B01_SPCA_Attachment_1_Draft_Statement_of_Work_1.pdf

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

STATEMENT OF WORK (SERVICES)

(SOW)

GENERAL INFORMATION

Title of Project:

Proteome-wide Cellular Thermal Shift Assay (CETSA) analysis of RR-Hydroxynorketamine (RR-HNK).

Statement of Need and Purpose:

This requisition is for melt and shift curves over 4000 protiens to deconvolute the target of RR-

HNK.

Background Information and Objective:

The National Institutes of Health (NIH) is the nation’s leading medical research agency and the primary Federal agency whose mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability, conducting, supporting and making medical discoveries that improve people’s health and save lives. The National Center for Advancing Translational Sciences (NCATS) is a translational science center that prides itself on its tremendously productive pipeline and is innovative in a number of ways.

One of these ways is the development of new Bioactive Small Molecules which can modulate key biological pathways in multiple disease indications.

The Bioactive small molecule development project (1ZIATR000472), Start date FY 2023 is one of the key projects that progresses the study of RR-HNK from a mechanistic and pharmacological perspective.

In our ongoing work to deconvolute the molecular target of RR-HNK, this requistion aims to perform a proteome wide CETSA analysis aiming for melt and shit curves for 4000 protiens.

Period of Performance:

1. Period of performance is within five (5) months from the contract award

SCOPE OF WORK

General Requirements:

Independently and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified personnel, material, equipment, and facilities, not otherwise provided by the Government as needed to perform the Statement of Work below:

Specific Requirements:

In vitro CETSA analysis 5 mCi of R and S Ketamine and 2R,6R-HNK.

LEVEL OF EFFORT:

1 senior scientist and 1 research associate over 4 months.

GOVERNMENT RESPONSIBILITIES

Government will not furnish property, facilities, workspace, computers, or other equipment.

Contractor will not use federal facilities. Government will have the responsibility to review and approve the final report. Government will have the responsibility to provide sufficient quantities of the compounds in order to contractor to accomplish the necessary work

DELIVERY OR DELIVERABLES

Perform a proteome wide CETSA analysis aiming for melt and shit curves for 4000 protiens.

REPORTING REQUIREMENTS

Protien hit list and all accompanying data.

OTHER CONSIDERATIONS

Travel:

N/A

Key Personnel:

Information System Security Plan:

Data Rights:

All data will be considered confidential and the property of the government

Section 508—Electronic and Information Technology Standards:

Publications and Publicity:

Data will not be published without permission of the government

Confidentiality of Information:

Data will be kept confidential

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