HR001125S0007_MICA_Attachment_H_Task_Description_Document__TDD__Template.docx

HR001125S0007

Attachment H

TASK DESCRIPTION DOCUMENT

FOR

MICROSYSTEMS INDUCED CATALYSIS (MICA)

BY

<<PERFORMER>>

<<DATE>>

1. Program Background The Microsystems Induced CAtalysis MICA program aims to create modeling/simulation tools and fabrication techniques that enable the control of catalytic activity of molecular catalysts, immobilized to microsystem surfaces, by physical forces generated by the microsystem. The ability to accurately predict and control catalytic activity requires co-design of both the molecule(s) and the microsystem. Catalyst activity has been controlled by various physical forces and has proven capable of executing reactions that provide insights into biological function. However, spatiotemporal control of catalyst activity is limited as registration between molecules and microsystems cannot be controlled with high precision at the nanoscale. Computational approaches to catalyst engineering have demonstrated novel molecules with desired chemistry and high-structural accuracy. However, predicting catalytic activity remains a challenge especially when catalysts are immobilized to inorganic surfaces, due to dynamic interactions between the catalyst, its substrate(s), solvents, immobilization chemistries and the inorganic surface. Accurate co-design of such molecular microsystems is enabled by closed-loop feedback between modeling/simulation and fabrication. Accurate co-design and fabrication will pioneer a “platform” molecular microsystem capability, enabling new molecular microsystem architectures for applications including novel materials synthesis, medical therapeutics and interventions, and biothreat detection and mitigation.

This vision requires the creation of accurate modeling and simulation tools, as well as high-precision nanoscale fabrication approaches. Model accuracy is a measure of simulated structure and catalytic activity compared to a measurement of the physical instantiation. Fabrication accuracy is a measure of the ability to immobilize molecules with high precision, while maintaining molecule structure and function, compared to the design model. Today’s technologies require a trade-off between accuracy, performance and yield. MICA seeks to break this limitation by improving model and fabrication accuracies while increasing the fabrication process yield.

2. Project Overview This section is focused on defining the specific project and should include a description that aligns with the technical proposal. Though not mean to be extensive (usually two to three paragraphs will suffice), it should capture: (1) what is the project about; (2) why it matters; (3) goals and objectives; (4) Government and performer defined metrics.

3. Technical Tasks & Deliverables This section should clearly and accurately identify the tasks and deliverables associated with the proposed effort. Please do not copy/paste charts or images into this section. Details on deliverable format or specific content should be contained here (versus the Milestone Plan Document). Tasks and deliverables must be delineated by Phase.

4. Program Management This Section should include any applicable program management tasks (to include subcontractor management, status reports, final report/s, etc.).

5. Meeting & Travel Requirements This Section can be utilized for any required meeting and travel requirements from the Program Solicitation.

6. Government Furnished Information (GFI)/Government Furnished Property (GFP) This Section can be utilized to capture any assumptions regarding GFI/GFP. Anything contained here would need to be reconciled with the GFP Article in the final Agreement.