PAR-25-179-Full-Announcement.html

This is a grant announcement (PAR-25-179) from the National Institutes of Health (NIH) for confirmatory efficacy clinical trials targeting mental health interventions. The funding opportunity supports testing of non-pharmacological therapeutic and preventive interventions for mental disorders in both adults and children, focusing on unmet therapeutic needs. The grant falls under the Mental Health Research Grants program (CFDA 93.242) and requires clinical trials that investigate the relationship between disease processes and intervention mechanisms.

The opportunity is open to a wide range of applicants including government entities, nonprofits, educational institutions, tribal organizations, and for-profit businesses. It is administered by the Department of Health and Human Services' National Institute of Mental Health (NIMH) and emphasizes an experimental therapeutics approach. This opportunity is part of NIMH's clinical trials pipeline NOFOs and requires clinical trials specifically designed to advance understanding of therapeutic change mechanisms.