B.10 Presolicitation Notice.pdf

Document Type: Presolicitation Notice

Solicitation No. 75N95022Q00277

Project No. N01DA-23-8936

Project Title: Rodent Behavioral Models to Identify Substance Use Disorder

Pharmacotherapies

Classification Code: AN11—Research & Development

NAICS Code: 541715 – Research and Development in Physical, Engineering and

Life Sciences (except Biotechnology)

Contracting Office Address

NIDA Contracts Management Branch Red, NIDA Section

National Institute on Drug Abuse (NIDA), Office of Acquisitions

National Institutes of Health c/o 3WFN MSC 6012

301 N STONESTREET AVE

BETHESDA MD 20892

Description

NIDA intends to solicit proposals for preclinical evaluation of test compounds as potential pharmacotherapies for substance abuse. To this end, the offeror and technical personnel need to have the capability and experience to conduct experiments evaluating compounds in the mouse locomotor activity, rat drug discrimination, rat conditioned place preference, mouse stressed inducted potentiation of conditioned place preference, and rat self administration paradigms. The offeror and technical staff also need to have experience conducting these types of experiments using cocaine, methamphetamine, nicotine, THC, and hallucinogens. Evidence of experience must be documented through publications using the relevant behavioral models listed above. In addition, the offeror needs to have the dedicated laboratory space, animal care facilities, and equipment required to conduct these behavioral assays. Proprietary compounds will be evaluated using established protocols, and the resulting data will be utilized by the Addiction

Treatment Discovery Program (ATDP) of the NIDA Division of Therapeutics and

Medical Consequences (DTMC).

MANDATORY REQUIREMENTS

Listed below are mandatory qualification criteria. The qualification criteria establish conditions that must be met at time of receipt of proposals in order for your proposal to be considered any further for award.

• DEA RESEARCH REGISTRATION: This project involves the use of scheduled drugs under the Controlled Substances Act of 1970. Due to the nature of the compounds which will be evaluated under this contract, it is mandatory that the Offeror possess, at the time of proposal submission, a DEA Research Registration for Schedules II to V in order to handle substances under the Controlled Substances Act of 1970. In addition, the successful offeror must possess a DEA registration for Schedule I controlled substances at the time of proposal submission.

• ANIMAL WELFARE: This research involves the use of animals. The Offeror must demonstrate its understanding and compliance with the NIH Guide for Care and

Use of Laboratory Animals. The Offeror shall submit evidence that its proposal was reviewed and approved by the Institution's Animal Care and Use Committee (IACUC) and that the Institution has an Animal Welfare Assurance on file with the Office of

Extramural Research (OER), Office of Laboratory Animal Welfare (OLAW). The

Assurance number shall be provided with the proposal. This policy is also available on the internet at http://www.grants.nih.gov/grants/olaw/olaw.htm.

NIDA anticipates the award of a single fixed-price level of effort contract with a base period of six months and four one-year option periods. The use of option quantities may also be included.

The RFP will be available electronically on or about September 6, 2022. You can access the RFP through the SAM.gov or through the NIDA website: (URL:

http://www.drugabuse.gov/funding/funding-opportunities/nida-requests-contract-proposals-rfps). All information required for the submission of a proposal will be contained in or accessible through the RFP package. Responses to the RFP will be due 30 days from the release date. NIDA will consider proposals submitted by any responsible offeror. This advertisement does not commit the Government to award a contract.

Based upon market research, the Government is not using the policies contained in Part

12, Acquisition of Commercial Items, in its solicitation for the described supplies or services. However, interested persons may identify to the Contracting Officer their interest and capability to satisfy the Government's requirement with a commercial item within 15 days of this notice.

Points of Contact

Primary Point of Contact:

Scott Duernberger

Contract Specialist scott.duernberger@nih.gov

Phone: (301) 594-0670

Secondary Point of Contact:

Josh Lazarus

Contracting Officer http://www.grants.nih.gov/grants/olaw/olaw.htm mailto:Llakim.dubroff@nih.gov

Josh.lazarus@nih.gov

Phone: (301) 827-6923 mailto:Josh.lazarus@nih.gov