D-Attachment-SOW ARIC Study.pdf

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

STATEMENT OF WORK (SERVICES)

(SOW)

GENERAL INFORMATION

Title of Project:

Proteomic analyses of dementia and related phenotypes in the Atherosclerosis Risk in Communities (ARIC) Study

Statement of Need and Purpose:

The National Institute on Aging (NIA) Laboratory of Behavioral Neuroscience (LBN) is in need of a Biostatistician with experience working with the large cohort dataset from the Atherosclerosis Risk in Communities (ARIC) Study. The LBN will work on multiple planned analyses which examine the proteomic signature of dementia risk and related phenotypes using data from the ARIC study. The Biostatistician shall provide statistical support for the LBN. Specific duties include statistical consulting, programming running statistical analyses, and generating publication quality tables and figures to be included in manuscripts.

Background Information and Objective:

The goal of this project is to use data from existing cohort studies to determine how immune and vascular risk factors affect brain structure and function in older adults. Specifically, NIA is examining how exposure to chronic systemic inflammation, acute inflammatory insults, and vascular risk factors affects the trajectory of brain structure, brain function, and progression of Alzheimer’s disease. NIA is using available data from several large cohort studies, including the Atherosclerosis Risk in Communities (ARIC). By leveraging ARIC data, NIA will be able to examine how past exposures relate to longitudinal changes in brain structure, cognition, and dementia risk spanning multiple decades. Currently, the LBN is also using Baltimore Longitudinal Study of Aging (BLSA), ARIC, and UK Biobank data to examine the immune proteins in circulation that are differentially expressed following infection and associated with neurodegeneration and dementia risk. Regarding vascular risk factors, much of the work continues to examine how subclinical measures of vascular risk factors – defined using proteomic risk scores – relates to Alzheimer’s disease and related dementia biomarkers and clinical progression of disease. In the coming years, the LBN will continue to characterize immune and vascular risk factors in these cohorts to determine whether these exposures are risk factors for Alzheimer’s disease, dementia, and dementia endophenotypes defined on neuroimaging.

Period of Performance:

May 8, 2025 - May 7, 2026

SCOPE OF WORK

General Requirements:

Independently and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified personnel, material, equipment, and facilities, not otherwise provided by the Government as needed to perform the Statement of Work below:

Specific Requirements:

Perform and present statistical analyses (e.g., cross-sectional, longitudinal and survival analyses) and data visualization (publication quality) using statistical software packages (e.g., R, SAS, or Stata) in collaboration with Principal Investigators (PI), staff, and outside collaborators of the Laboratory of Behavioral Neuroscience.

Collaborate with project leaders and staff on data analysis and data management on various large datasets.

Provide statistical support and informal statistical training for postdoctoral and postbaccalaureate fellows.

Collaborate with PIs and staff on manuscript and grant preparation, study design, and preparation of progress reports (as an active co-author).

Present analysis results and data visualization at laboratory meetings.

DELIVERY OR DELIVERABLES

Work products and documents related to performing and presenting statistical analyses and data visualization using statistical software packages in collaboration with PI, staff and outside collaborators of the LBN at the NIA.

Work products and documents related to working with team on data analysis and data coordination on various large datasets.

Work products and documents related to working with staff on research coordination of projects within the LBN and with outside collaborators and institutions.

Work products and documents related to working with PI and staff on the design of experiments, routine progress reports and manuscript preparation, presenting analysis results and data visualization at laboratory meetings.

REPORTING REQUIREMENTS

The contractor shall provide verbal and/or written progress reports for specific tasks or projects on a biweekly basis.

OTHER CONSIDERATIONS

Travel:

N/A

Key Personnel:

Biostatistician with specialized technical and procedural knowledge and relevant experience running analysis on ARIC study data. Biostatistician must have current access to the ARIC dataset.

Information System Security Plan:

Data Rights:

The National Institute on Aging shall have unlimited rights to and ownership of all deliverables provided under this contract including reports, recommendations, briefings, work plans and all other deliverables. This includes the deliverables provided under the basic contract and any optional task deliverables exercised by the contracting officer. In addition, it includes any additional deliverables required by contract change. The definition of “unlimited rights” is contained in Federal Acquisition Regulation (FAR) 27.401, “Definitions.” FAR clause 52.227-14, “Rights in Data-General,” is hereby incorporated by reference and made a part of this contract/order.

Section 508—Electronic and Information Technology Standards:

Publications and Publicity:

The contractor shall work with the National Institute on Aging on publications. Any publications are required to follow the National Institute on Aging publication procedures.

Confidentiality of Information: