D1 SOW.pdf

FAR Part 11—Describing Agency Needs

STATEMENT OF WORK (SERVICES)

(SOW)

GENERAL INFORMATION

Title of Project:

Annual Service and Maintenance Agreement for a Thermo Fisher Orbitrap Fusion Lumos Tribrid Mass Spectrometer.

Statement of Need and Purpose:

The Analytical Chemistry Core (ACC), within the Division of Preclinical Innovation (DPI) at the National Center for Advancing Translational Sciences (NCATS) requires an annual service and maintenance contract for a Thermo Fisher Orbitrap Fusion Lumos Tribrid Mass Spectrometer (MS) instrument used by NCATS analytical chemists.

Background Information and Objective:

The National Institutes of Health (NIH) is the nation’s leading medical research agency and the primary Federal agency whose mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability, conducting, supporting and making medical discoveries that improve people’s health and save lives.

NCATS is one of 27 Institutes and Centers at the NIH and its mission is to catalyze the generation of innovative methods and technologies that will enhance the development, testing and implementation of diagnostics and therapeutics across a wide range of human diseases and conditions. The NCATS DPI plans, conducts and uses both internal and contract resources to advance collaborative research projects across the preclinical phases of the translational science spectrum.

The NCATS DPI ACC maintains a state-of-the-art laboratory whose mission is to support translational research throughout NCATS by providing analytical chemistry services involving the isolation, purification, identification and analysis of various therapeutic modalities for targeted disease states. With the successful development and set up of the Mass Spectrometry laboratory within the NCATS DPI ACC, chemists have greatly expanded analytical capabilities at NCATS. Currently NCATS DPI ACC maintains and operates five high resolution mass spectrometers, which include a Thermo Fisher Orbitrap Fusion Lumos Tribrid Mass Spectrometer. Current mass spectrometry (MS) capabilities include high-throughput MS sample analysis, peptide and protein analysis (top-down and bottom-up), post-translational modifications analysis, multiple reaction monitoring (MRM), deep sequence proteomics, metabolomics, and ultra-high resolution analysis of small molecules. This has allowed NCATS to establish collaborations for numerous ongoing projects at DPI where ACC’s involvement includes assay development, methods optimization, mass spectroscopy experimentation, and data analysis.

To date, the ACC has received collaborative requests from the Biology and Chemistry groups within the three scientific branches at NCATS (ETD, TDB, and CGB), as well as external collaborators. From these requests, ACC has successfully completed method development and conducted compound screens for numerous projects. This was possible by maintaining instrumentation and equipment for constant use and maximum productivity.

To help maintain and ensure the functionality of the Thermo Fisher Orbitrap Fusion Lumos Tribrid Mass Spectrometer, NCATS DPI ACC has a need for an annual service and maintenance agreement for the instruments listed in this Statement of Work. Without such a contract in place, repair costs are extremely high and instrument downtime is much longer causing a significant decrease in scientific productivity.

Period of Performance:

The acquisition of these instruments occurred at different dates which led to unsynchronized warranty expirations. To synchronize the servicing of these instruments, the Period of Performance for the Base Period A shall start on the award day for the first three (3) line items, and the Base Period B shall start on February 1, 2023 for the other four (4) line items. The government anticipates two (2) Option periods of 12-months increments.

Part Number Description PoP Base FSN02-10002 Orbitrap Fusion Lumos ETD award day – (award day + 12 months) – Base Period A

5041.0010A UltiMate 3000 NCS-3500RS NANO Nano-Cap-S award day – (award day + 12 months) – Base Period A

5826.0020 Dionex WPS-3000TPL RS

Autosampler award day – (award day + 12 months) – Base Period A

5040.0046 UltiMate 3000 HPG-3400RS

High Pressure M 02/01/23 – (award day + 12 months) – Base Period B

5730.0010 UltiMate 3000 TCC-3000SD

Thermostatted C 02/01/23 – (award day + 12 months) – Base Period B

5042.0011 UltiMate 3000 ISO-3100BM

Biocompatible I 02/01/23 – (award day + 12 months) – Base Period B

5841.0020 UltiMate 3000 WPS-3000TBRS

Thermostatted 02/01/23 – (award day + 12 months) – Base Period B

Base Period A: award day – (award day + 12 months) Base Period B: February 1, 2023 – (award day + 12 months) Option Period 1: 12 months Option Period 2: 12 months

SCOPE OF WORK

General Requirements:

Independently and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified personnel, material, equipment, and facilities, not otherwise provided by the Government as needed to perform the Statement of Work below:

Part Number Description Serial Number Coverage Type

FSN02-10002 Orbitrap Fusion Lumos ETD FSN20565 UNITY ESSENTIAL SUPPORT PLAN-

MSPEC-LC-MS

5041.0010A UltiMate 3000 NCS-3500RS NANO Nano-Cap-S 8152207 UNTY ESSENTIAL PLAN CHROM LC DNX

5826.0020 Dionex WPS-3000TPL RS Autosampler 8152587 UNTY ESSENTIAL PLAN CHROM LC DNX

5040.0046 UltiMate 3000 HPG-3400RS High Pressure M 8152587 Essential Plan - HPLC

5730.0010 UltiMate 3000 TCC-3000SD Thermostatted C 6028306 Essential Plan - HPLC

5042.0011 UltiMate 3000 ISO-3100BM Biocompatible I 8136860 Essential Plan - HPLC

5841.0020 UltiMate 3000 WPS-3000TBRS Thermostatted 8139461 Essential Plan - HPLC

Options: Two 12-month Option Periods for the support plan

Specific Requirements:

Coverage Plan: Unity Essential Support Plan-MSPEC-LC-MS

a. Thermo Fisher Field Service Engineer labor, travel, and parts required for Corrective Maintenance visits with a targeted response time of 3 business days.

b. Priority status for technical support inquiries with a targeted immediate response time. A certified service engineer will conduct diagnosis and Corrective Maintenance procedures using the latest digital remote support tools.

c. One (1) scheduled annual Preventive Maintenance visit (a standard PM kit is included)

d. Discount on additional Preventive Maintenance.

e. Instrument Requalification (RQ) in conjunction with a scheduled Corrective Maintenance with a purchase of an add-on Operational Qualification (OQ).

f. Premium subscription to Unity Lab Services Online Knowledge Base.

g. 10% discount on parts, accessories, and consumables during the effective period of the contract.

h. Computers that were purchased from Thermo Fisher Scientific and required for the operation of the analytical system.

i. Software and firmware updates upon request and in conjunction with a scheduled Preventive Maintenance or Corrective Maintenance visit (updates are defined as changes of the existing software version that are intended to improve its performance).

Coverage Plan: Unity Essential Plan Chrom LC DNX

a. Unlimited number of demand on-site service visits with a maximum 72-hour response.

b. Engineer labor and travel is included.

c. Priority status for technical support inquiries.

d. One (1) Scheduled Preventative Maintenance visit.

e. Thermo Scientific supplied personal computers are covered.

f. Factory-certified replacement parts included.

g. Subscription to e-Support Online Technical Resources.

h. 10% Loyalty discount on Parts, Accessories or Consumables for end user during active contract.

j. Software updates and notifications (Updates are defined as changes of the existing software version that are intended to improve its performance).

k. Computers purchased from Thermo Fisher Scientific and required for the operation of the analytical system.

Coverage Plan: Unity Essential Plan HPLC

a. Thermo Fisher Field Service Engineer labor, travel, and parts required for Corrective Maintenance visits with a targeted response time of 3 business days.

b. Priority status for technical support inquiries with a targeted immediate response time. A certified service engineer will conduct diagnosis and Corrective Maintenance procedures using the latest digital remote support tools.

c. One (1) scheduled annual standard Preventive Maintenance visit (standard PM kit included).

d. Access to Unity Lab Services Online Knowledge Base.

e. 10% discount on spare parts (not covered by corrective maintenance), accessories, and consumables for the instruments covered under this contract and during the effective period of this contract.

f. Software and firmware updates upon request and in conjunction with a scheduled Preventive Maintenance or Corrective Maintenance visit (updates are defined as changes of the existing software version that are intended to improve its performance).

GOVERNMENT RESPONSIBILITIES

Government shall provide the Contractor access to NCATS facilities: 9800 Medical Center Dr, Rockville MD 20850. Access will be restricted during federal holidays and after business hours.

DELIVERY OR DELIVERABLES

Contractor is responsible for providing the evaluation and repairs, including labor, parts and materials as required.

REPORTING REQUIREMENTS

The Contractor’s field service engineer will provide documentation outlining the performance attributes of the Thermo Fisher MS and HPLC instruments.

OTHER CONSIDERATIONS

Travel:

Travel may be required to the Government facility in which the equipment is installed, which it shall be covered by the contractor on its service plan price.