F_CSS_NonComp Posting.doc

Exhibit 11

NON-COMPETITIVE

SEQ CHAPTER \h \r 1COMBINED SYNOPSIS / SOLICITATION

Title:

Electrophysiological Characterization of Ion Channels of iPSC Derived Sensory Neurons (i) This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued.

(ii) The solicitation number is 75N95020Q00267 and the solicitation is issued as a request for quotation (RFQ).

This acquisition is for a commercial item or service and is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13—Simplified Acquisition Procedures; and FAR Part 12—Acquisition of Commercial Items, and is not expected to exceed the simplified acquisition threshold.

THIS IS A NON-COMPETITIVE (NOTICE OF INTENT) COMBINED SYNOPSIS SOLICITATION TO AWARD A CONTRACT OR PURCHASE ORDER WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME).

The National Institute on Drug Abuse (NIDA), NIDA Office of Acquisitions – National Center for Advancing Translational Sciences (NCATS) Section, on behalf of the NCATS intends to negotiate and award a purchase order without providing for full and open competition (Including brand-name) to Sophion Bioscience.

(iii) The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2020-07, dated 08/03/2020.

(iv) The associated NAICS code 541990 and the small business size standard is $16.5M. This requirement has no set-aside restrictions.

(v) Project requirements:

The Stem Cell Translation Laboratory (SCTL) within the National Center for Advancing Translational Sciences (NCATS) Division of Preclinical Innovation (DPI) requires the service of Sophion to do automated whole-cell patch clamp (APC) using Qube instrument on iPSC derived sensory neuron in order to functionally characterize iPSC derived neuron for pain related screening projects. The services offered that are of interest to the SCTL include functional characterization of two ion channels (TRPV1 and P2X3) expressed in SCTL provide sensory neurons and separate into three projects:

1. Characterize VR1 (TRPV1) receptor expressed in iPS neurons

a. Calculate percentage of neurons that express sufficient VR1 current.

b. Carry out CRC for VR1 agonist: Capsaicin.

c. Carry out CRC for VR1 antagonist: Capsazepine.

2. Characterize P2x3 receptor expressed in iPS neurons

a. Calculate percentage of neurons that express sufficient P2x3 current.

b. Carry out concentration response curve (CRC) for P2x3 agonist: -MeATP

c. Carry out CRC for P2x3 antagonist: TNP-ATP.

3. Characterize cross talk between P2x3 and VR1 (TRPV1) receptors expressed in iPS neurons

a. Calculate percentage of neurons that express both P2x3 and VR1 current.

b. Carry out the current interaction when both receptors are activated comparing to when only single one is activated

These services will be utilized by the SCTL to obtain preliminary data in order to study the electrophysiology of voltage-gated ion channels of human pluripotent stem cells and their differentiated progeny, with a particular focus on sensory neurons. The data obtained from this study will be used to assess the functionality and heterogeneity of iPSC derived neuron. The long term goal is to applied this technology as a functionality screening platform for iPSC derived neurons.

(vi) Delivery shall be to:

The National Center for Advancing Translational Sciences (NCATS)

9800 Medical Center Drive

Rockville, MD 20850

One-time delivery to ship within 30 days ARO (vii) The provision at FAR clause 52.212-1, Instructions to Offerors – Commercial Items, applies to this acquisition.

(viii) The provision at FAR clause 52.212-2, Evaluation – Commercial Items, applies to this acquisition.

(a) The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation will be most advantageous to the Government, price and other factors considered.

(b) Offers will be evaluated for technical criteria, price, and past performance. Technical criteria consists of matching the line item identified above. Technical and past performance, when combined, are significantly more important than price.

(c) A written notice of award or acceptance of an offer, mailed or otherwise furnished to the successful offeror within the time for acceptance specified in the offer, shall result in a binding contract without further action by either party. Before the offer’s specified expiration time, the Government may accept an offer (or part of an offer), whether or not there are negotiations after its receipt, unless a written notice of withdrawal is received before award.

(ix) Offerors are to include a completed copy of the provision at FAR clause 52.212-3, Offeror Representations and Certifications—Commercial Items, with its offer.

(x) The FAR clause at 52.212-4, Contract Terms and Conditions – Commercial Items, applies to this acquisition.

The following FAR provisions or clauses are incorporated by reference:

52.204-7, System for Award Management (Oct 2018)

52.204-13, System for Award Management Maintenance (Oct 2018)

52.204-16, Commercial and Entity Code Reporting (Jul 2016)

52.204-18, Commercial and Entity Code Maintenance (Jul 2016)

52.204-24, Representation Regarding Certain Telecommunications and Video Surveillance Services of Equipment

HHSAR 352.222-70, Contractor Cooperation in Equal Employment Opportunity Investigations (December 18, 2015).

52.212-4(g), Invoice, is supplemented by the NIH Invoice and Payment Instructions (2/2014).

(xi) FAR clause at 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders–Commercial Items, applies to this acquisition (xii) The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement.

(xiii) The offeror must complete and return FAR 52.204-24 with its offer.

(xiv) Responses to this solicitation must include sufficient information to establish the interested parties’ bona-fide capabilities of providing the product or service. The price quote shall include: unit price, list price, shipping and handling costs, delivery days after contract award, delivery terms, prompt payment discount terms, F.O.B. Point (Destination or Origin), product or catalog number(s); product description; and any other information or factors that may be considered in the award decision. Such factors may include: past performance; special features required for effective program performance; trade-in considerations; probable life of the item selected as compared with that of a comparable item; warranty considerations; maintenance availability; and environmental and energy efficiency considerations.

Respondents that believe that they are manufacturers or authorized resellers of the brand-name product specified in this announcement must provide, as part of their response: (a) product, catalog, model, and/or part number(s); (b) product description; (c) all relevant information and documentation that the item(s) offered meets the salient physical, functional, or performance characteristics as specified in the purchase description; quantity; estimated price or cost; shipping, handling, and/or installation charges; and delivery date after receipt of order.

In addition the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.”

All responses must be received by August 26, 2020, 9:00 am, Eastern Standard Time and reference number 75N95020Q00267. Responses shall be submitted electronically to Kevin Alvarez, Contracting Officer, kevin.alvarez@nih.gov.

Fax responses will not be accepted.

(xv) The name of the individual to contact for information regarding the solicitation:

Kevin Alvarez, Contracting Officer, kevin.alvarez@nih.gov.