CDC-RFA-CK17-1707.pdf

Centers for Disease Control

National Center for Emerging and Zoonotic Infectious Diseases

CDC-Mexico Cooperative Agreement for Surveillance, Epidemiology, and Laboratory Capacity

CDC-RFA-CK17-1707

Application Due Date: 04/10/2017

Signature Date

CDC

Use Only

CDC-Mexico Cooperative Agreement for Surveillance, Epidemiology, and Laboratory Capacity

CDC-RFA-CK17-1707

TABLE OF CONTENTS

Part I. Overview Information Federal Agency NameA.

Funding Opportunity TitleB.

Announcement TypeC.

Agency Funding Opportunity NumberD.

Catalog of Federal Domestic Assistance (CFDA) NumberE.

Dates F.

Executive Summary G.

Part II. Full Text Funding Opportunity Description A.

Award Information B.

Eligibility Information C.

Application and Submission Information D.

Review and Selection Process E.

Award Administration Information F.

Agency Contacts G.

Other Information H.

Glossary I.

Part I. Overview Information Applicants must go to the synopsis page of this announcement at www.grants.gov and click on the "Send Me Change Notifications Emails" link to ensure they receive notifications of any changes to CDC-RFA-CK17-1707. Applicants also must provide an e-mail address to www.grants.gov to receive notifications of changes.

A. Federal Agency Name:

Centers for Disease Control and Prevention (CDC) / Agency for Toxic Substances and Disease Registry

(ATSDR)

B. Funding Opportunity Title:

CDC-Mexico Cooperative Agreement for Surveillance, Epidemiology, and Laboratory Capacity C. Announcement Type: New - Type 1 This announcement is only for non-research activities supported by CDC. If research is proposed, the application will not be considered. For this purpose, research is defined at https://www.gpo.gov/fdsys/pkg /CFR-2007-title42-vol1/pdf/CFR-2007-title42-vol1-sec52-2.pdf. Guidance on how CDC interprets the definition of research in the context of public health can be found at http://www.cdc.gov/od/science/integrity /docs/cdc-policy-distinguishing-public-health-research-nonresearch.pdf.

D. Agency Funding Opportunity Number:

CDC-RFA-CK17-1707

E. Catalog of Federal Domestic Assistance (CFDA) Number:

93.283 F. Dates:

1. Due Date for Letter of Intent (LOI): N/A

2. Due Date for Applications: 04/10/2017, 11:59 p.m. U.S. Eastern Standard Time, at www.grants.gov.

3. Date for Informational Conference Call:

n/a

G. Executive Summary:

1. Summary Paragraph:

The Centers for Disease Control and Prevention (CDC) intends to establish a cooperative agreement with the George E. Brown Foundation U.S. Mexico for the Sciences (FUMEC) as part fo the CDC strategy to address emerging infectious diseases of public health importance to both countries. CDC has used this organization as the intermediary with the Ministry of Health in Mexico under cooperative agreement CK 11-1106 with efficiency, transparency, and accountability. Strategies reducing disease in a neighbor country have been demonstrated to protect the health of Americans and the region. Supporting these strategies in Mexico:

conducting surveillance, monitoring and response; map, identify, and predict infectious diseases of public health risk; support food safety; and prevent and control disease emergence and re-emergence will allow CDC to further its global public health programs in a coordinated manner, not only with public health governmental institutions of Mexico but also with academic partners. This FOA aims to conduct complementary activities to reach CDC specific goals and objectives related to US Mexico bi-national health, through the prevention and control of infectious diseases that are public health threats, and the strengthening of key public health services.

a. Eligible Applicants: Single

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Use Only https://foa.grantsolutions.gov/www.grants.gov https://foa.grantsolutions.gov/www.grants.gov https://www.gpo.gov/fdsys/pkg/CFR-2007-title42-vol1/pdf/CFR-2007-title42-vol1-sec52-2.pdf https://www.gpo.gov/fdsys/pkg/CFR-2007-title42-vol1/pdf/CFR-2007-title42-vol1-sec52-2.pdf http://www.cdc.gov/od/science/integrity/docs/cdc-policy-distinguishing-public-health-research-nonresearch.pdf http://www.cdc.gov/od/science/integrity/docs/cdc-policy-distinguishing-public-health-research-nonresearch.pdf http://www.grants.gov

b. FOA Type: Cooperative Agreement

c. Approximate Number of Awards: 1

d. Total Project Period Funding: $5,000,000

e. Average One Year Award Amount: $1,000,000

f. Total Project Period Length: 5

g. Estimated Award Date: 09/30/2017

h. Cost Sharing and / or Matching Requirements:

N

Cost sharing or matching funds are not required for this program.

Part II. Full Text A. Funding Opportunity Description

Part II. Full Text

1. Background

a. Overview The U.S. and Mexico have a 2,000 mile border which has over 400 million legal northbound crossings a year through ports of entry located in at least 7 major sister-city regions. Mexico is the second largest trading partner of the US (after Canada and before China). Over 54 million persons of Mexican origin (2/3 of all US Hispanics) live in the United States. This close geographic and socioeconomic relationship between the US and Mexico has profound public health implications for the health systems of the two countries. Numerous bi-national infectious disease outbreaks including vaccine-preventable, foodborne, vector-borne, and mycobacteriosis and mycotic diseases have been documented over the last two decades. In addition, the Ministry of Health in Mexico is responding to a Zika virus outbreak in their territory since November 2015.

Optimal investigation and control for these bi-national outbreaks and cases require binational coordination;

therefore, a sustained support to the already existing shared surveillance and communication systems between Mexican and US public health officials is a priority for protecting Americans against imported infectious diseases. The Mexico Secretariat of Health has collaborated with CDC since 1997 in the development and implementation of binational infectious disease surveillance (BIDS). BIDS helps the two countries monitor infectious disease reports for a variety of infectious disease syndromes and conditions in a uniform manner, using similar clinical screening criteria and similar laboratory testing protocols when agreed upon by both countries. In addition to Mexican immigrants, thousands of other immigrants arrive from other countries and use Mexico's territory as a crossing bridge to get to the more than 14 crossing points at the US-Mexico border region. This critical situation lends justification to providing support to Mexico’s Public Health system, to among other uses, improve the current screening and treatment of foreigners entering through Mexico’s Northern Border to the U.S. Clearly, the binational infectious disease surveillance collaborations have been valuable for both countries. It is a binational health priority to continue the now established binational epidemiologic network and laboratory infrastructure and expand the syndromes and diseases under surveillance, the public health activities conducted, and the geographic scope within the U.S.

and Mexico.Priority areas for this cooperative agreement include: 1) enhancement of the surveillance for infectious diseases of binational concern; 2) continuation of the Binational Communication Platform; 3) enhancement of the laboratory data reporting capacity; 4) enhancement of a binational outbreak response capacity; 4) evaluation of programs and systems in place and implementation of lessons learned, in the plan to develop strong bilateral response efforts to public health events of importance. The purpose of this FOA is to establish the collaboration to work in a coordinated manner, not only with Public Health governmental institutions of Mexico but also with academic partners and to conduct complementary activities to reach

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institutions of Mexico but also with academic partners and to conduct complementary activities to reach CDC-specific Goals and Objectives related to U.S.-Mexico binational strategies to prevent and control infectious diseases, within the period of validity of this cooperative agreement

b. Statutory Authorities This program is authorized under the Public Health Service Act, Sections 307 and 317(k)(1) [42 U.S.C. 242l and 247b(k)(1)], as amended.

c. Healthy People 2020 This program addresses the Health People 2020 focus topic areas of: Global Health (https://www.healthypeo ple.gov/2020/topics-objectives/topic/global-health), and Immunization and Infectious Diseases (https://www ,healthypeople.gov/2020/topics-objectives/topic/immunization-and-infectious-diseases).

GH-2 Reduce the tuberculosis (TB) case rate for Mexican immigrants living in the United States

GH-3 Create a Global Disease Detection (GDD) Regional Center to detect and contain emerging health threats

GH-4 Increase the number of public health professionals trained by the Global Disease Detection (GDD) program in Mexico

GH-5 Increase diagnostic testing capacity in Mexico (and regionally)

d. Other National Public Health Priorities and Strategies This FOA supports CDC’s Global Health Strategy (http://www.cdc.gov/globalhealth/strategy/), which focuses on improving the health and well-being of people around the world, improving capabilities to prepare for and respond to infectious diseases, other emerging health threats and public health emergencies;

building country public health capacity as means to achieving lasting health improvements; and maximizing the potential of CDC’s global programs to achieve public health impact

e. Relevant Work The DGMQ-US-Mexico Unit combines binational efforts and improves communication systems pertaining to public health issues. The border health surveillance systems exchange surveillance data and conduct case reporting of infectious diseases of binational public health importance. The implementation of this effort started in the previous Cooperative Agreement between CDC and FUMEC signed in 2011, with the stated purpose of enhancing public health capacity (including epidemiology and laboratory) for the U.S and Mexico. The work proposed aligns strategically with CDC/NCEZID global strategy http://intranet.cdc.gov/ncezid/resources/ncezid-global -strategy-2013.pdf

2. CDC Project Description

a. Approach

Bold indicates project period outcome.

CDC-RFA-CK17-1707 Logic Model: CDC-Mexico Cooperative Agreement for Surveillance, Epidemiology, and Laboratory Capacity

Strategies and

Activities

Outputs Short-term

Outcome

Long-Term

Outcomes

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Use Only https://www.healthypeo https://www,healthypeople.gov/2020/topics-objectives/topic/immunization-and-infectious-diseases https://www,healthypeople.gov/2020/topics-objectives/topic/immunization-and-infectious-diseases http://www.cdc.gov/globalhealth/strategy/ http://intranet.cdc.gov/ncezid/resources/ncezid-global-strategy-2013.pdf http://intranet.cdc.gov/ncezid/resources/ncezid-global-strategy-2013.pdf

Enhance Public Health Epidemiologic and Laboratory Capacity

1. Create enhanced epidemiologic and lab surveillance systems

2. Strengthen binational reporting of urgently notifiable diseases

3. Establish preparedness to respond to binational bioterrorism threats

4. Training on methods to enhance binational reporting/response and notifiable disease identification

-Accurate and timely epidemiologic and lab. surveillance information sharing

-Accurate and timely assessment of disease exposures

-Improved data sharing between CDC and

DGE/CENAPRECE

of the Mexico MOH

-Improved use of shared data to inform public health action

-Demonstrated use of shared epidemiologic intelligence

-Use of shared information to launch early outbreak alerts and prevention messages

-Production of reliable epidemiologic and laboratory data for public health policy changes and new policy creation

-Timely dissemination of epidemiologic information to the CDC, the US border state and local public health offices, and the Binational Technical Working Group (BTWG)

-Reduced incidence of infectious diseases of binational public health importance

-Improved health outcomes for residents and immigrants of US and Mexico

-Reduced health disparities in infectious diseases among binational/border residents

Enhance surveillance network for binational activities for detection, prevention, and control of diseases

1. Implement and evaluate the Bi-national Communications Protocol

2. Conduct laboratory training

-Improved data sharing exchange and use among CDC and

DGE/CENAPRECE

and other stakeholders

-Improved sharing and understanding of testing and reporting protocols between the US and Mexico

-Expand partnerships in response networks including academic institutions

-Active federal, state and local participation in Mexico in BTWG and preparedness exercises with support and promotion by the Mexican Ministry of Health

-More timely detection and response to exposures and risk conditions for infectious diseases

-Institutionalize binational notifications and coordinated response

-Improved health outcomes in border/binational populations

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Transform program evaluation findings into prevention and control

1. Assessment on timeliness of disease reporting and between disease reporting and start of PH action

2. Develop and implement a Core Capacities Plan for the Binational PH Network

3. Develop and implement a monitoring and evaluation plan for priority binational public health programs

-Well trained staff capable of using and improving surveillance health information systems

-Regular surveillance reports produced and disseminated

-Make baseline and ongoing data available to describe status and progress in disease prevention and control of priority public health conditions.

-Maintenance and ongoing improvement in timely and efficient response to priority public health conditions

-Activate and enforce Core Capacities Plan for the Binational PH network

i. Purpose Enhance public health capacity to better prevent and respond to public health threats of binational concern (including epidemiology and laboratory), and to strengthen the surveillance and reporting system between the U.S. and Mexico. This work will be accomplished by working collaboratively with both existing governmental public health infrastructure and science/educational organizations such as local universities interested and dedicated in the development and/or enhancement of the public health care services in alignment with public health interests especially through surveillance projects

ii. Outcomes

1. Use of shared information to launch early outbreak alerts and prevention messages: Improvement in completeness and timeliness of laboratory and case information (demographic, geographic, and risk) reported through the Binational Public Health Network. a) Cases submitted to CDC with complete demographic, geographic, risk information and date of onset: at least 99 % complete for age and gender; at least 80% complete for race/ethnicity, location of residence, source of testing, date of onset and risk information and b) D documentation that at least 53% of contacted at-risk persons successfully linked to prevention and mitigation messages and interventions

2. Production of reliable epidemiologic and laboratory data for public health policy changes and new policy creation: With complete and timely laboratory and case information (demographic, geographic, and risk) reported through the Binational Public Health Network information will be used to create mutually approved guidelines for the prevention and control of public health events of binational concern

3. Active federal, state and local participation from Mexico in the Binational Technical Working Group and in preparedness exercises: Increase knowledge of the “true” burden of infectious diseases of public health importance and their regional (Border) and binational (US and Mexico) impact, by sharing

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surveillance data and by supplementing case surveillance data with data from other sources such as hospital discharge data and data from the surveys and other data gathering interventions conducted by the Offices of Border Health.

4. More timely detection and response to exposures and risk conditions for infectious diseases: Reduce cases of infectious diseases of public health importance due to interrupted transmission in identified outbreaks by using surveillance data to identify outbreaks early, analyzing emerging trends in case reports in binational communities, and/or increases in warning signs. Includes the use of established Binational Protocol guidelines for investigating outbreaks and report to appropriate authorities and Surveillance databases.

5. Improved health outcomes in border/binational populations: Include promoting health and early disease detection in venues likely to serve at risk and infected persons who are traditionally very difficult to reach. Increase by at least 10% over baseline, the number of diagnostic tests provided and results reported to the appropriate health department.

iii. Strategies and Activities

1. Create enhanced epidemiologic and laboratory surveillance systems: Establishing new surveillance projects for diseases of mutual interest to both nations, through the enhancement of quality laboratory systems and diagnostic capacity and in coordination of surveillance projects with sister city and sister state partners.On the laboratory capacity field, this |FOA contemplates the strengthening the support the Mexico Secretariat of Health’s (Dirección General de Epidemiología-DGE) and the National Reference Laboratory (InDRE, for Instituto Nacional de Diagnóstico y Referencia in Spanish), implement and evaluate evidence-based public health programs, conduct laboratory based public health surveillance, carry-out epidemiological analysis that support national and regional disease prevention and control efforts.

2. Strengthen binational reporting of urgently notifiable diseases: Re-designing the existing system into an agile model that includes a mechanism to notify CDC of urgent notifiable diseases and routine reporting of binational cases between sister cities and sister states. Includes sharing control and containment strategies for public health events of binational importance.

3. Establish preparedness to respond to binational bioterrorism threats: By reinforcing the use the binational case reporting network as a platform for early detection of bioterrorism threats. In addition, increment the capacity and preparedness of the BSL-3 laboratory in Mexico, conduct clinical management and epidemiologic training exercises focus on bioterrorism agents, and maintain communication protocols using secure internet communications such as the Epi-X system developed by CDC.

4. Trainings on methods to enhance binational reporting/response and notifiable disease reporting:

Through work force capacity development plan for staff that are part of the binational surveillance network in the areas of detection, prevention, and control of said notifiable diseases. This capacity building plan is aligned with the U.S. binational surveillance network. The training plan will include workshops and table top exercises opportunities on epidemiologic surveillance and laboratory techniques, management, epidemiology, health communications, evidence-based program planning, evaluation, data collection and analysis.

5. Implement and evaluate the Binational Communications Protocol: To improve coordinated binational preparedness and epidemiologic response and continue working towards binational protocol enforcement. To effectively communicate early alerts to prevent and mitigate binational outbreaks and cases at early stages.

The existence and use of the Binational Communications Protocol and its purpose and objectives is disseminated amongst all partners and collaborative institutions related with epidemiologic surveillance in the US and Mexico.

6. Conduct laboratory training: Conduct CDC-lead trainings for laboratorians form the National Reference Lab (Instituto Nacional de Diagnóstico y Referencia-InDRE), the 6 Mexico northern Border States, and other states affected by migrant populations or food safety issues, to enhance laboratory

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diagnostics, evaluation, and data collection and analysis.

7. Assessment on timeliness of disease reporting and between disease reporting and start of public health action: Conduct the appropriate national and international epidemiologic method forums at all levels to ensure that epidemiological and laboratory information are translated into public health practice

8. Develop and implement a Core Capacities Plan for the Binational Public Health Network: Develop, implement, and evaluate a Core Capacities Plan between US and Mexico. These Core Capacities are the essential skills to support the goals of this cooperative agreement: technical and scientific (epidemiology, surveillance, outbreak investigation, laboratory diagnostics, health promotion and communications, data management, information technology) and managerial (cooperative agreement management, financial management, human resource administration), but the final list in priority order will be decided in the first six months of work.

9. Develop and implement a monitoring and evaluation plan for priority binational public health programs: Develop, implement, and evaluate a Monitoring Plan for the Core Capacities Plan selected, which will include but are not limited to: technical and scientific (epidemiology, surveillance, outbreak investigation, laboratory diagnostics, health promotion and communications, data management, information technology) and managerial (cooperative agreement management, financial management, human resource administration).

1. Collaborations

a. With other CDC programs and CDC-funded organizations:

The awardee will be required to establish, build, and maintain relationships with the CDC Project Officer and with the specific responsible office or branch at CDC for all projects proposed to address strategies and activities described in this FOA.

Collaboration will include consultation for the development of plans and budgets for specific proposed projects, in order to ensure the projects meet the overall objectives of this FOA, and are consistent with and meet CDC program-specific objectives and available resources. Collaboration will additionally include development of evaluation measures for tracking performance of each specific proposed project.

The awardee will be required to collaborate with CDC monitor and evaluate the scientific and operational accomplishments of individual projects, as well as the overall progress in achieving the purpose of the program.

b. With organizations not funded by CDC:

Awardees are encouraged to establish, build,and/or maintain collaborative relationships with external programs (e.g.,universities, community based organizations providing prevention services, health care providers, commercial laboratories) to support the implementation of the proposed program. Memoranda of Agreements (MOA), Memoranda of Understanding (MOU), letters of commitment, or service agreements are required to formally document proposed and current collaborations. These documents should describe the scope of work, intensity, duration, specific activities,and which parties are responsible for each specific activities

2. Target Populations All persons susceptible to disease with infectious agents of public health importance. Women in reproductive age. Children. People with limited health literacy as well as any population within the scope of vulnerable populations. Funded programs must include people with disabilities in all aspects of the program (e.g., advisory boards, planning committees, project staff, consultants, etc.). Where appropriate, applicants are encouraged to also include: tribal organizations; rural populations. For additional information about disability inclusion, go to:

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Use https://www.cdc.gov/ncbddd/disabilityandhealth/disability-inclusion.html

a. Health Disparities Overall the strategies and activities described in this FOA are designed to benefit and include people with disabilities;tribal populations; non-Spanish speaking populations; people with limited health literacy.. For all these populations the strategies and activities in this FOA will help prevent human illness and death from infectious diseases and food and/or water poisoning. One of the main goals of this FOA is to prevent infectious diseases to travel across the borders along with the thousands of people who live on one side of the border and cross it every day to go to work, school or business. Early detection of infectious diseases outbreaks and a binational communication system between border health offices will ultimately improve human health among disadvantaged populations living in both sides of the border and immigrant populations.

iv. Funding Strategy n/a

b. Evaluation and Performance Measurement

i. CDC Evaluation and Performance Measurement Strategy Performance measures and evaluation findings will be used by grantee to determine the burden of infectious disease. The information will be used by CDC to understand trends in incidence and prevalence of disease;

develop, implement, and evaluate binational prevention programs and policies. Details of the infectious diseases of binational public health interest are provided in Attachment 1 - “Operational Protocol for U.S.-Mexico Binational Communication and Coordination on Disease Notifications and Outbreaks” page 8. Awardee is expected to collaborate fully and transparently with the CDC in the following activities:

• Facilitate and systematize communications about disease events between all public health entities in the United States and Mexico that need awareness

• Promote effective collaboration of public health systems of the United States and Mexico on outbreaks or binational cases affecting both countries

• Provide a recommended list of binationally notifiable conditions

• Provide clear and practical steps for preventing miscommunication and maximizing productive binational collaboration

• Work within and complement existing communications mechanisms within each state and country to report events

Use of shared information to launch early outbreak alerts and prevention messages

1. Process measure: The grantee notified CDC of 100% of infectious disease cases of notifiable and public health importance, including congenital infections.

Years 1 – 5 Outcome Measures: Case demographic, geographic, date of onset and risk information completeness, as notified to CDC, should be at least 95% complete for source of diagnostic testing, 90 % complete for age and gender, 75% complete for location of residence. risk factor information, and date of onset.

2. Process measure: The grantee used data from existing data sources, including binational public health network source, to launch early outbreak alerts and create guidelines for the detection, prevention and control of relevant infectious diseases.

Years 1-5 Outcome Measures: For the purpose of reporting outbreaks, the outbreak is considered over when the rate of new infections return to the baseline rate.

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Use

Production of reliable epidemiologic and laboratory data for public health policy changes and new policy creation

1. Process Measure: The grantee used data from at least 2 existing data sources, supplementing case surveillance data to estimate the true burden of acute and chronic infectious diseases of interest (See Attachment 1).

Years 1-5 Outcome Measures: identified outbreaks were investigated and for each outbreak the number of cases linked to the investigation were identified and provided appropriate notification and testing and treatment recommendations. Summary reports describing cases that were related to the outbreak and actions taken were developed and disseminated to appropriate health department(s) in the US and Mexico and to CDC

Active federal, state, and local participation from Mexico in the Binational Technical Working Group (BTWG) and in preparedness exercises

1. Process Measure: Participate in monthly conference calls and annual preparedness exercises related to

BTWG.

Years 1-5 Outcome Measures: At least 1 site participant from federal, state, and Border/local (Border/local definition Attachment 1, Table 2, Page 10): 90%.

More timely detection and response to exposures and risk conditions for infectious diseases

1. Process Measure: The grantee uses data from multiple sources to determine the burden of infectious disease transmission among the most vulnerable and hard to reach populations; expand partnerships and collaborations to combat transmission, develop, implement, and evaluate prevention efforts that target hard to reach populations, and plan more comprehensive approaches to directing prevention services.

Years 1-5 Outcome Measures: Number of MOU’s signed with new partners including academic institutions, university research laboratory and institutions, etc. Number of summary reports describing cases that were related to outbreaks and actions taken that were created and effectively disseminated.

Improved health outcomes in border/binational populations

1. Process Measure: The grantee documents burden of disease among vulnerable and hard to reach populations; understand trends in incidence and prevalence of disease; develops, implements, and evaluate prevention programs and policies, formulate recommendations for testing, and for working with State and Border Health partners to control and prevent new infections

Years 1-3 Outcome Measures:

1.1 Increase by at least 10% over baseline the number of diagnostic test provided and results reported to the appropriate public health officials;

1.2 Identify all public health and other laboratories located within and adjacent to the mutually agreed-upon surveillance areas that test a significant proportion of clinical specimens from surveillance area residents:

100%

Year 4-5:

2.1 Complete audit of all clinical laboratories to verify completeness of case ascertainment: 100% ;

2.2.Obtain isolates from identified outbreak cases share them with CDC laboratories for expanded laboratory characterization: >85%;

2.3 Conduct quality checks of case report form data by selecting ≥10% of case report forms (stratified by facility and/or region) and be re-abstracted by a second reviewer. An analysis of discrepancies should be used to train staff conducting case report form reviews.

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ii. Applicant Evaluation and Performance Measurement Plan Applicants must provide an evaluation and performance measurement plan that demonstrates how the awardee will fulfill the requirements described in the CDC Evaluation and Performance Measurement and Project Description sections of this FOA. At a minimum, the plan must describe:

How applicant will collect the performance measures, respond to the evaluation questions, and use evaluation findings for continuous program quality improvement.

How key program partners will participate in the evaluation and performance measurement planning processes.

Available data sources, feasibility of collecting appropriate evaluation and performance data, and other relevant data information (e.g., performance measures proposed by the applicant) Plans for updating the Data Management Plan (DMP), if applicable, for accuracy throughout the lifecycle of the project. The DMP should provide a description of the data that will be produced using these FOA funds; access to data; data standards ensuring released data have documentation describing methods of collection, what the data represent, and data limitations; and archival and long-term data preservation plans. For more information about CDC’s policy on the DMP, see https://www.cdc.gov/grants/additionalrequirements/ar-25.html.

Where the applicant chooses to, or is expected to, take on specific evaluation studies, they should be directed to:

Describe the type of evaluations (i.e., process, outcome, or both).

Describe key evaluation questions to be addressed by these evaluations.

Describe other information (e.g., measures, data sources).

Awardees will be required to submit a more detailed Evaluation and Performance Measurement plan, including a DMP, within the first 6 months of award, as described in the Reporting Section of this FOA.

c. Organizational Capacity of Awardees to Implement the Approach The awardee is expected to be a public health non-profit organization that has operational work capacity in Mexico and direct access to the governments, health ministries, agricultural ministries and animal health agencies in Mexico.

Awardee is expected to have a record of transparent management capacity administrating of U.S. federal funds.

The awardee is expected to have organizational programs and identify qualified personnel with expertise in public health projects, epidemiology and laboratory activities addressing diseases of local and international impact.

The awardee is expected to have program planning skills to implement: disease surveillance and surveillance training development with the ministry of health; workforce development and training; development of public health capacity for outbreak response and disease control of governmental institutions, the ability to identify and work with academic institutions whose work focuses in public health, and the ability to aid in the development or enhancement of public health laboratory capacity.

The awardee is expected to have demonstrated financial responsibility and budget administration and expenditures reporting experience of U.S. Federal funds on or over US$ 5,000,000.00.

d. Work Plan Applicant must present a 2-4 page detailed work plan and should focus on the first year of the project period

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Use https://www.cdc.gov/grants/additionalrequirements/ar-25.html

Applicant must present a 2-4 page detailed work plan and should focus on the first year of the project period with only a high level plan for subsequent years. Work plan should demonstrate alignment among the outcomes, strategies, activities, timelines, staffing, collaborations and evaluation and performance measures presented in the logic model and the narrative sections of the FOA.

Additional information on performance measures, data sources, and target population will also be included.

An example of. A work plan in table format is included here:

Project Period Outcome:

[from Outcomes section and/or logic model]

Outcome Measure:

[from Evaluation and Performance

Measurement section]

Outcomes Process Measure

[from Evaluation and

Performance

Measurement section]

Responsible

Position /

Party

Completion

Date

e. CDC Monitoring and Accountability Approach Monitoring activities include routine and ongoing communication between CDC and awardees, site visits, and awardee reporting (including work plans, performance, and financial reporting). Consistent with applicable grants regulations and policies, CDC expects the following to be included in post-award monitoring for grants and cooperative agreements:

Tracking awardee progress in achieving the desired outcomes.

Ensuring the adequacy of awardee systems that underlie and generate data reports.

Creating an environment that fosters integrity in program performance and results.

Monitoring may also include the following activities deemed necessary to monitor the award:

Ensuring that work plans are feasible based on the budget and consistent with the intent of the award.

Ensuring that awardees are performing at a sufficient level to achieve outcomes within stated timeframes.

Working with awardees on adjusting the work plan based on achievement of outcomes, evaluation results and changing budgets.

Monitoring performance measures (both programmatic and financial) to assure satisfactory performance levels.

Monitoring and reporting activities that assist grants management staff (e.g., grants management officers and specialists, and project officers) in the identification, notification, and management of high-risk grantees.

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Using the Performance measure and evaluation data reported by awardees CDC program tracks the progress and provides feedback to awardees and assess whether the CDC program is achieving the FOA outcomes.

Convene awardee administrative and technical team for an orientation briefing to discuss applicable U.S.

Government regulations and key management requirements, as well as report formats and contents

Review and approve the process used by the awardees to select key personnel and/or post-award sub-contractors and/or sub-awardees to be involved in the activities performed under this agreement

1.

Adjust the work plan based on achievement of outcomes, evaluation results and budget before the every budget period begins

2.

Review and approve the awardee’s monitoring and evaluation plan3.

Organize teleconferences on a monthly basis with the awardee to assess monthly expenditures in relation to approved work plan, and modify plans as needed.

4.

In person meeting with awardee’s administrative and technical team every six months to ensure technical assistance is being provided according to needs and to work plan.

5.

Provide feedback from Grants Management Office (GMO) and the technical officer from CDC to awardee on performance evaluation.

6.

Provide feedback after quarterly, bi-annual and annual progress reports7.

Organize in-person meeting to revise the annual audit results.8.

The following are monitoring actions necessary to ensure that the activities in the work plan are feasible based on the budget and consistent with the intent of the award.

f. CDC Program Support to Awardees (THIS SECTION APPLIES ONLY TO COOPERATIVE

AGREEMENTS)

Program has substantial involvement to support awardee in the implementation of activities, execution of federal funds.

Technical assistance:

Program provides in-country administrative support assure CoAg execution meets U.S. Government financial and reporting requirements, and that activities also meet the compliance requirements issued by the Office of Management and Budget (OMB).

Provide technical oversight for all activities under this award.1.

Provide training on subjects related with the activities listed in the work plan.2.

If required by awardee, CDC- subject matter expert or program will support emergency interventions conducted by subject matter experts.

3.

Provide intervention and planning support and assistance for awardee personnel through short and long-term exchanges of experts.

4.

Provide personnel and/or resources available to help awardee overcome unexpected challenges during a project execution.

5.

CDC will maintain open communication with awardee and is committed to inform any administration change within the U.S. Government that may impact directly the execution of the CoAg activities.

6.

Provide technical assistance in support on planning, implementation and evaluation of disease surveillance and intervention activities as well as training activities.

7.

Provide assistance in developing program activities, data management and analysis, quality assurance, the presentation and possibly publication of program results and findings.

8.

Advice and assist in the provision of special reagents or other materials and laboratory supplies as needed.

9.

ii. Program Assistance/ Information Sharing:

Facilitates sharing of publications, lessons learned, and best practices with awardee through conference

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Facilitates sharing of publications, lessons learned, and best practices with awardee through conference calls, webinars or table top meetings.

Promotes data and/or information exchange between Ministries of Health in the Latin-American region.

1.

Shares with awardee data, information and publications pertinent to the work plan produced by CDC and HHS, to ensure that new activities are not being duplicated.

2.

Provides consultation a scientific and technical assistance based on appropriate HHS/CDC documents to promote the use of best practices known at the time.

3.

Promotes binational surveillance and laboratory data sharing between U.S. and Mexico epidemiologic intelligence systems.

4.

Facilitates binational reporting of urgently notifiable diseases5.

B. Award Information

1. Funding Instrument Type: Cooperative Agreement CDC's substantial involvement in this program appears in the CDC Program

Support to Awardees Section.

2. Award Mechanism: U50

3. Fiscal Year: 2017

4. Approximate Total Fiscal Year Funding:

$1,000,000

5. Approximate Project Period Funding:

$5,000,000

This amount is subject to the availability of funds.

Estimated Total Funding: $5,000,000

6. Total Project Period Length:

5 year(s)

7. Expected Number of Awards:

8. Approximate Average Award:

$1,000,000 Per Budget Period

9. Award Ceiling: $0 Per Budget Period

This amount is subject to the availability of funds.

10. Award Floor: $0 Per Budget Period

11. Estimated Award Date: 09/30/2017

12. Budget Period Length: 12 month(s)

Throughout the project period, CDC will continue the award based on the availability of funds, the evidence of satisfactory progress by the awardee (as documented in required reports), and the determination that continued funding is in the best interest of the federal government. The total number of years for which federal support has been approved (project period) will be shown in the “Notice of Award.” This information does not constitute a commitment by the federal government to fund the entire period. The total project period comprises the initial competitive segment and any subsequent non-competitive continuation award(s).

13. Direct Assistance Direct Assistance (DA) is not available through this FOA.

CDC

Direct Assistance (DA) is not available through this FOA.

C. Eligibility Information

1. Eligible Applicants Eligibility Category: Others (see text field entitled "Additional Information on Eligibility" for clarification)

Additional Eligibility Category:

2. Additional Information on Eligibility This FOA is intended to be a single eligibility award.

3. Justification for Less than Maximum Competition The CDC and the Mexico Secretariat of Health have developed and strengthened ties during the past 9 years and have expressed mutual interest in putting in place this cooperative agreement to facilitate bi-national collaborations. The Secretariat of Health has made clear to CDC that the cooperative agreement funds cannot go directly to the Secretariat of Health because of major administrative barriers within the Government of Mexico system. The US Mexico Foundation for Science (FUMEC) was set up for just this purpose, to facilitate the movement of funds and to implement bi-national scientific and technology projects and programs. It is the only such bi-national organization with government sanction from both governments. Furthermore, the Mexico Secretariat of Health has directed CDC to use this organization and no other as the first intermediary for the cooperative agreement. CDC has worked with FUMEC previously in Mexico on the Border Infectious Disease Surveillance Program through the Epidemiology and Laboratory Capacity Cooperative Agreement funding bi-national surveillance activities with complete efficiency, transparency and accountability. Over the past 5 years, FUMEC has been exceptionally competent in the management of the CK11-1106 providing quality implementation and reporting services of the enhanced public health surveillance activities described under the scope of work, and administrative experience in the management of cooperative agreements with CDC. As an experienced non-profit bi-national organization they are uniquely qualified to work with our government institution and with the Mexican public health government and academic institutions, and follow the USG procurement and grants technical requirements. The impact of not using FUMEC for these continuation activities would be that there would be no ability to achieve protection of the health of the US population as working with the Mexico surveillance and control establishments would not be possible. This is significant as the U.S. and Mexico share the largest and most frequently crossed international land border in the world.

4. Cost Sharing or Matching Cost Sharing / Matching Requirement:

No

Cost sharing or matching funds are not required for this program.

5. Maintenance of Effort Maintenance of effort is not required for this program.

D. Application and Submission Information

CDC

1. Required Registrations An organization must be registered at the three following locations before it can submit an application for funding at www.grants.gov.

a. Data Universal Numbering System:

All applicant organizations must obtain a Data Universal Numbering System (DUNS) number. A DUNS number is a unique nine-digit identification number provided by Dun & Bradstreet (D&B). It will be used as the Universal Identifier when applying for federal awards or cooperative agreements.

The applicant organization may request a DUNS number by telephone at 1-866-705-5711 (toll free) or internet at http:// fedgov.dnb. com/ webform/ displayHomePage.do. The DUNS number will be provided at no charge.

If funds are awarded to an applicant organization that includes sub-awardees, those sub-awardees must provide their DUNS numbers before accepting any funds.

b. System for Award Management (SAM):

The SAM is the primary registrant database for the federal government and the repository into which an entity must submit information required to conduct business as an awardee. All applicant organizations must register with SAM, and will be assigned a SAM number. All information relevant to the SAM number must be current at all times during which the applicant has an application under consideration for funding by CDC.

If an award is made, the SAM information must be maintained until a final financial report is submitted or the final payment is received, whichever is later. The SAM registration process can require 10 or more business days, and registration must be renewed annually. Additional information about registration procedures may be found at www.SAM.gov.

c. Grants.gov:

The first step in submitting an application online is registering your organization at www.grants.gov, the official HHS E-grant Web site. Registration information is located at the “Get Registered” option at www.grants.gov.

All applicant organizations must register at www.grants.gov. The one-time registration process usually takes not more than five days to complete. Applicants should start the registration process as early as possible.

Step System Requirements Duration Follow Up

1 Data Universal Number System

(DUNS)

1. Click on http:// fedgov.dnb.com/ webform

2. Select Begin

DUNS

search/request process

3. Select your country or territory and follow the instructions to obtain your DUNS 9-digit #

4. Request appropriate staff member(s) to obtain DUNS number, verify & update information

1-2 Business Days

To confirm that you have been issued a new DUNS number check online at (http:// fedgov.dnb.com/ webform) or call 1-866-705-5711

CDC

Use Only http://www.grants.gov/ http://fedgov.dnb.com/webform/displayHomePage.do https://www.sam.gov/portal/public/SAM/ http://grants.gov/ http://www.grants.gov/ http://www.grants.gov/ http://www.grants.gov/ http://fedgov.dnb.com/webform http://fedgov.dnb.com/webform http://fedgov.dnb.com/webform http://fedgov.dnb.com/webform http://fedgov.dnb.com/webform http://fedgov.dnb.com/webform under DUNS number

2 System for Award Management

(SAM)

formerly Central Contractor Registration

(CCR)

1. Retrieve organizations DUNS number

2. Go to www.sam.gov and designate an E-Biz POC (note CCR username will not work in SAM and you will need to have an active SAM account before you can register on grants.gov)

3-5 Business Days but up to 2 weeks and must be renewed once a year

For SAM Customer Service Contact https://fsd.gov/ fsd-gov/ home.do Calls:

866-606-8220

3 Grants.gov 1. Set up an individual account in Grants.gov using organization new DUNS number to become an authorized organization representative

(AOR)

2. Once the account is set up the E-BIZ POC will be notified via email

3. Log into grants.gov using the password the

E-BIZ POC

received and create new password

4. This authorizes the AOR to submit applications on behalf of the organization

Same day but can take 8 weeks to be fully registered and approved in the system (note, applicants MUST obtain a DUNS number and SAM account before applying on grants.gov)

Register early! Log into grants.gov and check AOR status until it shows you have been approved

2. Request Application Package Applicants may access the application package at www.grants.gov.

CDC

Use Only http://www.sam.gov https://fsd.gov/fsd-gov/home.do https://fsd.gov/fsd-gov/home.do https://fsd.gov/fsd-gov/home.do

3. Application Package Applicants must download the SF-424, Application for Federal Assistance, package associated with this funding opportunity at www.grants.gov. If Internet access is not available, or if the online forms cannot be accessed, applicants may call the CDC OGS staff at 770-488-2700 or e-mail OGS ogstims@cdc.gov for assistance. Persons with hearing loss may access CDC telecommunications at TTY 1-888-232-6348.

4. Submission Dates and Times If the application is not submitted by the deadline published in the FOA, it will not be processed. Office of Grants Services (OGS) personnel will notify the applicant that their application did not meet the deadline.

The applicant must receive pre-approval to submit a paper application (see Other Submission Requirements section for additional details). If the applicant is authorized to submit a paper application, it must be received by the deadline provided by OGS.

a. Letter of Intent Deadline (must be emailed or postmarked by) Due Date for Letter of Intent: N/A

b. Application Deadline Due Date for Applications: 04/10/2017 , 11:59 p.m. U.S. Eastern Standard Time, at www.grants.gov. If Grants.gov is inoperable and cannot receive applications, and circumstances preclude advance notification of an extension, then applications must be submitted by the first business day on which grants.gov operations resume.

Date for Information Conference Call n/a

5. CDC Assurances and Certifications All applicants are required to sign and submit “Assurances and Certifications” documents indicated at http://wwwn.cdc.gov/ grantassurances/…