IP17-1702 VIETNAM.pdf

Image Description: Centers for Disease Control

Centers for Disease Control

National Center for Immunization and Respiratory Diseases

Surveillance at the Animal-Human Interface of Influenza and Other Zoonotic Diseases in Vietnam

CDC-RFA-IP17-1702

Application Due Date: 06/16/2017

Surveillance at the Animal-Human Interface of Influenza and Other Zoonotic Diseases in Vietnam

CDC-RFA-IP17-1702

TABLE OF CONTENTS

Part I. Overview Information Federal Agency NameA.

Funding Opportunity TitleB.

Announcement TypeC.

Agency Funding Opportunity NumberD.

Catalog of Federal Domestic Assistance (CFDA) NumberE.

Dates F.

Executive Summary G.

Part II. Full Text Funding Opportunity Description A.

Award Information B.

Eligibility Information C.

Application and Submission Information D.

Review and Selection Process E.

Award Administration Information F.

Agency Contacts G.

Other Information H.

Glossary I.

Part I. Overview Information Applicants must go to the synopsis page of this announcement at www.grants.gov and click on the "Send Me Change Notifications Emails" link to ensure they receive notifications of any changes to CDC-RFA-IP17-1702. Applicants also must provide an e-mail address to www.grants.gov to receive notifications of changes.

A. Federal Agency Name:

Centers for Disease Control and Prevention (CDC) / Agency for Toxic Substances and Disease Registry

(ATSDR)

B. Funding Opportunity Title:

Surveillance at the Animal-Human Interface of Influenza and Other Zoonotic Diseases in Vietnam C. Announcement Type: New - Type 1 This announcement is only for non-research activities supported by CDC. If research is proposed, the application will not be considered. For this purpose, research is defined at https://www.gpo.gov/fdsys/pkg /CFR-2007-title42-vol1/pdf/CFR-2007-title42-vol1-sec52-2.pdf. Guidance on how CDC interprets the definition of research in the context of public health can be found at http://www.cdc.gov/od/science/integrity /docs/cdc-policy-distinguishing-public-health-research-nonresearch.pdf.

New non-research FOA

D. Agency Funding Opportunity Number:

CDC-RFA-IP17-1702

E. Catalog of Federal Domestic Assistance (CFDA) Number:

93.283 F. Dates:

1. Due Date for Letter of Intent (LOI): N/A

2. Due Date for Applications: 06/16/2017, 11:59 p.m. U.S. Eastern Standard Time, at www.grants.gov.

3. Date for Informational Conference Call:

N/A

G. Executive Summary:

1. Summary Paragraph:

The purpose of this funding opportunity announcement (FOA) is to strengthen capabilities and maintain the government run laboratory-supported surveillance at the animal-human interface for influenza and other zoonotic diseases in Vietnam. This FOA aligns with and supports the Global Health Security Agenda, and One Health Initiative and country ownership investing in the public health system, health policies and public health workforce development. Key components include support for laboratory-supported surveillance for influenza viruses at live bird markets and other zoonotic diseases; sharing of influenza and other zoonotic viruses with the CDC laboratory; identifying and responding to outbreaks of influenza viruses and other zoonotic diseases in Vietnam. Activities supported through this FOA will enhance the capacity of the Vietnamese Government to identify and monitor outbreaks of influenza among poultry and other zoonotic diseases as well as mitigate risk factors for such outbreaks; improved participation of Vietnam in global WHO vaccine strain selection and development; and increased use of surveillance data for decision making.

a. Eligible Applicants: Single https://www.grants.gov https://www.grants.gov https://www.gpo.gov/fdsys/pkg/CFR-2007-title42-vol1/pdf/CFR-2007-title42-vol1-sec52-2.pdf https://www.gpo.gov/fdsys/pkg/CFR-2007-title42-vol1/pdf/CFR-2007-title42-vol1-sec52-2.pdf http://www.cdc.gov/od/science/integrity/docs/cdc-policy-distinguishing-public-health-research-nonresearch.pdf http://www.cdc.gov/od/science/integrity/docs/cdc-policy-distinguishing-public-health-research-nonresearch.pdf https://www.grants.gov

b. FOA Type: Cooperative Agreement

c. Approximate Number of Awards: 1

d. Total Project Period Funding: $2,000,000

e. Average One Year Award Amount: $400,000

f. Total Project Period Length: 5

g. Estimated Award Date: 09/30/2017

h. Cost Sharing and / or Matching Requirements:

N

Cost sharing or matching funds are not required for this program. Although no statutory matching requirement for this FOA exists, leveraging other resources and related ongoing efforts to promote sustainability is strongly encouraged.

Part II. Full Text A. Funding Opportunity Description

Part II. Full Text

1. Background

a. Overview Influenza is a naturally occurring viral disease of birds which can also infect a wide range of mammals, including humans. While birds remain the original natural reservoir, influenza viruses have established infection in populations of various mammals, most importantly in swine and humans. Influenza viruses are constantly undergoing point mutations and re-assortments, sometimes within species, sometimes across species. Preparedness is the key to substantially reducing the health, social, and economic impacts of an influenza pandemic and other public-health emergencies.

A cornerstone of a country's preparedness for pandemic influenza is a robust and timely laboratory-supported, active surveillance capability, both in humans and animals, particularly domesticated poultry and swine. The systematic collection of influenza surveillance data over time is necessary to detect and track influenza virus and disease activity and is essential to understanding the impact influenza has on a country's population. Between 2005 and 2015, various active surveillance programs were conducted in the high risk areas throughout Vietnam. Data from the national surveillance program for influenza in poultry at the live bird markets between 2014 and April 2016 indicated that the average prevalence of influenza type A in poultry was more than 20%, for H5 subtype was more than 5% and for HPAI H5N1 virus was about 3%.

Over this time the prevalence of highly pathogenic avian influenza (HPAI) H5N1 virus by month declined from 7% to 2% while the prevalence of HPAI H5N6 virus increased from 4 to 5%. Molecular epidemiological studies of viruses found in poultry also demonstrated that several new clades and subtypes of H5N1 were introduced and caused clinical outbreaks in poultry throughout Vietnam between late 2012 and early 2016.

These findings suggest that an active surveillance system among poultry is necessary to identify and monitor the risks of and risk factors for cross-species transmission of influenza viruses and other avian pathogens and to use knowledge gained to support recommendations for better surveillance, response, and control efforts of influenza and other zoonotic diseases, in both humans and animals, with the aim of improving both animal and public health. Surveillance of poultry throughout the country can also provide influenza viruses to the WHO Collaborating Centre for the Surveillance, Epidemiology and Control of Influenza at U.S. CDC for further characterization and as candidate vaccine viruses. If there is a lack of viruses shared from participating countries, this will potentially create a gap in understanding what is emerging.

Rabies virus and lyssaviruses are global pathogens of significant public health concern, especially in Southeast Asia. Over the past decade, Vietnam has reported a substantial burden of canine-mediated rabies, with an average of 91 human deaths per year. Vietnam mirrors the approach of rabies control in many countries in Asia, incurring large expenditures on Post-Exposure Prophylaxis (PEP) and relatively limited investment on surveillance and canine vaccination. Approximately 90% of the estimated 66 million USD expended annually on rabies was spent on PEP. To address this substantial mortality and economic burden, Vietnam set an ambitious goal of eliminating canine-mediated rabies by 2020. To achieve elimination, surveillance among domestic and wildlife reservoirs are needed to guide control efforts. Currently, very limited surveillance is being conducted and there is limited laboratory capacity.

b. Statutory Authorities PHS Act 307; 42 U.S.C 242

c. Healthy People 2020 Improve public health and strengthen U.S. national security through global disease detection, response, prevention, and control strategies (https://www.healthypeople.gov/2020/topics-objectives /topic/global-health/objectives )

1.

Increase the number of public health laboratories monitoring influenza virus resistance to antiviral agents (https://www.healthypeople.gov/2020/topics-objectives/topic/immunization-and-infectious-disea ses/objectives )

2.

Increase the number of States that use electronic data from rabies animal surveillance to inform public health prevention programs (https://www.healthypeople.gov/2020/topics-objectives/topic/immunization -and-infectious-diseases/objectives )

3.

d. Other National Public Health Priorities and Strategies National Strategy for Pandemic Influenza (https://www.cdc.gov/flu/pandemic-resources/pdf/pandemic -influenza-strategy-2005.pdf)

1.

National Strategy for Pandemic Influenza: Implementation Plan (http://www.cdc.gov/flu/) 2.

Updated Preparedness Response Framework for Influenza Pandemic (http://www.cdc.gov/flu/) 3.

e. Relevant Work This FOA builds on FOA# RFA-IP-12-002: Studies at the animal-human interface of influenza and other zoonotic diseases in Vietnam. The cooperative agreement associated with this FOA is now in its 5th year, which supports the development and implementation of animal-human interface activities related to influenza and other zoonotic diseases. That cooperative agreement identified risk factors in poultry that should be monitored by surveillance and viral risk factors that should be monitored by surveillance associated laboratory work. This FOA will expand surveillance in poultry and surveillance associated laboratory work on influenza viruses from poultry to monitor these risk factors.

2. CDC Project Description

a. Approach

Bold indicates project period outcome.

CDC-RFA-CDC-RFA-IP17-1702 Logic Model: Surveillance at the Animal-Human Interface of Influenza and Other Zoonotic Diseases in Vietnam https://www.healthypeople.gov/2020/topics-objectives/topic/global-health/objectives https://www.healthypeople.gov/2020/topics-objectives/topic/global-health/objectives https://www.healthypeople.gov/2020/topics-objectives/topic/immunization-and-infectious-diseases/objectives https://www.healthypeople.gov/2020/topics-objectives/topic/immunization-and-infectious-diseases/objectives https://www.healthypeople.gov/2020/topics-objectives/topic/immunization-and-infectious-diseases/objectives https://www.healthypeople.gov/2020/topics-objectives/topic/immunization-and-infectious-diseases/objectives https://www.cdc.gov/flu/pandemic-resources/pdf/pandemic-influenza-strategy-2005.pdf https://www.cdc.gov/flu/pandemic-resources/pdf/pandemic-influenza-strategy-2005.pdf http://www.cdc.gov/flu/ http://www.cdc.gov/flu/

Strategies and Activities Short-term Outcomes

(1-2 Years)

Intermediate Outcomes

(3-4 Years)

Long-Term Outcomes

(5+ Years)

Conduct laboratory-supported surveillance at the animal-human interface related to influenza and other zoonotic diseases

Support surveillance for influenza viruses at live bird markets in selected provinces in the four regions of Vietnam.

Improved quality and timeliness of specimen collection from live bird markets and reception at the laboratory

Improved identification and characterization of the antigenic and genetic characteristics of influenza viruses circulating among poultry in Vietnam.

Recommendations for better surveillance, response, and control efforts of influenza, in both humans and animals

Increased use of surveillance data for decision making around prevention and control activities to protect human population

Share influenza viruses from poultry with the CDC laboratory

Improved quality of specimens for poultry viruses shipped to the CDC laboratory

Improved participation from Vietnam in global WHO vaccine strains selection and development

Identify and respond to outbreaks of influenza viruses in poultry flocks in Vietnam through routine surveillance

Improved capacity of animal health workers on surveillance activities, including sample collection, laboratory testing, data management, reporting and detecting and responding to outbreaks

Identify outbreaks of influenza in poultry and track risk factors for such outbreaks.

Identify and monitor risks of transmission of influenza viruses.

Training of Department of Animal Health’s staff on surveillance activities in animal populations.

Formal evaluation of the laboratory-supported surveillance system for influenza viruses at live bird markets

Improved understanding of the current needs of the Vietnamese government to detect, respond to, control and prevent influenza at live bird markets, including providing viruses for vaccine development.

A national plan developed to maintain the laboratory-supported surveillance system

Conduct laboratory supported surveillance for other zoonotic diseases, such as rabies

Increased number of pathogens from other zoonotic diseases included in routine laboratory, collection, reception, and testing algorithms

Increased knowledge of the epidemiology of other zoonotic diseases

Increased prevention, detection and response to other zoonotic diseases

Increased quality of laboratory data associated with other zoonotic disease surveillance

i. Purpose The purpose of this cooperative agreement is to further develop and conduct laboratory-supported surveillance at the animal-human interface for influenza and other zoonotic diseases in Vietnam, helping to identify and monitor the risks of transmission of influenza and other pathogens. Data gained will support recommendations for better surveillance, response, and control of influenza and other zoonotic diseases, in both humans and animals. The continued timely provision of influenza viruses from this surveillance system are crucial to the global efforts to monitor and control influenza.

ii. Outcomes Outcomes: Grantee will be expected to have achieved the following corresponding short-term and intermediate outcomes by the end of the project period. It is expected that achieving the short-term outcomes will lead to the long-term outcomes identified below and in the logic model.

Below are the activities conducted as part of this project and the associated outcomes to be achieved.

1. Support surveillance for influenza viruses at live bird markets in selected provinces in the four regions of Vietnam

Short-term outcomes: Improved quality and timeliness of specimen collection from live bird markets and reception at the laboratory

100% specimens collected, stockpiled, transferred and tested as scheduled following the surveillance protocol.

Strengthen support and supervise routine surveillance activities through checklists, reports and regular meetings.

At least 80% of specimens are tested and the results reported on time as per the surveillance protocol.

Intermediate outcomes: Improved identification and characterization of the antigenic and genetic characteristics of influenza viruses circulating among poultry in Vietnam.

Provide on-going training for laboratory staff at national level on identification and characterization of the antigenic and genetic characteristics of influenza viruses.

Long-term outcomes: Recommendations for better surveillance, response, and control efforts of influenza, in both humans and animals

All lessons learned will be documented and presented at annual review meetings and in technical reports.

2. Share influenza viruses from poultry with the CDC laboratory

Short-term outcomes: Improved quality of specimens for poultry viruses shipped to the CDC laboratory

100% of specimens: laboratory meets standard requirement for testing and stockpile of collected samples.

100% of specimens: attempt viral isolation on positive samples and representative isolates will be sent to CDC Atlanta laboratory/ WHO collaborating center.

Intermediate outcomes: Improved participation from Vietnam in global WHO vaccine strain selection and development

Specimens will be sent twice annually to WHO collaborating centers.

Long-term outcomes: Increased use of surveillance data for decision making

Publish at least two manuscripts in international journals Results from the cooperative agreement will be presented at national and international conferences.

3. Identify and respond to outbreaks of influenza viruses in poultry flocks in Vietnam

Short-term outcomes: Identify outbreaks of influenza in poultry and track risk factors for such outbreaks

Provide information for outbreak investigations in selected high risk areas.

100% of birds selected for sampling have their origin identified.

Intermediate outcomes: Identify and monitor risks of transmission of influenza viruses.

100% of poultry from outbreaks will not be traded/sold at markets.

Long-term outcomes: Recommendations for better surveillance, response, and control efforts of influenza, in both humans and animals.

4. Training of awardee’s staff on surveillance activities.

Short-term outcomes: Improved capacity of animal health workers on surveillance activities, including sample collection, laboratory testing, data management, reporting and detecting and responding to outbreaks.

Annual refresher training for 15-20 staff of awardee department about technical and management issues. Selected key staff from the national and provincial level will participate in this refresher training on management (financial requirements, reporting requirements) and technical issues, such as the collection, handling, storage, transport and testing of samples and data management, analysis and reporting.

Intermediate outcomes: Identify and monitor risks of transmission of influenza viruses.

At least 80% of surveillance staff trained to conduct an outbreak investigation.

Long-term outcomes: Recommendations for better surveillance, response, and control efforts of influenza, in both humans and animals.

5. Formal evaluation of the laboratory-supported surveillance system for influenza viruses at live bird markets

Short-term outcomes: Improved understanding of the current needs of the Government of Vietnam to detect, respond to, control and prevent influenza at live bird markets, including providing viruses for vaccine development.

100% of specimens collected, stockpiled, transferred and tested as scheduled following the surveillance protocol.

Strengthen support and supervise routine surveillance activities through checklists, reports and regular meetings.

At least 80% of specimens are tested and the results reported on time as per the surveillance protocol.

Specimens will be sent twice annually to WHO collaborating centers.

Intermediate outcomes: A national plan developed to maintain the laboratory-supported surveillance system.

Laboratory-supported surveillance system will be maintained annually in high risk areas in Vietnam.

The Government of Vietnam convenes meetings periodically to assess the risk for influenza in poultry by province – high, medium and low risk. The most recent meeting was in January 2017. There is not a simple formula to determine the risk, but rather all available data are examined, including surveillance data and outbreak reports in animals and humans as well as data from neighboring countries including Cambodia, China and Laos. The patterns of poultry transport and marketing are also taken into account.

Long-term outcomes: Increased use of surveillance data for decision making.

6. Conduct laboratory supported surveillance for other zoonotic diseases, such as rabies

Short-term outcomes:

Increased number of other zoonotic disease pathogens included in routine laboratory, collection, handling, transportation, and testing algorithms.

Increased proficiency for rabies diagnostic testing.

Increased quality of laboratory data associated with other zoonotic disease surveillance.

Long-term outcomes:

Increased use of rabies diagnostic data for clinical decision making regarding human bite case management.

iii. Strategies and Activities

1. Support surveillance for influenza viruses at live bird markets in selected provinces in the four regions of Vietnam

Develop a surveillance protocol for monitoring of influenza viruses at live bird markets in selected provinces in the four regions of Vietnam.

Refresher training for local staff on technical and management issues of how to implement influenza surveillance at live bird markets.

Provide logistic support to regional laboratories for testing and administrative management.

CDC country office and CDC / Atlanta and DAH will conduct site visits to support and monitor surveillance activities to help ensure the activities are done on time with high quality at each of the regional sites.

Maintain regular meetings between DAH and regional institutes with participation from CDC country office to update, discuss the challenges and report the progress of surveillance activities.

Submit reports to CDC on time as required.

Consult with CDC country office and CDC / Atlanta when there is any change in the technical or management protocol.

2. Share influenza viruses from poultry with the CDC / Atlanta laboratory

Send influenza virus specimens to CDC laboratory at least twice a year.

Inform the CDC country office and CDC / Atlanta which specimens are sent to CDC / Atlanta for additional laboratory assessment.

Responsible for quality control of stockpile and transportation of samples.

Publish at least two manuscripts in international journals.

Results from the CoAg will be presented at national and international conferences.

3. Identify and respond to outbreaks of influenza viruses in poultry flocks in Vietnam

Be actively involved in investigation of outbreaks of influenza virus in poultry flocks in Vietnam.

Share information from outbreak investigations with CDC and other stakeholders and compare with surveillance results.

Develop/update the national prevention and control program for HPAI.

4. Training of awardee’s staff on surveillance activities.

Conduct annual trainings for local staff on technical and administrative management issues concerning surveillance activities.

5. Formal evaluation of the laboratory-supported surveillance system for influenza viruses at live bird markets

Develop evaluation tools and a protocol to evaluate the laboratory-supported surveillance system for influenza viruses at live bird markets.

Pilot the evaluation tools and revise the tools after piloting.

Train the evaluation team (or hire an external evaluation team) to do the evaluation.

Complete evaluation report and recommendations.

Develop a national plan to maintain the laboratory-supported surveillance system.

6. Conduct laboratory supported surveillance for other zoonotic diseases, such as rabies through

Expansion of integrated bite case management.

Development of surveillance for wildlife zoonotic diseases.

Development of strategies for mass vaccination of dogs.

1. Collaborations

a. With other CDC programs and CDC-funded organizations:

The awardee is required to collaborate with the CDC country office and CDC / Atlanta for technical oversight of project activities in each technical area. In addition to the project officer(s), the awardee will collaborate with contacts in Vietnam and technical leads from CDC Divisions and Offices. The project officer for this award will provide all relevant contacts and coordinate discussions with the awardee.

While strengthening their influenza detection, diagnosis, and response capabilities and timeliness, the awardee should increase collaboration with CDC’s Global Health Security Agenda program (GHSA);

Vietnam is a GHSA focus country and the awardee must ensure their activities under this cooperative agreement compliment the broader respiratory surveillance package and the activities which aim to expand existing surveillance and laboratory capacities for GHSA goals in Vietnam.

b. With organizations not funded by CDC:

The applicant should demonstrate collaboration with international animal health and public-health institutions, including the Food and Agriculture Organization (FAO), the World Organization for Animal Health (OIE), and the World Health Organization (WHO), and the WHO National Influenza Center laboratories in Vietnam.

The applicant must agree to share influenza viruses with WHO and the OIE/FAO Network on Animal Influenza (OFFLU) for global influenza surveillance purposes, and in accordance with the International Health Regulations.

Cooperative scientific data sharing and unrestricted sharing of influenza virus isolates and other zoonotic pathogens is expected for public health purposes, with such agencies as the U.S. Department of Agriculture’s (USDA) Agricultural Research Service (ARS), USDA Animal and Plant Health Inspection Service (APHIS), OFFLU (OIE and FAO), and WHO, as appropriate, for global zoonotic disease surveillance and research purposes at the animal-human interface. Research described here will not be conducted under the auspices of the current cooperative agreement.

2. Target Populations The target population for this FOA is, primarily, the entire Vietnamese population benefitting from enhanced control of influenza among poultry. Accomplishment of outcomes will benefit the global population and especially WHO-identified high-risk target groups for influenza prevention.

a. Health Disparities

NA

iv. Funding Strategy

NA

b. Evaluation and Performance Measurement

i. CDC Evaluation and Performance Measurement Strategy Throughout the 5-year FOA period, CDC country office and CDC / Atlanta will work with the awardee to demonstrate program effectiveness and impact through process and outcome evaluations of funded activities.

Process evaluations will assess the extent to which planned program activities have been implemented and lead to feasible and sustainable programmatic outcomes. Outcome evaluations will assess whether funded activities lead to intended outcomes including public health impact.

CDC country office and CDC / Atlanta will use performance measures for process and outcome evaluation (see Evaluation Questions and Performance Measures Matrix below). Awardee will manage and analyze performance measures and data both quarterly and annually through spend plans and regular meetings. These performance measures will comprise program targets, time frames, and assessments. Applicants can propose and develop additional measures, if applicable.

Evaluations will be reviewed by program activity managers and will adhere to awardee and CDC evaluation procedures. Evaluation findings will be used to establish key recommendations on program implementation and effectiveness, sustainability, and continued program improvement upon project completion.

Performance Measurement and Evaluation Plan

Support surveillance for influenza viruses at live bird markets in selected provinces in the four regions of Vietnam and trainings for local staff

1.

% of monthly surveillance reports released complete and on time.

Data source: Monthly surveillance reports Frequency: Monthly

% of high risk provinces participating in this live bird market surveillance by region.

Data source: awardee list of provinces categorized as high risk for avian influenza

% of sentinel sites with fully trained staff capable of performing sample collection (target 100%); data quality assurance plan development and regional teams trained.

Data source: refresher training reports Frequency: Annually

% of sites visited at live bird market with recommendation made for data quality improvement.

Data source: site visit reports Frequency: monthly per site during surveillance period

2. Share influenza viruses from poultry with the CDC / Atlanta laboratory

Number of specimens sent to CDC / Atlanta laboratory.

Data source: shipment documents

Frequency: twice a year Number of reports on final sample testing results, including results from consultant laboratories such as CDC / Atlanta.

Data source: DAH surveillance and laboratory reports Frequency: at least twice a year

Number of publications in international journals.

Data source: Copies of the published articles Frequency: at least 2 publications after 5-year CoAg

Number of attendees participating in international conferences.

Data source: international conference announcements Frequency: annually

3. Identify and respond to outbreaks of influenza viruses in poultry flocks in Vietnam

Number of influenza outbreaks in poultry investigated by DAH.

Data source: outbreak reports Frequency: whenever occur

Update the national prevention and control program for HPAI.

Data source: annual report Frequency: every two years

4. Formal evaluation of the laboratory-supported surveillance system for influenza viruses at live bird markets

% of specimens collected, stockpiled, transferred and tested as scheduled following the surveillance protocol.

Data source: regular reports and meetings, spend plan Frequency: quarterly

% of specimens tested and the results reported on time.

Data source: regular reports and meetings Frequency: bi-annually and annually

5. Conduct laboratory supported surveillance for other zoonotic diseases, such as rabies

Number of integrated bite case management investigations conducted.

Data source: case investigation forms Frequency: once a month

Number of specimens tested at National laboratory.

Data source: laboratory forms Frequency: once a month

Number of confirmatory samples sent to CDC / Atlanta laboratory.

Data source: shipment documents, CLIA and non-CLIA database Frequency: twice a year

Number of dogs vaccinated, vaccinator efficiency, mass vaccination methodology.

Data source: Mass vaccination records Frequency: Once a year

Data Management Plan: All data collected will be used for surveillance purposes only. CDC provides technical support for data analysis and quality assurance. Awardee owns the surveillance data. Awardee will continue to share surveillance results with other stakeholders both national and international, including but not limited to other governments, United Nations’ agencies, and domestic and international non-governmental organizations.

ii. Applicant Evaluation and Performance Measurement Plan Applicants must provide an evaluation and performance measurement plan that demonstrates how the awardee will fulfill the requirements described in the CDC Evaluation and Performance Measurement and Project Description sections of this FOA. At a minimum, the plan must describe:

How applicant will collect the performance measures, respond to the evaluation questions, and use evaluation findings for continuous program quality improvement.

How key program partners will participate in the evaluation and performance measurement planning processes.

Available data sources, feasibility of collecting appropriate evaluation and performance data, and other relevant data information (e.g., performance measures proposed by the applicant) Plans for updating the Data Management Plan (DMP), if applicable, for accuracy throughout the lifecycle of the project. The DMP should provide a description of the data that will be produced using these FOA funds; access to data; data standards ensuring released data have documentation describing methods of collection, what the data represent, and data limitations; and archival and long-term data preservation plans. For more information about CDC’s policy on the DMP, see https://www.cdc.gov/grants/additionalrequirements/ar-25.html.

Where the applicant chooses to, or is expected to, take on specific evaluation studies, they should be directed to:

Describe the type of evaluations (i.e., process, outcome, or both).

Describe key evaluation questions to be addressed by these evaluations.

Describe other information (e.g., measures, data sources).

Awardees will be required to submit a more detailed Evaluation and Performance Measurement plan, including a DMP, within the first 6 months of award, as described in the Reporting Section of this FOA.

c. Organizational Capacity of Awardees to Implement the Approach A successful applicant must demonstrate core organizational capacity to manage and conduct the activities for which the award is made. Applicants will demonstrate the local experience and institutional capacity (both management and technical) to achieve the goals of the FOA with documented good governance practices. Ideal applicants should have proven experience in delivering and overseeing essential public health functions in Vietnam including support of regional laboratory networks and management of regional surveillance networks and public health emergency response.

The application must include a clear plan for the administration and management of the proposed activities, and to manage the resources of the program, prepare reports, monitor and evaluate activities, audit expenditures and collect and analyze performance data. Applicant should provide a staffing plan and project management structure that will be sufficient to achieve the project outcomes and which clearly defines staff roles. Provide CVs or resumes for key personnel along with a current organizational chart with their application.

Applicant must be able to manage program performance, evaluation, performance monitoring, financial reporting, and must have capacity to manage the required funds in accordance with the HHS Grants Policy Statement, which can be found at: http://www.hhs.gov/grants/grants/grants-policies-regulations/index.html#

d. Work Plan Applicants must include a work plan that demonstrates how the outcomes, strategies, activities, timelines, https://www.cdc.gov/grants/additionalrequirements/ar-25.html http://www.hhs.gov/grants/grants/grants-policies-regulations/index.html

Applicants must include a work plan that demonstrates how the outcomes, strategies, activities, timelines, and staffing will take place over the course of the award. Applicants must submit a detailed work plan for the first year of the project and a high-level plan for the subsequent years.

The work plan must include, at minimum:

- Activities and timelines to support achievement of expected outcomes. These activities must be in alignment with the overall logic model and have appropriate performance measures or milestones for accomplishing tasks;

- Work plans must include activities and performance measures that are specific, measurable, achievable, relevant and time-specific;

- Information on data sources and target population(s);

- Staff and administrative roles and functions to support implementation of the award; and

- Monitoring and evaluation plan to determine quality and effectiveness of program activities.

- In this format, the table would be completed for each project period outcome. If a particular activity leads to multiple outcomes, it should be described under each outcome measure.

Project Period Outcome:

[from Outcomes section and/or logic model]

Outcome Measure:

[from Evaluation and Performance

Measurement section]

Strategies and

Activities

Process Measure

[from Evaluation and

Performance

Measurement section]

Responsible

Position /

Party

Completion

Date

1.

2.

3.

4.

5.

e. CDC Monitoring and Accountability Approach Monitoring activities include routine and ongoing communication between CDC and awardees, site visits, and awardee reporting (including work plans, performance, and financial reporting). Consistent with applicable grants regulations and policies, CDC expects the following to be included in post-award monitoring for grants and cooperative agreements:

Tracking awardee progress in achieving the desired outcomes.

Ensuring the adequacy of awardee systems that underlie and generate data reports.

Creating an environment that fosters integrity in program performance and results.

Monitoring may also include the following activities deemed necessary to monitor the award:

Ensuring that work plans are feasible based on the budget and consistent with the intent of the award.

Ensuring that awardees are performing at a sufficient level to achieve outcomes within stated timeframes.

Working with awardees on adjusting the work plan based on achievement of outcomes, evaluation results and changing budgets.

Monitoring performance measures (both programmatic and financial) to assure satisfactory performance levels.

Monitoring and reporting activities that assist grants management staff (e.g., grants management officers and specialists, and project officers) in the identification, notification, and management of high-risk grantees.

f. CDC Program Support to Awardees (THIS SECTION APPLIES ONLY TO COOPERATIVE

AGREEMENTS)

In a cooperative agreement, CDC staff are substantially involved in the program activities, above and beyond routine grant monitoring. CDC activities for this program are as follows:

Organize an orientation meeting with the awardee for a briefing on applicable U.S. Government, and HHS/CDC expectations, regulations and key management requirements, as well as report formats and contents.

1.

Meet on a regular basis with the awardee to assess expenditures in relation to approved work plan and modify plans as necessary.

2.

Review and approve the awardees’ Evaluation and Performance Measurement Plan.3.

Staff from the CDC country office and CDC / Atlanta will participate in quarterly meetings with the awardee to assess quarterly technical and financial progress reports and modify plans as required. CDC staff can participate in person or remotely.

4.

Facilitate in-country planning and review meetings for technical assistance activities.5.

B. Award Information

1. Funding Instrument Type: Cooperative Agreement CDC's substantial involvement in this program appears in the CDC Program

Support to Awardees Section.

2. Award Mechanism: 41

3. Fiscal Year: 2017

4. Approximate Total Fiscal Year Funding:

$400,000

5. Approximate Project Period Funding:

$2,000,000

This amount is subject to the availability of funds.

Estimated Total Funding: $2,000,000

6. Total Project Period Length:

5 year(s)

7. Expected Number of Awards:

8. Approximate Average Award:

$400,000 Per Budget Period

9. Award Ceiling: $1,000,000 Per Budget Period

This amount is subject to the availability of funds.

10. Award Floor: $100 Per Budget Period

11. Estimated Award Date: 09/30/2017

12. Budget Period Length: 12 month(s)

Throughout the project period, CDC will continue the award based on the availability of funds, the evidence of satisfactory progress by the awardee (as documented in required reports), and the determination that continued funding is in the best interest of the federal government. The total number of years for which federal support has been approved (project period) will be shown in the “Notice of Award.” This information does not constitute a commitment by the federal government to fund the entire period. The total project period comprises the initial competitive segment and any subsequent non-competitive continuation award(s).

13. Direct Assistance Direct Assistance (DA) is not available through this FOA.

C. Eligibility Information

1. Eligible Applicants Eligibility Category: Others (see text field entitled "Additional Information on Eligibility" for clarification)

Additional Eligibility Category:

2. Additional Information on Eligibility Eligibility is limited to Department of Animal Health, Ministry of Agriculture and Rural Development, Government of Vietnam

3. Justification for Less than Maximum Competition Single-eligibility justifications (SEJ) for FOA CDC-RFA-IP17-1702 to support the Department of Animal Health (DAH) in conducting the laboratory-supported surveillance at the Animal-Human Interface of Influenza and Other Zoonotic Diseases in Vietnam are as follows:

Since 2003, Vietnam has experienced human cases and poultry outbreaks of highly pathogenic avian influenza A/H5N1 virus, which continues to cause human deaths and economic losses to the poultry industry. While both human cases and poultry outbreaks have decreased since 2007, influenza A/H5N1 remains an important virus to better understand for control and elimination efforts;

Vietnam experiences significant close geographic proximity of human and animal populations, such as poultry and pigs that are susceptible to influenza viruses including A/H5N1 and pandemic A/H1N1 2009, respectively;

DAH, under Vietnam's Ministry of Agriculture and Rural Development (MARD) is the central level management agency for animal health. DAH is at the center of a national network of collaborating animal health institutes and centers and regional offices of animal health including the National Center for Veterinary Diagnosis;

DAH possesses the scientific and management capabilities to meet program requirements without jeopardizing or compromising the quality of activities;

DAH has established multiple field sites and surveillance systems in Vietnam that are critical for carrying out surveillance and other activities addressing zoonotic and other animal diseases;

DAH is the sole Vietnam agency with the authority to conduct animal surveillance. No other government agency, non-governmental organization or private entity can conduct surveillance in government agency, non-governmental organization or private entity can conduct surveillance in animal sectors. Poultry surveillance for influenza should be conducted throughout the country and DAH is the only agency that can do this. This was recognized by both the Government of Vietnam and U.S. CDC when the previous cooperative agreement “Studies at the Animal-Human Interface of Influenza and other Zoonotic Diseases in Vietnam” was signed in 2012. The good performance of DAH during that cooperative agreement proves they have capacity to continue this surveillance.

No other agency or non-profit organization in Vietnam has developed such an extensive network of laboratory scientists and epidemiologists as DAH, whose work focuses on influenza and other zoonotic and animal diseases;

DAH offers special opportunities for further surveillance, prevention, and control programs in Vietnam because of its central placement in national animal diseases surveillance systems, and experience in laboratory supported animal health activities on zoonotic and animal diseases;

DAH has an already established framework and mechanism to develop a systematic surveillance network in communication to generate data on the occurrence of animal diseases and disease burden, evaluate new diagnostic approaches, develop standards for specimen collection and handling, and communicate important new scientific developments;

DAH is located in Hanoi; has adequate space, including office space, laboratories, meeting space, and advanced communications network, and capacity to expand to accommodate additional staff;

DAH has the BSL containment laboratory capabilities necessary to safely work with highly pathogenic strains of avian influenza and other dangerous zoonotic diseases;

DAH possesses the high quality laboratory and epidemiologic capacities to analyze influenza and other zoonotic and animal disease pathogens in the molecular, antigenic, diagnostic, and epidemiologic efforts;

DAH and CDC have had fruitful collaboration on influenza through development and maintenance of active surveillance for avian influenza (AI) among animals and humans as well as sharing AI and swine influenza virus isolates with CDC and the international community. This Cooperative Agreement is to expand the existing partnership, including enhancing data and virus sharing;

DAH is uniquely positioned in terms of legal and regulatory authority, ability, and credibility in developing the technical and administrative capacity to conduct the activities requested by

CDC.

To identify, control, and prevent the next influenza pandemic, countries around the world, specifically countries such as Vietnam where there is a large unregulated poultry industry, must conduct routine surveillance among wild, commercial, and backyard poultry. Without such systems, early detection of poultry outbreaks would not be possible putting human populations at risk for novel influenza virus infections with limited immunity and potentially leading to next pandemic. Eligibility is limited to the Ministries of Agriculture and Rural Development or their bona fide agents in Vietnam that have been supported by CDC under funding opportunity announcements IP12-002 for the studies at the Animal-Human Interface of Influenza and Other Zoonotic Diseases.

Should this cooperative agreement not be funded through this entity, it is possible that monitoring of novel virus strains among animal populations will be disrupted or discontinued. Without such a surveillance system, it is possible that some of these novel viruses will go undetected in birds, especially those viruses which do not cause severe disease in birds. Thus, human populations would be at risk for novel influenza virus infection without any indication from bird populations. Thus, the risk to human populations is greater and the potential for a pandemic is greater given that more individuals will be exposed. By the time human infections are identified, it is possible that the virus could be widespread in global populations due to global travel and thus control and prevention measures would be limited. Ideally, if animal surveillance is established and functioning correctly, the first detections of novel influenza viruses will be in poultry populations allowing proper prevention and control measures in human populations.

populations allowing proper prevention and control measures in human populations.

For the reasons cited above, the Department of Animal Health is the only Vietnamese institution that possesses the requisite scientific and technical expertise, the infrastructure capacity, and the network to carry out this work.

4. Cost Sharing or Matching Cost Sharing / Matching Requirement:

No

Cost sharing or matching funds are not required for this program. Although no statutory matching requirement for this FOA exists, leveraging other resources and related ongoing efforts to promote sustainability is strongly encouraged.

5. Maintenance of Effort Maintenance of effort is not required for this program.

D. Application and Submission Information

1. Required Registrations An organization must be registered at the three following locations before it can submit an application for funding at www.grants.gov.

a. Data Universal Numbering System:

All applicant organizations must obtain a Data Universal Numbering System (DUNS) number. A DUNS number is a unique nine-digit identification number provided by Dun & Bradstreet (D&B). It will be used as the Universal Identifier when applying for federal awards or cooperative agreements.

The applicant organization may request a DUNS number by telephone at 1-866-705-5711 (toll free) or internet at http:// fedgov.dnb. com/ webform/ displayHomePage.do. The DUNS number will be provided at no charge.

If funds are awarded to an applicant organization that includes sub-awardees, those sub-awardees must provide their DUNS numbers before accepting any funds.

b. System for Award Management (SAM):

The SAM is the primary registrant database for the federal government and the repository into which an entity must submit information required to conduct business as an awardee. All applicant organizations must register with SAM, and will be assigned a SAM number. All information relevant to the SAM number must be current at all times during which the applicant has an application under consideration for funding by CDC.

If an award is made, the SAM information must be maintained until a final financial report is submitted or the final payment is received, whichever is later. The SAM registration process can require 10 or more business days, and registration must be renewed annually. Additional information about registration procedures may be found at www.SAM.gov.

c. Grants.gov:

The first step in submitting an application online is registering your organization at www.grants.gov, the official HHS E-grant Web site. Registration information is located at the “Get Registered” option at www.grants.gov.

All applicant organizations must register at www.grants.gov. The one-time registration process usually takes not more than five days to complete. Applicants should start the registration process as early as possible.

Step System Requirements Duration Follow Up https://www.grants.gov/ http://fedgov.dnb.com/webform/displayHomePage.do https://www.sam.gov/portal/public/SAM/ https://grants.gov/ https://www.grants.gov/ https://www.grants.gov/ https://www.grants.gov/

1 Data Universal Number System

(DUNS)

1. Click on http:// fedgov.dnb.com/ webform

2. Select Begin

DUNS

search/request process

3. Select your country or territory and follow the instructions to obtain your DUNS 9-digit #

4. Request appropriate staff member(s) to obtain DUNS number, verify & update information under DUNS number

1-2 Business Days

To confirm that you have been issued a new DUNS number check online at (http:// fedgov.dnb.com/ webform) or call 1-866-705-5711Image Description:

2 System for Award Management

(SAM)

formerly Central Contractor Registration

(CCR)

1. Retrieve organizations DUNS number

2. Go to www.sam.gov and designate an E-Biz POC (note CCR username will not work in SAM and you will need to have an active SAM account before you can register on grants.gov)

3-5 Business Days but up to 2 weeks and must be renewed once a year

For SAM Customer Service Contact https://fsd.gov/ fsd-gov/ home.do Calls:

866-606-8220Image Description:

3 Grants.gov 1. Set up an individual account in Grants.gov using organization new DUNS number to become an authorized

Same day but can take 8 weeks to be fully registered and approved in the system

Register early! Log into grants.gov and check AOR status until it shows you have been approved http://fedgov.dnb.com/webform http://fedgov.dnb.com/webform http://fedgov.dnb.com/webform http://fedgov.dnb.com/webform http://fedgov.dnb.com/webform http://www.sam.gov https://fsd.gov/fsd-gov/home.do https://fsd.gov/fsd-gov/home.do organization representative

(AOR)

2. Once the…