NIKON INSTRUMENTS INC.NOTICE OF INTENT.75N94024Q00028.pdf

RFQ# 75N94024Q00028

INTRODUCTION

THIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS TO AWARD A CONTRACT OR PURCHASE ORDER WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME).

The National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Office of Acquisitions (OA) on behalf of the on behalf of the National Institute of Digestive, Diabetes & Kidney Diseases intends to award a purchase order without providing for full and open competition (Including brand-name) to NIKON INSTRUMENTS INC for the Acquisition of a CSU-W1 Spinning Disk Laser System Service Agreement.

NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE

The intended procurement is classified under NAICS code 811210 with a Size Standard of $34.0.

REGULATORY AUTHORITY

The resultant contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular FAC 2023-06 Effective December 4, 2023.

This acquisition is conducted under the procedures as prescribed in FAR subpart 13—Simplified Acquisition Procedures at an amount not exceeding the simplified acquisition threshold ($250,000).

STATUTORY AUTHORITY

This acquisition is conducted under the authority of 41 U.S.C. 253(c) under provisions of the statutory authority of FAR Subpart 6.302- FAR 6.302-1—Only one responsible source and no other supplies or services will satisfy agency requirements 41 U.S.C. 253(c)(1).

PERIOD OF PERFORMANCE

Base Year: January 1, 2024 – December 31, 2024 Option Year 1: January 1, 2025 – December 31, 2025

Place of Performance National Institutes of Health National Institute of Digestive, Diabetes & Kidney Diseases 5 South Drive Bethesda, MD 20892

PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS

DESCRIPTION OF REQUIREMENT

The mission of the National Institutes of Health (NIH) is to seek fundamental knowledge about the nature and behavior of living systems and to apply that knowledge to enhance health, lengthen life, and reduce illness and disability.

As part of the NIH, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Intramural Research Program (IRP) conducts biomedical research and training related to diabetes mellitus; endocrine, bone, and metabolic diseases; digestive diseases, including liver diseases and nutritional disorders; and kidney, urologic, and hematologic diseases. Intramural research is conducted in the Institute's laboratories and clinical facilities in Bethesda, Maryland and in Phoenix, Arizona.

Miroshnikova lab and the Section on Nuclear Mechanotransduction and Cell Fate Dynamics is part of the Laboratory of Molecular Biology (LMB), which is one of NIDDK IRP’s 17 Laboratories and Branches. The Miroshnikova lab’s work requires, on an ongoing basis, advanced mechanical characterization methods to qualitatively complement other assays, as well as quantitate the major experimental conditions of the section in living cells and organisms. The Spinning Disk Confocal System is a leading, live-sample microscope that is fast and sensitive confocal imagine system capable of following processes in live samples as well as laser ablation capabilities for mechanical qualifications. It is designed to provide optical super-Resolution improved by a factor of 1.4 compared to widefield. Thus, it is ideal for live cell and tissue/organism imaging and quantitation, which is at the core of the Miroshnikova lab’s operations. This system possesses unique features requiring unique maintenance capabilities for their ultra-wide view, enhanced signal-to-noise- ratio and flexible configurations for confocal pin-hold sizes (50um, 25um or both disks).

PURPOSE AND OBJECTIVES

The objective of this contract is to obtain a preventive maintenance contract for the live-sample microscope.

Without this service, the three primary functions for the CSU-W1 Spinning Disk Laser System cannot be maintained: 1) fast and sensitive confocal imaging suitable for following processes in live samples; 2) optical super-resolution (in xy) improved by a factor of 1.4x compared to widefield; and 3) laser ablation capability for mechanical quantifications.

SALIENT / REQUIRED FEATURES AND SPECIFICATIONS

The new equipment needs yearly maintenance to ensure accurate readings and repeatability. These operations must remain in continuous working order. Thus, a preventive maintenance package needs to remain on this unit at all times to ensure that there will be no down time for this instrument which would disrupt the continuous research taking place and our NIH mission. All original items that will need maintenance, checked for proper function, upgrade, or replaced are:

Spinning Disc Confocal System Maintenance Agreement – maintenance applies to the following (to include, but no limited to):

Ti2 Inverted Motorized Microscope TI2-E Inverted Microscope Main Body

TI2-CTRE TI2-E Controller USB 2.0 A-B Device Cable 15'

Power Cord (Lead Free UL Listed).

TI2-T-BS S Eyepiece Tube Base Unit TC-T-TS S Binocular Tube CFI 10X Eyepiece F.N. 22mm-NC TI2-N-ND-E Motor DIC Sextuple Nosepiece TI2-D-PD Diascopic Illumination Pillar TI2-D-LHLED Transmitted LED Lamp House TI2-C-TC-I Intelligent Condenser Turret TC-C-ME-PH2 ELWD Module TC-C ELWD Condenser Lens TI2-F-FLT-E Motorized Epi Fluorescence Turret S-TI2-DCL Daisy Cable Long TI2-FP Fixing Plate

Fluorescence Module TI2-LA-BF Fixed Main Branch TI2-LA-FL EPI Fluorescence Module SOLA SE U-NIR W/Control Pod LUMENCOR Liquid Light Guide; 3MM, 2M VIS C-FL AT DAPI/HOECHST/Alexa Fluorescence 350 C-FL AT EGFP/FITC/CY2/ALEXA Fluorescence 488 C-FL AT TRITC (Red Shifted) ELEMENTS: EXFO Illuminator

Objectives

CFI SUPER PLAN Fluoresecnce ELWD 20XC ADM

CFI PLAN APO VC 60X WI NA1.2 WD 0.27MM

cMOS Camera

ORCA-FLASH 4.0 SCI CMOS V3; USB 3.0

400W Thermo Cube for Image/Flash 4.0 Hose Set for ORCA-R2/Flash 4.0/Image EM C-DA C-Mount/ISO Camera Adapter 1X

Ti2-E Motorized Research Microscope TI2-E Inverted Microscope Main Body TI2-LA-SUE TI2-E Stage Up Kit

TI2-CTRE TI2-E Controller USB 2.0 A-B Device Cable 15' Power Cord (Lead Free UL Listed) TI2-T-BS S Eyepiece Tube Base Unit TC-T-TS S Binocular Tube CFI 10X Eyepiece F.N. 22mm-NC TI2-N-ND-P Perfect Focus Motor Nosepiece TI2-D-PD Diascopic Illumination Pillar TI2-D-LHLED Transmitted LED Lamp House TI2-C-TC-I Intelligent Condenser Turret TI-C-LWD LWD LENS UNIT F/SYS Condenser Turret S-TI2-LU Interlock Cable TI2-FP Fixed Plate

XY Encoded Motorized Stage TI2-S-SE-E Motorized Stage with Encoder TI2-S-JS Joystick

Z Piezo Stage Insert PI NANO K Plate Scan SYS 200UM with Controller PI NANO Z Universal Holder F/SLD and Dishes

Fluorescence System S-TI2-DCL Daisy Cable Long S-TI2-DCS Daisy Cable Short

TI2-LA-BM-E Motorized Main Branch TI2-LA-FL EPI Fluorescence Module TI2-LA-BS SUB Branch TI-LA-Exchangeable Mirror (100% Reflect) TI2-F-FLT-E Motorized EPI Fluorescence Turret C-FL AT DAPI/HOECHST/Alexa Fluorescence 350 C-FL AT EGFP/FITC/CY2/ Alexa Fluorescence 488 C-FL AT TRITC/CY3/TagRFP/ Alexa Fluorescence 546 SOLA SE U-NIR with Control Pod LUMENCOR LLG 3MM 2M Reinforced Jacket

Objectives CFI Super Plan Fluorescence ELWD 20XC

CFI APO LWD 40X WI 1.15 NA LAMBDA S

CFI APO 100X Oil TIRF NA 1.49 WD 0.12MM

CSU-W1 Dual Camera Confocal System CSU-W1 50UM PH Single Disk 2 CAM with Laser ET455/50M, DAPI-ET Emission Filter 25MM ET525/36M Emission Filter, 25MM ET605/52M Emission Filter 25MM ET705/72M Emission Filter 25MM FAR Red F/SPCTRAX 69000M DAPI/FITC/TRITC Triple BP Filter 25MM

Back Illuminated sCMOS Cameras ORCA-FUSIONBT SCMOS USB3.0 Card C-MT

Imaging Workstation and NIS-Elements Software Z4 Advanced Imaging Workstation V3 27" LCD Monitor, Z27N G2 NIS-Elements AR ELEMENTS: 6D Imaging NIS-ELEMENTS: Wavelengh Switcher

NIS-ELEMENTS MODULE: YOKOGAWA CSU-W1

ELEMENTS: SUTTER/UNIBLITZ FILTRWHL+SHUTR

NIS-ELEMENTS: Triggered Device Ccontrol NIS-ELEMENTS MODULE: Jobs Acquisition

ELEMENTS: PRIOR/MAERZHAUSER/RFA/PI-PIEZO

ELEMENTS: EXFO Illumination NIIPXI-1033 Controller

NII PXI 6723 DAQ

Custom Cable 6723 DAQ TO 16 BNC BNC Connect Black F/NI6723 with 24 AO BNC Connect NI SHC68-68-EPM Shielded Cable 6 Foot Male TO Male BNC Cable NI BNC-2110 Shielded Break Out Box PC Accessory Kit

Stage Top Incubation System THERMOBOX Incubation System

Vibration Isolation Table VIB ISO Table 36X60 CLN BNCH M6 ON 25MM

Ablation and Photostimulation System PHOTOSIM Scanner with Optics F/TI2 LAPP NIS-Elements Module: XY Galvo C-TIRF 405 Reflect 320 & 720 Transmit C-TIRF Ultra HI S/N 561NM TIRF Set Custom High-Power Laser for OMS

TASK AREAS:

Independently, and not as an agent of the Government, the contractor shall perform all of the detailed Task Areas listed below:

Task Area 1 – Service Agreement – The Contractor shall provide service coverage(s) supported by certified Biosystem Service Specialists, to include consultation with technical experts. The service agreement includes one-time (1) preventative maintenance inspection with eligible Service Agreement Selection. Repair parts, labor and travel included. Pre-approved repair and service authorization (no separate purchase orders required for repair).

Task Area 2 – Software Upgrades – The Contractor shall provide NIS-Element software version upgrades available on an “as-issued” basis.

CONTRACTING WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME)

DETERMINATION

The determination by the Government to award a contract without providing for full and open competition is based upon the market research conducted as prescribed in FAR Part 10—Market Research. Only one source is available: Per FAR 13.106-1(b)(1) the Contracting Officer has determined NIKON INSTRUMENTS, INC to be the only reasonable available source to provide a CSU-W1 Spinning Disk Laser System Service Agreement.

This acquisition was pursued on a sole source basis centered on the following: the purchase of said supplies is mission critical in the continuation of ongoing research. We are limited to these specific reagents so to assure continuity of experimental design, continuity of sample usage, and back-compatibility with high-value datasets that we already generated using said supplies.

In order to ensure accurate readings and repeatability, the lab is need of a preventative maintenance contract for the live sample microscope. Without this service, the three primary functions for the CSU-W1 Spinning Disk Laser System cannot be maintained: 1) fast and sensitive confocal imaging suitable for following processes in live samples; 2) optical super-resolution (in xy) improved by a factor of 1.4x compared to widefield; and 3) laser ablation capability for mechanical quantifications.

As this is a newer technology, only Nikon can manage and maintain their new technology properly to ensure reproducibility and accurate and consistent readings. This system possesses unique features requiring unique maintenance capabilities for their ultra-wide view, enhanced signal-to-noise- ratio and flexible configurations for confocal pinhold sizes (50um, 25um or both disks). Nikon, therefore, is the only vendor that can provide the necessary repair/replacement parts and certified technicians to promptly get this system back in working condition should there be any break in service.

CLOSING STATEMENT

This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice shall contain sufficient information to establish the interested parties’ bona-fide capabilities for fulfilling the requirement and include: descriptive literature, delivery timeframe, warranties and/or other information that demonstrates that the offer meets all the foregoing requirements, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Unique Entity Identifier (UEI), the Taxpayer Identification Number (TIN), and the certification of business size.

All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.”

A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement.

All responses to this notice shall be submitted electronically by 9:00 am Eastern Standard Time, on Tuesday, December 19, 2023 to the Contract Specialist, Amber Harris, at amber.harris@nih.gov .

Assessment of Capability Lowest Price Technically Acceptable http://www.sam.gov/ mailto:amber.harris@nih.gov