Chemical_Library_Purchase_Description_for_FBO.pdf

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

PURCHASE DESCRIPTION

1. Statement of Need and Purpose:

The purpose of this acquisition is procurement of a chemical library inclusive of eighty-five (85) identified small molecules. The chemical library shall be added to existing NCATS small molecule screening libraries.

2. Background Information and Objective:

The National Center for Advancing Translational Sciences (NCATS) works to catalyze the generation of innovative methods and technologies that will enhance the development, testing and implementation of diagnostics and therapeutics across a wide range of human diseases and conditions. Small molecule screening is often the starting point in NCATS structure-activity relationship (SAR) design efforts towards synthesizing novel compounds that have more desirable properties. A diverse and novel screening collection library is imperative for translational sciences to obtain effective small molecules with on-target effects.

3. Generic Name of Product: Chemical Library

4. Purchase Description: The Government requires delivery of a chemical library inclusive of eighty-five (85) identified small molecules with purity of >=95%. Samples may be provided in liquid or powder form and shall be delivered in barcoded vials.

Please see the attached spreadsheet for a list of the required chemicals and associated required quantities.

In addition to provision of the required small molecules, the Government also requires the following electronic information for each required chemical compound:

• Chemical Structure

• Supplier Catalog Number

• Compound Name

• CAS ID

• Molecule Weight

• Simplified Molecular-Input Line-Entry System (SMILES) or equivalent chemical structure information

• Accurate Weight of Compound Shipped measured to 1 decimal point in milligrams

5. Quantity: Please see the attached spreadsheet for a list of the required eighty-five compounds and the associated amounts required.

6. Delivery Date: Delivery of compounds and associated information must be completed

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs within six (6) weeks after contractor receipt of order. Delivery shall be made to NIH/NCATS, 9800 Medical Center Dr, Bldg. B, Room 2002, Rockville, MD 20850, Attn:

Paul Shinn. Electronic information associated with the compounds shall be delivered via email or through FTP/download service if the file size exceeds 10 MB.