B SBSS 75N95022Q00172.pdf

SOURCES SOUGHT NOTICE

1. Sources Sought Number: 75N95022Q00172

2. Title: Purchase of JEOL JNM-ECZL400S NMR Spectrometer system with Royal

HFX NMR Probe, accessories, shipping, and installation (Brand-name or equal).

This is a COVID-19 related activity.

3. Classification Code: 6640 - Laboratory Equipment And Supplies

4. NAICS Code: 334516 - Analytical Laboratory Instrument Manufacturing

5. Description:

This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses;

or small disadvantaged businesses; (3) their size classification relative to the

North American Industry Classification System (NAICS) code for the proposed acquisition; and (4) availability of domestic sources manufactured in the United

States in sufficient and reasonably available commercial quantities and of a satisfactory quality. Your responses to the information requested will assist the

Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS may submitted a response to this notice.

This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the

Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only.

Background: The National Institutes of Health (NIH) is the nation’s leading medical research agency and the primary Federal agency whose mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability, conducting, supporting and making medical discoveries that improve people’s health and save lives.

NCATS is one of 27 Institutes and Centers at the NIH and its mission is to catalyze the generation of innovative methods and technologies that will enhance the development, testing and implementation of diagnostics and therapeutics across a wide range of human diseases and conditions. The NCATS DPI plans, conducts and uses both internal and contract resources to advance collaborative research projects across the preclinical phases of the translational science spectrum.

The NCATS DPI Analytical Chemistry Core (ACC) maintains a state-of-the-art laboratory whose mission is to support translational research throughout NCATS by providing analytical chemistry services involving the isolation, purification, identification and analysis of various therapeutic modalities for targeted disease states.

Moreover, NCATS has become a key partner in the Antiviral Program for Pandemics

(APP), a multi-agency initiative that includes National Institute of Allergy and Infectious

Diseases (NIAID) and Biomedical Advanced Research and Development Authority

(BARDA), to accelerate antiviral development through early discovery and preclinical development of safe and effective oral antivirals. The initial priority for the APP is to develop treatments for SARS-CoV-2 and other coronaviruses, with the program expanding to address other virus families with pandemic potential. NCATS will apply its proficiency in drug discovery and development and its cutting-edge technologies to fill critical needs of the APP, such as (i) target validation, (ii) high-throughput screening

(HTS) for drug starting points, (iii) medicinal chemistry for lead optimization, and (iv) preclinical, investigational new drug (IND)-enabling development.

Nuclear magnetic resonance (NMR) spectroscopy is arguably the most powerful analytical tool a chemist has at their disposal for the identification and confirmation of organic molecules. Medicinal chemists at DPI use the NMR instruments daily to collect compound data, as well as conduct more advanced NMR experiments overnight.

Constant access to fully functioning NMR instruments is imperative to maintain productivity in the successful pursuit of the DPI mission. Moreover, with chemical and pharmaceutical technologies continuing to evolve, NMR systems have improved and evolved to meet their needs. It is crucial that the medicinal chemists at DPI have access to the latest NMR technologies to streamline and simplify their analytical chemistry workflows. In this case, one of the ACC's NMR systems (NMR2) is approaching 15 years old, has components that are beginning to show substantial ware, and, consequently, is near end-of-life.

As such, the ACC seeks to replace NMR2 with a new NMR Spectrometer capable of simultaneously tuning to both fluorine (19F) and proton (1H) in a single high-frequency channel, effectively creating a three-channel NMR system with no additional hardware— this increases ACC’s NMR capabilities without increasing the total cost of the NMR system. Moreover, the NMR software shall integrate with the CRAFT (Complete

Reduction to Amplitude-Frequency Table) data processing on top of the standard NMR operating and data processing procedures. CRAFT is a tool that automatically and efficiently performs quantitative and statistical analyses in NMR systems.

Thus, without acquisition of the JEOL JNM-ECZL400S NMR Spectrometer system with

Royal HFX NMR Probe, accessories, shipping, and installation (Brand-name or equal), the ACC will be unable to advance NCATS capabilities aimed at meeting the support and resource needs of the APP and DPI.

Purpose and Objectives: The Analytical Chemistry Core (ACC), within the Division of

Preclinical Innovation (DPI) at the National Center for Advancing Translational Sciences

(NCATS) seeks to purchase a Waters ACQUITY UPLC I-Class PLUS Triple with QDa system (Brand-name or equal) in order to advance NCATS purification capabilities aimed at meeting the support and resource needs of the APP and DPI Chemistry.

Project Requirements: F For reference purposes, the 400 MHz NMR spectrometer that meets the need of this requirement is the JEOL JNM-ECZL400S NMR system with

Royal HFX NMR Probe, accessories, shipping, and installation.

See the attached Purchase Description for the complete list of brand-name items, descriptions, and salient characteristics.

Contract Type and Anticipated Period of Performance / Delivery Date: The

Government anticipates awarding a firm fixed-price purchase order under a future solicitation. The anticipated delivery date is within six (6) months after receipt of order

(ARO).

Delivery shall be made to the below address with FOB Destination. Shipping and handling shall be included in the quote.

National Center for Advancing Translational Sciences (NCATS), 9800 Medical Center Drive, Rockville, MD 20850

The installation and training shall be conducted on dates and times agreed upon by the vendor and the NCATS point of contact designated on the award.

In case domestic sources are available and capable of fulfilling the Government’s need, and a future solicitation is published, the Government will use evaluation preferences in accordance with FAR 25.

Capability statement /information sought. Respondents must provide clear and convincing documentation of their capability of providing the products specified in this sources sought notice.

Moreover, interested vendors must provide a capability statement for:

• the difficulty and/or feasibility of the potential requirement or proposed acquisition, possible solutions and approaches that may currently exist in the marketplace, and information regarding innovative ideas or concepts; and

• information regarding respondents’: (a) staff expertise, including their availability, experience, and formal and other training; (b) current in-house capability and capacity to perform the work; (c) prior completed projects of similar nature; (d) corporate experience and management capability; and (e) examples of prior completed Government contracts, references, and other related information.

• written capability statements should demonstrate organization’s capability to provide the brand-name or equal items listed in the Project Requirements section above. If the entity believes to be an authorized resellers of the brand-name product specified in this announcement or it desires to offer an equal product, the entity’s capability statement must include: (a) product, catalog, model, and/or part number(s); (b) product description; (c) all relevant information and documentation that the item(s) offered meets the salient physical, functional, or performance characteristics as specified in the Project Requirements section above; and country of manufacture of the product.

The respondent must also provide their DUNS number, organization name, address, point of contact, GSA Schedule (if any), and size and type of business (e.g., 8(a), HubZone, etc., pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements.

Submission Instructions:

One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2” x 11” paper size, with 1” top, bottom, left and right margins, and with single or double spacing.

The information submitted must be in and outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein. A cover page and an executive summary may be included but is not required.

The response is limited to ten (10) pages. The 10-page limit does not include the cover page, executive summary, or references, if requested.

The response must include the respondents’ technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses.

All responses to this notice must be submitted electronically to the Contract Specialist.

Facsimile responses are NOT accepted.

Responses must be received by 9:00 a.m., Eastern Time, on April 12, 2022, and reference Sources Sought Number 75N95022Q00172. Responses must be submitted by email to Renato Gomes, Contract Specialist, renato.gomes@nih.gov.

“Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The

Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this mailto:renato.gomes@nih.gov notice should ensure that its response is complete and sufficiently detailed to allow the

Government to determine the organization’s qualifications to perform the work.

Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation.

Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).”

Sources Sought Number: 75N95022Q00172

Purchase Description

For reference purposes, the 400 MHz NMR spectrometer that meets the need of this requirement is the JEOL JNM-ECZL400S NMR system with Royal HFX NMR Probe, accessories, shipping, and installation, as follows:

Item Part Number Description Qty

1 JNM-ECZL400S 400 MHz, 9.4 T NMR Spectrometer 1

2 NM-04890SCMYWSD NMR Magnet, 9.4T, Shielded, 54mm, Year Hold 1

3 NM-04620SB-K5-4S Vibration Damping Table for 400 MHz Magnet, Pneumatic

4 NMR-WS-PC Workstation 16GB mem, 2TB Disk, 2GB graphics 1

5 - Color Laser Printer, 22 ppm or equivalent 1

6 NM-80008HFXS 400MHZ 5MM FG/RO HFX DIGITAL AUTO TUNE

PROBE

7 NM-04920HOU4JY SPINNER HOUSING 400JJYH 1

8 NM-71190AT-4S AUTO TUNING UNIT 1

9 NM-51740DW10-4S 10L N2 Dewar 1

10 NM-05210ASC100 Auto Sample Changer for 400, 100 Samples 1

11 NM-SCH5D 5MM SAMPLE HOLDER 8 SET 13

12 AI-Table NMR Workstation Table 1

13 - Shipping and Installation 1

14 - Training 1

The salient characteristics of the NMR spectrometer system include:

• 400 MHz, 9.4 T NMR Spectrometer o NMR Pulse Programmer

▪ Pulse programming language with support for eight-dimensional data collection

▪ Automatic high-speed pulse sequence decomposition to identify and exploit parallelism within a pulse sequence

▪ Master timing sequencer unit with 5 ns timing resolution

▪ Minimum event time 20 ns depending on event

▪ 2 GB pulse sequence / waveform memory for shaped rf control o Spectrometer RF Generation System

▪ Modular RF backplane with sequencer bus controlling 8 frequency sources

▪ Two full-band transmitter modules covering 5 to 1,300 MHz with up to

▪ 159 dB attenuation, the final output frequencies are filtered appropriately to match the NMR spectrometer operational frequencies.

▪ With direct digital synthesis (DDS) units of the intermediate frequency (IF) with:

• 0.001 Hz offset frequency resolution

• 0° to 360° phase shift with 0.005° phase resolution

• 0 to 100% RF shape amplitude with 0.01% resolution

▪ 0 dB to 79 dB Step Attenuator with 1 dB step

▪ User-defined pulse shapes (phase, frequency, amplitude) including predefined pulse shapes (sinc, gauss, seduce, eburp, iburp, uburp, shifted laminar)

▪ User-defined decoupler modulations including pre-defined modulations (Waltz, Waugh, Garp, MPF, Wurst)

▪ Homonuclear and heteronuclear decoupling modes o NMR RF Power and Field Gradient Amplifiers

▪ Linear, class AB 50-watt RF power amplifier for high-band (365 to 430 MHz)

▪ Linear, class AB 150-watt RF power amplifier for low-band (10 to 170 MHz)

▪ Z-axis pulsed field gradient amplifier delivering 10-ampere current.

o Magnet Console and Preamplifiers

▪ Low noise GaAs high sensitivity preamplifier for high-band and low noise wideband SiGe preamplifier low-band frequencies

▪ Active transmit/receive duplexer

▪ Liquid cryogenic level monitoring system for helium and nitrogen

▪ Includes relay switching for automatic 2H gradient shimming o Digital Receiver

▪ Wide-band high sensitivity Digital Quadrature Detection receiver with 16 bit 100 MHz ADC digital IF with 64 bit signal averaging and phase and frequency offset control providing sweep widths from 50 Hz to 10 MHz o Lock and Shim System

▪ Deuterium internal digital lock system with computer-controlled auto-lock functions

▪ Gradient shimming capability using shim set Z1 gradient or PFG Z gradient

▪ Room temperature matrix shim system (25 shims) and power supply.

▪ Matrix shim design minimizes orthogonal shim interactions o AIR/VT System

▪ Computer controlled air controller for sample loading and spinning

▪ Variable temperature controller, range -170° C to +250° C in 0.1° C steps.

▪ (The operational VT range varies with the probe.)

▪ The NMR system includes a heater for operation above ambient temperature.

▪ An optional 10-liter LN2 Dewar kit is required for operation below ambient temperature.

o Spectrometer power supply, chassis, and table

▪ Single phase 100 to 240 V AC, 50/60 Hz, 15A

▪ Includes worktable for computer and printer o Software

▪ Comprehensive Delta FT-NMR Software including 1, 2, 3-D data acquisition, processing, display, and plotting for Microsoft Windows™ or Apple macOS™ operating systems

▪ Customer site-wide license for Delta NMR software

▪ JEOL "Flex Automation" automated 'point and click' NMR operation software with automatic gradient shimming, user-defined automation and data presentation

▪ Macro programming language

▪ DOSY data analysis and presentation.

• NMR Magnet, 9.4T, Shielded, 54mm, Year Hold o Shielded superconducting magnet solenoid, cryostat and cryo-shims with room temperature bore diameter of 54 mm operating at 9.39T providing NMR observation of 1H at 400MHz.

o 400/54/JJ/YH Performance Specifications:

▪ Field Drift: ≤ 4 Hz/hr

▪ Radial 5 Gauss Line: 0.5 m (19.7 in)

▪ Minimum Ceiling Height: ≥ 2.84 m (112 in)

▪ Helium Hold Time: ≥ 365 days

▪ Nitrogen Hold Time: ≥ 14 days o Includes: Liquid cryogenic level sensors for helium and nitrogen, liquid nitrogen braided stainless steel fill hose, and liquid helium transfer tube.

• Vibration Damping Table for 400 MHz Magnet, Pneumatic o Pneumatic Anti-Vibration Table for 400 MHz Magnet o Effective for:

▪ Vertical Vibration greater than 2 Hz

▪ Horizontal Vibration greater than 2.2 Hz o Note Resonance Conditions:

▪ Vertical 1.3 Hz

▪ Horizontal 1.5 Hz

• Workstation o Complete spectrometer control and data processing through a computer that equals or exceeds the following specifications:

▪ 3.0 GHz (4.4 GHz Turbo) 6 Core CPU, 16 Gbyte RAM, 2 Tbyte disk drive,

▪ 2 Gbyte color graphics card, 24" color flat screen display,

▪ DVD+/-RW drive, alphanumeric keyboard, optical mouse, and

▪ Microsoft Windows 10 Pro 64-bit operating system

• Printer o Color Laser Printer, 22 ppm or equivalent

• 400MHZ 5MM FG/RO HFX DIGITAL AUTO TUNE PROBE

o 5 mm high sensitivity ROYAL HFX NMR probe o Provides 1H{19F}, 19F{1H}, 13C{1H,19F}, and X{1H,19F} experiments with switchable magnet idler coil tuning and no performance loss in standard 1H or 19F mode.

o Coils optimized for proton, fluorine, and multinuclear observation and decoupling o Digital auto-tune and match ready, Z-axis pulsed field gradient coil, 2H lock o Nuclei include: 1H, 19F, 31P to 15N, 39K, and 109Ag o Variable Temperature operation from -100° C to +150°C

• AUTO TUNING UNIT

o Provides for automatic tuning and matching of compatible NMR probes with optimal sensitivity and pulse widths

• 10L N2 Dewar o For low temperature NMR operation (Ambient to -150° C) o Includes: Non-Magnetic 10 liter liquid nitrogen Dewar, Dewar Adapter with heater and LN2 Dewar filling tool.

• Auto Sample Changer for 400, 100 Samples o 100-position Auto-Sample changer for 400 MHz NMR systems ADA compliant sample access for height and reach o Mounts on lower magnet flange

• 5MM SAMPLE HOLDER 8 SET

o 8 each per pack, 5 mm Spinners for Liquids Samples

• Training o Initial customer training performed by installation personnel.

o Three days of on-site training with an NMR applications chemist after instrument acceptance.

• Shipping and Installation at NCATS Site o In-place delivery, setup, installation, and performance of specifications done in the customer's laboratory o Set of NMR reference standards for NMR tests and calibration

• Warranty o One year all parts and labor warranty.