PAR-25-450-Full-Announcement.html

This document is a Notice of Funding Opportunity (NOFO) from the National Institutes of Health (NIH) focusing on clinical trial readiness for rare diseases. The funding opportunity, assigned to the Child Health and Human Development Extramural Research program (CFDA 93.865) and the National Center for Advancing Translational Sciences program (CFDA 93.350), seeks R21 grant applications to facilitate rare diseases research by enabling efficient movement of candidate therapeutics or diagnostics toward clinical trials.

The initiative specifically targets research projects that can develop and test rigorous biomarkers, clinical outcome assessment measures, or define the presentation and course of rare diseases to improve clinical trial design. While applications are not currently being solicited, potential applicants are encouraged to begin developing collaborations and responsive projects. The grant is part of the Department of Health and Human Services' efforts to advance translational science, with a focus on reducing bottlenecks in research and accelerating the delivery of new medical treatments and diagnostics for rare diseases, disorders, and syndromes.