Attachment 2 - FFRDC Statement of Work Metrics.xlsx
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FAR info Source Selection Information See FAR 2.101 and FAR 3.104
Metrics-composite
| Technical Services & Capabilities | Metrics (number of activities or projects per year) | Notes |
| Advanced scientific computing and bioinformatics | Maintain 2 data coordinating centers |
Maintain the NCI Cancer Research Data Commons and its associated nodes, including data curation, quality assurance, and establishing new nodes (with CBIIT)
Number of projects encompassing the following activities ≈ 500
- Engineer, install, configure, and maintain the scientific research computing environment based on modern HPC CPU and GPU nodes
- Support and enhance the computing environment (Data analysis pipelines)
- Cloud computing (Adopt and migrate plans, cloud application design and cloud management and monitoring)
- Maintain and support bioinformatics tools and databases, e.g., gene sequencing
- Provide software tools and computational algorithms to collect, integrate, analyze, visualize, and interpret data
- Statistical design of experiments; data mining & knowledge discovery techniques; data workflow applications dev
- Scientific web development
- Develop and deploy web applications to support lab logistics and FNL business operations.
- AI, Machine learning and/or Deep learning
- Computational modeling, e.g., prediction of drug properties, molecular dynamics simulations, digital pathology
- Quality assurance and control of software and data, e.g., harmonization of new and existing data
- Bioinformatics Training (BTEP)
- Bioinformatics Analysis Animal sciences Animal cages: 2.3 million, including 350 non-human primate cages Mice: ~625,000 Rats: ~650 ~275 investigators supported and ~600 Active ASPs Animal Research & Tech Support project: ~30,000, including species identification and technical support for colony maintenance and experimentation.
Gnotobiotics Animal Science project: ~2000 Genetically-engineered mouse models generated: ~65K mice STR profiling assays: 3500 Assay development and execution Clinical trial support CLIA assays (domestic): 5,000 samples Clinical trial support CLIA assays (ex-US): 30,000 sanples Clinical trial support Research Use Only (RUO) assays: 22,000 samples
| Preclinical RUO assays: 8,000 samples | Includes serology assays and multiple assay formats. "Preclinical" includes basic and translational research phases. Nucleic acid-based assays are covered primarily under Molecular Biology. | |
| Biospecimen processing | DNA extractions: 35,000 |
Clinical sample processing: 30,000 Aliquoting: 2.2 M vials Sample shipping: 30,000 shipping events Cancer cell biology Mass cytometry projects: 10 Flow cytometry projects, including cell sorts, cell line/organoid analysis : ~13,000 Cell sort projects: 300 cGMP production of clinical materials, including validation assays Vaccine production projects: ~15, up to 100K vials. Combination of broadly neutralizng mAbs, plasmid DNA, recombinant glycoproteins, antigen presenting nanoparticles
Recombinant protein and antibody projcts: 10 projects (200-10,000 vials, 200L bioreactor/fermenter scale, 100 mg – 1 kg deliverable) Viral vectors: 12 (each avg 500 vials, 10e15 vp deliverable) Individual Cell Therapies: 80 (each avg 2 x 50 mL doses, 10e8 cells/dose) Chemistry Small scale synthesis projects (~25 mg scale): 750 Larger scale synthesis projects (gram scale): 15
| Clinical studies support | 600 active clinical trial protocols (50/50 US and ex-US); ~50 sites domestic and ex-US | |
| No. INDs: 45 | Most ex-US trials are run by NIAID in Africa. | |
| Drug discovery and development | In vitro screening projects: 80 |
Toxicology studies: 60 Pharmacokinetic (PK) studies: 25 Patient Derived Xenograftr drug studies: 160 Xenograft drug studies (efficacy, PK/PD, tumor targeting): 80
| Imaging | In vivo tumor imaging projects: 200 |
| IT services | Maintain 500+ biomedical databases to support multiple scientific projects. |
Maintain 100+ biomedical annotation databases used by multiple FNL/NCI projects.
Maintain 30 databases to support ERP, Purchase Support Request Systems, FNL and NCI websites, electronic lab notebooks, and custom applications.
Websites supported: >50 Molecular biology Low and high-throughput gneotyping assays: ~ 80K assays (animal sciences facility) Samples studied with NGS and single cell sequencing platforms, specialized genomics applications and technologies, spatial genomics and in situ sequencing technologies: 32,000 Small-scale protein production projects: 75 (ug --> mg) Large scale protein production project: 50 (10s mg) Molecular cloning projects associated with protein expression: 150 DNA extractions: >2000
| Nanotechnology | 2 formulation projects, including physical characterization and pharmacokinetics. |
| Omics | Number of projects encompassing the following activities ≈ 800 |
- Identification of proteins and post-translational modifications
- Post-translational modification (PTM) studies using established methods
- Protein-protein and protein-DNA/RNA/peptide interactions
- Large scale proteomics (including PTM) and analytical separation projects involving mass spectrometry analysis
- Surface plasmon resonance studies
- Targeted metabolite analysis using established assays
- New targeted metabolite assays developed followed by sample analysis Pathology (preclinical & clinical) H&E staining slides: 22,000 Immunohistochemistry slides: 9,000 Necropsies: 900 Laser capture microdissections: 1,100
| Repositories | Main Repository: 18.5 million samples. Anticipated to grow to 56 million over next 20 years. |
| Structural biology | Cryo-Electron Microscopy: 350 data collections |
SEM & TEM (non-cryo): 20 data collections
| Virology | |
| Develop virus like particles for 9 HPV subtypes; 2-3 subtypes/yr | Viral DNA/RNA quantitation and serology assays included under Assay Development & Execution and Molecular Biology. |
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