MSD Sole Source Justification Letter.pdf
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- Attached to
- MSD Catalog K15059D, V-PLEX Proinflammatory Panel 2 Rat Kits Federal contract opportunity
- Solicitation number
- N3239825Q4052
About this file
This document is a Sole Source Statement from Meso Scale Discovery (MSD) justifying the unique nature of their SECTOR® Imagers and QuickPlex® laboratory analytical instruments. The statement details three key technological differentiators: their proprietary electrochemiluminescence (ECL) detection using SULFO-TAG labels, high-speed sample throughput (approximately 17 plates per hour with 16,450 data points), and non-fluidic, high-reliability instrument design. The document emphasizes that MSD's instruments are exclusively compatible with their own microwell plates and immunoassay kits, and that no other technologies provide multiplexed measurement using electrochemiluminescence detection without reliance on beads or flow cells.
The sole source statement is directly related to a Naval Medical Research Command (NMRC) solicitation (N3239825Q4052) for V-PLEX Proinflammatory Panel 2 Rat Kits to be used with an MSD Meso QuickPlex SQ 120 Electrochemiluminescence analyzer. The government intends to award a firm-fixed-price contract for quantities including 2 (1-plate), 3 (5-plate), and 1 (25-plate) kits under NAICS code 325413, following commercial item procurement guidelines. Vendors must be registered in the Systems for Award Management (SAM) to be eligible for award.
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| File | Type | Posted |
|---|---|---|
| 4.2 Sole Source Justification Form FY25 - MesoScale Discovery.pdf |
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Sole Source Statement
The SECTOR® Imagers 6000 and 2400, and QuickPlex laboratory analytical instruments are manufactured and sold solely by Meso Scale Discovery (MSD), a division of Meso Scale Diagnostics, LLC of Gaithersburg, MD. The Imagers are compatible only with microwell plates and immunoassay kits sold by MSD and vice versa.
MSD utilizes electrochemiluminescence to detect binding events on patterned arrays. There are no other technologies that enable multiplexed measurement using electrochemiluminescence for detection. And there are no other suppliers that provide an electrochemiluminescence detection system that is not reliant on beads or flow cells. The MSD platform is unique in its method for detection as outlined below.
Electrochemiluminescence (ECL) Detection - MSD’s ECL detection utilizes proprietary SULFO-TAG labels that emit light upon electrochemical stimulation initiated at the electrode surfaces of MULTI-ARRAY® and MULTI-SPOT® microplates through biomolecular interactions between the analyte and labeled reporter at the surface.
Sample Throughput - The SECTOR Imager instruments can read plates in 1 to 3.5 minutes regardless of the multiplexing level. As an illustrative example, the Imager 2400 can read approximately 17 96-well, 10-spot plates (measuring 10 analytes per each well) per hour resulting in 16,450 data points collected per hour.
Non-fluidic, high-reliability instruments - All assay processing and readout steps take place in
MSD’s disposable plate-based format. No sample is transferred from the plate to the instrument and hence there are no complicated fluidics that may be prone to clogging and other failures. MSD’s instrumentation has been highly praised by customers for exceptional reliability.
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