PAR-25-271-Full-Announcement.html

This Notice of Funding Opportunity (NOFO) PAR-25-271 from the National Center for Complementary and Integrative Health (NCCIH) seeks applications for mid-phase clinical trials of natural products, including botanicals, dietary supplements, probiotics, and standardized nutritional regimens. The funding falls under CFDA 93.213 for Research and Training in Complementary and Integrative Health, administered by the Department of Health and Human Services National Institutes of Health.

Applicants must provide preliminary data showing bioavailability and target engagement of the natural product, with limited exceptions. The trials should either determine optimal dosing/formulation for future multi-site efficacy trials or identify patient phenotypes that respond to the treatment. Eligible applicants include higher education institutions, nonprofits, businesses, tribal organizations, and government entities. The NOFO specifically excludes single-site or multi-site efficacy trials and trials related to cancer treatment/prevention. Applicants are advised to contact NCCIH scientific staff before submission. No specific award amounts or dates are provided in this excerpt.