B Sources Sought.pdf

Beta SAM.gov

SOURCES SOUGHT NOTICE

1. Solicitation Number: 75N95021Q00357

2. Title: Acquisition of five Molecular Devices ImageXpress Confocal High-Content

Imaging Systems and one FLIPR Penta high-throughput cellular screening system with customization and software

3. Classification Code: 6640 -- LABORATORY EQUIPMENT AND SUPPLIES

4. NAICS Code: 334516

5. Description: ANALYTICAL LABORATORY INSTRUMENT MANUFACTURING

This is a Sources Sought Notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of all qualified sources to perform a potential requirement.

This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only.

Background: The National Center for Advancing Translational Sciences (NCATS) seeks to purchase five Molecular Devices ImageXpress Confocal HT.ai High-Content Imaging Systems and one Molecular Devices FLIPR Penta high-throughput cellular screening system and associated robotics and reagents to address key technological needs for our labs. Our main screening robot has been using the FLIPR Tetra high-throughput cellular screening system for existing screening projects. The addition of this FLIPR Penta instrument will make it possible for program staff to perform state-of-the-art assays in these timely and extremely important scientific domains in a fully automated fashion.

As the program has developed and the need has arisen for a more sophisticated camera and software to meet additional screening demands, the FLIPR Tetra will be replaced by the newer FLIPR Penta camera and software, increasing capabilities as well as to bring it up to the specs of the offline FLIPR in the biolab which will be used for validating protocols prior to running them in an automated capacity on the main screening robot. If the 2 devices have different cameras and different software it will require additional work to set up an automated protocol on the FLIPR, the data quality would be decreased and methods would not be transferrable. The new camera and associated software must work in conjunction with the current FLIPR Tetra system. This equipment is necessary in order to meet the center's increased screening demands. The ImageXpress Confocal HT.ai High-Content Imaging Systems are going to be replacing our outdated GE InCell units which are no longer serviced or supported by the manufacturer. In order to provide continuity of science, we have to upgrade these units to avoid costly downtime in the future.

Purpose and Objectives: The purpose of this procurement is the acquisition of five Molecular Devices ImageXpress Confocal High-Content Imaging Systems and one FLIPR Penta high-throughput cellular screening system with customization and software, for use by NCATS.

Project requirements:

See Attachment A – Project Requirements for full list of required equipment.

Salient Characteristics:

The salient characteristics of the HS-EMCCD camera include:

• Real-time screening of iPSC-derived cardiomyocytes or neurons, GPCRs, and ion channels.

• High speed, high sensitivity EMCCD camera for both fluorescent and luminescent detection

• Data acquisition of up to 100 Hz (flourescence) and up to 2Hz (Luminescence)

• Peak Pro 2 analysis module with easy oscillation anomaly detection

• Over 30 peak measurement options

• Compatible with the FLIPR Tetra

• Able to operate with the FLIPR Tetra under a Molecular Devices service plan

The salient characteristics of the High- Content Imaging System include:

• Eight imaging channels with laser excitation enable more assay flexibility, higher image brightness, and will be able to use targeted imaging such as QuickID.

• Automated Water Immersion objectives offer greater numerical aperture and matched refractive index between the sample and the immersion media for enhanced resolution and decreased aberrations.

• Micro-lens enhanced spinning disk confocal provides a flat field of view for more accurate and reproducible image analysis.

• Shorter exposure times generate up to a two-fold boost in scan speed. FRET experiments using lasers for CFP and YFP expand research.

• IN Carta Image Analysis Software will perform complex segmentation and classification.

• Phenoglyphs will provide a robust trainable classification, and SINAP will provide trainable segmentation for any image type.

• Must accelerate analysis speeds by 40X with multi-threaded, parallel processing with MetaXpress® PowerCore Software. Will reduce time from hours to minutes, eliminating 3D analysis as a bottleneck.

Anticipated period of performance: One-time delivery to ship within 8-12 weeks after receipt of order.

Requested Response:

The intent of this sources sought notice is to define the procurement strategy (e.g. set-aside, sole source, unrestricted) for a solicitation that is intended to be posted soon.

Interested contractors are requested to respond by (1) identifying how their proposed product meets or exceeds the project requirements listed above; and (2) providing product literature, white papers, or capability statements that demonstrate their bona fide ability to supply such an item within the time frame described above.

In addition, please state your business size status and whether you are the manufacturer or authorized distributor of the item you propose.

Please note that NCATS is particularly interested in small business sources. If you are a small business, please state the type of small business (small business; HUBZone;

service-disabled, veteran-owned; 8(a); veteran-owned; woman-owned; or small disadvantaged businesses) and your size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible.

The respondent must also provide their DUNS number, organization name, address, point of contact, and size and type of business (e.g., 8(a), HubZone, etc.), pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements.

The information submitted must be must be in an outline format that addresses each of the elements of the project requirements and in the capability statement /information sought paragraphs stated herein. A cover page and an executive summary may be included but is not required.

The response must include the respondents’ technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses.

All responses to this notice must be submitted electronically to the Contracting Officer.

Facsimile responses are NOT accepted.

The response must be submitted to Kevin Alvarez, Contracting Officer, at e-mail address kevin.alvarez@nih.gov.

The response must be received on or before August 16, 2021, 9:00am, Eastern Time.

Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization’s qualifications to perform the work.

Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published at beta.SAM.gov. However, responses to this notice will not be considered adequate responses to a solicitation.

Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).

mailto:kevin.alvarez@nih.gov

Attachment A – Project Requirements

Line # Part Number Description Qty

1.00 IX CONFOCAL

HTAI-G

ImageXpress Confocal HT.ai High-Content Imaging System. Includes: 7-channel Laser Illumination source (405 nm, 445 nm, 475 nm, 520 nm, 555 nm, 640 nm, 730 nm), micro lens confocal launcher, filters for 8 channel detection (DAPI, CFP, FITC, YFP, TRITC, TxRed, Cy5, Cy7), 10X Plan Apo 0.5 NA objective, MetaXpress Imaging and Analysis software preloaded and configured on a Windows Acquisition computer with License to run 4 cores of MetaXpress PowerCore, MDCStore database and Microsoft SQL Express (10GB size-limited database), Toolkit with slide holder, and bead plate. 1 year warranty covering parts & labor.

1.01 1-6300-0121 OBJECTIVE, 4X, PLAN APO LAMBDA, 0.2 NA,

20mm WD

1.02 6500-0120 OBJECTIVE, 10X, PLAN APO LAMBDA, 0.45 NA,

4 mm WD

1.03 5038915 OBJECTIVE, 60X, PLAN APO LAMBDA, 0.95 NA,

0.11mm TO 0.21mm WD

1.04 1-6300-0412 OBJECTIVE, 40X, PLAN APO LAMBDA, 0.95 NA,

0.25mm TO 0.16mm WD, WITH CORRECTION

Line # Part Number Description Qty

1.05 5021413 STANDARD, MICROSOFT SQL SERVER, 64 Bit

License. Includes Licensing for 5 Device CAL ( Client Access License)

1.06 5041311G ImageXpress (IXM-Confocal, IXM-4 and IX- Nano ) ENVIRONMENT CONTROL OPTION, 120VAC, INCLUDES TEMPERATURE, CO2, AND

HUMIDITY.

1.07 5016604 Digital Confocal Option in MetaXpress Software. For any ImageXpress Micro model includes XLS, 4 and confocal Only.

1.08 5039730 ImageXpress Confocal Option. Includes: 8 position filter wheel, 5 position dichroic wheel, single disk unit allowing selection between 2 modes A) 60 micron pinhole disk for your basic confocal requirements B) widefield (not-confocal) imaging mode.

1.09 MX

ANALYSISPRE

MBUND

MetaXpress Analysis Premium Bundles Includes: MetaXpress Offline Analysis Software with MDCStore Database and MDCStoreTools Utility (5 SEATS) , Custom application module editor, any 15 Application modules and MDCStore Xchange

1.10 9500-0124M MetaXpress Offline Analysis Software with MDCStore Database and MDCStoreTools Utility

(5 SEATS; NETWORK)

1.11 9500-0042 CELL PROLIFERATION HT APPLICATION

MODULE (METAXPRESS)

1.12 9500-0041 Nuclear Translocation HT Application Module 1

1.13 9500-0016 Angiogenesis Application Module 1

1.14 9500-0037 Cell Scoring Application Module 1

1.15 9500-0017 Count Nuclei Application Module 1

1.16 9500-0043 Transfluor HT Application Module 1

Line # Part Number Description Qty

1.17 9500-0032 Granularity Application Module 1

1.18 9500-0034 Live/Dead Application Module 1

1.19 9500-0044 Multi Wavelength Translocation App Module 1

1.20 9500-0038 Multiwavelength Cell Scoring Application Module

1.21 9500-0035 Cell Health Application Module 1

1.22 9500-0045 Micronuclei Application Module 1

1.23 9500-0015 Neurite Outgrowth Application Module 1

1.24 9500-0033 Transfluor Application Module 1

1.25 9500-0040 Cell Cycle Application Module 1

1.26 5029333 27 INCH Monitor; 2560 X 1140 with >3 USB PORTs and multiple video INPUTS

1.27 5084788G Gas Mixer for ImageXpress Systems. Mixes CO2, O2, and Air. Flow and mixture are electronically controlled and stabilized for healthy and accurate long term time lapses of living cells.

1.28 5036753G Robot friendly plate holder for use with environmental control. Replaces standard plate holder inside of the ImageXpress system.

Line # Part Number Description Qty

2.00 IX CONFOCAL

HTAI-G

ImageXpress Confocal HT.ai High-Content Imaging System. Includes: 7-channel Laser Illumination source (405 nm, 445 nm, 475 nm, 520 nm, 555 nm, 640 nm, 730 nm), micro lens confocal launcher, filters for 8 channel detection (DAPI, CFP, FITC, YFP, TRITC, TxRed, Cy5, Cy7), 10X Plan Apo 0.5 NA objective, MetaXpress Imaging and Analysis software preloaded and configured on a Windows Acquisition computer with License to run 4 cores of MetaXpress PowerCore, MDCStore database and Microsoft SQL Express (10GB size-limited database), Toolkit with slide

2.01 1-6300-0121 OBJECTIVE, 4X, PLAN APO LAMBDA, 0.2 NA,

20mm WD

2.02 6500-0120 OBJECTIVE, 10X, PLAN APO LAMBDA, 0.45 NA,

4 mm WD

2.03 5038915 OBJECTIVE, 60X, PLAN APO LAMBDA, 0.95 NA,

0.11mm TO 0.21mm WD

2.04 1-6300-0412 OBJECTIVE, 40X, PLAN APO LAMBDA, 0.95 NA,

0.25mm TO 0.16mm WD, WITH CORRECTION

2.05 5021413 STANDARD, MICROSOFT SQL SERVER, 64 Bit License. Includes Licensing for 5 Device CAL ( Client Access License)

2.06 5041311G ImageXpress (IXM-Confocal, IXM-4 and IX- Nano ) ENVIRONMENT CONTROL OPTION, 120VAC, INCLUDES TEMPERATURE, CO2, AND

HUMIDITY.

2.07 5016604 Digital Confocal Option in MetaXpress Software. For any ImageXpress Micro model includes XLS, 4 and confocal Only.

2.08 5039730 ImageXpress Confocal Option. Includes: 8 position filter wheel, 5 position dichroic wheel, single disk unit allowing selection between 2 modes A) 60 micron pinhole disk for your basic confocal requirements B) widefield (not-confocal) imaging mode.

2.09 MX

ANALYSISPRE

MBUND

MetaXpress Analysis Premium Bundles Includes: MetaXpress Offline Analysis Software with MDCStore Database and MDCStoreTools Utility (5 SEATS) , Custom application module editor, any 15 Application modules and

Line # Part Number Description Qty MDCStore Xchange

2.10 9500-0124M MetaXpress Offline Analysis Software with MDCStore Database and MDCStoreTools Utility

(5 SEATS; NETWORK)

2.11 9500-0042 CELL PROLIFERATION HT APPLICATION

MODULE (METAXPRESS)

2.12 9500-0041 Nuclear Translocation HT Application Module 1

2.13 9500-0016 Angiogenesis Application Module 1

2.14 9500-0037 Cell Scoring Application Module 1

2.15 9500-0017 Count Nuclei Application Module 1

2.16 9500-0043 Transfluor HT Application Module 1

2.17 9500-0032 Granularity Application Module 1

2.18 9500-0034 Live/Dead Application Module 1

2.19 9500-0044 Multi Wavelength Translocation App Module 1

2.20 9500-0038 Multiwavelength Cell Scoring Application Module

Line # Part Number Description Qty

2.21 9500-0035 Cell Health Application Module 1

2.22 9500-0045 Micronuclei Application Module 1

2.23 9500-0015 Neurite Outgrowth Application Module 1

2.24 9500-0033 Transfluor Application Module 1

2.25 9500-0040 Cell Cycle Application Module 1

2.26 5029333 27 INCH Monitor; 2560 X 1140 with >3 USB PORTs and multiple video INPUTS

2.27 5084788G Gas Mixer for ImageXpress Systems. Mixes CO2, O2, and Air. Flow and mixture are electronically controlled and stabilized for healthy and accurate long term time lapses of living cells.

2.28 5036753G Robot friendly plate holder for use with environmental control. Replaces standard plate holder inside of the ImageXpress system.

3.00 IX CONFOCAL

HTAI-G

ImageXpress Confocal HT.ai High-Content Imaging System. Includes: 7-channel Laser Illumination source (405 nm, 445 nm, 475 nm, 520 nm, 555 nm, 640 nm, 730 nm), micro lens confocal launcher, filters for 8 channel detection (DAPI, CFP, FITC, YFP, TRITC, TxRed, Cy5, Cy7), 10X Plan Apo 0.5 NA objective, MetaXpress Imaging and Analysis software preloaded and configured on a Windows Acquisition computer with License to run 4 cores of MetaXpress PowerCore, MDCStore database and Microsoft SQL Express (10GB size-limited database), Toolkit with slide

3.01 1-6300-0121 OBJECTIVE, 4X, PLAN APO LAMBDA, 0.2 NA,

20mm WD

Line # Part Number Description Qty

3.02 6500-0120 OBJECTIVE, 10X, PLAN APO LAMBDA, 0.45 NA,

4 mm WD

3.03 5038915 OBJECTIVE, 60X, PLAN APO LAMBDA, 0.95 NA,

0.11mm TO 0.21mm WD

3.04 1-6300-0412 OBJECTIVE, 40X, PLAN APO LAMBDA, 0.95 NA,

0.25mm TO 0.16mm WD, WITH CORRECTION

3.05 5021413 STANDARD, MICROSOFT SQL SERVER, 64 Bit License. Includes Licensing for 5 Device CAL ( Client Access License)

3.06 5041311G ImageXpress (IXM-Confocal, IXM-4 and IX- Nano ) ENVIRONMENT CONTROL OPTION,

3.07 5016604 Digital Confocal Option in MetaXpress Software. For any ImageXpress Micro model includes XLS, 4 and confocal Only.

3.08 5039730 ImageXpress Confocal Option. Includes: 8 position filter wheel, 5 position dichroic wheel, single disk unit allowing selection between 2 modes A) 60 micron pinhole disk for your basic confocal requirements B) widefield (not-confocal) imaging mode.

3.09 MX

ANALYSISPRE

MBUND

MetaXpress Analysis Premium Bundles Includes: MetaXpress Offline Analysis Software with MDCStore Database and MDCStoreTools Utility (5 SEATS) , Custom application module editor, any 15 Application modules and MDCStore Xchange

3.10 9500-0124M MetaXpress Offline Analysis Software with MDCStore Database and MDCStoreTools Utility

(5 SEATS; NETWORK)

3.11 9500-0042 CELL PROLIFERATION HT APPLICATION

MODULE (METAXPRESS)

3.12 9500-0041 Nuclear Translocation HT Application Module 1

3.13 9500-0016 Angiogenesis Application Module 1

Line # Part Number Description Qty

3.14 9500-0037 Cell Scoring Application Module 1

3.15 9500-0017 Count Nuclei Application Module 1

3.16 9500-0043 Transfluor HT Application Module 1

3.17 9500-0032 Granularity Application Module 1

3.18 9500-0034 Live/Dead Application Module 1

3.19 9500-0044 Multi Wavelength Translocation App Module 1

3.20 9500-0038 Multiwavelength Cell Scoring Application Module

3.21 9500-0035 Cell Health Application Module 1

3.22 9500-0045 Micronuclei Application Module 1

3.23 9500-0015 Neurite Outgrowth Application Module 1

3.24 9500-0033 Transfluor Application Module 1

3.25 9500-0040 Cell Cycle Application Module 1

Line # Part Number Description Qty

3.26 5029333 27 INCH Monitor; 2560 X 1140 with >3 USB

PORTs and multiple video INPUTS

3.27 5084788G Gas Mixer for ImageXpress Systems. Mixes CO2, O2, and Air. Flow and mixture are electronically controlled and stabilized for healthy and accurate long term time lapses of living cells.

3.28 5036753G Robot friendly plate holder for use with environmental control. Replaces standard plate holder inside of the ImageXpress system.

4.00 IX CONFOCAL

HTAI-G

ImageXpress Confocal HT.ai High-Content Imaging System. Includes: 7-channel Laser Illumination source (405 nm, 445 nm, 475 nm, 520 nm, 555 nm, 640 nm, 730 nm), micro lens confocal launcher, filters for 8 channel detection (DAPI, CFP, FITC, YFP, TRITC, TxRed, Cy5, Cy7), 10X Plan Apo 0.5 NA objective, MetaXpress Imaging and Analysis software preloaded and configured on a Windows Acquisition computer with License to run 4 cores of MetaXpress PowerCore, MDCStore database and Microsoft SQL Express (10GB size-limited database), Toolkit with slide

4.01 1-6300-0121 OBJECTIVE, 4X, PLAN APO LAMBDA, 0.2 NA,

20mm WD

4.02 6500-0120 OBJECTIVE, 10X, PLAN APO LAMBDA, 0.45 NA,

4 mm WD

4.03 5021413 STANDARD, MICROSOFT SQL SERVER, 64 Bit License. Includes Licensing for 5 Device CAL ( Client Access License)

4.04 5041311G ImageXpress (IXM-Confocal, IXM-4 and IX- Nano ) ENVIRONMENT CONTROL OPTION,

4.05 5016604 Digital Confocal Option in MetaXpress Software. For any ImageXpress Micro model includes XLS, 4 and confocal Only.

4.06 5039730 ImageXpress Confocal Option. Includes: 8 position filter wheel, 5 position dichroic wheel, single disk unit allowing selection between 2 modes A) 60 micron pinhole disk for your basic confocal requirements B) widefield (not-confocal) imaging mode.

Line # Part Number Description Qty

4.07 MX

ANALYSISPRE

MBUND

MetaXpress Analysis Premium Bundles Includes: MetaXpress Offline Analysis Software with MDCStore Database and MDCStoreTools Utility (5 SEATS) , Custom application module editor, any 15 Application modules and MDCStore Xchange

4.08 9500-0124M MetaXpress Offline Analysis Software with MDCStore Database and MDCStoreTools Utility

(5 SEATS; NETWORK)

4.09 9500-0042 CELL PROLIFERATION HT APPLICATION

MODULE (METAXPRESS)

4.10 9500-0041 Nuclear Translocation HT Application Module 1

4.11 9500-0016 Angiogenesis Application Module 1

4.12 9500-0037 Cell Scoring Application Module 1

4.13 9500-0017 Count Nuclei Application Module 1

4.14 9500-0043 Transfluor HT Application Module 1

4.15 9500-0032 Granularity Application Module 1

4.16 9500-0034 Live/Dead Application Module 1

4.17 9500-0044 Multi Wavelength Translocation App Module 1

4.18 9500-0038 Multiwavelength Cell Scoring Application Module

Line # Part Number Description Qty

4.19 9500-0035 Cell Health Application Module 1

4.20 9500-0045 Micronuclei Application Module 1

4.21 9500-0015 Neurite Outgrowth Application Module 1

4.22 9500-0033 Transfluor Application Module 1

4.23 9500-0040 Cell Cycle Application Module 1

4.24 5076626 20X AND 40X WATER IMMERSION SYSTEM

INCLUDES 20X APO LWD 0.95 NA AND 40X APO

LWD 1.15 NA WATER IMMERSION OBJECTIVES

AND DISPENSER MODULE

4.25 5029333 27 INCH Monitor; 2560 X 1140 with >3 USB PORTs and multiple video INPUTS

4.26 5084788G Gas Mixer for ImageXpress Systems. Mixes CO2, O2, and Air. Flow and mixture are electronically controlled and stabilized for healthy and accurate long term time lapses of living cells.

4.27 5036753G Robot friendly plate holder for use with environmental control. Replaces standard plate holder inside of the ImageXpress system.

5.00 IX CONFOCAL

HTAI-G

ImageXpress Confocal HT.ai High-Content Imaging System. Includes: 7-channel Laser Illumination source (405 nm, 445 nm, 475 nm, 520 nm, 555 nm, 640 nm, 730 nm), micro lens confocal launcher, filters for 8 channel detection (DAPI, CFP, FITC, YFP, TRITC, TxRed, Cy5, Cy7), 10X Plan Apo 0.5 NA objective, MetaXpress Imaging and Analysis software preloaded and configured on a Windows Acquisition computer with License to run 4 cores of MetaXpress PowerCore, MDCStore database and Microsoft SQL Express (10GB size-limited database), Toolkit with slide

5.01 1-6300-0121 OBJECTIVE, 4X, PLAN APO LAMBDA, 0.2 NA,

20mm WD

5.02 6500-0120 OBJECTIVE, 10X, PLAN APO LAMBDA, 0.45 NA,

4 mm WD

5.03 5021413 STANDARD, MICROSOFT SQL SERVER, 64 Bit License. Includes Licensing for 5 Device CAL ( Client Access License)

5.04 5041311G ImageXpress (IXM-Confocal, IXM-4 and IX- Nano ) ENVIRONMENT CONTROL OPTION,

5.05 5016604 Digital Confocal Option in MetaXpress Software. For any ImageXpress Micro model includes XLS, 4 and confocal Only.

5.06 5039730 ImageXpress Confocal Option. Includes: 8 position filter wheel, 5 position dichroic wheel, single disk unit allowing selection between 2 modes A) 60 micron pinhole disk for your basic confocal requirements B) widefield (not-confocal) imaging mode.

5.07 MX

ANALYSISPRE

MBUND

MetaXpress Analysis Premium Bundles Includes: MetaXpress Offline Analysis Software with MDCStore Database and MDCStoreTools Utility (5 SEATS) , Custom application module editor, any 15 Application modules and MDCStore Xchange

5.08 9500-0124M MetaXpress Offline Analysis Software with MDCStore Database and MDCStoreTools Utility

(5 SEATS; NETWORK)

5.09 9500-0042 CELL PROLIFERATION HT APPLICATION

MODULE (METAXPRESS)

5.10 9500-0041 Nuclear Translocation HT Application Module 1

5.11 9500-0016 Angiogenesis Application Module 1

5.12 9500-0037 Cell Scoring Application Module 1

Line # Part Number Description Qty

5.13 9500-0017 Count Nuclei Application Module 1

5.14 9500-0043 Transfluor HT Application Module 1

5.15 9500-0032 Granularity Application Module 1

5.16 9500-0034 Live/Dead Application Module 1

5.17 9500-0044 Multi Wavelength Translocation App Module 1

5.18 9500-0038 Multiwavelength Cell Scoring Application Module

5.19 9500-0035 Cell Health Application Module 1

5.20 9500-0045 Micronuclei Application Module 1

5.21 9500-0015 Neurite Outgrowth Application Module 1

5.22 9500-0033 Transfluor Application Module 1

5.23 9500-0040 Cell Cycle Application Module 1

5.24 5076626 20X AND 40X WATER IMMERSION SYSTEM

INCLUDES 20X APO LWD 0.95 NA AND 40X APO

LWD 1.15 NA WATER IMMERSION OBJECTIVES

AND DISPENSER MODULE

Line # Part Number Description Qty

5.25 5029333 27 INCH Monitor; 2560 X 1140 with >3 USB

PORTs and multiple video INPUTS

5.26 5084788G Gas Mixer for ImageXpress Systems. Mixes CO2, O2, and Air. Flow and mixture are electronically controlled and stabilized for healthy and accurate long term time lapses of living cells.

5.27 5036753G Robot friendly plate holder for use with environmental control. Replaces standard plate holder inside of the ImageXpress system.

10.00 TL-LED-AWES Transmitted Light LED for IXM-C (red 630nm

LED) that enables brightfield imaging 4x-40x.

The LED is built-into the top door of the IXM Confocal.

11.00 5058774 TRANSMITTED LIGHT SEGMENTATION

APPLICATION MODULE

12.00 5047663 MetaXpress 3D Analysis Option. Requires custom module editor

13.00 5058772 CURVE FITTING APPLICATION MODULE 5

14.00 DD-CUSTOM Laser Safe Environment and Fluidics

Combination for Laser Light Source on IXM HT.ai. Technical Document Required.

15.00 CELLIMAGE-

TRAINING-OS

CELLULAR IMAGING INSTRUMENT TRAINING,

ONSITE, ONE DAY, MAX 4 PEOPLE

16.00 CELLIMAGE-

INSTALL-OS

CELLULAR IMAGING INSTRUMENT

INSTALLATION, ONSITE

17.00 IXC-HTAI-PM1-

OS

1PM ONSITE PERFORMANCE ASSURANCE

SERVICE PLAN FOR IMAGEXPRESS CONFOCAL

HTai

18.00 IXMC-WI-

PM1-OS

1PM ONSITE PERFORMANCE ASSURANCE

SERVICE PLAN FOR WATER IMMERSION

6.00 FLIPR PENTA FLIPR Penta System Includes: Win 10 Computer

Tip Washer Heated Stage 1 year warranty covering parts & labor. Requires: Standard, Aequorin or High-Speed Camera Pipettor Head Installation & Training.

6.01 NO CELL

SUSPEN

NO CELL SUSPENSION KIT, FLIPR 1

6.02 5073652 HIGH SPEED CAMERA, EMCCD, PENTA 1

6.03 0200-6073 FLIPR Penta or Tetra Pipettor Head Kit, 1536-well

6.04 0200-6072 FLIPR Penta or Tetra Pipettor Head Kit, 384-well

6.05 384 HOLDER

ASSY

FLIPR PENTA OR TETRA+ 384 pin tool holder.

Pin tool head and pins need to be purchased separately.

6.06 1536 HOLDER

ASSY

FLIPR PENTA OR TETRA+ 1536 pin tool holder.

Pin tool head and pins need to be purchased separately.

6.07 384 HEAD

ASSY

FLIPR PENTA OR TETRA+ 384 pin tool head kit.

Pin holder and pins need to be purchased separately.

6.08 1536 HEAD

ASSY

FLIPR PENTA OR TETRA+ 1536 pin tool head kit. Pin holder and pins need to be purchased separately.

6.09 1310-FP1NS10 PIN, SLOTTED, .457 DIA, 10NL, Set of Qty. 1540 1

6.10 1310-FP1NS50 PIN, SLOTTED, .457 DIA, 50NL, Set of Qty. 1540 1

6.11 1310-

FP3NS100

PIN, SLOTTED, .787 DIA, 100NL, Set of Qty. 388 1

Line # Part Number Description Qty

6.12 0200-6071 FLIPR Penta or Tetra Pipettor Head Kit, 96-well 1

6.13 5074364 FLIPR Cycler (previously TetraCycler) Factory installation.

6.14 0200-6207 FLIPR Penta or Tetra, Membrane Potential Optics Kit

19.00 5074843 ScreenWorks Peak Pro 2 Software Module.

Purchase delivers product key and instructions for activation of the software features within ScreenWorks Software.

20.00 5069580 FLIPR Tetra+ or Penta field camera update kit, EMCCD or ICCD to HS-EMCCD. Includes Win 10 computer.

21.00 PENTA96/384-

PM1-OS

1PM ONSITE PERFORMANCE ASSURANCE

SERVICE PLAN FOR FLIPR PENTA 96/384

22.00 DD-CUSTOM IonFields TipCharger 1536 Customization for

the FLIPR Includes installation

23.00 FLIPR-INSTALL-

OS

FLIPR INSTRUMENT INSTALLATION, ONSITE 2

24.00 FLIPR-

TRAINING-OS

FLIPR INSTRUMENT TRAINING, ONSITE, ONE

DAY, MAX 4 PEOPLE

7.00 IMAGEXPRESS

PICO EC

ImageXpress Pico EC System with CellReporterXpress Automated Image Acquisition and Analysis Software. Includes:

FLUOTAR 4X/NA 0.13 and 10x/NA 0.32 objectives, transmitted light capability, and FITC filter cube for fluorescence imaging.

Equipped with a solid state light source and optical train, a large imaging field of view is possible. Capable of incubation up to 40°C, CO2 control between ambient and 15%, O2 control between 1 and 15% and ambient O2, and humidity control for minimizing evaporation. Includes microtiter plate adapter and 4-slide adapter. CellReporterXpress Software license is included which enables 5 concurrent logins from a desktop or laptop with up to 2 logins from a tablet device per desktop login. License allows up to 10 computer cores to be run for distributed image

Line # Part Number Description Qty analysis. Standard image analysis algorithms include cell counting, cell scoring, apoptosis, and other analysis modules for a total of 17 analysis modules. License for Z-stack acquisition is included. System includes 1 year MDCare PhD Technical Support Plan, and 1-year warranty covering parts & labor.

7.01 5058414 ImageXpress Pico CellReporterXpress Small Form-Factor Workstation and Touchscreen Monitor: includes Windows 10 Pro workstation with 10 Core CPU, 32GB RAM, 1TB Solid State Drive, 2 network (NIC) ports, and a 24 inch touchscreen monitor.

7.02 GU 03 827 03 FLUOTAR 20x/NA 0.40 Objective 1

7.03 GU 03 826 04 Cy5 Filter Cube 1

7.04 GU 03 826 03 TRITC Filter Cube 1

7.05 GU 03 826 01 DAPI Filter Cube 1

7.06 GU 03 827 05 FLUOTAR 63x/NA 0.70 Objective 1

7.07 GU 03 827 04 FLUOTAR 40x/NA 0.60 Objective 1

8.00 IMAGEXPRESS

PICO EC

ImageXpress Pico EC System with CellReporterXpress Automated Image Acquisition and Analysis Software. Includes:

FLUOTAR 4X/NA 0.13 and 10x/NA 0.32 objectives, transmitted light capability, and FITC filter cube for fluorescence imaging.

Equipped with a solid state light source and optical train, a large imaging field of view is possible. Capable of incubation up to 40°C, CO2 control between ambient and 15%, O2 control between 1 and 15% and ambient O2, and humidity control for minimizing evaporation. Includes microtiter plate adapter and 4-slide adapter. CellReporterXpress Software license is included which enables 5 concurrent logins from a desktop or laptop with up to 2 logins from a tablet device per desktop login. License allows up to 10 computer cores to be run for distributed image analysis. Standard image analysis algorithms include cell counting, cell scoring, apoptosis, Line # Part Number Description Qty and other analysis modules for a total of 17 analysis modules. License for Z-stack acquisition is included. System includes 1 year

8.01 5058414 ImageXpress Pico CellReporterXpress Small

Monitor: includes Windows 10 Pro workstation with 10 Core CPU, 32GB RAM, 1TB Solid State Drive, 2 network (NIC) ports, and a 24 inch touchscreen monitor.

8.02 GU 03 827 03 FLUOTAR 20x/NA 0.40 Objective 1

8.03 GU 03 826 04 Cy5 Filter Cube 1

8.04 GU 03 826 03 TRITC Filter Cube 1

8.05 GU 03 826 01 DAPI Filter Cube 1

8.06 GU 03 827 05 FLUOTAR 63x/NA 0.70 Objective 1

8.07 GU 03 827 04 FLUOTAR 40x/NA 0.60 Objective 1

9.00 IMAGEXPRESS

PICO EC

ImageXpress Pico EC System with CellReporterXpress Automated Image Acquisition and Analysis Software. Includes:

FLUOTAR 4X/NA 0.13 and 10x/NA 0.32 objectives, transmitted light capability, and FITC filter cube for fluorescence imaging.

Equipped with a solid state light source and optical train, a large imaging field of view is possible. Capable of incubation up to 40°C, CO2 control between ambient and 15%, O2 control between 1 and 15% and ambient O2, and humidity control for minimizing evaporation. Includes microtiter plate adapter and 4-slide adapter. CellReporterXpress Software license is included which enables 5 concurrent logins from a desktop or laptop with up to 2 logins from a tablet device per desktop login. License allows up to 10 computer cores to be run for distributed image analysis. Standard image analysis algorithms include cell counting, cell scoring, apoptosis, and other analysis modules for a total of 17 analysis modules. License for Z-stack

Line # Part Number Description Qty acquisition is included. System includes 1 year

9.01 5058414 ImageXpress Pico CellReporterXpress Small

Monitor: includes Windows 10 Pro workstation with 10 Core CPU, 32GB RAM, 1TB Solid State Drive, 2 network (NIC) ports, and a 24 inch touchscreen monitor.

9.02 GU 03 827 03 FLUOTAR 20x/NA 0.40 Objective 1

9.03 GU 03 826 03 TRITC Filter Cube 1

9.04 GU 03 826 01 DAPI Filter Cube 1

9.05 GU 03 827 05 FLUOTAR 63x/NA 0.70 Objective 1

9.06 GU 03 827 04 FLUOTAR 40x/NA 0.60 Objective 1

9.07 GU 03 826 04 Cy5 Filter Cube 1

25.00 PICO-INSTALL-

OS

PICO INSTRUMENT INSTALLATION, ONSITE 3

26.00 IXPICOEC-

PM1-OS

1PM ONSITE PERFORMANCE ASSURANCE

SERVICE PLAN FOR IMAGEXPRESS PICO EC

27.00 9200-0016 Estimated Shipping & Handling ***Charges are determined at the time of order processing and could vary****