Amendment000001.pdf

(x)

NIHOD2007039

x x copies of the amendment; (b) By acknowledging receipt of this amendment on each copy of the offer submitted; or (c) By separate letter or telegram which includes a reference to the solicitation and amendment numbers. FAILURE OF YOUR ACKNOWLEDGEMENT TO BE RECEIVED AT

THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by virtue of this amendment you desire to change an offer already submitted, such change may be made by telegram or letter, provided each telegram or letter makes reference to the solicitation and this amendment, and is received prior to the opening hour and date specified.

x

MD 20892-7511

ADM-OD/OLAO

Bethesda

Acquisition Operations

OD - Office of Logistics and

National Institutes of Health

MD 20892-7511

IO-OD/OLAO

Bethesda

Acquisition Operations

OD - Office of Logistics and

National Institutes of Health

01/31/2008000001

13. THIS ITEM ONLY APPLIES TO MODIFICATION OF CONTRACTS/ORDERS. IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

12. ACCOUNTING AND APPROPRIATION DATA (If required) is not extended.is extended, Items 8 and 15, and returning

Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of the following methods: (a) By completing

The above numbered solicitation is amended as set forth in Item 14. The hour and date specified for receipt of Offers

11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

FACILITY CODE CODE

10B. DATED (SEE ITEM 11)

10A. MODIFICATION OF CONTRACT/ORDER NO.

9B. DATED (SEE ITEM 11)

9A. AMENDMENT OF SOLICITATION NO.

CODE

8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP Code)

7. ADMINISTERED BY (If other than Item 6)CODE 6. ISSUED BY

PAGE OF PAGES

4. REQUISITION/PURCHASE REQ. NO.3. EFFECTIVE DATE2. AMENDMENT/MODIFICATION NO. 5. PROJECT NO. (If applicable)

1. CONTRACT ID CODE

AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

11/26/2007

CHECK ONE

A. THIS CHANGE ORDER IS ISSUED PURSUANT TO: (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT

B. THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office, C. THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:

D. OTHER (Specify type of modification and authority) appropriation date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).

E. IMPORTANT: Contractor is not, is required to sign this document and return __________________ copies to the issuing office.

ORDER NO. IN ITEM 10A.

14. DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible.)

The referenced solicitation number listed in item

9A of this Standard Form 30, is hereby amended to reflect the following questions and answers generated as a result of the referenced solicitation.

1Q. Can you clarify the pricing structure you desire for this contract?

1A. We anticipate a cost reimbursement completion type contract, which includes revenue from the sales of tissue. Please follow the instructions highlighted in the Technical

Proposal Cost Summary listed in Part III; section J of the subject RFP.

2Q. Is there a uniform cost assumption for the purchase fee of these tissues that can be

Continued ...

16A. NAME AND TITLE OF CONTRACTING OFFICER (Type or print)15A. NAME AND TITLE OF SIGNER (Type or print)

15C. DATE SIGNED 16B. UNITED STATES OF AMERICA 15B. CONTRACTOR/OFFEROR 16C. DATE SIGNED

(Signature of person authorized to sign) (Signature of Contracting Officer)

ANDREW L. MAINE

STANDARD FORM 30 (REV. 10-83)

Prescribed by GSA

FAR (48 CFR) 53.243

NSN 7540-01-152-8070

Previous edition unusable

Except as provided herein, all terms and conditions of the document referenced in Item 9A or 10A, as heretofore changed, remains unchanged and in full force and effect.

ITEM NO. SUPPLIES/SERVICES QUANTITY UNIT UNIT PRICE AMOUNT

NAME OF OFFEROR OR CONTRACTOR

2 3

CONTINUATION SHEET

REFERENCE NO. OF DOCUMENT BEING CONTINUED PAGE OF

(A) (B) (C) (D) (E) (F)

NIHOD2007039/000001

used for costing this contract?

2A. We do not buy tissue from investigators, we get it donated.

3Q. Are there uniform cost assumptions for the reimbursement of the provider for staff time?

3A. No.

4Q. Can we use the assumption that all shipments will be domestic?

4A. yes.

5Q. What are the sizes of the shipments?

5A. It varies. Approximately 5-10 vials of tissue.

6Q. Are you going to consider having negotiations?

6A. No. The Government intends to award a contract without discussions. (See section L, f4, page 28 and section 10, page 33 of the RFP).

7Q. For costing purposes, how much time should be allocated (out of the 3,900 hours per year) to pathology orientation, embedding, sectioning, and slide preparation?

7A. It is rather difficult to predict what future needs will be. However It could be 0 hours in one year and 300 hours in another year.

8Q. What is the ratio of fixed vs. frozen tissue to be collected?

8A. It varies depending on availability.

9Q. What is the ratio of fixed tissue vs. frozen tissue to be ultimately stored in the repository?

9A. It depends on availability.

10Q. Of the fixed tissue that is further processed, what proportion will be preserved in paraffin block, what proportion will be paraffin section slides, what proportion will be frozen section slides, and what proportion will be

Continued ...

NSN 7540-01-152-8067 OPTIONAL FORM 336 (4-86)

Sponsored by GSA

FAR (48 CFR) 53.110

ITEM NO. SUPPLIES/SERVICES QUANTITY UNIT UNIT PRICE AMOUNT

NAME OF OFFEROR OR CONTRACTOR

3 3

CONTINUATION SHEET

REFERENCE NO. OF DOCUMENT BEING CONTINUED PAGE OF

(A) (B) (C) (D) (E) (F)

NIHOD2007039/000001

frozen tissue blocks?

10A. Fixed tissue will be stored at room temperature.

11Q. What is the likelihood that tissue will be arriving to the contractor site unfixed and contaminated with potential infectious agents or other hazardous compounds?

11A. All tissue will arrive either fixed or frozen.

12Q. Are there requirements for BSL-3 containment facilities?

12A. No.

13Q. What is the current volume of NHP tissue bank? What proportion are frozen, in fixative, and embedded en bloc?

13A. We have approximately 338 blocks that take up about 1-2 cubit foot of space. We have approximately 308 fixed tissues that take up about 3-4 cubic feet of space. We have approximately 3300 frozen tissues that take up about 25% of two upright freezers.

NOTE: Offerors are required to acknowledge receipt of this amendment prior to 02/29/2008, 3 pm local time.

Period of Performance: 09/01/2008 to 08/31/2012

NSN 7540-01-152-8067 OPTIONAL FORM 336 (4-86)

Sponsored by GSA

FAR (48 CFR) 53.110