Purchase_Description_.pdf

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

PURCHASE DESCRIPTION

1. Statement of Need and Purpose: The NIDA IRP Pre-Clinical Pharmacology Section needs an integrated respiration monitoring system compatible for use in awake, jacketed, non-human primates engaged in behavioral studies. The Model 1200T 3-

Channel Monitoring & Gating System identified utilizes a small pneumatic pillow that can be placed inside the jacket the non-human primate wears, such that the subject cannot reach it. Other manufacturers utilize either a surgically placed probe in an artery, which is not an option for the animals in the planned studies, an elastic band around the torso that can be easily removed by the animals, or an enclosed chamber the animal resides in, which precludes behavioral studies. These considerations make this particular product the most suitable for our needs.

2. Background Information and Objective: The NIDA IRP Pre-Clinical Pharmacology

Section (PPS) is a part of a multi-lab (both clinical and preclinical) ongoing collaboration to evaluate opiates that may, as a class, produce less respiratory depression, the primary cause of death by overdose. PPS needs to be able to monitor respiration in awake behaving non-human primates without surgical implantation of sensors. These animals are being used for preclinical behavioral pharmacology experiments that evaluate the reinforcing (i.e. abuse potential) properties of drugs. PPS is trying to develop safer opiates, by studying a newly discovered class of these compounds known as "biased agonists." The properties these compounds are predicted to display, include equivalent analgesia, but decreased respiratory depression. The Model 1200T 3-

Channel Monitoring & Gating System will enable them to measure how these drugs alter respiration (i.e. breathing rate) in awake primates, which has not been done before. This is a critical step needed for the development and eventual clinical application of safer opiates.

3. Generic Name of Product: Small Animal Respiration Monitoring System

4. Purchase Description: Model 1200T 3-Channel Monitoring & Gating System

5. Salient characteristics: The most important characteristic of the monitoring system is that it is compatible with non-surgical monitoring of respiration by placing a sensor (a small pneumatic pillow) underneath the jacket that non-human primates wear. The system requested is perfect for this, in that the sensor is a small pressure sensor that picks up respiration.

The monitoring and gating system shall include the following:

• One Respiration Measurement Module

• Three channels for respiration data acquisition.

• Accessories kit includes three pneumatic pillow respiration sensors.

Gating - Gating feature with one spare user gate input and two output gates for each channel.

Features will include:

• Audible beeps for heart and respiration rate

• Waveform grid lines to facilitate measurements

• Time stamping to couple scanner operation with the measured physiological data set

• Auto track for respiration gates

• User control of waveform and display panel colors

• Freeze/thaw for waveforms

• Ability to record events

Specifications:

ERT Module (each channel):

ECG Range: 40 - 900 BPM Accuracy: ±1% Input range: -2.50 mV to 2.5mV Input Impedance: >10 MΩ @ 10 Hz CMRR: 100 dB @ 60 Hz Resp Range 13 - 300 bpm Accuracy 1 count Temp Probe type thermister, rectal Tip OD, mm 1.0 Range 0 – 100 ºC Accuracy +/-0.2 ºC, 10–70ºC Module Isolated power 5.0 VDC

PC Interface Module (each channel):

Gating R-wave to gate delay selectable - 0 to 600 ms Expiration gate width selectable - 1 ms and delay step size Temp Heater control fiber optic PWM from selected channel

Heater System:

Heater Heater control fiber optic PWM power 115 – 230 VAC Size: hxwxd cm 16.4x8.9x26.0 Fan power 115 – 230 VAC Size: hxwxd cm 6.4x18.0x18.4

PC Requirements:

Software: Windows 95, 98, NT, Me, 2000, XP, Vista, 7, 8 & 10 Hardware: >1 GHz processor, >760 vertical display pixels

Serial or USB port

Systems shall include 12 month warranty.

6. Quantity: Four (4) systems, each of which has three inputs, enabling the monitoring of

12 animals.

7. Delivery Date: 30 days after receipt of order to the following address:

Dr. Charles Bradberry

National Institute on Drug Abuse

Intramural Research Program

251 Bayview Boulevard

Room 05A711A

Baltimore, Maryland 21224