JnA_Diff_iPSCs_Redacted.pdf

465 SCIENCE DR.

MADISON, WI 53711

608-310-5100 fcdi-ordersupport@fujifilm.com

Nature of the acquisition and proposed unique qualifications of the contractor(s).

This sole source (including brand name) justification uses the format at 6.303-2, but is modified to reflect that the procedures in FAR subpart 13.5 are used in accordance with 41 U.S.C.1901.

NCATS is developing human 3D tissue models, and the only source of large amounts of human dopaminergic, gabanergic and glutaminergic is through differentiation of iPSC cells. Fujifilm Cellular Dynamics Inc. (CDI) is a reputable source of iPSC-derived neurons and NCATS has been using their different type of neuronal cells (dopaminergic, gabanergic and glutaminergic) and endothelial cells for the biofabrication of 3D tissue models and have obtained and verified excellent results on a smaller scale.

Using CDI’s iPSC’s will help protect the large investment the government has already made to fulfill the scientific mission of the institute. To keep uniform data going forward and not change any of the variables, thus skewing results, it is imperative to continue to use the same vendor’s cells that NCATS has established to be the best value for its science.

NCATS needs to continue using these optimized cells rather than having to develop tissues with other types of cells and develop new protocols and testing at great cost to the federal government.

Description of the efforts made to ensure that the offers are solicited from as many potential sources as practicable. Indicate whether a FedBizOpps notice was or will be publicized as required by FAR Subpart 5.2 and, if not, which exception under FAR 5.202 applies.

As stated above Fujifilm CDI is the only entity that can supply genuine cells for our lab. Market research was previously conducted for same or similar items for this NCATS project within the prior seven months for PO No. 75N95020P00552, and that information is still current, accurate, and relevant. Consequently, the Contracting Officer relies upon that market research for this acquisition.

The previous market research consisted of posting a pre-solicitation, non-competitive notice of intent on beta.SAM.gov (Notice ID: NCATS-20-003434) and receiving no responses.

Determination by the Contracting Officer that the anticipated cost/price to the Government will be fair and reasonable.

Pursuant to FAR 13.106-3(a), before making award, the contracting officer will determine the proposed price is fair and reasonable.

Description of the market research conducted (see FAR Part 10) and the results, or a statement of the reasons market research was not conducted.

Market research was previously conducted for same or similar items for this NCATS project within the prior seven months for PO No. 75N95020P00552, and that information is still current, accurate, and relevant. Consequently, the Contracting Officer relies upon that market research for this acquisition. The previous market research consisted of (1) posting a pre-solicitation, non-competitive