Presolicitation notice.doc

Notice: N02CN25001-26 Contracting Office Address

Department of Health and Human Services, National Institutes of Health (NIH), National Cancer Institute (NCI), Office of Acquisitions, 6120 Executive Boulevard, Suite 600, Room 6008, Bethesda, MD 20892-7195.

Note: This synopsis follows a Sources Sought notice that was released on November 30, 2011 under N01CN25001-26 Description

The Division of Cancer Prevention (DCP) of the National Cancer Institute (NCI) is planning to award a contract for Preclinical In Vitro and In Vivo Agent Development Assays. This contract will support the development of potential cancer preventive agents using mechanism-based screening assays in vitro and in vivo. The screening assays will evaluate the potential of test agents to inhibit, reverse, or delay early carcinogenesis through a variety of endpoints, such as histopathology, pharmacokinetics, pharmacodynamics , molecular targets and pathways, transformation, proliferation, and apoptosis, using state-of-the-art experimental methodologies.

The successful Contractor shall be able to complete tasks in the following areas:

1. Evaluation of Chemopreventive Agents by Screening Assays In Vitro:

A. Experimental Material – general: Establish cell free systems, grow, and maintain rodent, human or other primary cell cultures, cell lines and tissues used in mechanism-based cell transformation studies B. Experimental Material – specific: Utilize well-defined biological reagents C. Experimental Approaches: Provide mechanism-based in vitro systems in order to prioritize agents for future studies

D. Experimental Endpoints: Establish assay endpoints in vitro 2.

Evaluation of Chemopreventive Agents Using Screening Assays In Vivo:

A. Animal Models: The Contractor shall conduct screening assays in vivo using animal models of chemoprevention B. Experimental approaches using animal models C. Endpoints using Animal Models D. Animal Facility: The Laboratories shall be accredited by or registered as follows:

i.

The Contractor shall have an approved Animal Welfare Assurance for the Office of Extramural Research (OER), Office of Laboratory Animal Welfare (OLAW) (http://grants.nih.gov/grants/olaw/olaw.htm), Office of the Director, NIH, as required by Section I-43-30 of the Public Health Service Policy on Humane Care and Use of Laboratory Animals. The Contractor shall maintain such assurance for the duration of this contract, and any subcontractors performing work under this contract involving the use of animals shall also obtain and maintain an approved Animal Welfare Assurance.

ii. The Contractor shall be fully accredited by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) International or equivalent and maintain that accreditation for the life of the contract. Information about AAALAC accreditation is available at www.aaalac.org.

iii. The Contractor shall comply with the Public Health Service (PHS) Policy on Humane Care and Use of Laboratory Animals (http://grants.nih.gov/grants/olaw/references/phspol.htm) and conduct work in compliance with recommendations established in the Guide for the Care and Use of Laboratory Animals (http://www.nap.edu/openbook.php?record_id=5140).

iv. United States Department of Agriculture (USDA).

v. Institutional Animal Care and Use Committee (IACUC) shall approve all animal procedures under this contract.

Mandatory Qualifications:

The following Mandatory qualification criteria establish conditions that must be met at the time of receipt of Proposals by the Contracting Officer in order for your proposal to be considered any further for award.

The offeror must have in order to propose:

1) Current Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) (or equivalent) accreditation.

It is anticipated that up to four (4) Indefinite Delivery Indefinite Quantity (IDIQ) type contracts will be awarded for a 2-year period of performance beginning on or about September 14, 2012. Request for Proposal Number N01CN25001-26 will be available on or about March 7, 2012, and may be accessed through the FedBizOpps website and the National Cancer Institute home page at http://rcb.cancer.gov/rcb-internet/index.jsp The NAICS Code is 541711. All responsible sources may submit a proposal, which shall be considered by the agency. This notice does not commit the Government to award a contract. No collect calls will be accepted. No facsimile transmissions will be accepted.

POTENTIAL OFFERORS WILL BE RESPONSIBLE FOR DOWNLOADING THEIR OWN COPY OF THE SOLICITATION AND ANY POSSIBLE AMENDMENTS. ALL INQUIRIES SHALL BE SUBMITTED ELECTRONICALLY TO THE CONTRACTING OFFICER’S BUSINESS REPRESENTATIVE LISTED AS THE POINT OF CONTRACT HEREIN.