B. 5887143 - SOW 1.12.pdf

STATEMENT OF WORK

(SOW)

GENERAL INFORMATION

Title of Project:

Off-Site Storage for Frozen Compound Management Samples and Freezers for NCATS

Project Purpose or Objectives:

The objective is to procure off-site storage of 600 cubic feet of space in a -20 walk-in freezer to store samples and to store nine ultra-low temperature freezers where they will all be monitored 24/7.

Background Information:

The NCATS Chemical Genomics Center (NCGC) is tasked with identifying and developing novel small molecule leads against a wide spectrum of human disease targets, which it accomplishes by screening thousands of small molecules in collaboration with both intra- and extramural researchers. In pursuit of this goal, the Center has a strong internal transdisciplinary team of scientists who continually discover novel small molecules for application against a wide range of human diseases.

NCATS, through the Molecular Libraries Small Molecules Repository (MLSMR), acquired nearly 400,000 novel small molecules for testing in our quantitative high throughput screening (qHTS) platform. These molecules were purchased at great expense and have been used in qHTS over the past 10 years in over 4,000 assays. Over 46,000 of these molecules cannot be acquired commercially and are unique to this collection. It would require great expense and effort to reacquire all these molecules so they have been returned to NCATS at the close of the contract in March 2017. To maintain their integrity NCATS requires the compounds to continue to be stored at -20C. The samples are currently stored at the Kamtek facility located at 4851 International Blvd #102, Frederick, MD 21703 . The need to continue storing off-site is imperative until the new NCATS Compound Management lab space is constructed.

Also, NCATS lacks the space on-site to store the excess of ultra-low freezers and the contents are not required on site for daily operations. These nine freezers are currently located at this storage facility, which provides 24/7 REES monitoring and monthly reports sent directly to the POC to ensure that the contents are kept at temperature. The facility also ensures that a yearly preventative maintenance inspection and calibration is completed.

REES is a freezer monitoring company/service. They monitor whether a freezer is operating as well as whether it is outside of the temperature set point. If either of those two parameters is not met, an alarm email/text/phone call goes to the subscriber (Kamtek) to take action. The REES system also records temperature over time so a technician can see the long term performance of a freezer and if it might need service or if sample loss occurred because of a single event and when.

Period of Performance:

Base Period: February 1, 2021 – December 31, 2021 (11-months) Option Period One (1): January 1, 2022 – December 31, 2022 (12-months)

SCOPE OF WORK

General Requirements:

Independently and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified personnel, material, equipment, and facilities, not otherwise provided by the Government as needed to perform the Statement of Work below:

Specific Requirements:

The Contractor shall:

• provide constantly monitored freezer space in an off-site facility.

• provide storage space for nine ultra-low freezers with constant monitoring

• provide annual preventative maintenance and calibration of nine freezer

The walk-in storage area must be temperature controlled to hold samples at a constant temperature not to exceed -20 Celsius. There must be logs kept of the temperature in the walk-in cold room 24 hours a day which can be provided to NCATS at our request. Any issues with temperature control shall be immediately reported to NCATS so NCATS may assess any sample degradation. Facility must provide uninterrupted power supply and REES alarm monitoring for all freezers and walk-in space utilized by

NCATS.

Facility must be cGMP compliant, strictly following ISBER and NCI "Best Practices

Level of Effort:

GOVERNMENT RESPONSIBILITIES

NCATS will provide to the contractor pre-packaged and pre-inventoried samples in appropriately sized containers to fit properly on the shelving. NCATS will also provide nine ultra-low freezers.

DELIVERY OR DELIVERABLES

Any temperature verification reports, documentation of calibrations, preventative maintenance, or repairs done on the walk-in freezer and ultra-low freezers. Timely submission of deliverables is essential to successful completion of this requirement. Deliverables are to be submitted in “electronic copy” to shinnp@mail.nih.gov.

REPORTING REQUIREMENTS

Contractor to provide any temperature verification reports, documentation of calibrations, preventative maintenance, or repairs done on the walk-in freezer and ultra-low freezers.

TRAVEL

N/A

KEY PERSONNEL

OTHER CONSIDERATIONS

Information System Security Plan:

Data Rights:

Section 508—Electronic and Information Technology Standards:

N/A

Publications and Publicity:

N/A

Confidentiality of Information: