Attachment No. 8 Business Proposal Budget Templates..xlsx

XLSX spreadsheet 43 KB Posted

Attached to
Pharmacology and Toxicology for Therapeutics Program (PTTP) Federal contract opportunity
Solicitation number
NIH-NINDS-75N95021R00017
Issued by
Department of Health and Human Services National Institutes of Health National Institute on Drug Abuse

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This document contains budget templates and cost summaries for a federal contract supporting the Pharmacology and Toxicology for Therapeutics Program. The contract involves management and operations support, as well as pharmacology and toxicology studies including rodent and non-rodent pharmacokinetic assessments, dose range findings, toxicology package development, and in vitro absorption, distribution, metabolism, excretion and toxicity panel screening. Templates provide formats for fixed price proposals on management support, individual study types and an overall program estimate assuming target numbers of studies annually. The National Institute of Neurological Disorders and Stroke is seeking these services to support preclinical assessment of potential new drug candidates under solicitation number NIH-NINDS-75N95021R00017.

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Other files for this federal contract opportunity

Other files attached to Pharmacology and Toxicology for Therapeutics Program (PTTP), newest first.
File Type Posted
Amendment 0001 - PTTP RampOn QandA.pdf PDF
RFP NIH-NINDS-75N95021R00017 PTTP Ramp-On-S.pdf PDF
Attachment No. 20 Financial Quest.pdf PDF
Attachment No. 11 Disclosure of Lobbyin.pdf PDF
Attachment No. 10 Offer Pts of Contact.pdf PDF
Attachment No. 7 Propos SummaryNIH-204.pdf PDF
Attachment No. 4 Technical Proposal Budget Templates.xlsx XLSX spreadsheet
Attachment No. 1 Pack and Delivery of Proposal.pdf PDF
Attachment No. 19 Employ Sep.pdf PDF
Attachment No. 16 Electronic Invoicing Instructions 20210210.pdf PDF
Attachment No. 15 NIH (RC)-4.pdf PDF
Attachment No. 14 NIH(RC)-2-2.pdf PDF
Attachment No. 13 Section K Reps.pdf PDF
Attachment No. 12 NIH Customer Perf.pdf PDF
Attachment No. 9 subcontractplan revised 2017.pdf PDF
Attachment No. 6 VAScontracts worksheet.pdf PDF
Attachment No. 3 Statement of Work.pdf PDF
Attachment No. 23 Privacy Act SORN 09-25-0124.pdf PDF
Attachment No. 17 Nondisclosure.pdf PDF
Attachment No. 22 Wage Determination March 2021.pdf PDF
Attachment No. 21 Project Obj.pdf PDF
Attachment No. 18 SuitabilityRoster.xlsx XLSX spreadsheet
Attachment No. 5 Summary of Related Activities.pdf PDF
Attachment No. 2 Propsal Intent Response Sheet.pdf PDF
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Contract Kick-Off Meeting Business Proposal Budget Template - Attachment #8a

Sample Task Order 1(a): Contract Kick-Off Meeting

Contract Type: Firm-Fixed-Price

Base Month
% effort or # of hoursRateTotal
Labor Costs - (List individuals by name / labor category. Indicate hourly rate or rate equivalent for each.)
Project Director/Principal Investigator$$
Senior Professional Information Technology$$
Administrative Operations Coordinator$$

Subtotal $

Fringe Benefits *% $

Subtotal Labor & Fringe $

Labor Overhead *% $

Other Direct Costs (List as Necessary)

Materials & Supplies$
Consultants$
Travel$

Subtotal Other Direct Costs $

Subtotal Labor/Fringe, Labor Overhead & Direct Costs $

General & Administrative Cost *% $

Subtotal: Labor, Direct Costs, Overhead, G&A $

Fee $

Total Firm-Fixed-Price$
*Include and cite % rates for fringe benefits, labor overhead, and G&A as appropriate to your organization.
Also, provide a copy of your organization's most recent Negotiated Indirect Cost Rate Agreement with cognizant Government Agency

PA 1 Summary Business Proposal Budget Template - Attachment #8b

Sample Task Order 1(b): Performance Area 1 - Management and Operations Support

Contract Type: Fixed-Price

SCHEDULE OF CHARGES FOR PERFORMANCE AREA 1

Description of ItemUnitPeriod of PerformancePrice/UnitUnitsTotal Price
Performance Area 1, "Management and Operations Support"MonthDate of Award - 09/12/2021$2$

Performance Area 1, "Management and Operations Support" Month 09/13/2021 - 09/12/2022 $ 12 $

Performance Area 1, "Management and Operations Support" Month 09/13/2022 - 09/12/2023 $ 12 $

Performance Area 1, "Management and Operations Support" Month 09/13/2023 - 09/12/2024 $ 12 $

Performance Area 1, "Management and Operations Support" Month 09/13/2023 - 09/12/2024 $ 12 $

Performance Area 1, "Management and Operations Support" Month 09/13/2025 - 09/12/2026 $ 12 $

Total Price $

PA 1 Breakdown Business Proposal Budget Template - Attachment #8c

Sample Task Order 1(b): Performance Area 1 - Management and Operations Support

Contract Type: Fixed-Price

Breakdown by Month (Base Year)
^Est. Monthly % effort or # of hoursMonthly RateTotal
Labor Costs - (List individuals by name / labor category. Indicate hourly rate or rate equivalent for each.)
Project Director/Principal Investigator0.83% or 17.5 hours$$
Senior Professional Information Technology0.42% or 8.75 hours$$
Administrative Operations Coordinator0.17% or 3.5 hours$$

Subtotal $

Fringe Benefits *% $

Subtotal Labor & Fringe $

Labor Overhead *% $

Other Direct Costs (List as Necessary)

Materials & Supplies$
Consultants$
Travel: 1 Trip by PI to NIH/BethesdaEst. 1/12 of 1 trip per year or option term$

Subtotal Other Direct Costs $

Subtotal Labor/Fringe, Labor Overhead & Direct Costs $

General & Administrative Cost *% $

Subtotal: Labor, Direct Costs, Overhead, G&A $

Fee $

Fixed Price per Month$
^Estimated Annual % Effort or # Hours is: Principal Investigator/Project Director 10% or 210 hours; Senior Professional Information Technology 5% or 105 hours; Administrative Operation Coordinator 2% or 42 hours
*Include and cite % rates for fringe benefits, labor overhead, and G&A as appropriate to your organization.
Also, provide a copy of your organization's most recent Negotiated Indirect Cost Rate Agreement with cognizant Government Agency

PA 2 Summary

COST SUMMARY FOR PERFORMANCE AREA 2 - PHARMACOLOGY AND TOXICOLOGY STUDIESATTACHMENT #8d
ASSUMPTIONS: It is estimated that 10 lead optimization stage projects and 5 GLP stage projects will be competed and awarded during each year of the 10 year contract program. The mix of study types and numbers typically conducted for each lead optimization stage and development/GLP stage project is as follows:
Lead Optimization Stage Project - 10 Projects Per Year - Estimated Mix & Number of Study Types Per Individual Project:COST PER STUDY# PER PROJECT# PROJECTS PER YEARYEARLY ESTIMATE
Single Dose Rodent (Rat) Pharmacokinetic Study – 5$510$
Single Dose Dog Pharmacokinetic Study – 2$210$
Multi-Dose Rodent (Rat) Pharmacokinetic Study – 2$210$
Rodent (Rat) Dose Range Finding Study – 1$110$
Non-Human Primate Dose Range Finding Study - 1$110$

Yearly Estimate for Lead Optimization Stage $

Development/GLP Stage Project - 5 Projects Per Year - Estimated Mix & Number of Study Types Per Individual Project: COST PER STUDY # PER PROJECT # PROJECTS PER YEAR YEARLY ESTIMATE

IND Toxicology and Safety Pharmacology package (includes chronic toxicity studies in two species, Safety Pharmacology (CNS, cardiovascular, pulmonary), genotoxicity assessment, and hERG activity assessment) – 1 $ 1 5 $

Yearly Total for Lead Optimization Stage and Development/GLP Components $

Single Dose Rodent (Rat) PK Performance Area 2 - Pharmacology and Toxicology Studies ATTACHMENT #8e

Single Dose Rodent (Rat) Pharmacokinetic Study Budget Template
% effort or # of hoursRate / QuantityTotal
Labor Costs - (List individuals by name / labor category. Indicate hourly rate or rate equivalent for each.)
$
$
$

Subtotal $

Fringe Benefits *% $

Subtotal Labor & Fringe $

Labor Overhead *% $

Other Direct Costs (List and Itemize as Necessary)

Subtotal Other Direct Costs $

Subtotal Labor/Fringe, Labor Overhead & Direct Costs $

General & Administrative Cost *% $

Subtotal: Labor, Direct Costs, Overhead, G&A $

Fee $

Total Estimated Cost Plus Fee$
*Include and cite % rates for fringe benefits, labor overhead, and G&A as appropriate to your organization.
Also, provide a copy of your organization's most recent Negotiated Indirect Cost Rate Agreement with cognizant Government Agency

Single Dose Dog PK Performance Area 2 - Pharmacology and Toxicology Studies ATTACHMENT #8f

Single Dose Dog Pharmacokinetic Study Budget Template
% effort or # of hoursRate / QuantityTotal
Labor Costs - (List individuals by name / labor category. Indicate hourly rate or rate equivalent for each.)
$
$
$

Subtotal $

Fringe Benefits *% $

Subtotal Labor & Fringe $

Labor Overhead *% $

Other Direct Costs (List and Itemize as Necessary)

Subtotal Other Direct Costs $

Subtotal Labor/Fringe, Labor Overhead & Direct Costs $

General & Administrative Cost *% $

Subtotal: Labor, Direct Costs, Overhead, G&A $

Fee $

Total Estimated Cost Plus Fee$
*Include and cite % rates for fringe benefits, labor overhead, and G&A as appropriate to your organization.
Also, provide a copy of your organization's most recent Negotiated Indirect Cost Rate Agreement with cognizant Government Agency

Multi-Dose Rodent (Rat) PK Performance Area 2 - Pharmacology and Toxicology Studies ATTACHMENT #8g

Multi-Dose Rodent (Rat) Pharmacokinetic Study Budget Template
% effort or # of hoursRate / QuantityTotal
Labor Costs - (List individuals by name / labor category. Indicate hourly rate or rate equivalent for each.)
$
$
$

Subtotal $

Fringe Benefits *% $

Subtotal Labor & Fringe $

Labor Overhead *% $

Other Direct Costs (List and Itemize as Necessary)

Subtotal Other Direct Costs $

Subtotal Labor/Fringe, Labor Overhead & Direct Costs $

General & Administrative Cost *% $

Subtotal: Labor, Direct Costs, Overhead, G&A $

Fee $

Total Estimated Cost Plus Fee$
*Include and cite % rates for fringe benefits, labor overhead, and G&A as appropriate to your organization.
Also, provide a copy of your organization's most recent Negotiated Indirect Cost Rate Agreement with cognizant Government Agency

Rodent (Rat) Dose Range Finding Performance Area 2 - Pharmacology and Toxicology Studies ATTACHMENT #8h

Rodent (Rat) Dose Range Finding Study Budget Template
% effort or # of hoursRate / QuantityTotal
Labor Costs - (List individuals by name / labor category. Indicate hourly rate or rate equivalent for each.)
$
$
$

Subtotal $

Fringe Benefits *% $

Subtotal Labor & Fringe $

Labor Overhead *% $

Other Direct Costs (List and Itemize as Necessary)

Subtotal Other Direct Costs $

Subtotal Labor/Fringe, Labor Overhead & Direct Costs $

General & Administrative Cost *% $

Subtotal: Labor, Direct Costs, Overhead, G&A $

Fee $

Total Estimated Cost Plus Fee$
*Include and cite % rates for fringe benefits, labor overhead, and G&A as appropriate to your organization.
Also, provide a copy of your organization's most recent Negotiated Indirect Cost Rate Agreement with cognizant Government Agency

Non-Human Primate Dose Range Performance Area 2 - Pharmacology and Toxicology Studies ATTACHMENT #8i

Non-Human Primate (NHP) Dose Range Finding Study Budget Template
% effort or # of hoursRate / QuantityTotal
Labor Costs - (List individuals by name / labor category. Indicate hourly rate or rate equivalent for each.)
$
$
$

Subtotal $

Fringe Benefits *% $

Subtotal Labor & Fringe $

Labor Overhead *% $

Other Direct Costs (List and Itemize as Necessary)

Subtotal Other Direct Costs $

Subtotal Labor/Fringe, Labor Overhead & Direct Costs $

General & Administrative Cost *% $

Subtotal: Labor, Direct Costs, Overhead, G&A $

Fee $

Total Estimated Cost Plus Fee$
*Include and cite % rates for fringe benefits, labor overhead, and G&A as appropriate to your organization.
Also, provide a copy of your organization's most recent Negotiated Indirect Cost Rate Agreement with cognizant Government Agency

IND Toxicology Package Performance Area 2 - Pharmacology and Toxicology Studies ATTACHMENT #8j

Investigational New Drug (IND) Toxicology Package Budget Template
% effort or # of hoursRate / QuantityTotal
Labor Costs - (List individuals by name / labor category. Indicate hourly rate or rate equivalent for each.)
$
$
$

Subtotal $

Fringe Benefits *% $

Subtotal Labor & Fringe $

Labor Overhead *% $

Other Direct Costs (List and Itemize as Necessary)

Subtotal Other Direct Costs $

Subtotal Labor/Fringe, Labor Overhead & Direct Costs $

General & Administrative Cost *% $

Subtotal: Labor, Direct Costs, Overhead, G&A $

Fee $

Total Estimated Cost Plus Fee$
*Include and cite % rates for fringe benefits, labor overhead, and G&A as appropriate to your organization.
Also, provide a copy of your organization's most recent Negotiated Indirect Cost Rate Agreement with cognizant Government Agency

In-Vitro ADMET Panel Performance Area 2 - Pharmacology and Toxicology Studies ATTACHMENT #8k

In-Vitro ADMET Panel Budget Template
% effort or # of hoursRate / QuantityTotal
Labor Costs - (List individuals by name / labor category. Indicate hourly rate or rate equivalent for each.)
$
$
$

Subtotal $

Fringe Benefits *% $

Subtotal Labor & Fringe $

Labor Overhead *% $

Other Direct Costs (List and Itemize as Necessary)

Subtotal Other Direct Costs $

Subtotal Labor/Fringe, Labor Overhead & Direct Costs $

General & Administrative Cost *% $

Subtotal: Labor, Direct Costs, Overhead, G&A $

Fee $

Total Estimated Cost Plus Fee$
*Include and cite % rates for fringe benefits, labor overhead, and G&A as appropriate to your organization.
Also, provide a copy of your organization's most recent Negotiated Indirect Cost Rate Agreement with cognizant Government Agency

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