B. Purchase_Description_MesoScale_12Jun25.doc
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- Attached to
- Multiplex Immunoassay Reader and Reagents
- Solicitation number
- 75N95025Q00262
About this file
This document is a Purchase Description for a Multiplex Immunoassay Reader and Reagents solicitation issued by the National Institutes of Health (NIH), specifically the National Institute on Drug Abuse. The procurement is for laboratory equipment to support neurogenetics research on neurodegenerative diseases, focusing on understanding sex differences in brain aging and disease risk. The specific purchase includes a MESO QuickPlex SQ 120MM Instrument (priced at $64,000), two R-PLEX Human MIS/AMH Assays ($3,462.90), and two U-PLEX Metabolic Combo 1 assays ($47,523.50), with total order cost of $115,436.40.
The solicitation (Number 75N95025Q00262) is a small business set-aside under NAICS code 334516, conducted using simplified acquisition procedures. Key technical requirements include an instrument with multiplexing capabilities for up to 10 assays per well, a dynamic range greater than 10^5, detection limits as low as 0.5-1 pg/ml, and a compact footprint of 14"x24"x22" or smaller. Delivery is expected within one month of purchase order completion, with a manufacturer's warranty of one calendar year. The research aims to investigate how hormonal fluctuations and sex chromosome dynamics influence brain aging and neurodegenerative disease risk across biological sexes.
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| File | Type | Posted |
|---|---|---|
| FAR 52.212-5 (Jan 2025).pdf | ||
| FAR_52.204-26_Oct_2020.pdf | ||
| FAR_52.204-24_Nov_2021.pdf |
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PURCHASE DESCRIPTION – MESO QuickPlex SQ 120MM Instrument
1. Statement of Need and Purpose: This acquisition is necessary to provide instrumentation and reagents to the Laboratory of Neurogenetics for neurodegenerative disease research for multiplexed immunoassay capabilities, specifically blood glycoproteins.
2. Background Information and Objective: imaging technology improves to capture Biological sex influences risk for neurodegenerative diseases (NDDs), with Alzheimer’s disease occurring more often in females and Parkinson’s disease occurring more often in males. Here, we propose to investigate how hormonal fluctuations (associated with menopause and andropause) and sex chromosome dynamics shape both sex differences and within-sex variability in brain aging and NDD risk. We will generate new blood-based endocrine measures and integrate these data with existing intramural and published single-nucleus RNA sequencing (snRNA-seq) datasets from various brain regions to examine how menopause stage, sex hormone concentrations, and sex chromosome loss contribute brain aging in specific brain cell types. Specifically, we will measure: 1) blood steroid hormones using high-performance liquid chromatography-mass spectrometry (HPLC-MS/MS) performed by OpAns, LLC; and 2) blood glycoproteins (FSH and AMH) using Enzyme-Linked Immunosorbent Assays (ELISAs) and an associated plate reader from Mesoscale Diagnostics, LLC. By sampling males and females across the reproductive aging period – including the menopause transition – this work can illuminate how hormonal fluctuations due to reproductive aging contribute to changes in brain gene expression in ways that may impact susceptibility to NDDs. Our findings will enhance our understanding of how sex-related mechanisms and aging interact to influence brain health, potentially revealing novel therapeutic targets for NDDs.
3. Generic Name of Product: Multiplex Immunoassay Reader and Reagents
4. Purchase Description:
| Item Description |
| Cat no |
| Quantity |
| Total Cost |
| MESO QuickPlex SQ 120MM Instrument |
| AI1AA-0 |
| 1 |
| $64,000.00 |
| R-PLEX Human MIS/AMH Assay, SECTOR (5 PL) |
| K15ARLR-2 |
| 2 |
| $3,462.90 |
| U-PLEX Metabolic Combo 1 (hu) SECTOR (5 PL) |
| K15281K-2 |
| 2 |
| $47,523.50 |
Shipping and Handling
$450.00
Order Total
$115,436.40
5. Salient characteristics All deliverables required under this contract shall be packaged, marked and shipped in accordance with Government specifications. At a minimum, all deliverables shall be marked with the contract number and Contractor name. The Contractor shall guarantee that all required materials shall be delivered in immediate usable and acceptable condition.
Vendor must be able to provide these specifications:
· Instrument must have multiplexing capabilities up to 10 assays per well
· Dynamic range of instrument must be greater than 105, with limits of detection as low as 005 – 1 pg/ml
· Due to laboratory space constraints, instrument must have a footprint equal to or lesser than 14”x24”x22”
· Must have plate stacking capabilities of up to 5 plates
· Detection must be measured via electrochemiluminescence and CCD camera
5. Quantity:
| Item Description |
| Cat no |
| Quantity |
| Total Cost |
| MESO QuickPlex SQ 120MM Instrument |
| AI1AA-0 |
| 1 |
| $64,000.00 |
| R-PLEX Human MIS/AMH Assay, SECTOR (5 PL) |
| K15ARLR-2 |
| 2 |
| $3,462.90 |
| U-PLEX Metabolic Combo 1 (hu) SECTOR (5 PL) |
| K15281K-2 |
| 2 |
| $47,523.50 |
Shipping and Handling
$450.00
Order Total
$115,436.40
6. Delivery Date: Delivery date of 1 month after receipt of completed purchase order
7. Period of Performance: Manufacturer warranty for one calendar year beginning date of receipt.
8. Option(s): Not applicable Version 11-30-2016-1
FAR Part 11—Describing Agency Needs
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