Combined Synopsis-Solicitation.pdf

Combined Synopsis/Solicitation

Title: Isotopes for isotopically labeling proteins for solution Nuclear Magnetic Resonance

(NMR) investigation.

Notice ID: 75N94025Q00177

Posted Date: August 11, 2025

Response Date: August 18, 2025

Product Service Code: 6505-Drugs and Biologicals

NAICS Code: 325412 – Pharmaceutical Preparation Manufacturing, size 1,300 employees

CONTRACTING OFFICE ADDRESS:

The Department of Health and Human Services, National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Office of Acquisitions, 6710B Rockledge Drive, Rockville, MD 20892.

DESCRIPTION:

This is a combined synopsis/solicitation for commercial products or services prepared in accordance with the format in FAR 12.6 (Streamlined Procedures for Evaluation and

Solicitation for commercial items) as applicable, and as supplemented with additional information included in this notice. This acquisition will be processed in accordance with

FAR Part 13 – Simplified Acquisition Procedures (SAP) for Certain Commercial Products and Services. This announcement constitutes the solicitation; quotes are being requested and a separate written solicitation will not be issued. This solicitation number is

75N94025Q00177 and is issued as a Request for Quotation (RFQ). The solicitation/contract will include all applicable provisions and clauses in effect through

Federal Acquisition Circular 2025-04 (May 12, 2025).

The North American Industry Classification (NAICS) Code is 325412 and the business size standard is 1,300 employees.

This solicitation is NOT set aside for total small businesses.

The Eunice Kennedy Shriver National Institute of Child Health and Human Development

(NICHD) on behalf of the National Institute of Diabetes and Digestive and Kidney Diseases

(NIDDK) intends to award a Firm Fixed Price (FFP) purchase order through full and open competition to fulfill this requirement.

STATEMENT OF NEED:

1.0 PURCHASE ORDER TITLE

Isotopes for isotopically labeling proteins for solution Nuclear Magnetic Resonance (NMR) investigation.

2.0 BACKGROUND

Structure/function studies of proteins, protein/protein complexes and protein complexes with other molecules (large like DNAs and RNA’s or small, like potential drug molecules) almost always requires proteins to be uniformly 13C/15N labeled, and most of the time proteins also need to be perdeuterated. To express these kinds of proteins, expressing media need 15N ammonium chloride and glucose in the form of 13C, 13C/deuterated and just deuterated as nitrogen and carbon sources and requires the medium prepared in D2O instead of H2O.

3.0 OBJECTIVE

The objective of this acquisition is to acquire isotopically labeled proteins.

4.0 CONTRACTOR REQUIREMENTS

The Contractor shall be responsible for the procurement and packaging of raw materials with the following items:

Product Description QTY

D-Glucose (U-¹³C₆, 99%) 2

D-Glucose (U-¹³C₆, 99%; 1,2,3,4,5,6,6-D₇, 97- 98%)

D-Glucose (1,2,3,4,5,6,6-D₇, 97-98%) 5

Ammonium chloride (¹⁵N, 99%) 10

5.0 Task Areas

5.1 Task Area 1 – Delivery

Contractor shall deliver the described isotopes by October 2025.

5.2 Task Area 2 –

Contractor shall arrange for shipment to the below specified location no later than 30 days after receipt of award (ARO).

National Institutes of Health, NIDDK, Bldg 5 Room B2-38

9000 Rockville Pike, Maryland 20892.

6.0 PURCHASE ORDER TYPE

This purchase order will be a firm fixed price

7.0 PERIOD OF PERFORMANCE

The anticipated period of performance for this requirement is:

Base Period: September 1, 2025, to October 1, 2025

8.0 PAYMENT TERMS

Payment will be made in one lump sum, in accordance with NIH Invoicing Instructions with

IPP.

9.0 REVIEW AND ACCEPTANCE

NIDDK Project Officer will inspect delivery, installation, and/or testing to ensure the products provided conform with contract requirements.

10.0 PROJECT OFFICER

The following Project Officer will represent the Government for the purpose of this Purchase Order:

TBD

The Contracting Officer’s Representative (COR) is responsible for: (1) monitoring the Contractor's technical progress, including the surveillance and assessment of performance and recommending to the Contracting Officer changes in requirements; (2) interpreting the statement of work and any other technical performance requirements; (3) performing technical evaluation as required; (4) performing technical inspections and acceptances required by this Purchase Order; and (5) assisting in the resolution of technical problems encountered during performance.

The Contracting Officer is the only person with authority to act as agent of the Government under this Purchase Order. Only the Contracting Officer has authority to: (1) direct or negotiate any changes in the statement of work; (2) modify or extend the period of performance; (3) change the delivery schedule; (4) authorize reimbursement to the Contractor any costs incurred during the performance of this Purchase Order; or (5) otherwise change any terms and conditions of this Purchase Order.

The following FAR Clauses are applicable to this solicitation:

CONTRACT CLAUSES:

FAR 52.252-2 Clauses Incorporated by Reference. (FEB 1998)

This contract incorporates one or more clauses by reference, with the same force and effect as if they were given in full text. Upon request, the Contracting Officer will make their full text available. Also, the full text of a clause may be accessed electronically at this/these address(es):

https://www.acquisition.gov/browse/index/far

FEDERAL ACQUISITION REGULATION (FAR) – CLAUSES INCORPORATED BY

REFERENCE:

Clause No. Title

FAR 52.203-17 Contractor Employee Whistleblower Rights (NOV 2023)

FAR 52.204-7 System for Award Management (OCT 2018)

FAR 52.204-13 System for Award Management Maintenance (OCT 2018)

FAR 52.211-6 Brand Name or Equal (AUG 1999)

FAR 52.212-3 Offeror Representations and Certifications – Commercial Products and Commercial Services (MAY 2024) [(DEVIATION

FEB 2025)]

FAR 52.212-4 Contract Terms and Conditions- Commercial Products and Services (NOV 2023)

FAR 52.212-5 Contract Terms and Conditions Required To Implement Statutes or Executive Orders—Commercial Products and Commercial Services (JAN 2025) [DEVIATION FEB 2025)] http://www.acquisition.gov/browse/index/far

HEALTH AND HUMAN SERVICES ACQUISITION REGULATION (HHSAR) – CLAUSES

INCORPORATED BY REFERENCE:

Clause No. Title

HHSAR 352.203-70 Anti-Lobbying (DEC 2015)

(END OF CONTRACT CLAUSES)

SOLICITATION PROVISIONS

FAR 52.204-24 Representation Regarding Certain Telecommunications and Video

Surveillance Services or Equipment (NOV 2021)

The Offeror shall not complete the representation at paragraph (d)(1) of this provision if the Offeror has represented that it "does not provide covered telecommunications equipment or services as a part of its offered products or services to the Government in the performance of any contract, subcontract, or other contractual instrument" in paragraph (c)(1) in the provision at 52.204-26, Covered Telecommunications Equipment or Services—Representation, or in paragraph (v)(2)(i) of the provision at 52.212-3, Offeror Representations and Certifications-Commercial Items. The Offeror shall not complete the representation in paragraph (d)(2) of this provision if the Offeror has represented that it "does not use covered telecommunications equipment or services, or any equipment, system, or service that uses covered telecommunications equipment or services" in paragraph (c)(2) of the provision at 52.204-26, or in paragraph (v)(2)(ii) of the provision at 52.212- 3.

(a) Definitions. As used in this provision—

Backhaul, covered telecommunications equipment or services, critical technology, interconnection arrangements, reasonable inquiry, roaming, and substantial or essential component have the meanings provided in the clause 52.204-25, Prohibition on Contracting for

Certain Telecommunications and Video Surveillance Services or Equipment.

(b) Prohibition.(1) Section 889(a)(1)(A) of the John S. McCain National Defense Authorization Act for Fiscal Year 2019 (Pub. L. 115-232) prohibits the head of an executive agency on or after August 13, 2019, from procuring or obtaining, or extending or renewing a contract to procure or obtain, any equipment, system, or service that uses covered telecommunications equipment or services as a substantial or essential component of any system, or as critical technology as part of any system. Nothing in the prohibition shall be construed to—

(i) Prohibit the head of an executive agency from procuring with an entity to provide a service that connects to the facilities of a third-party, such as backhaul, roaming, or interconnection arrangements; or

(ii) Cover telecommunications equipment that cannot route or redirect user data traffic or cannot permit visibility into any user data or packets that such equipment transmits or otherwise handles.

(2) Section 889(a)(1)(B) of the John S. McCain National Defense Authorization Act for Fiscal Year 2019 (Pub. L. 115-232) prohibits the head of an executive agency on or after August 13, 2020, from entering into a contract or extending or renewing a contract with an entity that uses any equipment, system, or service that uses covered telecommunications equipment or services as a substantial or essential component of any system, or as critical technology as part of any system.

This prohibition applies to the use of covered telecommunications equipment or services, regardless of whether that use is in performance of work under a Federal contract. Nothing in the prohibition shall be construed to—

(i) Prohibit the head of an executive agency from procuring with an entity to provide a service that connects to the facilities of a third-party, such as backhaul, roaming, or interconnection arrangements; or

(ii) Cover telecommunications equipment that cannot route or redirect user data traffic or cannot permit visibility into any user data or packets that such equipment transmits or otherwise handles.

(c) Procedures. The Offeror shall review the list of excluded parties in the System for Award Management (SAM) (https://www.sam.gov) for entities excluded from receiving federal awards for "covered telecommunications equipment or services".

(d) Representation. The Offeror represents that—

(1) It will, ☐ will ☐ not provide covered telecommunications equipment or services to the

Government in the performance of any contract, subcontract or other contractual instrument resulting from this solicitation. The Offeror shall provide the additional disclosure information required at paragraph (e)(1) of this section if the Offeror responds "will" in paragraph (d)(1) of this section; and

(2) After conducting a reasonable inquiry, for purposes of this representation, the Offeror represents that—

It ☐ does, ☐ does not use covered telecommunications equipment or services, or use any equipment, system, or service that uses covered telecommunications equipment or services. The Offeror shall provide the additional disclosure information required at paragraph (e)(2) of this section if the Offeror responds "does" in paragraph (d)(2) of this section.

(e) Disclosures.

(1) Disclosure for the representation in paragraph (d)(1) of this provision. If the Offeror has responded "will" in the representation in paragraph (d)(1) of this provision, the Offeror shall provide the following information as part of the offer:

(i) For covered equipment—

(A) The entity that produced the covered telecommunications equipment (include entity name, unique entity identifier, CAGE code, and whether the entity was the original equipment manufacturer (OEM) or a distributor, if known).

http://www.sam.gov/

(B) A description of all covered telecommunications equipment offered (include brand; model number, such as OEM number, manufacturer part number, or wholesaler number; and item description, as applicable); and

(C) Explanation of the proposed use of covered telecommunications equipment and any factors relevant to determining if such use would be permissible under the prohibition in paragraph (b)(1) of this provision.

(ii) For covered services—

(A) If the service is related to item maintenance: A description of all covered telecommunications services offered (include on the item being maintained: Brand; model number, such as OEM number, manufacturer part number, or wholesaler number; and item description, as applicable);

or

(B) If not associated with maintenance, the Product Service Code (PSC) of the service being provided; and explanation of the proposed use of covered telecommunications services and any factors relevant to determining if such use would be permissible under the prohibition in paragraph (b)(1) of this provision.

(2) Disclosure for the representation in paragraph (d)(2) of this provision. If the Offeror has responded "does" in the representation in paragraph (d)(2) of this provision, the Offeror shall provide the following information as part of the offer:

(i) For covered equipment—

(A) The entity that produced the covered telecommunications equipment (include entity name, unique entity identifier, CAGE code, and whether the entity was the OEM or a distributor, if known).

(B) A description of all covered telecommunications equipment offered (include brand; model number, such as OEM number, manufacturer part number, or wholesaler number; and item description, as applicable); and

(C) Explanation of the proposed use of covered telecommunications equipment and any factors relevant to determining if such use would be permissible under the prohibition in paragraph (b)(2) of this provision.

(ii) For covered services—

(A) If the service is related to item maintenance: A description of all covered telecommunications services offered (include on the item being maintained: Brand; model number, such as OEM number, manufacturer part number, or wholesaler number; and item description, as applicable);

or

(B) If not associated with maintenance, the PSC of the service being provided; and explanation of the proposed use of covered telecommunications services and any factors relevant to determining if such use would be permissible under the prohibition in paragraph (b)(2) of this provision.

(End of provision)

52.204-26 Covered Telecommunications Equipment or Services-Representation (OCT

2020).

(a) Definitions. As used in this provision, "covered telecommunications equipment or services" and "reasonable inquiry" have the meaning provided in the clause 52.204-25, Prohibition on Contracting for Certain Telecommunications and Video Surveillance Services or Equipment.

(b) Procedures. The Offeror shall review the list of excluded parties in the System for Award Management (SAM) (https://www.sam.gov) for entities excluded from receiving federal awards for "covered telecommunications equipment or services".

(c)

(1) Representation. The Offeror represents that it □ does, □ does not provide covered telecommunications equipment or services as a part of its offered products or services to the Government in the performance of any contract, subcontract, or other contractual instrument.

(2) After conducting a reasonable inquiry for purposes of this representation, the offeror represents that it □ does, □ does not use covered telecommunications equipment or services, or any equipment, system, or service that uses covered telecommunications equipment or services.

FAR 52.252-1 Solicitation Provisions Incorporated by Reference (FEB 1998)

This solicitation incorporates one or more solicitation provisions by reference, with the same force and effect as if they were given in full text. Upon request, the Contracting Officer will make their full text available. The offeror is cautioned that the listed provisions may include blocks that must be completed by the offeror and submitted with its quotation or offer. In lieu of submitting the full text of those provisions, the offeror may identify the provision by paragraph identifier and provide the appropriate information with its quotation or offer. Also, the full text of a solicitation provision may be accessed electronically at this/these address(es):

www.acquisition.gov/browse/index/far

FEDERAL ACQUISITION REGULATION (FAR) – PROVISIONS INCORPORATED BY

REFERENCE:

Provision No. Title

FAR 52.203-18 Prohibition on Contracting with Entities that Require Certain

Internal Confidentiality Agreements or Statements- Representation (JAN 2017) http://www.sam.gov/ http://www.acquisition.gov/browse/index/far

FAR 52.204-7 System for Award Management (NOV 2024) FAR 52.204-16 Commercial and Government Entity Code Reporting (AUG 2020) FAR 52.204-22 Alternative Line Item Proposal (JAN 2017) FAR 52.212-1 Instructions to Offerors – Commercial Products and Commercial

Services (SEP 2023) FAR 52.212-2 Evaluation – Commercial Products and Commercial Services (NOV 2021) FAR 52.212-3 Offeror Representations and Certifications-Commercial Products and

Commercial Services (MAY 2024)

(END OF PROVISIONS)

BASIS FOR AWARD AND EVALUATION

Evaluation of quotes will be conducted in accordance with FAR 13.106-2 (b)(3) procedures.

The Government intends to award a Firm-Fixed-Priced Purchase Order from this solicitation to the responsible Offeror using Lowest Price Technically Acceptable (LPTA) procedures.

The Government may reject any quote that is evaluated to be non-compliant with the solicitation requirements, unreasonably high or low in price, or reflects a failure to comprehend the complexity and risks of the work to be performed. The Government intends to make award selection without clarifications but may determine after evaluating the quotes submitted that clarifications are necessary and conduct them as appropriate with all, some, or none of the firms’ submitting quotations in response to this RFQ. The

Government reserves the right to make no award if quotes do not meet the requirements of this solicitation.

The Government intends to evaluate quotations and make a single award without conducting "discussions" as defined in FAR Part 15. Therefore, the quoter’s initial quote should contain the quoter’s best terms from a price and technical standpoint. However, the Government reserves the right to contact the quoter (or multiple quoters) to request quotation revisions that seek additional price discounts, provide revisions to the technical quotation or explain other aspects of the quotation to improve the terms of the deal reflected in the quotation. In the event quotation revisions are requested, the Government will not necessarily be seeking revisions from all quoters. The Government may reject any or all quotes if such action is in the public interest; accept other than the lowest quote; and waive informalities and minor irregularities in quotes received. The Government reserves the right to make no award if quotes do not meet the requirements of this solicitation.

Award will be made to the responsible offeror, whose quote is responsive to the solicitation, technically acceptable, and has the lowest evaluated price among all proposals meeting or exceeding the specified technical acceptability standards.

Award will be made to the contractor providing the most advantageous quote to the government, technical factors and cost/price considered.

Vendors will be evaluated on their capabilities to provide the product to the specifications described on the Statement of Needs section.

SUBMISSION & GENERAL INSTRUCTIONS

This Request for Quotation (RFQ) does not commit the Government to pay any cost for preparation and submission of a quote. In addition, the Contracting Officer is the only individual who can legally commit to the expenditure of public funds in connection with this proposed acquisition. By submitting a quote in response to this solicitation, it is understood that your firm’s quote shall become a part of the official contract file. The Government is not responsible for locating or securing any information which is not identified in the quote.

Quotes must contain a statement to the effect that the offer is valid for a period of at least

30 days from the date of receipt by the Government.

Quote submittal must also include the following:

• All submittals must include a completed FAR Provision 52.204-24, 52.204-26 and

52.213-3 unless already completed in the System for Award Management (SAM). If already provided in the vendors SAM.gov profile, and do not conflict with the requirements as stated in this solicitation, please provide a statement to the effect of

“Provisions 52.204-24, 52.204-26 and 52.213-3 are complete and accurate per our

SAM.gov registration dated 00/00/0000.

• All attachments must be in Microsoft Word or Adobe Portable Format (PDF).

• All correspondence must have Notice ID “75N94025Q00177” included in the subject line.

SOLICITATION QUESTIONS

If there are questions regarding this requirement, please submit your inquiries immediately via email but no later than 1:00 PM Eastern Standard Time Wednesday, August 13, to the points of contact listed below:

Usha Raman Contracting Officer Email: ramanu2@mail.nih.gov

Kimesha Leake

Email: kimesha.leake@nih.gov

Note: Questions submitted by a method other than email will not be accepted. Any questions received after the specified cut-off time and date above will not be accepted or mailto:ramanu2@mail.nih.gov mailto:kimesha.leake@nih.gov answered unless the Contracting Officer deems it necessary. All email inquiries must have the Solicitation number 75N94025Q00177 included in the subject line.

QUOTATION SUBMITTAL

Quotations submitted in response to this solicitation must be submitted via email no later than Monday, August 18, 2025, by 1:00 PM Eastern Standard Time to the points of contact listed below:

Name: Usha Raman Contracting Officer Email: ramanu2@mail.nih.gov

Name: Kimesha Leake

Email: kimesha.leake@nih.gov

Note: It’s the Offeror’s responsibility to read the RFQ and all related documents carefully.

Additionally, it is the Offeror’s responsibility to ensure/verify the Government receives its submission on or before the date/time specified. The Government reserves the right to not accept any late quotes. Please do not wait until the deadline to submit your quotation.

LIST OF ATTACHMENTS:

Attachment 1 – Visit NIH Vendor Memo

Attachment 2 – FAR 52.212-3 (MAY 2024) [(DEVIATION FEB 2025)]

Attachment 3 – FAR 52.212-5 (JAN 2025) [(DEVIATION FEB 2025)]

Attachment 4 – FAR 52.223-23 (MAY 2024) [(DEVIATION FEB 2025)]

Attachment 5 – NIH Invoicing Instructions with IPP (MAR 2023) mailto:ramanu2@mail.nih.gov mailto:kimesha.leake@nih.gov