D.CSS_Attach1-Purchase_Description.pdf

Purchase Description

Statement of Need and Purpose:

Induced pluripotent stem (iPS) cell-derived differentiated cells for the National Center for Advancing Translational Sciences (NCATS).

Background Information and Objective:

The Tissue BioPrinting Lab at NCATS is using these iPS cells to bioprint 3D tissue models of the brain to study the effects of new therapies for pain, opioid addiction and overdose. With these cells we are developing human 3D tissue models, and the only source of large amounts of human dopaminergic, gabanergic and glutaminergic is through differentiation of iPSC cells.

Generic Name of Product:

Induced pluripotent stem (iPS) cell-derived differentiated cells

Purchase Description:

The items needed for our bioprinting lab are as follows:

Product # Description Quantity R1092 iCell Astrocytes Kit, 01434 50 R1088 iCell DopaNeurons, 01279 20 R1032 iCell DopaNeurons, 01279 10 C1028 iCell DopaNeurons, 01279 [CELL 40

ONLY]

R1013 iCell GABANeurons, 01434 10 C1012 iCell GABANeurons, 01434 [CELL 45

ONLY]

R1116 iCell GlutaNeurons 3 Pack, 01279 15 R1034 iCell GlutaNeurons, 01279 40

Salient Characteristics:

These iPS cell-derived products are generated from cells, such as adult skin or blood, obtained from donors. They are delivered through an episomal reprogramming process that utilizes circular DNA vectors to deliver the pluripotency genes.

Quantity:

See list above in Purchase Description

Delivery Date:

Delivery will be in four (4) separate shipments with each containing a quarter quantity of all items.

Delivery dates will be as follows:

Shipment 1: On or before June 1.

Shipment 2: Not sooner than June 15 or later than July 1.

Shipment 3: Not sooner than August 15 or later than September 1.

Shipment 4: Not sooner than September 15 or later than September 30.

Period of Performance:

One Year from Date of Award

Option(s):

N/A