CSS_Attachment_No._01-Purchase_Description.pdf

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

PURCHASE DESCRIPTION

1. Statement of Need and Purpose:

The National Center for Advancing Translational Sciences (NCATS) is in need of two ion channel-focused small molecule libraries to be added to NCATS Chemical Genomics Center (NCGC) panel of screening libraries. These proposed libraries – IONSet (4,546 compounds) and IONCore (3,572 compounds) cover distinct ion channel pharmacophore space, and will provide novel functional space to NCGC’s current screening collections.

2. Background Information and Objective:

The National Institutes of Health (NIH) is the nation’s leading medical research agency and the primary Federal agency whose mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability, conducting, supporting and making medical discoveries that improve people’s health and save lives.

NCATS is a part of NIH, whose mission it is to catalyze the generation of innovative methods and technologies that will enhance the development, testing and implementation of diagnostics and therapeutics across a wide range of human diseases and conditions.

Adding diversity to chemical libraries is imperative to our operation, as we screen a variety of targets against these in-house collections. Given the outsized role that ion channels and receptor-mediated signaling pathways have in the pain/addiction fields, these libraries will help NCGC address an upcoming anticipated influx of collaborative projects in these scienitifc areas. These well-curated and focused chemical libraries will help serve as important toolsets for pain/addiction and other projects, and in combination with separately sourced GPCR collections, will be ideal first-pass library choices for these collaborations, in terms of assay validation, control molecule identification and preliminary screening.

3. Generic Name of Product: Chemical Libraries

4. Type of Purchase Description

Two (2) brand name or equal chemical libraries with a combined total of 8,118 specific compounds equivalent to the following brand name items:

IONCore Library Compounds (Regular Stock Level), quantity: one (1).

IONSet Library Compounds (Regular Stock Level), quantity: one (1).

Manufacturer: ChemBridge Corporation https://www.chembridge.com/documents/IONCore_IONSet_Libraries.pdf

RFQ No. NIHDA201800507 Attachment No. 01 https://www.chembridge.com/documents/IONCore_IONSet_Libraries.pdf

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

5. Physical, Functional, and Performance Specification

Salient characteristics: The brand name equal items must meet the following salient physical, functional, or performance characteristics of the brand name item to be acceptable for award:

• The small molecule libraries should be comprised of known ion channel modulators, as well as pharmacophore-derived potential modulators, across a variety of channel families (including but not limited to voltage-gated channels such as calcium, potassium, sodium channels and ligand-gated channels such as 5-HT3, GABA, glycine, nAChR, and PCP receptors)

• The Contractor must be able to provide the NCATS DPI with 8,118 compounds at 4mg/powder or 800ul/10mM DMSO solution each, packaged in NCATS supplied Matrix tubes at 88 compounds per plate

• Each small molecule must be guaranteed to have a purity of >90% (accuracy +/-5%) that is to be confirmed by NMR and/or LCMS spectra

• In addition to the molecules themselves, the Contractor must be able to provide the following electronic information for each required molecule: chemical structure or simplified molecular-input line-entry system (SMILES) or equivalent chemical structure information, supplier ID, plate ID, well location, tube ID, concentration in millimolar, and volume in microliters. This information shall be provided via email referencing individual compound vial barcodes.

• The contractor must provide for shipping and handling to send small molecules in the provided vials to the NCATS

• Samples will be delivered as 4mg in barcoded tubes provided by NCATS

6. Quantity: Two (2) libraries with combined total of 8,118 compounds.

7. Delivery Date: Delivery shall be made within forty-five (45) days after receipt of tubes from NCATS.

8. Delivery Location:

ATTN: Paul Shinn National Center for the Advancing Translational Sciences 9800 Medical Center Dr., Bldg B Rockville, MD 20850

RFQ No. NIHDA201800507 Attachment No. 01