Involved?" on the R&R Other Project Information form, you must include at least one human subjects study record using the Study Record: PHS Human Subjects and Clinical Trials Information form or Delayed Onset Study record.

Study Record: PHS Human Subjects and Clinical Trials Information

Delayed Onset Study

Note: Delayed onset does NOT apply to a study that can be described but will not start immediately (i.e., delayed start). All instructions in the How to Apply - Application Guide must be followed.

PHS Assignment Request Form

3. Unique Entity Identifier and System for Award Management (SAM) See Part 2. Section III.1 for information regarding the requirement for obtaining a unique entity identifier and for completing and maintaining active registrations in System for Award Management (SAM), NATO Commercial and Government Entity (NCAGE) Code (if applicable), eRA Commons, and Grants.gov

4. Submission Dates and Times Part I. contains information about Key Dates and times. Applicants are encouraged to submit applications before the due date to ensure they have time to make any application corrections that might be necessary for successful submission. When a submission date falls on a weekend or Federal holiday, the application deadline is automatically extended to the next business day.

Organizations must submit applications to Grants.gov (the online portal to find and apply for grants across all Federal agencies). Applicants must then complete the submission process by tracking the status of the application in the eRA Commons, NIH's electronic system for grants administration. NIH and Grants.gov systems check the application against many of the application instructions upon submission. Errors must be corrected and a changed/corrected application must be submitted to Grants.gov on or before the application due date and time. If a Changed/Corrected application is submitted after the deadline, the application will be considered late. Applications that miss the due date and time are subjected to the NIH Grants Policy Statement Section 2.3.9.2 Electronically Submitted Applications.

Applicants are responsible for viewing their application before the due date in the eRA Commons to ensure accurate and successful submission.

Information on the submission process and a definition of on-time submission are provided in the How to Apply – Application Guide.

5. Intergovernmental Review (E.O. 12372) This initiative is not subject to intergovernmental review.

6. Funding Restrictions All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.

Pre-award costs are allowable only as described in the NIH Grants Policy Statement Section 7.9.1 Selected Items of Cost.

Under the S10 mechanism, funding requests are limited to the purchase cost of the instrument only. Support for technical personnel, service contracts, extended warranties, software (except as defined in Part 2, Section I), and supplies are not allowable. Cost sharing toward the purchase of the instrument is not required and any institutional funds contributed to the costs of the purchase of the instrument are voluntary. If the amount of funds requested does not cover the total cost of the instrument, the application should describe the proposed source(s) of funding to cover the balance of the cost of the instrument and document their availability in a letter signed by an appropriate institutional official. Note that any voluntarily committed cost will be noted in the Notice of the Award and the institution will be held to the commitment and reporting requirements.

This Program does not provide indirect costs or support for construction, alterations, or renovations. Commitment of an appropriate level of institutional support, to ensure the associated sustaining infrastructure, is expected and should be described. The appropriate Grant will be awarded for a period of one year and is not renewable.

Applicants proposing the purchase of an instrument that the institution is planning to lease prior to an award are required to consult with their institutional sponsored projects office and the NIH Grant Management Office (see Section VII for contact information) regarding the applicable NIH policy prior to executing the leasing agreement. If the leasing agreement was executed prior to submission of the application, the applicant must provide a strong justification for the amount of the requested Federal funds requested, with adjustments to depreciation.