Notice of Intent to Sole Source.pdf

Synopsis No. 75N94025Q00239

NICHD, Office of Acquisitions

Title: Acquisition of Bruker timsMetabo and associated components

Presolicitation

SYNOPSIS

General Information

Document Type: Presolicitation

Synopsis Number: 75N94025Q00239

Posted Date: September 10, 2025

Original Response Date: September 20, 2025

Current Response Date: September 20, 2025

Set Aside: N/A

NAICS Code: 334516

Contracting Office Address

NICHD

6710B Rockledge Dr.

Bethesda, Maryland 20892

Description

INTRODUCTION

THIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS

TO AWARD A CONTRACT OR PURCHASE ORDER WITHOUT PROVIDING FOR FULL

OR OPEN COMPETITION (INCLUDING BRAND-NAME).

The National Institutes of Health (NIH), National Institute of Child Health and Human

Development (NICHD), Office of Acquisitions (OA) intends to negotiate and award a contract without providing for full and open competition (Including brand-name) to:

Bruker Scientific LLC

40 Manning Rd.

Billerica, MA 01821

NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE

The intended procurement is classified under NAICS code 334516 with a Size Standard 1,000.

REGULATORY AUTHORITY

The resultant contract will include all applicable provisions and clauses in effect through the

Federal Acquisition Circular (FAC) 2005-99-1, July 16, 2018. This acquisition is conducted under the procedures as prescribed in FAR subpart 13-Simplified Acquisition Procedures at an amount not exceeding the simplified acquisition threshold ($250,000).

STATUTORY AUTHORITY

This acquisition is conducted under the authority of the Federal Acquisition Regulation (FAR)

Part 13-Simplified Acquisition Procedures, Subpart 13.106-1 (b) (1), Soliciting from a single source and is not expected to exceed the simplified acquisition threshold. Contracts awarded using

FAR Part 13-Simplified Acquisition Procedures are exempt from the requirements of FAR Part 6-

Competition Requirements.

GENERAL INFORMATION

1. Title: Acquisition of Bruker timsMetabo and associated components

2. Background Information: The acquisition of a liquid chromatography – ion mobility spectrometry – mass spectrometry (LC-IMS-MS) system is necessary to meet the scientific and operational requirements of the National Institute of Environmental Health Sciences

(NIEHS). LC-IMS-MS technology provides a critical capability that supports the agency’s core mission in the biomedical and environmental health sciences. It enables the separation and molecular analysis of biological samples, such as biofluids, cells, and tissues, and such an approach is often referred to as metabolomics, lipidomics, or exposomics analysis.

The NIEHS requires an updated LC-IMS-MS platform to support ongoing and future research in metabolomics, lipidomics, and exposomics. LC separates chemicals based on polarity, size, or other chemical or physical properties. IMS separates chemicals based on charge and shape.

MS measures a chemical mass from which chemical formulae can be calculated as well as structure information from tandem mass spectrometry. By integrating complementary dimensions of separation and structural information, LC-IMS-MS greatly enhances sensitivity, confidence in identification, and coverage of low-abundance and isomeric chemicals including metabolites, lipids, and exposures.

NIEHS research is focused on identifying and understanding the changes in cells, biofluids, and tissues that occur directly or indirectly by environmental exposure. This includes understanding diseases related to exposure and the molecular mechanisms of exposure-related disease. LC-IMS-MS is the only technology that allows researchers to study these chemical exposures and disease mechanisms with confident molecular identification and quantification.

Such data directly inform risk assessments, regulatory decision-making, and the development of diagnostic or prognostic testing.

The National Institute of Environmental Health Sciences (NIEHS) requires a LC-IMS-MS system that offers a high sensitivity, high-resolution, and high-duty cycle mass spectrometer with ion mobility capability to meet the demanding analytical needs of its research programs.

A high-duty cycle is essential to maximize ion utilization and data acquisition efficiency, enabling rapid tandem mass spectrometry (MS/MS) data without sacrificing ion mobility measurement. High sensitivity is critical for detecting low-abundance metabolites, environmental toxicants, and endogenous signaling molecules that may be present at trace levels. The ability to perform ion mobility measurements adds an additional dimension of molecular separation based on collisional cross section (CCS), improving the discrimination of isobaric or structurally similar compounds and enhancing molecular annotation confidence.

High-resolution (mass) is required to compute the molecular formulae to support chemical identification, characterize unknown chemicals, and quantitively measure specific chemicals.

Together, these capabilities are essential to achieve the NIEHS’s scientific goals.

CLOSING STATEMENT

This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include a technical proposal, a cost-price proposal, the period of performance, the

Unique Entity ID (UEI), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management

(SAM) www.sam.gov.

A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement.

All responses must be received by September 20, 2025 at 9:00 AM Eastern time and must reference solicitation number 75N94025Q00239. Responses may be submitted electronically to

Mr. Michael Falzone, Contracting Officer at Michael.falzone@nih.gov. Fax responses will not be accepted.

"All responsible sources may submit a capability statement, proposal, or quotation, which shall be considered by the agency.”

http://www.sam.gov/