D-Attachment SOW Cystatin C analysis of a racially diverse cohort.pdf

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

STATEMENT OF WORK (SERVICES)

(SOW)

GENERAL INFORMATION

Title of Project:

Cystatin C analysis of a racially diverse cohort

Statement of Need and Purpose:

The contractor shall provide all resources necessary to quantify the levels of cystatin C in serum from Health Aging in Neighborhoods of Diversity across the Life Span (HANDLS) participants.

Background Information and Objective:

Health disparities in age-related chronic conditions such as chronic kidney disease (CKD) are well documented. Importantly, CKD has been linked to accelerated aging, the risk for age-associated conditions at younger ages than usual. Multiple molecular markers exist for classifying CKD cases, such as estimated glomerular filtration rate (eGFR) using serum creatinine, eGFR using cystatin C, and urine albumin:creatinine ratio. The objective of this work is to explore the implementation of these 3 markers to classify CKD progression across 2 time points in the HANDLS cohort. Creatinine and albumin measurements are available for both time points, but cystatin C measurements are only available for 1 time point. Therefore, the government requires a contract to examine cystatin C levels for an additional time point.

Period of Performance:

12/1/2021 – 11/30/2022

SCOPE OF WORK

General Requirements:

Independently and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified personnel, material, equipment, and facilities, not otherwise provided by the Government as needed to perform the Statement of Work below:

Specific Requirements:

The contractor shall quantitatively analyze the levels of cystatin C in human serum for 2000 samples. The contractor shall perform quality control checks on all samples. The contractor shall provide a data report with quantities of cystatin C for each sample in an electronic data file along with information on quality controls. The contractor shall provide written summaries and documentation of the methods used to run the cystatin C pipeline. Following data delivery and upon request by the Government, the contractor shall participate in Government laboratory staff meetings to provide technical consultations as needed.

GOVERNMENT RESPONSIBILITIES

The government will provide the deidentified human serum samples, each with a unique ID.

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

DELIVERY OR DELIVERABLES

The contractor shall provide a data report with quantities of cystatin C for each sample in an electronic data file along with information on quality controls.

REPORTING REQUIREMENTS

N/A

OTHER CONSIDERATIONS

Travel:

Travel is not required.

Key Personnel:

Information System Security Plan:

Data Rights:

The National Institute on Aging shall have unlimited rights to and ownership of all deliverables provided under this contract, including reports, data updates and statistical results. This includes the deliverables provided under the basic contract and any optional task deliverables exercised by the contracting officer.

In addition, it includes any additional deliverables required by contract change. The definition of “unlimited rights” is contained in Federal Acquisition Regulation (FAR) 27.401, “Definitions.”

Section 508—Electronic and Information Technology Standards:

Publications and Publicity:

Confidentiality of Information: