Sole_Source_Justification.pdf

Sole Source information for Qiagen Ingenuity Variant Analysis

The Ingenuity Variant Analysis (IVA) from Qiagen is an advanced genomic product, the only product offering features that meet our research needs, and only offered through Qiagen.

1. An expertly Proprietary curated Knowledge Base assembled by PhD level Scientists that currently has over 5.3 million human phenotype associated findings.

2. Access to all common public data repositories, 1000 Genomes, Complete Genomics, Exome Server Project, TCGA, ExAC, and Allele Frequency Community for comparison and narrowing the lists of variants of interest.

3. Access to the proprietary data base HGMD and PGMD as part of the product offering.

4. The ability to create and utilize a local data base of findings for interpreting NGS data.

Data Security:

1. For IPA and IVA, analysis is performed on a secure server cluster maintained by Qiagen and is both HIPPA (CFR45) and Safe Harbors compliant. Data is 256 bit encrypted in transit and at rest.

2. Sharing of Data is controlled by the end user.

3. Data is retained until the end user deletes the data from the server.

4. The workbench applications are locally installed on the owner’s computer hardware.

Tools/User interface:

1. Upload of sample data from all common vendor formats, .vcf file format is the standard file format. Exomes, whole genomes or panels may be analyzed or a mixture of each.

2. Access to data from the customer’s personal computer via password and account security.

3. Drop down menu for logical analysis criteria settings for rapid reanalysis. No limit to analysis and reanalysis.

4. Comparison of samples includes familial analysis, trio and extended, and data sets of this type can consist of 10,000 or more subjects.

5. Compatible with Apple or Microsoft operating systems.

6. Export of data in industry standard formats.

7. No loss of data.