PAR-25-449-Full-Announcement.html

This document is a Notice of Funding Opportunity (NOFO) from the National Center for Complementary and Integrative Health (NCCIH), part of the National Institutes of Health (NIH), soliciting research applications under the Research and Training in Complementary and Integrative Health program (CFDA 93.213). The funding opportunity seeks rigorous mechanistic research studies examining how mind and body interventions (such as mindfulness meditation, yoga, acupuncture, and massage) impact emotional well-being and whole person health.

The grant will use a two-phased R61/R33 award mechanism, with an initial feasibility phase (R61) followed by a full-scale clinical trial phase (R33), contingent upon successful completion of initial milestones. Applicants must provide preliminary data comparable to an R01 proposal, focusing on innovative mechanisms of emotional well-being as the primary outcome and the Whole Person Health Index as a secondary outcome. The research aims to understand biological mechanisms by which mind and body interventions potentially restore health, addressing fundamental knowledge gaps in complementary and integrative health approaches.