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This document is a Notice of Funding Opportunity (NOFO) for the Mood and Psychosis Symptoms during the Menopause Transition (R21 Clinical Trial Optional) grant. The purpose of this funding opportunity is to advance translational research to better understand the emergence and worsening of mood and psychotic disorders during the menopause transition, with the goal of identifying targets for future treatment interventions. The grant is open to a wide range of applicant types, including tribal governments, nonprofits, small businesses, and higher education institutions. This funding opportunity is assigned to the NIH Office of Research on Women's Health (ORWH) and the National Institute of Mental Health (NIMH) grant programs. The review criteria will focus on the comprehensiveness of the neurobiology and mechanisms underlying mood and psychosis symptoms during the menopause transition.