D. A1_Purchase Description.pdf

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

PURCHASE DESCRIPTION

Promega Reagent Kits and Assays (Brand Name or Equal)

1. Statement of Need and Purpose: The National Center for Advancing Translational

Sciences (NCATS), Division of Preclinical Innovation (DPI), Chem Tech Biology Group performs research to test the activity of reporter cell-lines following the treatment with high-throughput drug-libraries. Assays used in this research are homogeneous and can be miniaturized into a 384 or 1536 well plate format and is ideally suited for high throughput applications. For this purpose, NCATS needs a quantity of two (2) Promega Corporation Nano-Glo Luciferase Assay or Equal; a quantity of two (2) Promega Corporation ADP-Glo Kinase Assay or Equal; and a quantity of three (3) Promega Corporation Nano-Glo(R) HiBiT Lytic Detection System or Equal.

2. Background Information and Objective: The NCATS aims to develop innovations to reduce, remove or bypass costly and time-consuming bottlenecks in the translational research pipeline in an effort to speed the delivery of new drugs, diagnostics and medical devices to patients. The NCATS DPI plans, conducts and uses both internal and contract resources to advance collaborative research projects across the preclinical phases of the translational science spectrum. The DPI’s Chem Tech Biology Group uses a number of reagents for assays in its laboratory for its ongoing research projects. The assay systems and kits allows the NCATS scientists and researchers to measure specific outcomes of cells which are specifically engineered for high throughput and automation settings which are essential standards at NCATS.

3. Generic Name of Product: Assay kits and reagents

4. Purchase Description:

Product’s brand name Manufacturer Catalog Number

Quantity

Nano-Glo Luciferase Assay Promega Corporation N1150 2 ADP-Glo Kinase Assay Promega Corporation V9102 2 Nano-Glo(R) HiBiT Lytic Detection System

Promega Corporation N3050 3

5. Salient characteristics: The salient physical, functional, or performance characteristics that “equal” products must meet are as follows:

a. The assay kits and reagents must be easily scalable and highly sensitive.

b. The assay kits and reagents must be engineered for live cell imaging.

c. The assay kits and reagents must be optimized for multi-well plates and automation equipment.

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

d. The assay kits and reagents must be easily scalable.

e. The assay kits and reagents must be optimized for Primary high-throughput screening, secondary screening, and lead optimization.

f. The size of the Nano-Glo Luciferase Assay or equal must be 10 x 100ml.

g. The size of the ADP-Glo Kinase Assay or equal must be 10,000 assays.

h. The size of the Nano-Glo(R) HiBiT Lytic Detection System or equal must be 10 x

100ml.

6. Quantity: See above under 4. Purchase Description.

7. Delivery Date: Delivery is expected within 30 days after contractor receipt of order

(ARO). Delivery shall be FOB Destination and shall be delivered to 9800 Medical Center Drive (Building B/ Room 1022), Rockville, MD, 20850 between the hours of 8:00 am and 5:00 pm, Eastern Standard Time, Monday through Friday (except on Federal Holidays).

8. Period of Performance: None

9. Option(s): None