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This document is a Presolicitation Notice for the National Cancer Institute (NCI) Small Business Innovation Research (SBIR) Innovative Concept Award Program for Fiscal Year 2025. The solicitation targets small businesses to develop innovative technologies focused on pediatric and rare cancers, specifically seeking proposals for therapeutic, preventative, diagnostic, and digital health technologies with survival rates under 50%. Eligible small businesses must have no more than 500 employees and will be evaluated on their ability to demonstrate technical feasibility and proof-of-concept.

Key details include an anticipated solicitation release on or around April 12, 2024, with a projected closing date in late September 2024. The program will include an interim deadline in June for white paper submissions, after which NCI will provide feedback on proposed ideas. The opportunity is a total small business set-aside, and proposals must clearly identify the clinical problem, cancer type, anticipated product development path, and include experiments for de-risking. Additionally, award requirements will include enhancing entrepreneurship skills and developing a business model and commercialization plan. The solicitation is administered by the Department of Health and Human Services' National Institutes of Health National Cancer Institute.

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