PAR-25-270-Full-Announcement.html

This Notice of Funding Opportunity (NOFO) PAR-25-270 from the Department of Health and Human Services National Institutes of Health seeks applications for early-phase clinical trials of natural products including botanicals, dietary supplements, probiotics, and standardized nutritional regimens. The funding mechanism is an R33 grant intended to accelerate translation of basic science findings about natural products into early clinical testing.

The NOFO provides up to 3 years of support for studies that replicate natural product impacts on target engagement in humans and assess associations between target engagement and clinical outcomes. Studies can optimize product delivery through different doses/formulations, combine products with known treatments, or study responsive target populations. Available to multiple applicant types including businesses, nonprofits, governments, and educational institutions, this opportunity falls under CFDA 93.213 (Research and Training in Complementary and Integrative Health). The NOFO specifically excludes efficacy and effectiveness trials.