PAR-25-185-Full-Announcement.html

This document is a full announcement for the federal grant opportunity titled "Screening and Functional Validation of Genomic Variants Associated with Human Congenital Anomalies (R01 Clinical Trial Not Allowed)".

The purpose of this $17.5 million initiative from the Department of Health and Human Services (HHS) National Institutes of Health (NIH) is to promote the screening, functional validation, and characterization of genetic variants associated with congenital anomalies using in-silico tools, animal models, in vitro systems, or multi-pronged approaches. The grant is open to a range of applicant types including state/local governments, higher education institutions, nonprofits, and small businesses. It is funded under NIH's Research Infrastructure Programs (CFDA 93.351) and Child Health and Human Development Extramural Research (CFDA 93.865) grant programs. Applications are due by January 26, 2027, with an anticipated award start date of July 2027. This opportunity aims to address the gap between identifying genetic variants and understanding their functional effects on congenital anomalies.